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    Increasing cerebral bioavailability of drugs
    1.
    发明授权
    Increasing cerebral bioavailability of drugs 失效
    增加药物的脑生物利用度

    公开(公告)号：US06818669B2

    公开(公告)日：2004-11-16

    申请号：US09955485

    申请日：2001-09-19

    申请人： Michael A. Moskowitz ,  James K. Liao ,  Eyal S. Ron ,  Mary Nallin Omstead

    发明人： Michael A. Moskowitz ,  James K. Liao ,  Eyal S. Ron ,  Mary Nallin Omstead

    IPC分类号： A61K31351

    CPC分类号： A61K31/7048 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2846 ,  A61K31/198 ,  A61K31/505 ,  A61K31/519 ,  A61K31/525 ,  A61K31/7076 ,  A61K31/195 ,  A61K2300/00

    摘要： A method and compositions are provided for increased cerebral bioavailability of blood-born compositions by administering the composition of interest while increasing brain NO levels. This increase in NO levels may be accomplished by stimulating increased production of NO by eNOS, especially by administering L-arginine, by administering agents that increase NO levels independent of ecNOS, or by any combination of these methods. As NO is increased, cerebral blood flow is consequently increased, and drugs in the blood stream are carried along with the increased flow into brain tissue. By increased flow, the site of action will be exposed to more drug molecules. By stimulating increased NO production, administration of drugs that are not easily introduced to the brain may be facilitated and/or the serum concentration necessary to achieve desired physiologic effects may be reduced.

    摘要翻译： 提供了通过在增加脑NO水平的同时施用感兴趣的组合物来提高血液出生组合物的脑生物利用度的方法和组合物。 NO水平的这种增加可以通过刺激通过eNOS增加NO的产生，特别是通过施用L-精氨酸，通过施用增加NO水平而不依赖于ecNOS的药剂或通过这些方法的任何组合来实现。 随着NO增加，脑血流量增加，血液中的药物随着流入脑组织的增加而被携带。 通过增加流动，作用部位将暴露于更多的药物分子。 通过刺激增加的NO产生，可以促进不容易引入脑的药物的给药和/或可以降低达到所需生理学效果所需的血清浓度。

    METHODS AND DEVICES FOR THE SUSTAINED RELEASE OF MULTIPLE DRUGS
    4.
    发明申请
    METHODS AND DEVICES FOR THE SUSTAINED RELEASE OF MULTIPLE DRUGS 有权
    用于持续释放多种药物的方法和装置

    公开(公告)号：US20090274654A1

    公开(公告)日：2009-11-05

    申请号：US12125581

    申请日：2008-05-22

    申请人： Eyal S. Ron ,  Robert S. Langer ,  William F. Crowley, JR.

    发明人： Eyal S. Ron ,  Robert S. Langer ,  William F. Crowley, JR.

    IPC分类号： A61K38/21 ,  A61K38/09 ,  A61K31/566

    CPC分类号： A61F6/08 ,  A61F6/142 ,  A61K9/0036 ,  A61K9/0056 ,  A61K31/565 ,  A61K31/57 ,  A61K38/09 ,  A61K45/06 ,  Y10S514/843 ,  A61K2300/00

    摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.

    摘要翻译： 本发明涉及药物递送装置和用于在长时间内递送多种药物的方法。 药物递送装置具有两个或多个包含药物可渗透的聚合物质的整体段，其中至少一个区段还包含药物活性剂。 本发明还涉及治疗女性哺乳动物良性卵巢分泌障碍的方法，避孕方法以及缓解与女性绝经期，绝经期和绝经后期相关的症状的方法。

    METHODS AND DEVICES FOR THE SUSTAINED RELEASE OF MULTIPLE DRUGS
    5.
    发明申请
    METHODS AND DEVICES FOR THE SUSTAINED RELEASE OF MULTIPLE DRUGS 审中-公开
    用于持续释放多种药物的方法和装置

    公开(公告)号：US20080286339A1

    公开(公告)日：2008-11-20

    申请号：US12125606

    申请日：2008-05-22

    申请人： Eyal S. Ron ,  Robert S. Langer ,  William F. Crowley, JR.

    发明人： Eyal S. Ron ,  Robert S. Langer ,  William F. Crowley, JR.

    IPC分类号： A61F6/14 ,  A61K31/565

    CPC分类号： A61F6/08 ,  A61F6/142 ,  A61K9/0036 ,  A61K9/0056 ,  A61K31/565 ,  A61K31/57 ,  A61K38/09 ,  A61K45/06 ,  Y10S514/843 ,  A61K2300/00

    摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.

    摘要翻译： 本发明涉及药物递送装置和用于在长时间内递送多种药物的方法。 药物递送装置具有两个或多个包含药物可渗透的聚合物质的整体段，其中至少一个区段还包含药物活性剂。 本发明还涉及治疗女性哺乳动物良性卵巢分泌障碍的方法，避孕方法以及缓解与女性绝经期，绝经期和绝经后期相关的症状的方法。

    End modified thermal responsive hydrogels
    6.
    发明授权
    End modified thermal responsive hydrogels 失效
    端修饰热响应水凝胶

    公开(公告)号：US06316011B1

    公开(公告)日：2001-11-13

    申请号：US09368440

    申请日：1999-08-04

    申请人： Eyal S. Ron ,  Lev Bromberg ,  Marina Temchenko

    发明人： Eyal S. Ron ,  Lev Bromberg ,  Marina Temchenko

    IPC分类号： A61K600

    CPC分类号： A61K9/0095 ,  A61K9/0007 ,  A61K9/2031 ,  A61K47/34

    摘要： A pharmaceutic composition includes a pharmaceutically acceptable carrier, comprising a reverse thermally viscosifying polymer. The polymer includes a linear block copolymer, wherein at least one block comprises a poloxamer; and at least one block comprises a biocompatible polymer or oligomer, in an aqueous medium. The composition also includes an active agent which imparts a pharmaceutic or cosmetic effect. The composition viscosities in response to an environmental stimulus. The composition is suitable for administration of the pharmaceutical agent across dermal, otic, rectal, vaginal, ophthalmic, esophageal and nasal mucosal membranes.

    摘要翻译： 药物组合物包括药学上可接受的载体，其包含反向热增粘聚合物。 聚合物包括线性嵌段共聚物，其中至少一个嵌段包含泊洛沙姆; 并且在水性介质中至少一个嵌段包含生物相容的聚合物或低聚物。 该组合物还包括赋予药物或美容效果的活性剂。 响应于环境刺激的组成粘度。 该组合物适用于通过皮肤，耳，直肠，阴道，眼用，食管和鼻粘膜的药物给药。

    Chemo-mechanical expansion delivery system
    10.
    发明授权
    Chemo-mechanical expansion delivery system 失效
    化学机械膨胀输送系统

    公开(公告)号：US5876741A

    公开(公告)日：1999-03-02

    申请号：US892920

    申请日：1997-07-15

    申请人： Eyal S. Ron

    发明人： Eyal S. Ron

    IPC分类号： A61K8/02 ,  A61K8/04 ,  A61K9/00 ,  A61K9/52 ,  A61L27/52 ,  A61L27/54 ,  A61L31/14 ,  A61L31/16 ,  A61Q13/00 ,  A61Q19/00 ,  C08B15/00 ,  C08B31/00 ,  A61F2/02 ,  A61K9/22

    CPC分类号： C08B31/006 ,  A61K9/0004 ,  C08B15/005 ,  A61K2800/88 ,  C12N2533/30 ,  C12N2533/70

    摘要： System for delivery of a biologically active substance into an environment. The container is comprised of a single member or two mated members and defines first and second compartments. The container includes pores in at least a portion of the container defining the first compartment. The first compartment contains a polymer gel network which undergoes a volume expansion in response to an environmental condition which varies in the biological environment. The second compartment contains an effective amount of a biologically active compound and may include at least one passageway communicating with the biological environment. Drug delivery is initiated and continues only when the appropriate environmental condition or trigger is met, whereupon volume expansion of the polymer gel network causes the biologically active compound to be discharged into the biological environment.

    摘要翻译： 将生物活性物质输送到环境中的系统。 容器由单个构件或两个配合构件组成，并且限定第一和第二隔室。 容器包括限定第一隔室的容器的至少一部分中的孔。 第一隔室包含聚合物凝胶网络，其响应于在生物环境中变化的环境条件而经历体积膨胀。 第二隔室包含有效量的生物活性化合物，并且可以包括与生物环境连通的至少一个通道。 仅当适当的环境条件或触发条件被满足时才启动并继续给药，因此聚合物凝胶网络的体积膨胀导致生物活性化合物被排放到生物环境中。