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公开(公告)号：US11312941B2
公开(公告)日：2022-04-26
申请号：US16434726
申请日：2019-06-07
发明人： Silviu Itescu , Paul Simmons
IPC分类号： C12N5/0775 , A61K35/28
摘要： The disclosure provides stem cells which express high levels of Angeopoetin-1 (Ang1) and methods for their production. Such stem cells may be used in a range of therapeutic applications.
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公开(公告)号：US20200281984A1
公开(公告)日：2020-09-10
申请号：US16828121
申请日：2020-03-24
发明人： Silviu Itescu , Paul Simmons
IPC分类号： A61K35/28 , A61K35/545 , A61K38/17 , A61K9/00 , A61K38/18
摘要： The present disclosure relates to stem cells which express high levels of Angeopoetin-1 (Ang1) and uses thereof in inhibiting M1-type macrophage production and treating inflammatory disease such as diabetes.
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公开(公告)号：US12115194B2
公开(公告)日：2024-10-15
申请号：US17964905
申请日：2022-10-12
发明人： Silviu Itescu , Lee Golden
IPC分类号： A61K35/28 , A61K9/00 , A61K35/12 , C12N5/0775
CPC分类号： A61K35/28 , C12N5/0662 , A61K9/0019 , A61K2035/124 , A61K2300/00
摘要： The present disclosure relates to methods for preventing progressive heart failure in subjects with persistent left ventricular (LV) dysfunction. Such methods may also be used for treating or preventing progressive heart failure in subjects with a proximal left anterior descending (LAD) lesion and persistent left ventricular dysfunction.
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公开(公告)号：US10400218B2
公开(公告)日：2019-09-03
申请号：US15300716
申请日：2015-04-07
发明人： Silviu Itescu , Paul Simmons
IPC分类号： C12N5/0775 , A61K35/28
摘要： The disclosure provides stem cells which express high levels of Angeopoetin-1 (Ang1) and methods for their production. Such stem cells may be used in a range of therapeutic application.
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公开(公告)号：US20170106023A1
公开(公告)日：2017-04-20
申请号：US15317673
申请日：2015-06-01
发明人： Silviu Itescu , Paul Simmons
IPC分类号： A61K35/28 , A61K38/18 , A61K9/00 , A61K35/545
CPC分类号： A61K35/28 , A61K9/0019 , A61K35/545 , A61K38/17 , A61K38/18
摘要： The present disclosure relates to stem cells which express high levels of Angeopoetin-1 (Ang1) and uses thereof in inhibiting M1-type macrophage production and treating inflammatory disease such as diabetes.
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公开(公告)号：US20230141347A1
公开(公告)日：2023-05-11
申请号：US17870936
申请日：2022-07-22
发明人： Silviu Itescu , Paul Simmons
CPC分类号： A61K35/28 , A61K35/545 , A61K38/17 , A61P29/00 , A61P3/10 , A61K9/0019 , A61K38/18
摘要： The present disclosure relates to stem cells which express high levels of Angeopoetin-1 (Ang1) and uses thereof in inhibiting M1-type macrophage production and treating inflammatory disease such as diabetes.
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公开(公告)号：US20230124294A1
公开(公告)日：2023-04-20
申请号：US17964905
申请日：2022-10-12
发明人： Silviu Itescu , Lee Golden
IPC分类号： A61K35/28 , C12N5/0775
摘要： The present disclosure relates to methods for preventing progressive heart failure in subjects with persistent left ventricular (LV) dysfunction. Such methods may also be used for treating or preventing progressive heart failure in subjects with a proximal left anterior descending (LAD) lesion and persistent left ventricular dysfunction.
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公开(公告)号：US11406669B2
公开(公告)日：2022-08-09
申请号：US16828121
申请日：2020-03-24
发明人： Silviu Itescu , Paul Simmons
摘要： The present disclosure relates to stem cells which express high levels of Angeopoetin-1 (Ang1) and uses thereof in inhibiting M1-type macrophage production and treating inflammatory disease such as diabetes.
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公开(公告)号：US20210388319A1
公开(公告)日：2021-12-16
申请号：US17286972
申请日：2019-10-31
发明人： Silviu Itescu , Paul Simmons
IPC分类号： C12N5/0789 , A61K35/28
摘要： The present disclosure relates to methods and compositions for expansion of human hematopoietic stem cells. The present disclosure also relates to methods of treatment involving the use of the expanded HSCs.
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公开(公告)号：US20230030428A1
公开(公告)日：2023-02-02
申请号：US17691028
申请日：2022-03-09
发明人： Silviu Itescu , Paul Simmons
IPC分类号： C12N5/0775 , A61K35/28
摘要： The disclosure provides stem cells which express high levels of Angeopoetin-1 (Ang1) and methods for their production. Such stem cells may be used in a range of therapeutic applications.
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