摘要:
The present invention relates to peptide of the amino acid sequence of formula (I): 82 85 90 Glu Thr His Lys Asp Asp Gln Leu Ile 95 100 Cys Val Asn Glu Asn Gly Gly Cys Glu Gln 105 110 Tyr Cys Ser Asp His Thr Gly Thr Lys Arg 115 120 Ser Cys Arg Cys His Glu Gly Tyr Ser Leu 125 128 Leu Ala Asp Gly Val Ser Cys Thr (SEQ ID NO. 1) and functional equivalents thereof in which amino acids in the above stated sequence are modified or absent and wherein at least one of the cysteine residues may be blocked or replaced and wherein any cysteine residues which remain unblocked or unreplaced may be present in a disulphide bonded state. The invention also includes slats and derivatives of said peptides. The peptides and their salts and derivatives are useful in the treatment of blood clotting disorders.
摘要翻译:PCT No.PCT / GB95 / 02946 Sec。 371日期1997年8月27日第 102(e)日期1997年8月27日PCT提交1995年12月15日PCT公布。 公开号WO96 / 18654 日期:1996年6月20日本发明涉及式(I)的氨基酸序列的肽: - 82 85 90 - Glu Thr His Lys Asp Asp Gln Leu Ile - - 95 100 - Cys Val Asn Glu Asn Gly Gly Cys Glu Gln - - 105 110 - Tyr Cys Ser Asp His Thr Gly Thr Lys Arg - - 115 120 - Ser Cys Arg Cys His Glu Gly Tyr Ser Leu - - 125 128 - Leu Ala Asp Gly Val Ser Cys Thr(SEQ ID NO.1 )和其功能等同物,其中上述序列中的氨基酸被修饰或不存在,并且其中至少一个半胱氨酸残基可被阻断或替换,并且其中保持未阻断或未置换的任何半胱氨酸残基可以存在于二硫键中 州。 本发明还包括所述肽的板条和衍生物。 肽及其盐和衍生物可用于治疗凝血障碍。
摘要:
The present invention relates to novel pyrazine compounds and their use in the regulation of haematopoiesis, in particular in the stimulation of haematopoiesis, and in the treatment of bacterial, viral and fungal diseases.
摘要:
Peptide reagents and compositions thereof which reduce blood clotting initiated by the ternary complex of tissue factor (TF), FVIIa and FXa. The peptides have the amino acid sequences Thr--Leu--Tyr--Tyr--Trp--Arg--Ala--Ser--Ser--Thr (SEQ. ID. NO: 3) and Ile--Ile--Thr--Tyr--Arg--Lys--Gly--Ser--Ser--Thr (SEQ. ID. NO: 2).
摘要翻译:肽试剂及其组合物,其减少由组织因子(TF),FVIIa和FXa的三元复合物引发的血液凝固。 肽具有氨基酸序列Thr-Leu-Tyr-Tyr-Trp-Arg-Ala-Ser-Ser-Thr(SEQ ID NO:3)和Ile-Ile-Thr-Tyr-Arg-Lys-Gly- Ser-Ser-Thr(SEQ.ID.NO:2)。
摘要:
The present invention relates to disulphide-cyclo-�H-Cys-Glu-Gln-Tyr-Cys-OH! and salts thereof which are useful in the treatment of blood clotting disorders.
摘要:
A structure stamp with a flexible stamp which has a microstructured or nanostructured stamp surface for embossing of an embossing structure which corresponds to the stamp surface on an embossing surface, and a frame for clamping the stamp. Moreover, the invention relates to a device for embossing an embossing pattern on an embossing surface with the following features: a stamp receiver for accommodating and moving a structure stamp, an embossing material receiver for accommodating and placing an embossing material opposite the structure stamp, an embossing element drive for moving an embossing element along the structure stamp.
摘要:
A system for assisted generation of composite applications which are composed of instantiable components includes a portal system executing in memory of a computer to:a) dynamically access a data source of one or more components being potentially suitable for being used within the composite application,b) parse the data source for a predetermined searched component according to a predetermined functionality specification standard,c) rank found components according to predetermined ranking criteria,d) define a list of selected usable components from the ranking,e) store at least a subset of the selected components locally, and,f) automatically deploy the composite application from the selected components.
摘要:
A predetermined business task of a composite application can be fulfilled. The composite application can include a set of components. The composite application is instantiated by a template means and a predefined collaborative context module controls the interaction of the set of components during the runtime of the composite application. A set of components fulfilling individual services on individual different server systems is leveraged by the composite application. During the instantiation of the composite application from a template, the referenced components (as types) are instantiated leading to runtime instances of these components. The interaction of the different components is controlled on individual different server systems utilizing a primary context module. The primary context module communicates with an appropriate collaborative module implemented locally on the respective set of servers, where the local context modules act as secondary context modules in relation to the primary context modules. For each of the secondary context modules, local components communicate to control the interaction of components.
摘要:
The invention relates to a method for monitoring and/or regulating fuel cells, in particular comprising determining the composition of the operating gases of the fuel cells. The method comprises the following steps: introducing the gas mixture to be analyzed into a measuring cell (1); producing an arc in the measuring cell (1); absorbing the radiation emitted by the arc; optical filtering of the emitted radiation and/or spectral decomposition of the emitted radiation; converting the emitted radiation into an electric signal; evaluating the electric signal.
摘要:
A method for producing adhesive-bound book blocks from gathered signatures for which the individual signatures forming a non-bound book block are supplied while positioned on the spine on a transfer section to an opened conveying clamp on a perfect binder and are subsequently held while clamped in by the closed conveying clamp along the flat outer surfaces. The gathered signatures of a book block are released in an additional conveying section from the conveying clamp in order to be aligned while guided. Prior to leaving the conveying section for aligning the signatures, the signatures are clamped in once more by the conveying clamps along the flat outer surfaces, so that they can be conveyed to further processing locations.