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12 条记录 (耗时 0.023 秒)

    Highly selective process for making o-arylbenzonitriles
    2.
    发明授权
    Highly selective process for making o-arylbenzonitriles 失效
    制备邻芳基苯腈的高选择性方法

    公开(公告)号：US6153810A

    公开(公告)日：2000-11-28

    申请号：US70467

    申请日：1998-04-30

    申请人： Bao-Guo Huang ,  David Y. Tang

    发明人： Bao-Guo Huang ,  David Y. Tang

    IPC分类号： C07C253/30 ,  C07C255/49 ,  C07C255/51 ,  C07C255/00

    CPC分类号： C07C253/30

    摘要： Disclosed is a method of making an o-arylbenzonitrile by reacting o-chlorobenzonitrile with a substituted phenylzinc halide. The reaction is performed in the presence of a nickel catalyst, an ethereal solvent, and N-methylpyrrolidinone as a cosolvent.

    摘要翻译： 公开了通过邻氯苄腈与取代的苯基卤化锌反应制备邻 - 芳基苄腈的方法。 该反应是在镍催化剂，醚类溶剂和作为助溶剂的N-甲基吡咯烷酮的存在下进行的。

    Process for making o-arylbenzonitriles
    3.
    发明授权
    Process for making o-arylbenzonitriles 失效
    制备邻芳基苯腈的方法

    公开(公告)号：US5874606A

    公开(公告)日：1999-02-23

    申请号：US52556

    申请日：1998-03-31

    申请人： Bao-Guo Huang ,  David Y. Tang

    发明人： Bao-Guo Huang ,  David Y. Tang

    IPC分类号： C07C253/30 ,  C07C255/50 ,  C07C255/00

    CPC分类号： C07C255/50 ,  C07C253/30

    摘要： Disclosed is a method of making an o-arylbenzonitrile. A mixture is prepared of o-chlorobenzonitrile and about 1.0 to about 2.0 equivalents per equivalent of o-chlorobenzonitrile of a substituted phenylmagnesium halide in about 5 to about 30 mL per gram of o-chlorobenzonitrile of a solvent system of an ethereal solvent and N-methyl pyrrolidinone. The o-chlorobenzonitrile is reacted with the substituted phenylmagnesium halide at a temperature of about 10-.degree. to about 25.degree. C.

    摘要翻译： 公开了一种制备邻 - 芳基苄腈的方法。 制备邻氯苯甲腈和约1.0至约2.0当量/当量邻氯苯甲腈的取代苯基卤化镁在约5至约30mL /克邻苯二甲酰氯溶剂体系的邻氯苄腈中的溶液和N- 甲基吡咯烷酮。 邻氯苯甲腈与取代的苯基卤化镁在约10-约25℃的温度下反应。

    Method of making 2-bromo-4-chloro substituted phenols
    4.
    发明授权
    Method of making 2-bromo-4-chloro substituted phenols 失效
    制备2-溴-4-氯取代的酚的方法

    公开(公告)号：US06417407B1

    公开(公告)日：2002-07-09

    申请号：US09502082

    申请日：2000-02-10

    申请人： Bao-Guo Huang ,  Lawrence B. Fertel

    发明人： Bao-Guo Huang ,  Lawrence B. Fertel

    IPC分类号： C07C4563

    CPC分类号： C07C45/63 ,  C07C47/565

    摘要： A 2-bromo-4-chloro substituted phenol is prepared from a first composition of a substituted phenol and benzotrifluoride in a weight ratio to the substituted phenol of about 2 to about 4. Into the first composition is sparged about 1 to about 1.5 equivalents of chlorine gas, whereby the substituted phenol is chlorinated to form a 4-chloro substituted phenol. The first composition is cooled to precipitate the 4-chloro substituted phenol, which can be isolated by filtration. A second composition is formed of the 4-chloro substituted phenol, acetic acid in an weight ratio to the 4-chloro substituted phenol of about 1 to about 2, about 1 to about 2 equivalents of a salt of a strong base and a weak acid, and about 1 to about 5 equivalents of a brominating agent, whereby the 4-chloro substituted phenol is brominated to form a 2-bromo-4-chloro substituted phenol.

    摘要翻译： 由与取代苯酚重量比为约2至约4的取代苯酚和三氟甲苯的第一组合物制备2-溴-4-氯取代的苯酚。向第一组合物中喷射约1至约1.5当量的 氯气，由此将取代的苯酚氯化以形成4-氯取代的苯酚。 将第一组合物冷却以沉淀4-氯取代的苯酚，其可以通过过滤分离。 第二组合物由4-氯取代的苯酚，与4-氯取代的苯酚的重量比为约1至约2，约1至约2当量的强碱和弱酸的盐形成的乙酸 和约1至约5当量的溴化剂，由此将4-氯取代的苯酚溴化以形成2-溴-4-氯取代的苯酚。

    Process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives
    7.
    发明授权
    Process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives 有权
    3-氨基-2-羟丙基次膦酸衍生物的制备方法

    公开(公告)号：US07186705B2

    公开(公告)日：2007-03-06

    申请号：US10946869

    申请日：2004-09-22

    申请人： Bao-Guo Huang ,  Witold Subotkowski ,  Duane Rudisill

    发明人： Bao-Guo Huang ,  Witold Subotkowski ,  Duane Rudisill

    IPC分类号： A61K31/66 ,  C07F9/28

    CPC分类号： C07F9/306 ,  C07F9/301

    摘要： The present invention relates to a process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives of the formula I, which are valuable pharmaceutical active ingredients and can be used, for example, as antidepressants. The process starts from O-ethyl phosphinates of the formula II into which, after silylation with hexamethyldisilazane, the 3-amino-2-hydroxypropyl moiety is introduced by reactions with epichlorohydrin and ammonia.

    摘要翻译： 本发明涉及一种制备式I的3-氨基-2-羟丙基次膦酸衍生物的方法，它是有价值的药物活性成分，可用作例如抗抑郁药。 该方法从式II的O-乙基次膦酸酯开始，其中在用六甲基二硅氮烷甲硅烷基化之后，通过与表氯醇和氨的反应引入3-氨基-2-羟丙基部分。

    Process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives
    8.
    发明申请
    Process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives 有权
    3-氨基-2-羟丙基次膦酸衍生物的制备方法

    公开(公告)号：US20050070507A1

    公开(公告)日：2005-03-31

    申请号：US10946869

    申请日：2004-09-22

    申请人： Bao-Guo Huang ,  Witold Subotkowski ,  Duane Rudisill

    发明人： Bao-Guo Huang ,  Witold Subotkowski ,  Duane Rudisill

    IPC分类号： C07F9/30 ,  A61K31/66 ,  C07F9/28

    CPC分类号： C07F9/306 ,  C07F9/301

    摘要： The present invention relates to a process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives of the formula I, which are valuable pharmaceutical active ingredients and can be used, for example, as antidepressants. The process starts from O-ethyl phosphinates of the formula II into which, after silylation with hexamethyldisilazane, the 3-amino-2-hydroxypropyl moiety is introduced by reactions with epichlorohydrin and ammonia.

    摘要翻译： 本发明涉及一种制备式I的3-氨基-2-羟丙基次膦酸衍生物的方法，它是有价值的药物活性成分，可用作例如抗抑郁药。 该方法从式II的O-乙基次膦酸酯开始，其中在用六甲基二硅氮烷甲硅烷基化之后，通过与表氯醇和氨的反应引入3-氨基-2-羟丙基部分。

    Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives
    9.
    发明授权
    Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives 有权
    制备（3-氧代-2,3-二氢-1H-异吲哚-1-基）乙酰基胍衍生物的方法

    公开(公告)号：US07531569B2

    公开(公告)日：2009-05-12

    申请号：US11001624

    申请日：2004-12-01

    申请人： Gerrit Schubert ,  Joerg Rieke-Zapp ,  Johannes Keil ,  Heinz-Werner Kleemann ,  Reda Hanna ,  Bao-Guo Huang ,  Xiao-Dong Wu ,  Yves Gouraud

    发明人： Gerrit Schubert ,  Joerg Rieke-Zapp ,  Johannes Keil ,  Heinz-Werner Kleemann ,  Reda Hanna ,  Bao-Guo Huang ,  Xiao-Dong Wu ,  Yves Gouraud

    IPC分类号： A61K31/4035 ,  C07D209/46 ,  C07C229/38

    CPC分类号： A61K31/4035

    摘要： A method and apparatus for preventing board warpage during the application and curing or drying of liquid epoxies, or the like, on printed circuit boards using a clamping fixture assembly, which includes at least one clamping fixture support and at least one clamping fixture overlay. If desired, a plurality of printed circuit boards may be processed using an appropriate clamping fixture assembly. Furthermore, the clamping fixture may be constructed so a slight bow or curvature thereof can counter either a convex or concave bow or curvature of the printed circuit board.In the method, at least one printed circuit board is mounted to a clamping fixture support whereby a clamping fixture overlay is placed on top of the first printed circuit board.

    摘要翻译： 一种用于在使用夹紧夹具组件的印刷电路板上施加和固化或干燥液体环氧树脂等期间防止板翘曲的方法和装置，其包括至少一个夹紧夹具支架和至少一个夹紧固定盖。 如果需要，可以使用适当的夹具组件来处理多个印刷电路板。 此外，夹持夹具可以被构造成轻微的弓形或其曲率可以对抗印刷电路板的凸形或凹形弓形或曲率。 在该方法中，至少一个印刷电路板安装到夹具固定支架上，由此夹紧夹具覆盖物放置在第一印刷电路板的顶部上。