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1.发明授权Means and method for field asymmetric ion mobility spectrometry combined with mass spectrometry 有权用于场非对称离子迁移光谱法与质谱联用的方法和方法公开(公告)号：US08399830B2
公开(公告)日：2013-03-19
申请号：US13115424
申请日：2011-05-25
CPC分类号： G01N27/624 , H01J49/0404 , Y10T29/49826
摘要： Analyte ions are analyzed first by field asymmetric ion mobility spectrometry (FAIMS) before being analyzed by a mass analyzer. Analyte ions are produced at near atmospheric pressure and transferred via a dielectric capillary into the vacuum system of the mass analyzer. While passing through the capillary, the ions are analyzed by FAIMS via electrodes on the interior wall of the capillary. Improved ion transmission is achieved by providing smooth geometric transitions between the channel in FAIMS analyzer and the channel in the remainder of the capillary.
摘要翻译： 首先通过场不对称离子迁移谱（FAIMS）分析分析离子，然后通过质谱仪进行分析。 分析离子在接近大气压下产生，并通过介电毛细管转移到质量分析仪的真空系统中。 当通过毛细管时，通过FAIMS通过毛细管内壁上的电极分析离子。 通过在FAIMS分析仪中的通道和毛细管剩余部分中的通道之间提供平滑的几何过渡来实现改进的离子透过。
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2.发明授权Selective ion mobility spectrometer formed from two consecutive mass selective filters 有权由两个连续质量选择滤光片形成的选择性离子迁移谱仪公开(公告)号：US08941054B2
公开(公告)日：2015-01-27
申请号：US13094128
申请日：2011-04-26
CPC分类号： H01J49/06 , G01N27/622 , G01N27/624
摘要： Ions with a predetermined range of ion mobilities are produced by filtering input ions with at least two consecutive ion mobility high pass and/or low pass filters. Each ion mobility filter is formed by entraining ions in a moving gas and applying a DC electric field to the ions which causes the ions to move in a direction opposite to the gas flow. An ion mobility high pass filter is formed when the DC electric field drives the ions against the flow of gas, whereas an ion mobility low pass filter is formed when a the gas flow drives entrained ions against an DC electric field barrier.
摘要翻译： 具有预定范围的离子迁移率的离子通过用至少两个连续的离子迁移率高通和/或低通滤波器过滤输入离子而产生。 每个离子迁移率过滤器是通过夹杂在移动气体中的离子形成的，并且对离子施加直流电场，这导致离子沿与气流相反的方向移动。 当DC电场驱动离子抵抗气体流时，形成离子迁移率高通滤波器，而当气流驱动夹带的离子抵抗DC电场屏障时，形成离子迁移率低通滤波器。
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3.发明授权Spectrum acquisition modes for ion mobility spectrometers using trapped ions 有权使用捕获离子的离子迁移谱仪的光谱采集模式公开(公告)号：US08766176B2
公开(公告)日：2014-07-01
申请号：US13094102
申请日：2011-04-26
IPC分类号： H01J49/26
CPC分类号： G01N27/626
摘要： In an ion mobility spectrometer in which a gas flows through a gas-tight tube with a radially quadrupolar RF field therein and blows ions against a DC electric field barrier, a mobility scan with a mobility scale that is linear in time is obtained by holding the height of the DC electric field barrier constant while changing the pressure and temperature conditions of the flowing gas. Alternatively, the mobility scan is performed by holding the pressure and temperature conditions of the flowing gas constant and reducing the height of the DC electric field barrier non-linearly with respect to time.
摘要翻译： 在离子迁移谱仪中，气体通过其中具有径向四极RF场的气密管流动，并将离子吹向DC电场势垒，通过保持 直流电场势垒的高度在改变流动气体的压力和温度条件的同时。 或者，通过保持流动气体的压力和温度条件恒定并且相对于时间非线性地降低DC电场屏障的高度来执行移动扫描。
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4.发明申请Spectrum Acquisition Modes For Ion Mobility Spectrometers Using Trapped Ions 有权离子迁移率光谱仪使用捕获离子的光谱采集模式公开(公告)号：US20120273670A1
公开(公告)日：2012-11-01
申请号：US13094102
申请日：2011-04-26
IPC分类号： H01J49/26
CPC分类号： G01N27/626
摘要： In an ion mobility spectrometer in which a gas flows through a gas-tight tube with a radially quadrupolar RF field therein and blows ions against a DC electric field barrier, a mobility scan with a mobility scale that is linear in time is obtained by holding the height of the DC electric field barrier constant while changing the pressure and temperature conditions of the flowing gas. Alternatively, the mobility scan is performed by holding the pressure and temperature conditions of the flowing gas constant and reducing the height of the DC electric field barrier non-linearly with respect to time.
摘要翻译： 在离子迁移谱仪中，气体通过其中具有径向四极RF场的气密管流动，并将离子吹向DC电场势垒，通过保持 直流电场势垒的高度在改变流动气体的压力和温度条件的同时。 或者，通过保持流动气体的压力和温度条件恒定并且相对于时间非线性地降低DC电场屏障的高度来执行移动扫描。
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公开(公告)号：US08941055B2
公开(公告)日：2015-01-27
申请号：US13474009
申请日：2012-05-17
CPC分类号： G01N27/622
摘要： Ions with a predetermined ion mobility range are produced by filtering ions entrained in a stream of moving gas with two ion mobility low pass filters located consecutively in the gas stream. Each filter is formed by applying a DC electric field to the gas stream which causes the ions to move in a direction opposite to the gas flow. Ions are collected between the two filters and transferred to a detector or analyzing device. In one embodiment, the maximum field strength of the electric field barrier in the first ion mobility low pass filter is continued as a plateau of essentially constant field strength up to the electric field barrier in the second ion mobility low pass filter, which has a maximum field strength higher that the maximum field strength of the electric field barrier in the first ion mobility low pass filter.
摘要翻译： 具有预定离子迁移率范围的离子通过在气流中连续排列两个离子迁移率低通过滤器来过滤夹带在移动气体流中的离子而产生。 每个过滤器通过向气流施加DC电场而形成，其导致离子沿与气流相反的方向移动。 离子在两个过滤器之间收集并转移到检测器或分析装置。 在一个实施例中，第一离子迁移率低通滤波器中的电场势垒的最大场强作为基本上恒定场强的平台直到第二离子迁移率低通滤波器中的电场势垒持续，其具有最大值 场强比第一离子迁移率低通滤波器中的电场势垒的最大场强高。
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公开(公告)号：US20120273673A1
公开(公告)日：2012-11-01
申请号：US13094128
申请日：2011-04-26
CPC分类号： H01J49/06 , G01N27/622 , G01N27/624
摘要： Ions with a predetermined range of ion mobilities are produced by filtering input ions with at least two consecutive ion mobility high pass and/or low pass filters. Each ion mobility filter is formed by entraining ions in a moving gas and applying a DC electric field to the ions which causes the ions to move in a direction opposite to the gas flow. An ion mobility high pass filter is formed when the DC electric field drives the ions against the flow of gas, whereas an ion mobility low pass filter is formed when a the gas flow drives entrained ions against an DC electric field barrier.
摘要翻译： 具有预定范围的离子迁移率的离子通过用至少两个连续的离子迁移率高通和/或低通滤波器过滤输入离子而产生。 每个离子迁移率过滤器是通过夹杂在移动气体中的离子形成的，并且对离子施加直流电场，这导致离子沿与气流相反的方向移动。 当DC电场驱动离子抵抗气体流时，形成离子迁移率高通滤波器，而当气流驱动夹带的离子抵抗DC电场屏障时，形成离子迁移率低通滤波器。
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公开(公告)号：US08575542B1
公开(公告)日：2013-11-05
申请号：US13449436
申请日：2012-04-18
IPC分类号： H01J49/00
CPC分类号： H01J49/0054
摘要： The invention relates to a device for performing electron capture dissociation on multiply charged cations. Provided is an electron emitter which, upon triggering, emits a plurality of low energy electrons suitable for efficient electron capture reactions to occur. Further, the device contains a particle emitter being located proximate to the electron emitter and being capable, upon triggering, to emit a plurality of high energy charged particles substantially in a direction towards the electron emitter in order that the electron emitter receives a portion of the emitted plurality of high energy charged particles and emission of the plurality of low energy electrons is triggered. A volume capable of containing a plurality of multiply charged cations is located in opposing relation to the electron emitter such that the volume receives the plurality of low energy electrons upon emission as to allow electron capture dissociation to occur.
摘要翻译： 本发明涉及用于在多电荷阳离子上进行电子捕获离解的装置。 提供了一种电子发射器，其在触发时发射适于发生有效电子捕获反应的多个低能电子。 此外，该装置包含位于电子发射器附近的粒子发射器，并且能够在触发时基本上沿朝向电子发射器的方向发射多个高能量带电粒子，以使电子发射器接收一部分 发射多个高能量带电粒子并发射多个低能电子。 能够容纳多个多电荷阳离子的体积位于与电子发射体相对的关系中，使得体积在发射时接收多个低能电子以允许发生电子俘获解离。
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8.发明授权Ion source for compact mass spectrometer and method of mass analyzing a sample 失效用于紧凑型质谱仪的离子源和质量分析样品的方法
公开(公告)号：US5659170A
公开(公告)日：1997-08-19
申请号：US357510
申请日：1994-12-16
CPC分类号： H01J49/147 , H01J49/08 , H01J49/40
摘要： A mass spectrometer 20 includes an electron multiplier 30 for producing an electron avalanche 58 directed toward an ionization region 38. A sample 40 enters the ionization region 38 through a sample inlet 68. In the ionization region 38 the electron avalanche 58 collides with the sample 40 and produces ions 60. A start detector 56 detects the electron avalanche 58 and provides a start signal. The ions 60 exit the ionization region 38 and enter a flight region 26. The ions 60 flow through the flight region 26 and interact with a stop detector 42. The stop detector 42 generates a stop signal in response to being activated. A low pressure enclosure 22 encloses at least the electron multiplier 30 and the ionization region 38. The start and stop signals are supplied to an analysis system for determining the mass of the sample using time-of-flight mass spectrometry.
摘要翻译： 质谱仪20包括用于产生朝向电离区域38的电子雪崩58的电子倍增器30.样品40通过样品入口68进入电离区域38.在电离区域38中，电子雪崩58与样品40碰撞 并产生离子60.启动检测器56检测电子雪崩58并提供启动信号。 离子60离开电离区域38并进入飞行区域26.离子60流过飞行区域26并与停止检测器42相互作用。停止检测器42响应于被激活而产生停止信号。 低压外壳22至少包围电子倍增器30和电离区38.启动和停止信号被提供给用于使用飞行时间质谱法确定样品质量的分析系统。
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公开(公告)号：US08624180B2
公开(公告)日：2014-01-07
申请号：US13094146
申请日：2011-04-26
申请人： Melvin Andrew Park , Jochen Franzen
发明人： Melvin Andrew Park , Jochen Franzen
IPC分类号： H01J49/00
CPC分类号： G01N27/626
摘要： In an ion mobility spectrometer in which a gas pushes ions along a spectrometer axis against and over an electrical field barrier, the electric field barrier is generated with a plateau of slightly increasing height along the axis of the spectrometer. Alternately, the electric filed barrier may have a plateau with constant height, but the gas flow decreases in velocity along the axis of the spectrometer in the vicinity of the plateau.
摘要翻译： 在离子迁移谱仪中，其中气体沿着光谱仪轴线推动离子抵抗和超过电场屏障，电场屏障是沿着光谱仪轴线的高度稍微增加的高原产生的。 或者，电场屏障可以具有恒定高度的平台，但气流在平台附近沿着光谱仪的轴线的速度减小。
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公开(公告)号：US07495212B2
公开(公告)日：2009-02-24
申请号：US11418171
申请日：2006-05-04
申请人： Taeman Kim , Melvin Andrew Park
发明人： Taeman Kim , Melvin Andrew Park
IPC分类号： H01J49/42
CPC分类号： H01J49/066
摘要： The present invention relates generally to mass spectrometry and the analysis of chemical samples, and more particularly to ion guides for use therein. The invention described herein comprises an improved method and apparatus for transporting ions from a first pressure region in a mass spectrometer to a second pressure region therein. More specifically, the present invention provides a segmented ion funnel for more efficient use in mass spectrometry (particularly with ionization sources) to transport ions from the first pressure region to the second pressure region.
摘要翻译： 本发明一般涉及质谱和化学样品的分析，更具体地涉及用于其中的离子导向器。 本文描述的本发明包括用于将离子从质谱仪中的第一压力区域输送到其中的第二压力区域的改进的方法和装置。 更具体地说，本发明提供了一种分段离子漏斗，用于在离子源（特别是电离源）中更有效地将离子从第一压力区域输送到第二压力区域。
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