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1.发明授权Polyvinylamine derivatives having hydrophilic centers, processes for their preparation and the use of the compounds as a medicament, active compound carrier and foodstuff auxiliary 失效具有亲水中心的聚乙烯胺衍生物，其制备方法和化合物作为药物的用途，活性化合物载体和食品助剂
公开(公告)号：US5430110A
公开(公告)日：1995-07-04
申请号：US95623
申请日：1993-07-21
申请人： Michael Ahlers , Heiner Glombik , Susanne Grabley , Ernold Granzer , Stefan Mullner , Axel Walch , Guan-Yu Xu
发明人： Michael Ahlers , Heiner Glombik , Susanne Grabley , Ernold Granzer , Stefan Mullner , Axel Walch , Guan-Yu Xu
IPC分类号： A23L33/00 , A61K31/785 , A61K47/30 , A61P3/06 , A61P3/12 , C08F8/12 , C08F26/00 , C08F226/02 , C08F8/30
CPC分类号： C08F8/12
摘要： Polyvinylamine derivatives having hydrophilic centers, processes for their preparation and the use of the compounds as a medicament, active compound carrier and foodstuff auxiliary.Polyvinylamine derivatives containing hydrophilic centers, of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, X, w, x, y and z have the meanings given, and a process for their preparation, and the use of these compounds as medicaments, active compound carriers and foodstuff auxiliaries are described. Highly pure polyvinylamines having the recurring unit of the formula Ia ##STR2## the preparation of which is likewise described, are used in particular as starting substances for the preparation.
摘要翻译： 具有亲水中心的聚乙烯胺衍生物，其制备方法和化合物作为药物的用途，活性化合物载体和食品助剂。 含有亲水中心的聚乙烯胺衍生物，其中R 1，R 2，R 3，X，W，x，y和z具有给定的含义的式I（I）及其制备方法，以及这些 描述了作为药物的化合物，活性化合物载体和食品助剂。 具有式Ia（Ia）的重复单元的高纯度聚乙烯胺其制备同样被描述，特别是用作制备的起始物质。
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2.发明授权Crosslinked, nitrogen-containing vinyl copolymers, processes for their preparation and the use of these compounds 失效交联的含氮乙烯基共聚物，其制备方法和这些化合物的应用
公开(公告)号：US5428112A
公开(公告)日：1995-06-27
申请号：US95624
申请日：1993-07-21
申请人： Michael Ahlers , Heiner Glombik , Stefan Mullner , Axel Walch
发明人： Michael Ahlers , Heiner Glombik , Stefan Mullner , Axel Walch
IPC分类号： A61K31/785 , A61P3/06 , C08F8/12 , C08F26/00 , C08F26/02
CPC分类号： C08F8/12 , C08F2810/20
摘要： Crosslinked, nitrogen-containing vinyl copolymers having units of the formula I ##STR1## and physiologically tolerated salts thereof, in which, in formula I, A1, A2, R, w, x, y and z have the meanings given, a process for their preparation and the use of the compounds as medicaments, active compound carriers and foodstuff auxiliaries are described.
摘要翻译： 具有式I的单元的交联的含氮乙烯基共聚物及其生理上耐受的盐，其中在式I，A1，A2，R，w，x，y和z中具有给定的含义，方法 为了制备和使用化合物作为药物，描述了活性化合物载体和食品助剂。
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3.发明授权
公开(公告)号：US5631326A
公开(公告)日：1997-05-20
申请号：US452797
申请日：1995-05-30
申请人： Michael Ahlers , Heiner Glombik , Stefan M ullner , Axel Walch
发明人： Michael Ahlers , Heiner Glombik , Stefan M ullner , Axel Walch
CPC分类号： C08F8/12 , C08F2810/20
摘要： Crosslinked, nitrogen-containing vinyl copolymers having units of the formula I ##STR1## and physiologically tolerated salts thereof, in which, in formula I, A1, A2, R, w, x, y and z have the meanings given, a process for their preparation and the use of the compounds as medicaments, active compound carriers and foodstuff auxiliaries are described.
摘要翻译： 具有式I的单元的交联的含氮乙烯基共聚物及其生理上耐受的盐，其中在式I，A1，A2，R，w，x，y和z中具有给定的含义，方法 为了制备和使用化合物作为药物，描述了活性化合物载体和食品助剂。
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4.发明授权1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof 有权被苄基取代的1,4-苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US07956085B2
公开(公告)日：2011-06-07
申请号：US12465911
申请日：2009-05-14
申请人： Wendelin Frick , Heiner Glombik , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
发明人： Wendelin Frick , Heiner Glombik , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
IPC分类号： A61K31/38 , C07D409/08
CPC分类号： C07H5/06 , A61K31/38 , A61K31/7028 , A61K45/06 , C07D409/12 , C07H5/04 , C07H7/02 , C07H7/027 , C07H13/12 , C07H15/26 , A61K2300/00
摘要： This invention relates to Novel 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof.
摘要翻译： 本发明涉及由苄基取代的新型1,4-苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途。
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5.发明授权Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use 有权二苯基氮杂环丁酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US07488829B2
公开(公告)日：2009-02-10
申请号：US11797720
申请日：2007-05-07
申请人： Heiner Glombik , Werner Krame , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schäfer
发明人： Heiner Glombik , Werner Krame , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schäfer
IPC分类号： C07D263/20
CPC分类号： C07D205/08 , C07F7/1804
摘要： Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
摘要翻译： 其中R1，R2，R3，R4，R5和R6具有说明书中给出的含义的式I化合物及其生理上可接受的盐。 该化合物适合用作例如降血脂药。
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6.发明申请NOVEL DIPHENYLAZETIDINONE WITH IMPROVED PHYSIOLOGICAL PROPERTIES, PROCESS FOR ITS PREPARATION, MEDICAMENTS COMPRISING THIS COMPOUND, AND ITS USE 失效具有改善的生理特性的新型二氢噻吩酮，其制备方法，包含该化合物的药物及其用途公开(公告)号：US20070197498A1
公开(公告)日：2007-08-23
申请号：US11690993
申请日：2007-03-26
申请人： Gerhard JAEHNE , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
发明人： Gerhard JAEHNE , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
IPC分类号： A61K31/397 , C07D205/02
CPC分类号： C07C233/18 , C07D205/08
摘要： Novel diphenylazetidinone, process for its preparation, medicaments comprising this compound and their use The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.
摘要翻译： 新型二苯基氮杂环丁酮，其制备方法，包含该化合物的药物及其用途本发明涉及式1的化合物及其生理上可接受的盐。 该化合物例如可用作降血脂药物。
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公开(公告)号：US20070043017A1
公开(公告)日：2007-02-22
申请号：US11544718
申请日：2006-10-10
申请人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
发明人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
IPC分类号： A61K31/397 , C07D205/02 , C07D403/02
CPC分类号： C07D403/12 , C07D205/08 , C07D453/02 , C07D487/08 , Y10S930/28
摘要： One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
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8.发明授权Combination product of a 1,4-benzothiepine 1,1-dioxide compound with at least one other active ingredient and the use of the product 有权1,4-苯并噻吩1,1-二氧化物化合物与至少一种其它活性成分的组合产物和产物的用途公开(公告)号：US07179792B2
公开(公告)日：2007-02-20
申请号：US10699967
申请日：2003-11-03
CPC分类号： A61K45/06 , A61K31/395 , A61K31/55 , A61K2300/00
摘要： The present invention is directed to a 1,4-benzothiepine 1,1-dioxide compound of formula I in which the radicals have the meanings defined herein, or a pharmaceutically acceptable salt or physiologically functional derivative thereof, with at least one other active ingredient, or a pharmaceutically acceptable salt or physiologically functional derivative thereof. The invention is also directed to the use of the combination product, pharmaceutical composition comprising the combination product and method for preparing the pharmaceutical composition.
摘要翻译： 本发明涉及其中基团具有本文定义的含义，或其药学上可接受的盐或生理功能衍生物的式I的1,4-苯并硫代1,1-二氧化物化合物与至少一种其它活性成分， 或其药学上可接受的盐或生理功能衍生物。 本发明还涉及组合产品，包含组合产品和方法的药物组合物用于制备药物组合物的用途。
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9.发明授权Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals 有权环烷基取代的链烷酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US07173151B2
公开(公告)日：2007-02-06
申请号：US10789324
申请日：2004-02-27
申请人： Christian Stapper , Heiner Glombik , Eugen Falk , Dirk Gretzke , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler
发明人： Christian Stapper , Heiner Glombik , Eugen Falk , Dirk Gretzke , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： C07C229/00 , C07C61/28 , C07C61/16 , C07C62/00 , C07C62/30
CPC分类号： C07C275/28 , C07C275/10 , C07C275/24 , C07C275/26 , C07C2601/14
摘要： The invention relates to arylcycloalkyl-substituted derivatives and to their physiologically acceptable salts and physiologically functional derivatives.What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
摘要翻译： 本发明涉及芳基环烷基取代的衍生物及其生理上可接受的盐和生理功能衍生物。 描述的是式I化合物，其中基团如所定义，以及它们的生理上可接受的盐及其制备方法。 所述化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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10.发明授权Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals 有权具有生物异丝氨酸羧酸基团的环烷基衍生物，其制备方法及其作为药物的用途公开(公告)号：US07148246B2
公开(公告)日：2006-12-12
申请号：US10789865
申请日：2004-02-27
申请人： Dirk Gretzke , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
发明人： Dirk Gretzke , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
IPC分类号： C07D277/04 , C07D209/54 , C07D257/04 , C07D413/00 , A61K31/42
CPC分类号： C07D417/12 , C07D263/32 , C07D413/12
摘要： Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals The invention relates to cycloalkyl derivatives having bioisosteric carboxylic acid groups and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
摘要翻译： 具有生物硅烷酸羧酸基团的环烷基衍生物及其制备方法及其作为药物的用途本发明涉及具有生物硅烷酸羧酸基团的环烷基衍生物及其生理上可接受的盐和生理功能衍生物。 所描述的是式I化合物，其中自由基如所定义，以及它们的生理上可接受的盐及其制备方法。 所述化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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