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1.发明申请Method of tailoring infant formulas to individual nutritional needs prior to use 审中-公开使用前将婴儿配方奶粉定制为个人营养需求的方法公开(公告)号：US20070243290A1
公开(公告)日：2007-10-18
申请号：US11406091
申请日：2006-04-18
IPC分类号： A23L1/30
CPC分类号： A23L33/16 , A23L33/10 , A23L33/15 , A23L33/30 , A23L33/40 , A23V2002/00 , A23V2250/1578 , A23V2250/1642 , A23V2250/1588 , A23V2250/1614 , A23V2250/702 , A23V2250/71 , A23V2250/7056 , A23V2250/7046 , A23V2250/705 , A23V2250/706 , A23V2250/708
摘要： Disclosed is a method of tailoring infant formulas to individual nutrition needs prior to use. The method comprises (A) determining the desired volume and optimal caloric density of a formula to be fed to a preterm or low birth weight infant; (B) obtaining a plurality of base infant formulas, all in liquid form, comprising fat, protein, carbohydrate, vitamins, and minerals, each of which has an osmolality of from about 200 to about 360 mOsm/kg water and a different caloric density within a range of from about 609 to about 1082 kcal/L; (C) selecting two of the base liquid formulas having a caloric density value above and below the optimal caloric density, (D) calculating the volume of each selected base formula needed to produce the desired volume of an infant formula blend having the optimal caloric density; (E) combining the calculated volumes to produce a an isotonic blend having the desired feeding volume and optimal caloric density. The formula is then fed to the preterm or low birth weight infant. Also disclosed is a hypercaloric infant formula suitable for use in the disclosed method, and infant formula kits comprising the plurality of base formulas and a device (e.g. calculator, computer program, chart with precalculated blend volumes) for calculating blend volumes.
摘要翻译： 公开了一种在使用前将婴儿配方调配到个体营养需求的方法。 该方法包括（A）确定要喂给早产或低出生体重婴儿的配方的期望体积和最佳热量密度; （B）获得多种液体形式的基础婴儿配方食品，包括脂肪，蛋白质，碳水化合物，维生素和矿物质，其各自具有约200至约360mOsm / kg水的重量摩尔渗透压浓度和不同的热量密度 在约609至约1082kcal / L的范围内; （C）选择具有高于和低于最佳热量密度的热量密度值的两种基础液体配方，（D）计算产生具有最佳热量密度的婴儿配方配方所需体积所需的每种所选碱基配方的体积 ; （E）组合计算的体积以产生具有所需进料体积和最佳热量密度的等渗混合物。 然后将该配方喂给早产或低出生体重的婴儿。 还公开了适用于所公开的方法的超热量婴儿配方食品，以及包含多种基础配方的婴儿配方药盒和用于计算混合体积的装置（例如计算器，计算机程序，具有预先计算的混合物体积的图表）。
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公开(公告)号：US20060204632A1
公开(公告)日：2006-09-14
申请号：US11370610
申请日：2006-03-08
IPC分类号： A23C9/154
CPC分类号： A23C9/206 , A23L33/18 , A23L33/185 , A23L33/19 , A23L33/40 , A23V2002/00 , A23V2250/1578 , A23V2250/1642 , A23V2250/1592 , A23V2250/1588 , A23V2250/1612 , A23V2250/1626 , A23V2250/1598 , A23V2250/702 , A23V2250/704 , A23V2250/71 , A23V2250/712 , A23V2250/714 , A23V2250/628 , A23V2250/54252 , A23V2250/5424 , A23V2250/1944 , A23V2250/1868 , A23V2250/1842 , A23V2250/1862 , A23V2250/70 , A23V2250/0644 , A23V2250/641 , A23V2250/54246
摘要： Disclosed are concentrated, liquid, human milk fortifier compositions comprising from about 15% to about 45% by weight of protein, on a dry weight basis, and having a caloric density of from about 1.25 kcauml to about 6.0 kcau/ml, wherein the liquid human milk fortifier composition is added to human milk in a volume-volume ratio of from about 1:3 to about 1:9. These composition include embodiments comprising carbohydrate and fat, that are formulated with improved stability by selecting any one of the following variations: 1) certain whey-casein protein blends, 2) water insoluble calcium-containing materials, 3) protein hydrolysates, and 4) aseptically packaged concentrates. The liquid concentrates are especially useful for providing nutrition to preterm infants in neonatal intensive care units or similar other institutional setting, and to minimize the risk of introducing microbial contaminants such as Enterobacter sakazakii to infant feedings during preparation in such institutional settings.
摘要翻译： 本发明公开了浓缩液体，人乳增强剂组合物，其包含按重量计约15％至约45％重量的蛋白质，其热密度为约1.25kcal / ml至约6.0kcau / ml，其中液体 将人乳强化剂组合物以体积比体积比为约1:3至约1:9添加到人乳中。 这些组合物包括含有碳水化合物和脂肪的实施方案，通过选择以下变化之一来改进稳定性：1）某些乳清酪蛋白混合物，2）水不溶性含钙材料，3）蛋白质水解产物，和4） 无菌包装浓缩液。 液体浓缩物特别适用于为新生儿重症监护病房或类似的其他机构环境中的早产儿提供营养，并且在制备过程中尽可能减少将阪崎肠杆菌等微生物污染物引入婴儿喂养的风险。
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3.发明申请公开(公告)号：US20110213039A1
公开(公告)日：2011-09-01
申请号：US13042802
申请日：2011-03-08
CPC分类号： A23L2/66 , A23L33/10 , A23L33/115 , A23L33/17 , A23L33/40 , A23V2002/00 , G01N33/82 , G01N2800/38
摘要： Disclosed is a method of reducing the risk or severity of retinopathy of prematurity in preterm infants. The method comprises (a) measuring skin carotenoid levels in preterm infants, preferably by Raman Spectroscopy, and then (b) administering supplemental carotenoids to those infants in need thereof, wherein the supplemental carotenoids comprise lutein, lycopene, beta-carotene, and zeaxanthin. The supplemental carotenoids may be provided by an infant formula comprising, on a ready-to-feed basis, from about 100 to about 2000 mcg/liter of total carotenoids, wherein the total carotenoids include at least about 50 mcg/liter of lutein. The formulas may further comprise docosahexaenoic acid.
摘要翻译： 公开了一种降低早产儿早产儿视网膜病变风险或严重程度的方法。 该方法包括：（a）优选通过拉曼光谱法测定早产儿的皮肤类胡萝卜素水平，然后（b）向有需要的那些婴儿施用补充类胡萝卜素，其中补充的类胡萝卜素包括叶黄素，番茄红素，β-胡萝卜素和玉米黄质。 补充的类胡萝卜素可以由婴儿配方提供，其包括在即食物基础上约100至约2000mcg /升的总类胡萝卜素，其中总类胡萝卜素包括至少约50mcg /升的叶黄素。 配方还可以包含二十二碳六烯酸。
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公开(公告)号：US20060171993A1
公开(公告)日：2006-08-03
申请号：US11391798
申请日：2006-03-29
申请人： Bridget Barrett-Reis , Marc Masor
发明人： Bridget Barrett-Reis , Marc Masor
IPC分类号： A61K47/00 , A61K31/355 , A61K36/889 , A61K36/899 , A61K36/31 , A61K36/48
CPC分类号： A61K31/355 , A23L33/15 , A23L33/40 , A23V2002/00 , A61K2300/00 , A23V2200/02 , A23V2250/712
摘要： The present invention relates generally to a method of improving the antioxidant status of an infant. More particularly, the present invention relates to a method of improving the antioxidant status of an infant by administering a mixture of natural tocopherols. The natural tocopherol mixture is an effective blend of α- and γ-tocopherol. For ease of administration and improved taste, the mixture of natural tocopherols are typically delivered in vehicle which may be in the form, for example, of a tablet, capsule, liquid, and nutritional formula. The present invention also relates to a method of improving the antioxidant status of an infant by supplementing the lactating woman wherein the supplemented breast milk is fed to the infant. Additionally, the present invention relates to a method of improving the antioxidant status of a newborn infant by supplementing the pregnant woman.
摘要翻译： 本发明一般涉及改善婴儿的抗氧化状态的方法。 更具体地，本发明涉及通过施用天然生育酚的混合物来改善婴儿的抗氧化状态的方法。 天然的生育酚混合物是α-和γ-生育酚的有效混合物。 为了易于施用和改善的味道，天然生育酚的混合物通常在载体中递送，其可以是例如片剂，胶囊，液体和营养配方的形式。 本发明还涉及一种通过补充哺乳期妇女来改善婴儿的抗氧化状态的方法，其中将补充的母乳喂给婴儿。 此外，本发明涉及通过补充孕妇来改善新生儿的抗氧化状态的方法。
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公开(公告)号：US08697115B2
公开(公告)日：2014-04-15
申请号：US11391798
申请日：2006-03-29
IPC分类号： A61K47/00 , A61K31/355 , A61K36/899 , A61K36/48 , A61K36/31 , A61K36/00
CPC分类号： A61K31/355 , A23L33/15 , A23L33/40 , A23V2002/00 , A61K2300/00 , A23V2200/02 , A23V2250/712
摘要： The present invention relates generally to a method of improving the antioxidant status of an infant. More particularly, the present invention relates to a method of improving the antioxidant status of an infant by administering a mixture of natural tocopherols. The natural tocopherol mixture is an effective blend of α- and γ-tocopherol. For ease of administration and improved taste, the mixture of natural tocopherols are typically delivered in vehicle which may be in the form, for example, of a tablet, capsule, liquid, and nutritional formula. The present invention also relates to a method of improving the antioxidant status of an infant by supplementing the lactating woman wherein the supplemented breast milk is fed to the infant. Additionally, the present invention relates to a method of improving the antioxidant status of a newborn infant by supplementing the pregnant woman.
摘要翻译： 本发明一般涉及改善婴儿的抗氧化状态的方法。 更具体地，本发明涉及通过施用天然生育酚的混合物来改善婴儿的抗氧化状态的方法。 天然的生育酚混合物是α-和γ-生育酚的有效混合物。 为了易于施用和改善的味道，天然生育酚的混合物通常在载体中递送，其可以是例如片剂，胶囊，液体和营养配方的形式。 本发明还涉及一种通过补充哺乳期妇女来改善婴儿的抗氧化状态的方法，其中将补充的母乳喂给婴儿。 此外，本发明涉及通过补充孕妇来改善新生儿的抗氧化状态的方法。
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公开(公告)号：US08263147B2
公开(公告)日：2012-09-11
申请号：US13042802
申请日：2011-03-08
IPC分类号： A61K38/01
CPC分类号： A23L2/66 , A23L33/10 , A23L33/115 , A23L33/17 , A23L33/40 , A23V2002/00 , G01N33/82 , G01N2800/38
摘要： Disclosed is a method of reducing the risk or severity of retinopathy of prematurity in preterm infants. The method comprises (a) measuring skin carotenoid levels in preterm infants, preferably by Raman Spectroscopy, and then (b) administering supplemental carotenoids to those infants in need thereof, wherein the supplemental carotenoids comprise lutein, lycopene, beta-carotene, and zeaxanthin. The supplemental carotenoids may be provided by an infant formula comprising, on a ready-to-feed basis, from about 100 to about 2000 mcg/liter of total carotenoids, wherein the total carotenoids include at least about 50 mcg/liter of lutein. The formulas may further comprise docosahexaenoic acid.
摘要翻译： 公开了一种降低早产儿早产儿视网膜病变风险或严重程度的方法。 该方法包括：（a）优选通过拉曼光谱法测定早产儿的皮肤类胡萝卜素水平，然后（b）向有需要的那些婴儿施用补充类胡萝卜素，其中补充的类胡萝卜素包括叶黄素，番茄红素，β-胡萝卜素和玉米黄质。 补充的类胡萝卜素可以由婴儿配方提供，其包括在即食物基础上约100至约2000mcg /升的总类胡萝卜素，其中总类胡萝卜素包括至少约50mcg /升的叶黄素。 配方还可以包含二十二碳六烯酸。
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7.发明申请Method of reducing the risk of retinopathy of prematurity in preterm infants 审中-公开降低早产儿早产儿视网膜病变风险的方法公开(公告)号：US20070166354A1
公开(公告)日：2007-07-19
申请号：US11646671
申请日：2006-12-28
申请人： Bridget Barrett-Reis
发明人： Bridget Barrett-Reis
IPC分类号： A61K47/00 , A61K31/12 , A61K31/015 , A61B5/00
CPC分类号： A23L2/66 , A23L33/10 , A23L33/115 , A23L33/17 , A23L33/40 , A23V2002/00 , G01N33/82 , G01N2800/38
摘要： Disclosed is a method of reducing the risk or severity of retinopathy of prematurity in preterm infants. The method comprises (a) measuring skin carotenoid levels in preterm infants, preferably by Raman Spectroscopy, and then (b) administering supplemental carotenoids to those infants in need thereof, wherein the supplemental carotenoids comprise lutein, lycopene, beta-carotene, and zeaxanthin. The supplemental carotenoids may be provided by an infant formula comprising, on a ready-to-feed basis, from about 100 to about 2000 mcg/liter of total carotenoids, wherein the total carotenoids include at least about 50 mcg/liter of lutein. The formulas may further comprise docosahexaenoic acid.
摘要翻译： 公开了一种降低早产儿早产儿视网膜病变风险或严重程度的方法。 该方法包括：（a）优选通过拉曼光谱法测定早产儿的皮肤类胡萝卜素水平，然后（b）向有需要的那些婴儿施用补充的类胡萝卜素，其中补充的类胡萝卜素包括叶黄素，番茄红素，β-胡萝卜素和玉米黄质。 补充的类胡萝卜素可以由婴儿配方提供，其包括在即食物基础上约100至约2000mcg /升的总类胡萝卜素，其中总类胡萝卜素包括至少约50mcg /升的叶黄素。 该配方还可以包含二十二碳六烯酸。
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公开(公告)号：US07090862B2
公开(公告)日：2006-08-15
申请号：US10112823
申请日：2002-03-29
CPC分类号： A61K36/31 , A23L33/15 , A23L33/40 , A23V2002/00 , A61K31/355 , A61K36/185 , A61K36/28 , A61K36/286 , A61K36/48 , A61K36/52 , A61K36/889 , A61K36/899 , A61K2300/00 , A23V2250/712
摘要： The present invention relates generally to a method of improving the antioxidant status of an infant. More particularly, the present invention relates to a method of improving the antioxidant status of an infant by administering a mixture of natural tocopherols. The natural tocopherol mixture is an effective blend of α- and γ-tocopherol. For ease of administration and improved taste, the mixture of natural tocopherols are typically delivered in vehicle which may be in the form, for example, of a tablet, capsule, liquid, and nutritional formula. The present invention also relates to a method of improving the antioxidant status of an infant by supplementing the lactating woman wherein the supplemented breast milk is fed to the infant. Additionally, the present invention relates to a method of improving the antioxidant status of a newborn infant by supplementing the pregnant woman.
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9.发明授权公开(公告)号：US09049884B2
公开(公告)日：2015-06-09
申请号：US12950989
申请日：2010-11-19
申请人： Bridget Barrett-Reis
发明人： Bridget Barrett-Reis
IPC分类号： A23L1/303 , A23L1/29 , A23L1/30 , A61K31/015 , A61K31/065 , A61K31/20 , A61K31/70 , A61K45/06
CPC分类号： A23L1/303 , A23L33/105 , A23L33/155 , A23L33/40 , A23V2002/00 , A61K31/015 , A61K31/065 , A61K31/20 , A61K31/70 , A61K45/06 , A61K2300/00 , A23V2200/318 , A23V2250/213 , A23V2250/211
摘要： The present disclosure relates to preterm infant formulas comprising lutein, lycopene, and beta-carotene, and the use of the preterm infant formulas to modulate inflammation, such as skin inflammation, in preterm infants. Also disclosed are methods of modulating the level of C-reactive protein in a preterm infant using preterm infant formulas comprising mixtures of carotenoids.
摘要翻译： 本公开涉及包含叶黄素，番茄红素和β-胡萝卜素的早产婴儿配方，以及早产婴儿配方在早产儿中调节炎症如皮肤炎症的用途。 还公开了使用包含类胡萝卜素混合物的早产婴儿配方来调节早产儿中C反应蛋白水平的方法。
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10.发明申请公开(公告)号：US20110136734A1
公开(公告)日：2011-06-09
申请号：US12950989
申请日：2010-11-19
申请人： Bridget Barrett-Reis
发明人： Bridget Barrett-Reis
CPC分类号： A23L1/303 , A23L33/105 , A23L33/155 , A23L33/40 , A23V2002/00 , A61K31/015 , A61K31/065 , A61K31/20 , A61K31/70 , A61K45/06 , A61K2300/00 , A23V2200/318 , A23V2250/213 , A23V2250/211
摘要： The present disclosure relates to preterm infant formulas comprising lutein, lycopene, and beta-carotene, and the use of the preterm infant formulas to modulate inflammation, such as skin inflammation, in preterm infants. Also disclosed are methods of modulating the level of C-reactive protein in a preterm infant using preterm infant formulas comprising mixtures of carotenoids.
摘要翻译： 本公开涉及包含叶黄素，番茄红素和β-胡萝卜素的早产婴儿配方，以及早产婴儿配方在早产儿中调节炎症如皮肤炎症的用途。 还公开了使用包含类胡萝卜素混合物的早产婴儿配方来调节早产儿中C反应蛋白水平的方法。
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