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19 条记录 (耗时 0.051 秒)

    C5a receptor antagonists
    8.
    发明授权
    C5a receptor antagonists 失效
    C5a受体拮抗剂

    公开(公告)号：US08071810B2

    公开(公告)日：2011-12-06

    申请号：US11915892

    申请日：2006-05-30

    申请人： Karsten Schnatbaum ,  Dirk Scharn ,  Elsa Locardi ,  Thomas Polakowski ,  Uwe Richter ,  Ulrich Reineke ,  Gerd Hummel

    发明人： Karsten Schnatbaum ,  Dirk Scharn ,  Elsa Locardi ,  Thomas Polakowski ,  Uwe Richter ,  Ulrich Reineke ,  Gerd Hummel

    IPC分类号： C07C275/00 ,  C07C273/00

    CPC分类号： C07C275/40 ,  C07C235/40 ,  C07C275/26 ,  C07C275/30 ,  C07C2602/08 ,  C07C2602/10 ,  C07D207/327 ,  C07D213/40 ,  C07D213/61 ,  C07D215/40 ,  C07D235/06 ,  C07D237/08 ,  C07D239/42 ,  C07D241/42 ,  C07D311/20 ,  C07D335/02

    摘要： The present invention is related to a compound, preferably a C5a receptor antagonist, having the following structure, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21 and R22 are individually and independently selected from the group comprising H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, alkoxyl, substituted alkoxyl, aryloxy, substituted aryloxy, arylalkyloxy, substituted arylalkyloxy, acyloxy, substituted acyloxy, halogen, hydroxyl, nitro, cyano, acyl, substituted acyl, mercapto, alkylthio, substituted alkylthio, amino, substituted amino, alkylamino, substituted alkylamino, bisalkyl amino, substituted bisalkyl amino, cyclic amino, substituted cyclic amino, carbamoyl (—CONH2), substituted carbamoyl, carboxyl, carbamate, alkoxycarbonyl, substituted alkoxycarbonyl, acylamino, substituted acylamino, sulfamoyl (—SO2NH2), substituted sulfamoyl, haloalkyl, haloalkyloxy, —C(O)H, trialkylsilyl and azido.

    摘要翻译： 本发明涉及具有以下结构的化合物，优选C5a受体拮抗剂：R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，R13，R14，R15， R16，R17，R18，R19，R20，R21和R22各自独立地选自H，烷基，取代的烷基，烯基，取代的烯基，炔基，取代的炔基，环烷基，取代的环烷基，杂环基，取代的杂环基，芳基 ，取代的芳基，杂芳基，取代的杂芳基，芳基烷基，取代的芳基烷基，杂芳基烷基，取代的杂芳基烷基，烷氧基，取代的烷氧基，芳氧基，取代的芳氧基，芳基烷氧基，取代的芳基烷氧基，酰氧基，取代的酰氧基，卤素，羟基，硝基，氰基， 酰基，巯基，烷硫基，取代的烷硫基，氨基，取代的氨基，烷基氨基，取代的烷基氨基，双烷基氨基，取代的双烷基氨基，环状氨基，取代的环状氨基，氨基甲酰基（-CONH 2） 氨基甲酰基，羧基，氨基甲酸酯，烷氧基羰基，取代的烷氧基羰基，酰氨基，取代的酰氨基，氨磺酰基（-SO2NH2），取代的氨磺酰基，卤代烷基，卤代烷氧基，-C（O）H，三烷基甲硅烷基和叠氮基。

    C5a Receptor Antagonists
    9.
    发明申请
    C5a Receptor Antagonists 失效
    C5a受体拮抗剂

    公开(公告)号：US20080220003A1

    公开(公告)日：2008-09-11

    申请号：US11915892

    申请日：2006-05-30

    申请人： Karsten Schnatbaum ,  Dirk Scharn ,  Elsa Locardi ,  Thomas Polakowski ,  Uwe Richter ,  Ulrich Reineke ,  Gerd Hummel

    发明人： Karsten Schnatbaum ,  Dirk Scharn ,  Elsa Locardi ,  Thomas Polakowski ,  Uwe Richter ,  Ulrich Reineke ,  Gerd Hummel

    IPC分类号： A61K38/13 ,  C07C275/28 ,  C07D213/02 ,  C07D235/24 ,  C07D209/14 ,  A61K31/17 ,  A61K31/436 ,  A61K31/57 ,  A61K39/395 ,  A61K31/196 ,  A61K31/65 ,  A61K31/4545 ,  A61K31/519 ,  A61K31/44 ,  A61K31/4184 ,  A61K31/4045 ,  A61K31/47 ,  A61P37/06 ,  A61P29/00

    CPC分类号： C07C275/40 ,  C07C235/40 ,  C07C275/26 ,  C07C275/30 ,  C07C2602/08 ,  C07C2602/10 ,  C07D207/327 ,  C07D213/40 ,  C07D213/61 ,  C07D215/40 ,  C07D235/06 ,  C07D237/08 ,  C07D239/42 ,  C07D241/42 ,  C07D311/20 ,  C07D335/02

    摘要： The present invention is related to a compound, preferably a C5a receptor antagonist, having the following structure, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21 and R22 are individually and independently selected from the group comprising H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, alkoxyl, substituted alkoxyl, aryloxy, substituted aryloxy, arylalkyloxy, substituted arylalkyloxy, acyloxy, substituted acyloxy, halogen, hydroxyl, nitro, cyano, acyl, substituted acyl, mercapto, alkylthio, substituted alkylthio, amino, substituted amino, alkylamino, substituted alkylamino, bisalkyl amino, substituted bisalkyl amino, cyclic amino, substituted cyclic amino, carbamoyl (—CONH2), substituted carbamoyl, carboxyl, carbamate, alkoxycarbonyl, substituted alkoxycarbonyl, acylamino, substituted acylamino, sulfamoyl (—SO2NH2), substituted sulfamoyl, haloalkyl, haloalkyloxy, —C(O)H, trialkylsilyl and azido.

    摘要翻译： 本发明涉及具有以下结构的化合物，优选C5a受体拮抗剂：R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，R13，R14，R15， R16，R17，R18，R19，R20，R21和R22各自独立地选自H，烷基，取代的烷基，烯基，取代的烯基，炔基，取代的炔基，环烷基，取代的环烷基，杂环基，取代的杂环基，芳基 ，取代的芳基，杂芳基，取代的杂芳基，芳基烷基，取代的芳基烷基，杂芳基烷基，取代的杂芳基烷基，烷氧基，取代的烷氧基，芳氧基，取代的芳氧基，芳基烷氧基，取代的芳基烷氧基，酰氧基，取代的酰氧基，卤素，羟基，硝基，氰基， 酰基，巯基，烷硫基，取代的烷硫基，氨基，取代的氨基，烷基氨基，取代的烷基氨基，双烷基氨基，取代的双烷基氨基，环状氨基，取代的环状氨基，氨基甲酰基（-CONH 2 取代的氨基甲酰基，羧基，氨基甲酸酯，烷氧基羰基，取代的烷氧基羰基，酰氨基，取代的酰基氨基，氨磺酰基（-SO 2 NH 2），取代的氨磺酰基，卤代烷基，卤代烷氧基， -C（O）H，三烷基甲硅烷基和叠氮基。