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14 条记录 (耗时 0.028 秒)

    Method and system for optimizing alignment performance in a fleet of exposure tools
    1.
    发明授权
    Method and system for optimizing alignment performance in a fleet of exposure tools 有权
    用于优化曝光工具的对准性能的方法和系统

    公开(公告)号：US07679069B2

    公开(公告)日：2010-03-16

    申请号：US11686871

    申请日：2007-03-15

    申请人： Michael E. Adel ,  John Robinson ,  Pavel Izikson ,  Brad Eichelberger ,  Amir Widmann ,  Atsuhiko Kato

    发明人： Michael E. Adel ,  John Robinson ,  Pavel Izikson ,  Brad Eichelberger ,  Amir Widmann ,  Atsuhiko Kato

    IPC分类号： G21K1/00

    CPC分类号： G03F7/70458 ,  G03F7/70525 ,  G03F7/706 ,  G03F9/7046

    摘要： A method for optimizing alignment performance in a fleet of exposure systems involves characterizing each exposure system in a fleet of exposure systems to generate a set of distinctive distortion profiles associated with each exposure system. The set of distinctive distortion profiles are stored in a database. A wafer having reference pattern formed thereon is provided for further pattern fabrication and an exposure system is selected from the fleet to fabricate a next layer on the wafer. Linear and higher order parameters of the selected exposure system are adjusted using the distinctive distortion profiles to model the distortion of the reference pattern. Once the exposure system is adjusted, it is used to form a lithographic pattern on the wafer.

    摘要翻译： 用于优化曝光系统队列中的对准性能的方法涉及表征曝光系统中的每个曝光系统，以产生与每个曝光系统相关联的一组独特的失真曲线。 一组有特色的失真简档存储在数据库中。 提供具有形成在其上的参考图案的晶片用于进一步的图案制造，并且从车队中选择曝光系统以在晶片上制造下一层。 使用不同的失真曲线来调整所选曝光系统的线性和高阶参数以对参考图案的失真进行建模。 一旦调整曝光系统，就用于在晶片上形成平版印刷图案。

    METHOD AND SYSTEM FOR OPTIMIZING ALIGNMENT PERFORMANCE IN A FLEET OF EXPOSURE TOOLS
    2.
    发明申请
    METHOD AND SYSTEM FOR OPTIMIZING ALIGNMENT PERFORMANCE IN A FLEET OF EXPOSURE TOOLS 有权
    在接触工具中优化对准性能的方法和系统

    公开(公告)号：US20080073589A1

    公开(公告)日：2008-03-27

    申请号：US11686871

    申请日：2007-03-15

    申请人： Michael Adel ,  John Robinson ,  Pavel Izikson ,  Brad Eichelberger ,  Amir Widmann ,  Atsuhiko Kato

    发明人： Michael Adel ,  John Robinson ,  Pavel Izikson ,  Brad Eichelberger ,  Amir Widmann ,  Atsuhiko Kato

    IPC分类号： G21K5/10

    CPC分类号： G03F7/70458 ,  G03F7/70525 ,  G03F7/706 ,  G03F9/7046

    摘要： A method for optimizing alignment performance in a fleet of exposure systems involves characterizing each exposure system in a fleet of exposure systems to generate a set of distinctive distortion profiles associated with each exposure system. The set of distinctive distortion profiles are stored in a database. A wafer having reference pattern formed thereon is provided for further pattern fabrication and an exposure system is selected from the fleet to fabricate a next layer on the wafer. Linear and higher order parameters of the selected exposure system are adjusted using the distinctive distortion profiles to model the distortion of the reference pattern. Once the exposure system is adjusted, it is used to form a lithographic pattern on the wafer.

    摘要翻译： 用于优化曝光系统队列中的对准性能的方法涉及表征曝光系统中的每个曝光系统，以产生与每个曝光系统相关联的一组独特的失真曲线。 一组有特色的失真简档存储在数据库中。 提供具有形成在其上的参考图案的晶片用于进一步的图案制造，并且从车队中选择曝光系统以在晶片上制造下一层。 使用不同的失真曲线来调整所选曝光系统的线性和高阶参数以对参考图案的失真进行建模。 一旦调整曝光系统，就用于在晶片上形成平版印刷图案。

    Chondrongenesis promotors and indolin-2-one derivatives
    3.
    发明授权
    Chondrongenesis promotors and indolin-2-one derivatives 失效
    二茂铁衍生物和二氢吲哚-2-酮衍生物

    公开(公告)号：US06500854B1

    公开(公告)日：2002-12-31

    申请号：US09890071

    申请日：2001-09-21

    申请人： Hidetomo Kitamura ,  Atsuhiko Kato ,  Toru Esaki

    发明人： Hidetomo Kitamura ,  Atsuhiko Kato ,  Toru Esaki

    IPC分类号： A61K31404

    CPC分类号： C07D401/06 ,  A61K31/404 ,  A61K31/405 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  C07D209/38 ,  C07D209/40 ,  C07D403/12 ,  C07D405/06

    摘要： A chondrogenesis promoter comprising as an active ingredient a compound represented by general formula (I) or a salt thereof: wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, etc.; R2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, an acyl group, an aryl group, a heterocyclic group, etc.; R1 represents a lower alkyl group, a cycloalkyl group, an aryl group, a heterocyclic group, etc.; R4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, etc.; X and Y represent —CH2—, —NH—or —O—; and n represents an integer of 0-4.

    摘要翻译： 一种软骨形成促进剂，其包含作为活性成分的由通式（I）表示的化合物或其盐：其中R1表示卤素原子，低级烷基，低级烷氧基等; R2表示氢原子，低级烷基，低级烯基，低级炔基，低级烷氧基，酰基，芳基，杂环基等。 R1表示低级烷基，环烷基，芳基，杂环基等; R4表示氢原子，低级烷基，芳基，杂环基等; X和Y表示-CH 2 - ， - NH-或-O-; n表示0〜4的整数。

    CANCER STEM CELL MASS AND PROCESS FOR PRODUCTION THEREOF
    5.
    发明申请
    CANCER STEM CELL MASS AND PROCESS FOR PRODUCTION THEREOF 审中-公开
    癌症干细胞质量及其生产方法

    公开(公告)号：US20130288248A1

    公开(公告)日：2013-10-31

    申请号：US13878181

    申请日：2011-10-06

    申请人： Tatsumi Yamazaki ,  Hisafumi Okabe ,  Shinta Kobayashi ,  Yu Jau Chen ,  Atsuhiko Kato ,  Masami Suzuki ,  Koichi Matsubara

    发明人： Tatsumi Yamazaki ,  Hisafumi Okabe ,  Shinta Kobayashi ,  Yu Jau Chen ,  Atsuhiko Kato ,  Masami Suzuki ,  Koichi Matsubara

    IPC分类号： C12N5/095

    CPC分类号： C12N5/0695 ,  G01N33/5011 ,  G01N33/5073

    摘要： The purpose of the present invention is to provide: a cancer stem cell mass from which cells incapable of forming cancer are substantially removed and which has a characteristic property of reproducing a layered structure of a cancer tissue; a process for producing the cancer stem cell mass; and use of the cancer stem cell mass. For achieving the purpose, the present inventors grew a human cancer tissue repeatedly in a NOG mouse, separated cancer cells from the grown cancer tissue, and made a comparison of various cancer cell culture processes with each other. As a result, a cancer stem cell composition which is homogeneous and is substantially free of the coexistence of cells capable of forming cancer and cells incapable of forming cancer in a mixed state can be produced successively by employing an attached culture process using a serum-free stem cell culture medium rather than a generally employed floating culture process, and consequently the present invention has been accomplished.

    摘要翻译： 本发明的目的是提供：基本上除去不能形成癌症的细胞的癌干细胞群，其具有再现癌组织的层状结构的特征; 一种生产癌症干细胞团的方法; 并使用癌干细胞团。 为了达到上述目的，本发明人在NOG小鼠中反复生长人类癌组织，从生长的癌组织中分离癌细胞，并进行各种癌细胞培养方法的比较。 结果，可以通过使用不含血清的附着培养方法，连续地制备均质且基本上不含可形成癌细胞的细胞和不能混合形成癌症的细胞的癌干细胞组合物 干细胞培养基而不是通常使用的浮动培养方法，因此本发明已经实现。

    Chondrogenesis promoters and indolin-2-one derivatives
    7.
    发明授权
    Chondrogenesis promoters and indolin-2-one derivatives 失效
    软骨形成启动子和二氢吲哚-2-酮衍生物

    公开(公告)号：US06716628B2

    公开(公告)日：2004-04-06

    申请号：US10224311

    申请日：2002-08-21

    申请人： Hidetomo Kitamura ,  Atsuhiko Kato ,  Toru Esaki

    发明人： Hidetomo Kitamura ,  Atsuhiko Kato ,  Toru Esaki

    IPC分类号： C12N502

    CPC分类号： C07D401/06 ,  A61K31/404 ,  A61K31/405 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  C07D209/38 ,  C07D209/40 ,  C07D403/12 ,  C07D405/06

    摘要： A chondrogenesis promoter comprising as an active ingredient a compound represented by general formula (I) or a salt thereof: wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, etc.; R2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, an acyl group, an aryl group, a heterocyclic group, etc.; R3 represents a lower alkyl group, a cycloalkyl group, an aryl group, a heterocyclic group, etc.; R4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, etc.; X and Y represent —CH2—, —NH— or —O—; and n represents an integer of 0-4.

    摘要翻译： 一种软骨形成促进剂，其包含作为活性成分的由通式（I）表示的化合物或其盐：其中R 1表示卤素原子，低级烷基，低级烷氧基等; R 2表示氢原子，低级烷基，低级烯基，低级炔基，低级烷氧基，酰基，芳基，杂环基等。 R 3表示低级烷基，环烷基，芳基，杂环基等; R 4表示氢原子，低级烷基，芳基，杂环基等; X和Y表示-CH 2 - ， - NH-或-O-; n表示0〜4的整数。

    Method for detection of liver cancer cell using anti-glypican-3 antibody
    10.
    发明授权
    Method for detection of liver cancer cell using anti-glypican-3 antibody 有权
    使用抗磷脂酰肌醇蛋白聚糖-3抗体检测肝癌细胞的方法

    公开(公告)号：US08663929B2

    公开(公告)日：2014-03-04

    申请号：US12736180

    申请日：2009-03-16

    申请人： Hiroaki Kataoka ,  Hirotake Takai ,  Atsuhiko Kato ,  Masami Suzuki ,  Masamichi Sugimoto

    发明人： Hiroaki Kataoka ,  Hirotake Takai ,  Atsuhiko Kato ,  Masami Suzuki ,  Masamichi Sugimoto

    IPC分类号： G01N33/53

    CPC分类号： G01N33/57438 ,  A61K2039/505 ,  C07K16/303

    摘要： The present invention relates to an in-vitro immunoassay method for detecting the presence of liver cancer cells in a subject. In the method of the present invention, antigen retrieval treatment based on heat-induced epitope retrieval method and antigen retrieval treatment based on protease-induced epitope retrieval method can be combined in the detection of glypican 3 antigen expression in liver cancer tissues to thereby detect the difference in the expression level or expression pattern of the glypican 3 antigen by immunohistochemical staining method. This enables samples, which has been determined by the conventional HIER method as highly expressing glypican 3, to be graded according to the expression level of glypican 3.

    摘要翻译： 本发明涉及用于检测受试者中肝癌细胞存在的体外免疫测定方法。 在本发明的方法中，基于热诱导表位检索方法和基于蛋白酶诱导表位检索方法的抗原恢复处理的抗原恢复处理可以结合在肝癌组织中检测磷脂酰肌醇蛋白聚糖3抗原表达，从而检测 通过免疫组织化学染色法观察磷脂酰肌醇蛋白聚糖3抗原的表达水平或表达模式差异。 这使得通过常规HIER方法确定的高度表达磷脂酰肌醇蛋白聚糖3的样品根据磷脂酰肌醇蛋白聚糖3的表达水平被分级。