公开(公告)号：US20230277323A1

公开(公告)日：2023-09-07

申请号：US18197311

申请日：2023-05-15

申请人： NANOHIVE MEDICAL LLC

发明人： Christopher Laine ,  Ian Helmar ,  Lucas Diehl ,  Jason Tinley ,  Kevin D. Chappuis ,  John F. Sullivan

IPC分类号： A61F2/30 ,  A61C13/00 ,  A61C8/00 ,  B33Y80/00 ,  A61F2/44 ,  A61F2/28 ,  A61L27/50 ,  A61L27/56

CPC分类号： A61F2/3094 ,  A61C13/0019 ,  A61C8/0013 ,  B33Y80/00 ,  A61F2/4455 ,  A61F2/28 ,  A61F2/30771 ,  A61F2/30942 ,  A61F2/44 ,  A61F2/2846 ,  A61F2/30907 ,  A61L27/505 ,  A61L27/56 ,  A61F2240/001 ,  A61F2/30767 ,  B29C64/165

摘要： The methods disclosed herein of generating three-dimensional lattice structures and reducing stress shielding have applications including use in medical implants. One method of generating a three-dimensional lattice structure can be used to generate a structure lattice and/or a lattice scaffold to support bone or tissue growth. One method of reducing stress shielding includes generating a structural lattice to provide sole mechanical spacing across an area for desired bone or tissue growth. Some examples can use a repeating modified rhombic dodecahedron or radial dodeca-rhombus unit cell. Some methods are also capable of providing a lattice structure with anisotropic properties to better suit the lattice for its intended purpose.

公开(公告)号：US11672885B2

公开(公告)日：2023-06-13

申请号：US15992996

申请日：2018-05-30

申请人： Abyrx, Inc.

发明人： Richard Kronenthal ,  John Pacifico ,  Aniq Darr

IPC分类号： A61L27/36 ,  A61L24/00 ,  A61L27/02 ,  A61L27/10 ,  A61L27/12 ,  A61L27/18 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  C08L33/12 ,  C08L33/14 ,  C08L71/02 ,  C08L75/04

CPC分类号： A61L27/3691 ,  A61L24/0005 ,  A61L27/025 ,  A61L27/10 ,  A61L27/12 ,  A61L27/18 ,  A61L27/3616 ,  A61L27/3687 ,  A61L27/505 ,  A61L27/54 ,  A61L27/58 ,  C08L33/12 ,  C08L33/14 ,  C08L71/02 ,  C08L75/04 ,  A61L2400/04 ,  C08L2203/02

摘要： Provided herein are settable and non-settable compositions for use in surgical procedures comprising a variety of disclosed particles and optionally including previously unclotted, lyophilized, optionally crosslinked mammalian blood plasma. Also provided are related compositions, including surgical kits and packages, as well as methods of making and using the compositions.

公开(公告)号：US20190218355A1

公开(公告)日：2019-07-18

申请号：US16275466

申请日：2019-02-14

申请人： Aesculap AG

发明人： Marie Anne Mulliez ,  Gerhard Reu

IPC分类号： C08J7/12 ,  G01V5/10 ,  B27N3/08

CPC分类号： C08J7/123 ,  A61L27/16 ,  A61L27/505 ,  A61L2430/24 ,  B27N3/08 ,  B29C59/14 ,  B29C59/16 ,  C08J3/24 ,  C08J2323/06 ,  C08K5/1545 ,  G01V5/104 ,  C08L23/06

摘要： The present invention relates to a method for producing a cross-linked moulded body from UHMWPE, comprising the steps of: providing a moulded body from UHMWPE which is added with an antioxidant; heating the moulded body to a temperature of 100° C. or more; and irradiating the moulded body in order to cross-link the UHMWPE in the moulded body. The irradiation of the moulded body is carried out with x-ray radiation. The invention also relates to a method for producing an implant or an implant part, in particular an inlay for an artificial hip joint, comprising the performance of the above method and the machining of the cross-linked moulded body.

公开(公告)号：US20180207315A1

公开(公告)日：2018-07-26

申请号：US15883970

申请日：2018-01-30

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： Ebru Oral ,  Chhavi Gupta ,  Orhun Muratoglu

IPC分类号： A61L27/16 ,  C08K5/1545 ,  A61L17/04 ,  A61L17/14 ,  A61L27/50 ,  A61L29/04 ,  A61L29/14 ,  A61L31/04 ,  A61L31/14 ,  B29C43/52 ,  A61F2/30 ,  C08J3/28 ,  C08J3/20 ,  B29C45/72 ,  B29C35/08 ,  C08K9/08 ,  C08F10/02 ,  B29C35/16 ,  B29L31/00

CPC分类号： A61L27/16 ,  A61F2/30 ,  A61F2/3094 ,  A61L17/04 ,  A61L17/14 ,  A61L27/50 ,  A61L27/505 ,  A61L29/041 ,  A61L29/14 ,  A61L31/048 ,  A61L31/14 ,  A61L2430/24 ,  B29C35/16 ,  B29C43/52 ,  B29C45/7207 ,  B29C71/0009 ,  B29C71/02 ,  B29C71/04 ,  B29C2035/0827 ,  B29C2035/0844 ,  B29C2035/085 ,  B29C2035/0877 ,  B29C2071/0027 ,  B29C2071/022 ,  B29L2031/00 ,  C08F10/02 ,  C08J3/203 ,  C08J3/28 ,  C08K5/1545 ,  C08K9/08 ,  C08L23/06

摘要： Provided is a method of making a polymeric material with a spatially controlled distribution of one or more additives including the steps of blending the one or more additives with a polymeric material, consolidating the polymeric material, heating at least a portion of at least one surface of the consolidated additive-blended polymeric material, and cooling the heated consolidated additive-blended polymeric material, thereby forming a polymeric material with a spatially controlled distribution of additive.

公开(公告)号：US09901663B2

公开(公告)日：2018-02-27

申请号：US14267620

申请日：2014-05-01

申请人： Abbott Cardiovascular Systems Inc.

发明人： Stephen D. Pacetti ,  Ni Ding

IPC分类号： A61F2/82 ,  A61L31/14 ,  A61L31/02 ,  A61L31/16 ,  B65B3/00 ,  A61L27/50 ,  A61L27/54

CPC分类号： A61L31/16 ,  A61F2/82 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L27/50 ,  A61L27/505 ,  A61L27/54 ,  A61L31/022 ,  A61L31/143 ,  A61L2300/00 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/604 ,  A61L2300/802 ,  B65B3/003 ,  Y10T29/49993

摘要： A composition for loading into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition may comprise a therapeutic agent, and a chelator, a precipitation agent, or a combination thereof. Medical devices, such as stents, with a structural element defined by a lumen and at least one opening to access the lumen, filled with the compositions are also described.

公开(公告)号：US20170304501A1

公开(公告)日：2017-10-26

申请号：US15510235

申请日：2015-10-21

申请人： BIOTRONIK SE & CO. KG ,  ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

发明人： Andreas Bunge ,  Michael Bergmann ,  Loic Ledernez ,  Josef Horak ,  Gerald Urban

IPC分类号： A61L27/44 ,  A61L27/30 ,  A61L27/36 ,  A61L27/50

CPC分类号： A61L27/44 ,  A61L27/303 ,  A61L27/34 ,  A61L27/3616 ,  A61L27/446 ,  A61L27/505 ,  A61L27/507 ,  A61L27/54 ,  A61L27/56 ,  A61L31/10 ,  A61L31/125 ,  A61L31/128 ,  A61L31/143 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/102 ,  A61L2300/406 ,  A61L2300/606 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2420/02

摘要： A method for treating a medical implant uses plasma polymerization to apply a coating At least one treatment parameter is selected so that the reactive chemical groups of the coating are chemically modified to prevent an adsorption of interfering substances into the coating. An implant includes a plasma polymer coating that is biocompatible, and includes a antibiotically acting metal. The coating is free from aldehyde groups

公开(公告)号：US09795714B2

公开(公告)日：2017-10-24

申请号：US15105710

申请日：2014-12-23

申请人： ARES TRADING S.A.

发明人： Fabiana Canal ,  Caterina Lo Presti

IPC分类号： A61L27/52 ,  A61L27/26 ,  A61L27/24 ,  A61L27/50 ,  A61L27/54 ,  A61L27/20 ,  C07K14/50 ,  C07K14/78 ,  A61K31/734 ,  A61K38/39

CPC分类号： A61L27/52 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  A61L27/505 ,  A61L27/54 ,  A61L2300/414 ,  A61L2400/06 ,  A61L2430/06 ,  C08L89/06 ,  C08L5/04

摘要： The invention relates to the field of pharmaceutical formulations. More particularly, it is directed to homogeneous hydrogels comprising Fibroblast Growth Factor 18 (FGF-18) compound and to methods of producing such hydrogels. The hydrogels of the invention can be used, once formed in situ, for the treatment of cartilage disorders such as osteoarthritis or cartilage injury.

公开(公告)号：US20170296709A1

公开(公告)日：2017-10-19

申请号：US15512740

申请日：2015-10-21

申请人： BIOTRONIK SE & CO. KG ,  ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

发明人： Andreas BUNGE ,  Michael Bergmann ,  Loic Ledernez ,  Alexander Borck ,  Gerald Urban

IPC分类号： A61L31/10 ,  A61L27/44 ,  A61L27/50 ,  A61L31/12 ,  A61L27/56 ,  A61L31/16 ,  A61L27/34 ,  A61L31/14 ,  A61L27/54

CPC分类号： A61L27/44 ,  A61L27/303 ,  A61L27/34 ,  A61L27/3616 ,  A61L27/446 ,  A61L27/505 ,  A61L27/507 ,  A61L27/54 ,  A61L27/56 ,  A61L31/10 ,  A61L31/125 ,  A61L31/128 ,  A61L31/143 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/102 ,  A61L2300/406 ,  A61L2300/606 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2420/02

摘要： A method for coating a medical implant applies at least one coating to at least one surface of the implant by plasma polymerization. The implant has pores sized in the nanometer range. The method stabilizes the pores. The plasma polymerization is conducted in the presence of a coating gas and oxygen. A coating parameter can be selected so that a rough surface of the implant is coated. An implant includes a membrane having pores sized in the nanometer range. A surface of the implant is at least partially coated with a plasma polymer. The interior of the pores is uncoated.

公开(公告)号：US09731047B2

公开(公告)日：2017-08-15

申请号：US14584519

申请日：2014-12-29

申请人： The General Hospital Corporation

发明人： Ebru Oral ,  Orhun K. Muratoglu

IPC分类号： C08F2/46 ,  C08G61/04 ,  A61L27/50 ,  C08J3/20 ,  C08J3/24 ,  C08J3/28 ,  B65B55/08 ,  B65B55/10 ,  B65B55/16 ,  B65B55/18 ,  A61L27/16 ,  A61L29/04 ,  A61L29/14 ,  A61L31/04 ,  A61L31/14 ,  C08K5/134

CPC分类号： A61L27/50 ,  A61L27/16 ,  A61L27/505 ,  A61L29/041 ,  A61L29/14 ,  A61L29/143 ,  A61L31/048 ,  A61L31/14 ,  A61L31/143 ,  B65B55/08 ,  B65B55/10 ,  B65B55/16 ,  B65B55/18 ,  C08J3/203 ,  C08J3/247 ,  C08J3/28 ,  C08J2323/06 ,  C08K5/134 ,  C08L23/06

摘要： The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided.

公开(公告)号：US09688004B2

公开(公告)日：2017-06-27

申请号：US14287723

申请日：2014-05-27

申请人： Orhun K. Muratoglu ,  Stephen H. Spiegelberg

发明人： Orhun K. Muratoglu ,  Stephen H. Spiegelberg

IPC分类号： B29C35/08 ,  A61L27/16 ,  A61L27/50 ,  B29C43/00 ,  C08K5/00 ,  C08K5/1545 ,  A61L29/04 ,  A61L29/14 ,  A61L31/04 ,  A61L31/14 ,  C08J3/28 ,  C08L23/06

CPC分类号： B29C35/0805 ,  A61L27/16 ,  A61L27/505 ,  A61L29/041 ,  A61L29/143 ,  A61L31/048 ,  A61L31/143 ,  B29C43/003 ,  C08J3/28 ,  C08K5/005 ,  C08K5/1545 ,  C08L23/06 ,  C08L2312/06 ,  Y10T29/49 ,  Y10T29/49995 ,  Y10T428/31855

摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.