公开(公告)号：US20230053254A1

公开(公告)日：2023-02-16

申请号：US17401716

申请日：2021-08-13

Applicant: Medtronic MiniMed, Inc.

Inventor： Chi-En Lin ,  Akhil Srinivasan ,  David L. Probst ,  Melissa Tsang ,  Mohsen Askarinya ,  Riley Clayton Kimball ,  Robert McKinlay ,  Vu Nguyen ,  Wally Dong ,  Xin Heng ,  Brennan Toshner

IPC: A61B5/1468 ,  A61B5/145

Abstract: A method of testing one or more analyte sensors each comprising a first electrode; a second electrode; and a material layer disposed on or above the first electrode; the method including (a) applying a voltage potential to the first electrode with respect to the second electrode; (b) measuring a test signal comprising an output current from the first electrode that results from the application of the voltage potential; (c) using the test signal from (b) to observe an electrical characteristic of the analyte sensor; and (d) correlating the electrical characteristic a parameter associated with an electrochemical response of the analyte sensor to an analyte, wherein the testing is under dry conditions without exposure of the electrodes to a fluid containing the analyte or an in-vivo environment containing the analyte.

公开(公告)号：US10543288B2

公开(公告)日：2020-01-28

申请号：US15581416

申请日：2017-04-28

Applicant: Medtronic MiniMed, Inc.

Inventor： Tri T. Dang ,  Soren Aasmul ,  Jesper Svenning Kristensen ,  Joseph Hanna ,  Robert McKinlay

IPC: A61K49/00

Abstract: The invention is directed to a competitive glucose binding affinity assay comprising a glucose receptor (typically mannan binding lectin) labeled with an assay fluorophore and a modified glucose analog (typically dextran) labeled with a reference fluorophore. In certain embodiments, the glucose analog is dextran and is coupled to both a reference fluorophore and a quencher dye (e.g. hexamethoxy crystalviolet-1). Optionally the reference fluorophore is blue shifted relative to the assay fluorophore.

公开(公告)号：US11186859B2

公开(公告)日：2021-11-30

申请号：US15891264

申请日：2018-02-07

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Robert McKinlay ,  Tri T. Dang

IPC: G01N27/327 ,  C12Q1/00 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/00

Abstract: Embodiments of the invention provide multilayer analyte sensors having material layers (e.g. high-density amine layers) and/or configurations of material layers that function to enhance sensor function, as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

公开(公告)号：US20210189450A1

公开(公告)日：2021-06-24

申请号：US16725957

申请日：2019-12-23

Applicant: Medtronic MiniMed, Inc.

Inventor： Robert McKinlay ,  Chi-En Lin ,  Tri T. Dang

IPC: C12Q1/00 ,  C12Q1/32 ,  A61L2/20 ,  A61L2/232

Abstract: An analyte biosensor is provided having an analyte biosensing layer and an ethylene oxide absorption layer. The ethylene oxide absorption layer is provided over the analyte biosensing layer. A method is also provided.

公开(公告)号：US20220073961A1

公开(公告)日：2022-03-10

申请号：US17528496

申请日：2021-11-17

Applicant: Medtronic MiniMed, Inc.

Inventor： Robert McKinlay ,  Tri T. Dang

IPC: C12Q1/00 ,  A61B5/1486 ,  A61B5/145 ,  G01N27/327 ,  A61B5/00

Abstract: Embodiments of the invention provide multilayer analyte sensors having material layers (e.g. high-density amine layers) and/or configurations of material layers that function to enhance sensor function, as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

公开(公告)号：US20200171173A1

公开(公告)日：2020-06-04

申请号：US16720299

申请日：2019-12-19

Applicant: Medtronic MIniMed, Inc.

Inventor： Tri T. Dang ,  Soren Aasmul ,  Jesper Svenning Kristensen ,  Joseph Hanna ,  Robert McKinlay

IPC: A61K49/00 ,  G01N33/66 ,  C08B37/02 ,  G01N33/542 ,  C08L5/02

Abstract: The invention is directed to a competitive glucose binding affinity assay comprising a glucose receptor (typically mannan binding lectin) labeled with an assay fluorophore and a modified glucose analog (typically dextran) labeled with a reference fluorophore. In certain embodiments, the glucose analog is dextran and is coupled to both a reference fluorophore and a quencher dye (e.g. hexamethoxy crystalviolet-1). Optionally the reference fluorophore is blue shifted relative to the assay fluorophore.

公开(公告)号：US20180311382A1

公开(公告)日：2018-11-01

申请号：US15581416

申请日：2017-04-28

Applicant: Medtronic MiniMed, Inc.

Inventor： Tri T. Dang ,  Soren Aasmul ,  Jesper Svenning Kristensen ,  Joseph Hanna ,  Robert McKinlay

IPC: A61K49/00

Abstract: The invention is directed to a competitive glucose binding affinity assay comprising a glucose receptor (typically mannan binding lectin) labeled with an assay fluorophore and a modified glucose analog (typically dextran) labeled with a reference fluorophore. In certain embodiments, the glucose analog is dextran and is coupled to both a reference fluorophore and a quencher dye (e.g. hexamethoxy crystalviolet-1). Optionally the reference fluorophore is blue shifted relative to the assay fluorophore.

公开(公告)号：US20240060111A1

公开(公告)日：2024-02-22

申请号：US18500708

申请日：2023-11-02

Applicant: Medtronic MiniMed, Inc.

Inventor： Robert McKinlay ,  Chi-En Lin ,  Tri T. Dang

IPC: C12Q1/00 ,  A61L2/20 ,  A61L2/232 ,  C12Q1/32

CPC classification number: C12Q1/006 ,  A61L2/206 ,  A61L2/232 ,  C12Q1/32

Abstract: An analyte biosensor is provided having an analyte biosensing layer and an ethylene oxide absorption layer. The ethylene oxide absorption layer is provided over the analyte biosensing layer. A method is also provided.

公开(公告)号：US11859231B2

公开(公告)日：2024-01-02

申请号：US17528496

申请日：2021-11-17

Applicant: Medtronic MiniMed, Inc.

Inventor： Robert McKinlay ,  Tri T. Dang

IPC: C12Q1/00 ,  G01N27/327 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/00

CPC classification number: C12Q1/006 ,  A61B5/1486 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/6849 ,  G01N27/3271 ,  A61B5/1451 ,  A61B2562/12 ,  G01N27/3272

Abstract: Embodiments of the invention provide multilayer analyte sensors having material layers (e.g. high-density amine layers) and/or configurations of material layers that function to enhance sensor function, as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

公开(公告)号：US11821022B2

公开(公告)日：2023-11-21

申请号：US16725957

申请日：2019-12-23

Applicant: Medtronic MiniMed, Inc.

Inventor： Robert McKinlay ,  Chi-En Lin ,  Tri T. Dang

IPC: C12Q1/00 ,  A61L2/20 ,  A61L2/232 ,  C12Q1/32

CPC classification number: C12Q1/006 ,  A61L2/206 ,  A61L2/232 ,  C12Q1/32

Abstract: An analyte biosensor is provided having an analyte biosensing layer and an ethylene oxide absorption layer. The ethylene oxide absorption layer is provided over the analyte biosensing layer. A method is also provided.