Factor VII fragment 82-128 and its use in blood-clotting disorders
    1.
    发明授权
    Factor VII fragment 82-128 and its use in blood-clotting disorders 失效
    因子VII片段82-128及其在血液凝固疾病中的应用

    公开(公告)号:US5948759A

    公开(公告)日:1999-09-07

    申请号:US849248

    申请日:1997-08-27

    摘要: The present invention relates to peptide of the amino acid sequence of formula (I): 82 85 90 Glu Thr His Lys Asp Asp Gln Leu Ile 95 100 Cys Val Asn Glu Asn Gly Gly Cys Glu Gln 105 110 Tyr Cys Ser Asp His Thr Gly Thr Lys Arg 115 120 Ser Cys Arg Cys His Glu Gly Tyr Ser Leu 125 128 Leu Ala Asp Gly Val Ser Cys Thr (SEQ ID NO. 1) and functional equivalents thereof in which amino acids in the above stated sequence are modified or absent and wherein at least one of the cysteine residues may be blocked or replaced and wherein any cysteine residues which remain unblocked or unreplaced may be present in a disulphide bonded state. The invention also includes slats and derivatives of said peptides. The peptides and their salts and derivatives are useful in the treatment of blood clotting disorders.

    摘要翻译: PCT No.PCT / GB95 / 02946 Sec。 371日期1997年8月27日第 102(e)日期1997年8月27日PCT提交1995年12月15日PCT公布。 公开号WO96 / 18654 日期:1996年6月20日本发明涉及式(I)的氨基酸序列的肽: - 82 85 90 - Glu Thr His Lys Asp Asp Gln Leu Ile - - 95 100 - Cys Val Asn Glu Asn Gly Gly Cys Glu Gln - - 105 110 - Tyr Cys Ser Asp His Thr Gly Thr Lys Arg - - 115 120 - Ser Cys Arg Cys His Glu Gly Tyr Ser Leu - - 125 128 - Leu Ala Asp Gly Val Ser Cys Thr(SEQ ID NO.1 )和其功能等同物,其中上述序列中的氨基酸被修饰或不存在,并且其中至少一个半胱氨酸残基可被阻断或替换,并且其中保持未阻断或未置换的任何半胱氨酸残基可以存在于二硫键中 州。 本发明还包括所述肽的板条和衍生物。 肽及其盐和衍生物可用于治疗凝血障碍。

    System for the discovery and provisioning of artifacts and composites
    7.
    发明授权
    System for the discovery and provisioning of artifacts and composites 有权
    用于发现和配置工件和复合材料的系统

    公开(公告)号:US09513881B2

    公开(公告)日:2016-12-06

    申请号:US12142952

    申请日:2008-06-20

    IPC分类号: G06F9/44 G06F9/445

    CPC分类号: G06F8/36 G06F8/60

    摘要: A system for assisted generation of composite applications which are composed of instantiable components includes a portal system executing in memory of a computer to:a) dynamically access a data source of one or more components being potentially suitable for being used within the composite application,b) parse the data source for a predetermined searched component according to a predetermined functionality specification standard,c) rank found components according to predetermined ranking criteria,d) define a list of selected usable components from the ranking,e) store at least a subset of the selected components locally, and,f) automatically deploy the composite application from the selected components.

    摘要翻译: f)从所选组件自动部署组合应用程序。

    Federation of composite applications
    8.
    发明授权
    Federation of composite applications 失效
    复合应用联合会

    公开(公告)号:US08332459B2

    公开(公告)日:2012-12-11

    申请号:US12388648

    申请日:2009-02-19

    IPC分类号: G06F15/16

    摘要: A predetermined business task of a composite application can be fulfilled. The composite application can include a set of components. The composite application is instantiated by a template means and a predefined collaborative context module controls the interaction of the set of components during the runtime of the composite application. A set of components fulfilling individual services on individual different server systems is leveraged by the composite application. During the instantiation of the composite application from a template, the referenced components (as types) are instantiated leading to runtime instances of these components. The interaction of the different components is controlled on individual different server systems utilizing a primary context module. The primary context module communicates with an appropriate collaborative module implemented locally on the respective set of servers, where the local context modules act as secondary context modules in relation to the primary context modules. For each of the secondary context modules, local components communicate to control the interaction of components.

    摘要翻译: 组合应用程序的预定业务任务可以满足。 复合应用程序可以包括一组组件。 复合应用程序由模板手段实例化,预定义的协作上下文模块控制组合应用程序运行时期间组件集的交互。 复合应用程序利用一组满足个别不同服务器系统上个性化服务的组件。 在从模板实例化复合应用程序期间,引用的组件(作为类型)被实例化,导致这些组件的运行时实例。 利用主上下文模块,在不同的服务器系统上控制不同组件的交互。 主上下文模块与在相应的服务器集合上本地实现的适当的协作模块进行通信,其中本地上下文模块作为相对于主上下文模块的辅助上下文模块。 对于每个辅助上下文模块,本地组件进行通信以控制组件的交互。

    METHOD FOR MONITORING AND/OR REGULATING FUEL CELLS
    9.
    发明申请
    METHOD FOR MONITORING AND/OR REGULATING FUEL CELLS 有权
    用于监测和/或调节燃料电池的方法

    公开(公告)号:US20120236311A1

    公开(公告)日:2012-09-20

    申请号:US13512602

    申请日:2010-12-06

    IPC分类号: G01N21/59

    摘要: The invention relates to a method for monitoring and/or regulating fuel cells, in particular comprising determining the composition of the operating gases of the fuel cells. The method comprises the following steps: introducing the gas mixture to be analyzed into a measuring cell (1); producing an arc in the measuring cell (1); absorbing the radiation emitted by the arc; optical filtering of the emitted radiation and/or spectral decomposition of the emitted radiation; converting the emitted radiation into an electric signal; evaluating the electric signal.

    摘要翻译: 本发明涉及用于监测和/或调节燃料电池的方法,特别地包括确定燃料电池的工作气体的组成。 该方法包括以下步骤:将要分析的气体混合物引入测量池(1)中; 在测量单元(1)中产生电弧; 吸收由电弧发射的辐射; 所发射的辐射的光学滤波和/或发射的辐射的光谱分解; 将发射的辐射转换成电信号; 评估电信号。

    Method for producing adhesive-bound book blocks from gathered signatures
    10.
    发明授权
    Method for producing adhesive-bound book blocks from gathered signatures 有权
    从收集的签名生产粘合剂书本块的方法

    公开(公告)号:US08235639B2

    公开(公告)日:2012-08-07

    申请号:US12196685

    申请日:2008-08-22

    摘要: A method for producing adhesive-bound book blocks from gathered signatures for which the individual signatures forming a non-bound book block are supplied while positioned on the spine on a transfer section to an opened conveying clamp on a perfect binder and are subsequently held while clamped in by the closed conveying clamp along the flat outer surfaces. The gathered signatures of a book block are released in an additional conveying section from the conveying clamp in order to be aligned while guided. Prior to leaving the conveying section for aligning the signatures, the signatures are clamped in once more by the conveying clamps along the flat outer surfaces, so that they can be conveyed to further processing locations.

    摘要翻译: 一种用于从收集的签名生成粘合剂书本块的方法,其中形成无约束书本块的各个签名在位于转印部分上的书脊上的同时被提供给在完美的粘合剂上的打开的输送夹具上,并且随后被夹持 通过沿着平坦的外表面的封闭输送夹具。 书本块的收集的签名从输送夹具释放在另外的输送部分中,以便在被引导的同时被对准。 在离开用于对准签名的输送部分之前,通过输送夹具沿着平坦的外表面再次夹紧签名,使得它们可以被输送到另外的处理位置。