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公开(公告)号：US20080096901A1
公开(公告)日：2008-04-24
申请号：US11787165
申请日：2007-04-13
申请人： Michael Arnost , Guy Bemis , Robert Davies , Cornelia Forster , Ronald Grey , Mark Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert Pierce , Francesco Salituro , Jian Wang
发明人： Michael Arnost , Guy Bemis , Robert Davies , Cornelia Forster , Ronald Grey , Mark Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert Pierce , Francesco Salituro , Jian Wang
IPC分类号： A61K31/4196 , C07D401/04 , A61K31/4439 , A61K31/496 , C07D403/04 , C07D249/08 , A61P11/06 , A61P27/14 , A61P29/00 , A61P37/08 , A61P37/00 , A61P35/00 , A61P25/16 , A61P25/28
CPC分类号： C07D401/04 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物，制备化合物的方法和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20080014189A1
公开(公告)日：2008-01-17
申请号：US11774702
申请日：2007-07-09
申请人： Albert Pierce , Michael Arnost , Robert Davies , Cornelia Forster , Vincent Galullo , Ronald Gray , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco Salituro , Jian Wang
发明人： Albert Pierce , Michael Arnost , Robert Davies , Cornelia Forster , Vincent Galullo , Ronald Gray , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco Salituro , Jian Wang
IPC分类号： A61K38/50 , A61K31/4196 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/47 , A61K31/505 , A61P19/00 , A61P3/00 , C07D239/28 , C07D239/24 , A61P9/00 , A61P37/08 , A61P35/00 , A61P25/28 , A61P11/06 , A61K31/519 , A61K31/5377 , A61K31/555 , A61K31/573 , A61K31/675
CPC分类号： C07D401/04 , C07D249/10 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US08921376B2
公开(公告)日：2014-12-30
申请号：US11438748
申请日：2006-05-22
申请人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
发明人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
IPC分类号： C07D471/04 , A61K31/437 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族和ROCK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20070135466A1
公开(公告)日：2007-06-14
申请号：US11438748
申请日：2006-05-22
申请人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
发明人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
IPC分类号： A61K31/506 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族和ROCK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20060183761A1
公开(公告)日：2006-08-17
申请号：US11346048
申请日：2006-02-01
申请人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
发明人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US07329652B2
公开(公告)日：2008-02-12
申请号：US11230221
申请日：2005-09-19
申请人： Francesco Salituro , Mark Ledeboer , Brian Ledford , Jian Wang , Albert Pierce , John Duffy , David Messersmith
发明人： Francesco Salituro , Mark Ledeboer , Brian Ledford , Jian Wang , Albert Pierce , John Duffy , David Messersmith
IPC分类号： A61K31/551 , A61K31/553 , A61K31/5377 , A61K31/496 , C07D413/02 , C07D403/02 , C07D267/10 , C07D239/24 , C07D413/12
CPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to inhibitors of protein kinases, particularly to inhibitors of JAK2 and JAK3. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂，尤其涉及JAK2和JAK3抑制剂。 本发明还提供包含本发明化合物的药物组合物，制备化合物的方法和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20060063756A1
公开(公告)日：2006-03-23
申请号：US11230221
申请日：2005-09-19
申请人： Francesco Salituro , Mark Ledeboer , Brian Ledford , Jian Wang , Albert Pierce , John Duffy , David Messersmith
发明人： Francesco Salituro , Mark Ledeboer , Brian Ledford , Jian Wang , Albert Pierce , John Duffy , David Messersmith
IPC分类号： C07D413/02 , C07D403/02 , A61K31/551 , A61K31/553 , A61K31/5377 , A61K31/496
CPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to inhibitors of protein kinases, particularly to inhibitors of JAK2 and JAK3. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂，尤其涉及JAK2和JAK3抑制剂。 本发明还提供包含本发明化合物的药物组合物，制备化合物的方法和使用该组合物治疗各种疾病的方法。
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![Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein kinases](/abs-image/US/2014/01/21/US08633205B2/abs.jpg.150x150.jpg)
8.发明授权公开(公告)号：US08633205B2
公开(公告)日：2014-01-21
申请号：US11346048
申请日：2006-02-02
申请人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
发明人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
IPC分类号： C07D487/04 , A61K31/519 , A61K31/497 , A61P35/00 , A61P37/06 , A61P25/28
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of the following formula: which are useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及下式的化合物：其可用作蛋白激酶的抑制剂。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20070004762A9
公开(公告)日：2007-01-04
申请号：US11346048
申请日：2006-02-02
申请人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
发明人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US07902239B2
公开(公告)日：2011-03-08
申请号：US11774702
申请日：2007-07-09
申请人： Albert C. Pierce , Michael Arnost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
发明人： Albert C. Pierce , Michael Arnost , Robert J. Davies , Cornelia J. Forster , Vincent Galullo , Ronald Grey, Jr. , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco G. Salituro , Jian Wang
IPC分类号： A61K31/541 , A61K31/55 , A61K31/4196 , A61K31/5377
CPC分类号： C07D401/04 , C07D249/10 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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