公开(公告)号：US12064236B2

公开(公告)日：2024-08-20

申请号：US16898941

申请日：2020-06-11

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Soroush Hossein Yazdi ,  Melissa Tsang ,  Ellis Garai ,  Sadaf S. Seleh ,  Steven Lai ,  Luis A. Torres ,  Bradley Petkus ,  Xin Heng ,  Zhenzhong Sun ,  Akhil Srinivasan ,  Tyler R. Wong

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1486 ,  G16H20/10

CPC classification number: A61B5/14532 ,  A61B5/1486 ,  A61B5/4848 ,  A61B5/7203 ,  G16H20/10

Abstract: Methods, systems, and devices for continuous glucose monitoring. More particularly, the methods, systems, and devices describe a working electrode with a GOx sensor and a background electrode in which the background electrode has no GOx sensor. The system may then compare the first signal and the second signal to detect ingestion of a medication by the user. The system may generate a sensor glucose value based on the comparison.

公开(公告)号：US20230053254A1

公开(公告)日：2023-02-16

申请号：US17401716

申请日：2021-08-13

Applicant: Medtronic MiniMed, Inc.

Inventor： Chi-En Lin ,  Akhil Srinivasan ,  David L. Probst ,  Melissa Tsang ,  Mohsen Askarinya ,  Riley Clayton Kimball ,  Robert McKinlay ,  Vu Nguyen ,  Wally Dong ,  Xin Heng ,  Brennan Toshner

IPC: A61B5/1468 ,  A61B5/145

Abstract: A method of testing one or more analyte sensors each comprising a first electrode; a second electrode; and a material layer disposed on or above the first electrode; the method including (a) applying a voltage potential to the first electrode with respect to the second electrode; (b) measuring a test signal comprising an output current from the first electrode that results from the application of the voltage potential; (c) using the test signal from (b) to observe an electrical characteristic of the analyte sensor; and (d) correlating the electrical characteristic a parameter associated with an electrochemical response of the analyte sensor to an analyte, wherein the testing is under dry conditions without exposure of the electrodes to a fluid containing the analyte or an in-vivo environment containing the analyte.

公开(公告)号：US20240398290A1

公开(公告)日：2024-12-05

申请号：US18802086

申请日：2024-08-13

Applicant: Medtronic MiniMed, Inc.

Inventor： Soroush Hossein Yazdi ,  Melissa Tsang ,  Ellis Garai ,  Sadaf S. Seleh ,  Steven Lai ,  Luis A. Torres ,  Bradley Petkus ,  Xin Heng ,  Zhenzhong Sun ,  Akhil Srinivasan ,  Tyler R. Wong

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1486 ,  G16H20/10

Abstract: Methods, systems, and devices for continuous glucose monitoring. More particularly, the methods, systems, and devices describe a working electrode with a GOx sensor and a background electrode in which the background electrode has no GOx sensor. The system may then compare the first signal and the second signal to detect ingestion of a medication by the user. The system may generate a sensor glucose value based on the comparison.

公开(公告)号：US20230123613A1

公开(公告)日：2023-04-20

申请号：US17501292

申请日：2021-10-14

Applicant: Medtronic MiniMed, Inc.

Inventor： Ashwin K. Rao ,  Quyen B. Ong ,  Michael E. Miller ,  Sarnath Chattaraj ,  Guangping Zhang ,  Poonam Gulati ,  Ariel Reider ,  Mohsen Askarinya ,  Michael N. Missaghi ,  Chi-En Lin ,  Xin Heng ,  Inthirai Somasuntharam ,  Melissa Tsang ,  Carlos E. Maldonado ,  Akhil Srinivasan

IPC: G01N27/327 ,  C12N9/04 ,  C12Q1/00 ,  G01N33/49

Abstract: The invention provides amperometric analyte sensor systems comprising one or more electrodes designed to monitor in vivo levels of 3-hydroxybutyrate (and optionally glucose as well) in order to facilitate the management of diabetic ketoacidosis. The invention further includes compositions, elements and methods useful with such amperometric analyte sensor systems.

公开(公告)号：US20230055521A1

公开(公告)日：2023-02-23

申请号：US17979204

申请日：2022-11-02

Applicant: Medtronic MiniMed, Inc.

Inventor： Zhenzhong Sun ,  Xin Heng ,  Rui Kong

IPC: A61B5/145 ,  A61B5/1486

Abstract: An electrochemical sensor including a working electrode having an arrangement of pillars defining channels between the pillars. The channels increase confinement of a byproduct produced in an electrochemical reaction used during sensing of an analyte, so as to increase interaction of the byproduct with the working electrode. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.

公开(公告)号：US11523757B2

公开(公告)日：2022-12-13

申请号：US16528813

申请日：2019-08-01

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Zhenzhong Sun ,  Xin Heng ,  Rui Kong

IPC: A61B5/145 ,  A61B5/1486

Abstract: An electrochemical sensor including a working electrode having an arrangement of pillars defining channels between the pillars. The channels increase confinement of a byproduct produced in an electrochemical reaction used during sensing of an analyte, so as to increase interaction of the byproduct with the working electrode. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.

公开(公告)号：US20210030322A1

公开(公告)日：2021-02-04

申请号：US16528813

申请日：2019-08-01

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Zhenzhong Sun ,  Xin Heng ,  Rui Kong

IPC: A61B5/145 ,  A61B5/1486

Abstract: An electrochemical sensor including a working electrode having an arrangement of pillars defining channels between the pillars. The channels increase confinement of a byproduct produced in an electrochemical reaction used during sensing of an analyte, so as to increase interaction of the byproduct with the working electrode. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.

公开(公告)号：US20250116625A1

公开(公告)日：2025-04-10

申请号：US18605190

申请日：2024-03-14

Applicant: Medtronic MiniMed, Inc.

Inventor： Robert M. McKinlay ,  Quyen B. Ong ,  Xin Heng ,  Weihong Cui

IPC: G01N27/327 ,  G01N27/02

Abstract: An analyte sensor includes a microcontroller, a base layer, a conductive layer disposed on the base layer where the conductive layer includes a working electrode configured to provide a current signal in presence of glucose, an interference rejection membrane (“IRM”) layer disposed on the working electrode where the IRM layer is negatively charged, and an enzyme layer disposed on the IRM layer where the enzyme layer includes an enzyme selected to generate a detectable electrical signal upon exposure to the glucose. The microcontroller is configured to process an electrochemical impedance spectroscopy (EIS) parameter to determine a state of the IRM layer.