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1.Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists 失效
标题翻译: 三环取代六氢苯并[e]异吲哚α-1肾上腺素能拮抗剂公开(公告)号:US5597823A
公开(公告)日:1997-01-28
申请号:US463528
申请日:1995-06-05
申请人: Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , Steven W. Elmore , James F. Kerwin, Jr. , Suzanne A. Lebold , Edmund L. Lee , Kevin B. Sippy , Karin R. Tietje , Michael D. Wendt
发明人: Michael D. Meyer , Robert J. Altenbach , Fatima Z. Basha , William A. Carroll , Irene Drizin , Steven W. Elmore , James F. Kerwin, Jr. , Suzanne A. Lebold , Edmund L. Lee , Kevin B. Sippy , Karin R. Tietje , Michael D. Wendt
IPC分类号: A61K31/437 , A61K31/519 , A61P13/00 , A61P13/08 , A61P43/00 , C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/048 , C07D491/14 , C07D491/147 , C07D495/04 , C07D495/14 , A61K31/505
CPC分类号: C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要: The present invention relates to a compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an .alpha.-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are .alpha.-1 antagonist compositions and a method for antagonizing .alpha.-1 receptors and treating BPH.
摘要翻译: 本发明涉及式IMA的化合物及其药学上可接受的盐,其中W是三环杂环体系; 其是α-1肾上腺素能拮抗剂,可用于治疗BPH; 还公开了α-1拮抗剂组合物和拮抗α-1受体并治疗BPH的方法。
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2.APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权
标题翻译: 用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号:US20110237553A1
公开(公告)日:2011-09-29
申请号:US13049569
申请日:2011-03-16
申请人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
发明人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
IPC分类号: A61K31/635 , C07D295/155 , A61P35/00 , A61P35/02 , C07D211/58 , C07C311/51 , A61K31/63
CPC分类号: C07D211/58 , C07C311/51 , C07C2601/14 , C07C2603/74 , C07D295/112 , C07D295/195 , C07D417/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物,含有化合物的组合物和治疗疾病的方法,其中表达抗凋亡Bcl-2蛋白。
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公开(公告)号:US20110124628A1
公开(公告)日:2011-05-26
申请号:US12951344
申请日:2010-11-22
申请人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
发明人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC分类号: A61K31/496 , C07D471/04 , C07D401/14 , C07D403/14 , C07D405/14 , A61K31/5377 , A61K31/517 , A61K31/541 , A61P35/00 , A61P35/02
CPC分类号: C07D471/04 , C07D491/052 , C07D519/00
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号:US07910742B2
公开(公告)日:2011-03-22
申请号:US11529845
申请日:2006-09-29
IPC分类号: C07D401/12
CPC分类号: C07D213/85 , C07D213/64 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/12
摘要: Compounds that inhibit survivin, compositions containing the compounds and methods of treating diseases in which survivin is unregulated or overexpressed are disclosed.
摘要翻译: 公开了抑制存活蛋白的化合物,含有化合物的组合物和治疗存活蛋白不受调节或过表达的疾病的方法。
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5.
公开(公告)号:US20100160322A1
公开(公告)日:2010-06-24
申请号:US12631367
申请日:2009-12-04
申请人: Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
发明人: Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
IPC分类号: A61K31/5377 , C07D405/02 , A61K31/496 , C07D403/02 , C07D401/02 , C07D413/02 , A61P35/00
CPC分类号: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号:US08188077B2
公开(公告)日:2012-05-29
申请号:US13049569
申请日:2011-03-16
申请人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
发明人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
IPC分类号: A61K31/5377 , A61K31/5375 , A61K31/435 , A61K31/437 , C07D413/02 , C07D241/02 , C07D295/00 , C07D211/00
CPC分类号: C07D211/58 , C07C311/51 , C07C2601/14 , C07C2603/74 , C07D295/112 , C07D295/195 , C07D417/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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7.Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases 有权
标题翻译: 凋亡诱导剂用于治疗癌症和免疫和自身免疫性疾病公开(公告)号:US08546399B2
公开(公告)日:2013-10-01
申请号:US12787682
申请日:2010-05-26
申请人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
发明人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC分类号: A61K31/407 , C07D401/12
CPC分类号: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物,含有化合物的组合物和治疗疾病的方法,其中表达抗凋亡Bcl-2蛋白。
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公开(公告)号:US08426422B2
公开(公告)日:2013-04-23
申请号:US12689106
申请日:2010-01-18
申请人: Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
发明人: Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
IPC分类号: A61K31/496 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D311/14 , C07D295/155
CPC分类号: C07D295/155 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D311/14
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号:US08343967B2
公开(公告)日:2013-01-01
申请号:US13458968
申请日:2012-04-27
申请人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
发明人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
IPC分类号: A61K31/5377 , A61K31/5375 , A61K31/435 , A61K31/437 , C07D413/02 , C07D241/02 , C07D295/00 , C07D211/00
CPC分类号: C07D211/58 , C07C311/51 , C07C2601/14 , C07C2603/74 , C07D295/112 , C07D295/195 , C07D417/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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10.APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开
标题翻译: 用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号:US20120190688A1
公开(公告)日:2012-07-26
申请号:US13430610
申请日:2012-03-26
申请人: Milan Bruncko , Hong Ding , George A. Doherly , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert A. Mantei , Todd M. Hansen
发明人: Milan Bruncko , Hong Ding , George A. Doherly , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert A. Mantei , Todd M. Hansen
IPC分类号: A61K31/496 , A61P37/00 , A61P35/02 , C07D471/04 , A61P35/00
CPC分类号: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物,含有化合物的组合物和治疗疾病的方法,其中表达抗凋亡Bcl-2蛋白。
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