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    Highly Concentrated Pharmaceutical Formulations
    1.
    发明申请
    Highly Concentrated Pharmaceutical Formulations 审中-公开
    高浓度药物制剂

    公开(公告)号：US20110076273A1

    公开(公告)日：2011-03-31

    申请号：US12879486

    申请日：2010-09-10

    申请人： Michael Adler ,  Hanns-Christian Mahler ,  Oliver Boris Stauch

    发明人： Michael Adler ,  Hanns-Christian Mahler ,  Oliver Boris Stauch

    IPC分类号： A61K39/395 ,  A61P35/00

    CPC分类号： C07K16/2887 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/47 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/10 ,  A61K47/183 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K47/42 ,  A61K2039/505 ,  C07K16/3061 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/734 ,  C07K2317/94

    摘要： The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-CD20 antibody, such as e.g. Rituximab, Ocrelizumab, or HuMab , or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-CD20 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. The said formulations comprise additionally at least one buffering agent, such as e.g. a histidine buffer, a stabilizer or a mixture of two or more stabilizers (e.g. a saccharide, such as e.g. α,α-trehalose dihydrate or sucrose, and optionally methionine as a second stabilizer), a nonionic surfactant and an effective amount of at least one hyaluronidase enzyme. Methods for preparing such formulations and their uses thereof are also provided.

    摘要翻译： 本发明涉及药物活性抗CD20抗体的高浓度，稳定的药物制剂，例如， 利妥昔单抗，奥昔布单抗或HuMab ，或用于皮下注射的这种抗体分子的混合物。 特别地，本发明涉及除了合适量的抗CD20抗体外，还包含有效量的至少一种作为组合制剂的透明质酸酶或用于共同制剂形式的制剂。 所述制剂还包含至少一种缓冲剂，例如， 组氨酸缓冲液，稳定剂或两种或更多种稳定剂的混合物（例如糖，例如α，α-海藻糖二水合物或蔗糖，以及任选的甲硫氨酸作为第二稳定剂），非离子表面活性剂和有效量的至少 一种透明质酸酶。 还提供了制备这些制剂的方法及其用途。

    Subcutaneous anti-HER2 antibody formulations and uses thereof
    2.
    发明授权
    Subcutaneous anti-HER2 antibody formulations and uses thereof 有权
    皮下抗HER2抗体制剂及其用途

    公开(公告)号：US09345661B2

    公开(公告)日：2016-05-24

    申请号：US12804703

    申请日：2010-07-27

    申请人： Michael Adler ,  Ulla Grauschopf ,  Hanns-Christian Mahler ,  Oliver Boris Stauch

    发明人： Michael Adler ,  Ulla Grauschopf ,  Hanns-Christian Mahler ,  Oliver Boris Stauch

    IPC分类号： C07K16/00 ,  A61K9/00 ,  A61K9/19 ,  A61K39/395 ,  A61K47/18 ,  A61K47/26 ,  A61K47/42 ,  C07K16/32

    CPC分类号： A61K39/39558 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  A61K38/47 ,  A61K39/39591 ,  A61K45/06 ,  A61K47/18 ,  A61K47/183 ,  A61K47/26 ,  A61K47/42 ,  C07K16/32 ,  C12Y302/01035

    摘要： The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-HER2 antibody, such as e.g. Trastuzumab (HERCEPTIN™), Pertuzumab or T-DM1, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-HER2 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. The formulations comprise additionally at least one buffering agent, such as e.g. a histidine buffer, a stabilizer or a mixture of two or more stabilizers (e.g. a saccharide, such as e.g. α,α-trehalose dihydrate or sucrose, and optionally methionine as a second stabilizer), a nonionic surfactant and an effective amount of at least one hyaluronidase enzyme. Methods for preparing such formulations and their uses thereof are also provided.

    摘要翻译： 本发明涉及药物活性抗HER2抗体的高浓度，稳定的药物制剂，例如， 曲妥珠单抗（HERCEPTIN TM），Pertuzumab或T-DM1，或用于皮下注射的这种抗体分子的混合物。 特别地，本发明涉及包含除合适量的抗HER2抗体之外的有效量的至少一种透明质酸酶作为组合制剂或用于共同制剂形式的制剂。 制剂还包含至少一种缓冲剂，例如， 组氨酸缓冲液，稳定剂或两种或更多种稳定剂的混合物（例如糖，例如α，α-海藻糖二水合物或蔗糖，以及任选的甲硫氨酸作为第二稳定剂），非离子表面活性剂和有效量的至少 一种透明质酸酶。 还提供了制备这些制剂的方法及其用途。

    Subcutaneous anti-HER2 antibody formulations and uses thereof
    3.
    发明申请
    Subcutaneous anti-HER2 antibody formulations and uses thereof 有权
    皮下抗HER2抗体制剂及其用途

    公开(公告)号：US20110044977A1

    公开(公告)日：2011-02-24

    申请号：US12804703

    申请日：2010-07-27

    申请人： Michael Adler ,  Ulla Grauschopf ,  Hanns-Christian Mahler ,  Oliver Boris Stauch

    发明人： Michael Adler ,  Ulla Grauschopf ,  Hanns-Christian Mahler ,  Oliver Boris Stauch

    IPC分类号： A61K39/395 ,  A61P35/00

    CPC分类号： A61K39/39558 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  A61K38/47 ,  A61K39/39591 ,  A61K45/06 ,  A61K47/18 ,  A61K47/183 ,  A61K47/26 ,  A61K47/42 ,  C07K16/32 ,  C12Y302/01035

    摘要： The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-HER2 antibody, such as e.g. Trastuzumab (HERCEPTIN™), Pertuzumab or T-DM1, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-HER2 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. The formulations comprise additionally at least one buffering agent, such as e.g. a histidine buffer, a stabilizer or a mixture of two or more stabilizers (e.g. a saccharide, such as e.g. α,α-trehalose dihydrate or sucrose, and optionally methionine as a second stabilizer), a nonionic surfactant and an effective amount of at least one hyaluronidase enzyme. Methods for preparing such formulations and their uses thereof are also provided.

    摘要翻译： 本发明涉及药物活性抗HER2抗体的高浓度，稳定的药物制剂，例如， 曲妥珠单抗（HERCEPTIN TM），Pertuzumab或T-DM1，或用于皮下注射的这种抗体分子的混合物。 特别地，本发明涉及包含除合适量的抗HER2抗体之外的有效量的至少一种透明质酸酶作为组合制剂或用于共同制剂形式的制剂。 制剂还包含至少一种缓冲剂，例如， 组氨酸缓冲液，稳定剂或两种或更多种稳定剂的混合物（例如糖，例如α，α-海藻糖二水合物或蔗糖，以及任选的甲硫氨酸作为第二稳定剂），非离子表面活性剂和有效量的至少 一种透明质酸酶。 还提供了制备这些制剂的方法及其用途。

    Data processing system
    7.
    发明授权
    Data processing system 有权

    公开(公告)号：US10685129B2

    公开(公告)日：2020-06-16

    申请号：US15689794

    申请日：2017-08-29

    申请人： Michael Adler ,  Klaus-Peter Hofmann

    发明人： Michael Adler ,  Klaus-Peter Hofmann

    IPC分类号： G06F21/60 ,  H04L29/06 ,  G06F21/64 ,  H04L29/08

    摘要： A data processing system is provided with a data verification system that is configured to perform a validation check upon receipt of a request from a field device to transfer data to the data processing system. The data verification system is also configured to verify a permission of the field device to exchange data and to validate the data integrity. A data landing zone is provided for temporary storage of the data in the event that a validation check fails, so that data errors may be corrected.

    DATA PROCESSING SYSTEM
    8.
    发明申请
    DATA PROCESSING SYSTEM 审中-公开

    公开(公告)号：US20180060594A1

    公开(公告)日：2018-03-01

    申请号：US15689794

    申请日：2017-08-29

    申请人： Michael Adler ,  Klaus-Peter Hofmann

    发明人： Michael Adler ,  Klaus-Peter Hofmann

    IPC分类号： G06F21/60 ,  G06F21/64

    摘要： A data processing system is provided with a data verification system that is configured to perform a validation check upon receipt of a request from a field device to transfer data to the data processing system. The data verification system is also configured to verify a permission of the field device to exchange data and to validate the data integrity. A data landing zone is provided for temporary storage of the data in the event that a validation check fails, so that data errors may be corrected.

    Flow rate meter
    9.
    发明授权
    Flow rate meter 有权
    流量计

    公开(公告)号：US09021878B2

    公开(公告)日：2015-05-05

    申请号：US13642602

    申请日：2011-04-04

    申请人： Mor Grinstein ,  Jack Yehoshua Mantinband ,  Shmuel Bentov ,  Michael Adler

    发明人： Mor Grinstein ,  Jack Yehoshua Mantinband ,  Shmuel Bentov ,  Michael Adler

    IPC分类号： G01F1/684 ,  G01F23/26 ,  A61B5/20 ,  G01F1/00

    CPC分类号： G01F23/266 ,  A61B5/208 ,  A61B2562/0271 ,  G01F1/007 ,  G01F1/684

    摘要： The present invention is flow rate meters which are able to accurately measure the volumetric rate of flow of a liquid through a conduit without requiring foreknowledge of the physicochemical characteristics of the liquid, e.g., for the purpose of calibration of the thermal mass flow rate. One application of the flow meters of the invention is to incorporate them in a system for measuring the flow rate of urine excreted by a catheterized patient. The invention also provides methods for using the flow rate meters.

    摘要翻译： 本发明是流量计，其能够精确地测量通过管道的液体的体积流速，而不需要预先知道液体的物理化学特性，例如用于校准热质量流量的目的。 本发明的流量计的一个应用是将它们并入用于测量由导管的患者排泄的尿液的流量的系统中。 本发明还提供了使用流量计的方法。

    Book binding machine and method for operating a book binding machine
    10.
    发明授权
    Book binding machine and method for operating a book binding machine 有权
    书籍装订机和操作书籍装订机的方法

    公开(公告)号：US08840351B2

    公开(公告)日：2014-09-23

    申请号：US12728355

    申请日：2010-03-22

    申请人： Michael Adler ,  Frank Sommerer ,  Andreas Steinert

    发明人： Michael Adler ,  Frank Sommerer ,  Andreas Steinert

    IPC分类号： B42C13/00 ,  B42C9/00 ,  B42C11/00 ,  B42C11/02 ,  B42B5/00 ,  B42C19/08 ,  B42C1/12

    CPC分类号： B42C19/08 ,  B42C1/12 ,  B42C9/0037 ,  Y10S412/901 ,  Y10S412/902

    摘要： A book binding machine includes a collating machine, a perfect binder and a transfer device disposed between the collating machine and the perfect binder. The collating machine and the perfect binder are actuated by a common control device. In each case, one transport segment is assigned to a respective book block clamp by the control device. The control device also has a program which, if a defective or missing book block clamp is detected, actuates the collating machine in such a way that no book block is collated for that book block clamp. A method for operating a book binding machine is also provided.

    摘要翻译： 书籍装订机包括整理机，完美的装订器和设置在整理机和完美的装订器之间的传送装置。 整理机和完美的装订器由公共控制装置致动。 在每种情况下，通过控制装置将一个传送段分配给相应的书本夹具。 控制装置还具有程序，如果检测到有缺陷或缺失的书夹夹具，则使得对照机器以对于该书夹夹不整理书本块的方式启动。 还提供了一种操作装订机的方法。