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公开(公告)号：US5993412A
公开(公告)日：1999-11-30
申请号：US858249
申请日：1997-05-19
CPC分类号： A61M5/30 , A61M2005/208 , A61M5/2053
摘要： The present invention typically is in the form of a needleless injector which includes the following components: (1) a needleless syringe installed in the injector for holding medication prior to injection, the syringe including an injection aperture at the forward end thereof; (2) a syringe plunger slidably mounted to the rear end of the syringe for forcing medication out the syringe aperture; (3) a syringe plunger drive mechanism providing power to drive the syringe plunger and thereby force medication out of the syringe; and (4) a syringe drive control mechanism for controlling the operation of the drive mechanism, the drive control mechanism including a warning system which warns the user if a pre-injection condition is not met, an interlock system which prevents injection from taking place if the pre-injection condition is not met, and a sensing system which senses whether the pre-injection condition is not met and conveys a signal to the warning and interlock systems informing as to whether the pre-injection condition is met.
摘要翻译： 本发明通常是无针注射器的形式，其包括以下部件：（1）安装在注射器中的无针注射器，用于在注射之前保持药物，注射器在其前端包括注射孔; （2）注射器柱塞，其可滑动地安装到注射器的后端，用于迫使药物从注射器孔中排出; （3）注射器柱塞驱动机构，其提供动力来驱动注射器柱塞，从而迫使药物离开注射器; 以及（4）用于控制驱动机构的操作的注射器驱动控制机构，所述驱动控制机构包括警告用户是否不满足预喷射条件的警告系统，防止喷射发生的互锁系统，如果 不能满足预喷射条件，以及检测是否满足预喷射条件并且向警告和互锁系统传送信号以及是否满足预喷射条件的传感系统。
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2.发明授权Intradermal injection system for injecting DNA-based injectables into humans 有权用于将DNA基注射液注射入人体内的注射系统公开(公告)号：US06319224B1
公开(公告)日：2001-11-20
申请号：US09378294
申请日：1999-08-20
IPC分类号： A61M530
CPC分类号： A61M5/30
摘要： A system for injecting DNA-based medications into humans is provided by the present invention. The system includes a needle-free injector with an injection orifice of approximately 0.004 inches for supplying DNA-based medication at an initial pressure of from 3900 to 4300 psi, and then immediately declining to a level of about 2800 to 3800 psi, and then immediately cutting off pressure to terminate the injection. The injector includes an annular adapter for spacing the injection orifice from the skin of the patient. The adapter includes an abutment against which the injector is disposed so that the orifice is spaced approximately 0.76-1.0 inch from the skin of the patient, the adapter having an inner diameter at the distal end of approximately 0.50-0.70 inches.
摘要翻译： 本发明提供了一种将基于DNA的药物注入人体的系统。 该系统包括具有大约0.004英寸的注射孔的无针注射器，用于在3900至4300psi的初始压力下提供基于DNA的药物，然后立即下降至约2800至3800psi的水平，然后立即 切断压力以终止注射。 注射器包括用于将注射孔与患者皮肤间隔开的环形适配器。 适配器包括抵靠件，注射器设置在支座上，使得孔口与患者皮肤间隔大约0.76-1.0英寸，适配器的远端的内径大约为0.50-0.70英寸。
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公开(公告)号：US6132395A
公开(公告)日：2000-10-17
申请号：US207398
申请日：1998-12-08
申请人： Sergio Landau , James M. Bonicatto
发明人： Sergio Landau , James M. Bonicatto
CPC分类号： A61M5/30 , A61M2005/2462 , A61M2005/287 , A61M2005/3106 , A61M2005/3123 , A61M2005/3128 , A61M2005/3132 , A61M5/2053 , A61M5/2459
摘要： A cartridge and nozzle assembly for use in a needless injection system is provided. The assembly includes: (1) a cartridge having a plunger disposed at a rearward end thereof, and including a throat at a forward portion thereof, with a displaceable outlet valve initially disposed within the throat, the outlet valve being formed of resilient material and having at least one axial channel defined in the forward and rearward portions thereof, between which is disposed a channel-less valve body; (2) a nozzle for receiving the cartridge, the nozzle defining a rearward, cartridge-receiving portion, and including a forward portion terminating in and defining a valve abutment surface with an injection orifice defined therein and a recessed portion, the recessed portion being configured to receive the valve when the valve is displaced to a forwardly disposed position such that the valve is disposed against the valve abutment surface, and so that the inner portion of the cartridge has fluid access to the orifice via the axial channels and around the valve body; and (3) a seal disposed between the cartridge and the nozzle adjacent the forward portions thereof for at least reducing leakage of injectate therebetween.
摘要翻译： 提供了一种用于不必要的喷射系统的墨盒和喷嘴组件。 组件包括：（1）具有设置在其后端处的柱塞并且在其前部包括喉部的柱塞，其中可移动的出口阀最初设置在喉部内，出口阀由弹性材料形成并且具有 限定在其前部和后部中的至少一个轴向通道，其间设置有无通道的阀体; （2）用于容纳盒的喷嘴，所述喷嘴限定向后的盒接收部分，并且包括终止于限定在其中的喷射孔并且限定与其形成的邻接表面的前部，所述凹部被配置 当阀被移动到向前布置的位置时接收阀，使得阀抵靠阀邻接表面设置，并且使得筒的内部部分经由轴向通道并且围绕阀体流体地进入孔口 ; 和（3）密封件，其设置在墨盒和喷嘴之间，邻近其前部，以至少减少其间的注射器泄漏。
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公开(公告)号：US07188941B2
公开(公告)日：2007-03-13
申请号：US10753112
申请日：2004-01-07
IPC分类号： B41J2/175
CPC分类号： B41J2/17596
摘要： A valve for a printing apparatus that uses liquid ink includes a valve seat, a valve stop and a valve member interposed between the valve seat and the valve stop.
摘要翻译： 用于使用液体油墨的打印装置的阀包括阀座，阀止动件和插在阀座和阀止动件之间的阀构件。
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公开(公告)号：US06783509B1
公开(公告)日：2004-08-31
申请号：US09661135
申请日：2000-09-13
IPC分类号： H61M530
CPC分类号： A61M5/30 , A61M5/2053 , A61M5/2459 , A61M5/425 , A61M2005/2073 , A61M2005/2462 , A61M2005/3104 , A61M2005/3132
摘要： A needleless injector system including: a first injector assembly; a gas capsule disposed within the first injector assembly and containing pressurized gas, with a pierceable surface at the forward end thereof to provide an injection source; a gas capsule piercing member disposed within the first injector assembly, where the piercing member and the gas capsule are movable relative to each other; a second injector assembly containing a medical treatment fluid and having a forward facing injection orifice for injecting the medical treatment fluid into a patient; and a resilient seal mounted between the gas capsule and the first injector assembly to contain all pressurized gas within a forward end of the first injector assembly after pressurized gas is released from the gas capsule following piercing of the gas capsule, in order to cause an immediate increase in pressure in the medical treatment fluid contained within the second injector assembly.
摘要翻译： 一种无针注射器系统，包括：第一注射器组件; 设置在所述第一注射器组件内并且包含加压气体的气囊，其前端具有可刺穿的表面以提供注射源; 设置在所述第一注射器组件内的气囊组件穿孔构件，其中所述穿刺构件和所述气囊可相对于彼此移动; 第二注射器组件，其包含医疗流体并具有用于将所述医疗流体注射到患者体内的向前注射孔口; 以及弹性密封件，其安装在所述气体胶囊和所述第一喷射器组件之间，以在所述气体胶囊刺穿之后从所述气体胶囊释放加压气体之后，将所述加压气体容纳在所述第一喷射器组件的前端内，以便立即 增加包含在第二注射器组件内的医疗液中的压力。
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公开(公告)号：US07717874B2
公开(公告)日：2010-05-18
申请号：US10857591
申请日：2004-05-28
申请人： Sergio Landau , Ryan R. Beylund , James M. Bonicatto , Keith K. Daellenbach , Robert A. Miller , Theodore Walaka Sedler , John L. Staylor
发明人： Sergio Landau , Ryan R. Beylund , James M. Bonicatto , Keith K. Daellenbach , Robert A. Miller , Theodore Walaka Sedler , John L. Staylor
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/2053 , A61M5/24 , A61M2005/2407 , A61M2005/2488 , A61M2005/287 , A61M2005/3104
摘要： A needle-free injection device in which a gas cartridge or other source of pressurized gas is used to advance a piston and forcibly expel injectable fluid out through an injection orifice. When a gas cartridge is used, the gas cartridge may be moveable from an initial position to an actuating position in which gas is released to drive the injection, and a recoil inhibiter may be employed to prevent the gas cartridge from moving back to the initial position. A gas cartridge seal may be disposed on the gas cartridge and moveable with the gas cartridge to seal the gas cartridge against an interior wall of a gas cartridge housing. The needle-free injection device may also be configured so that sealing is compromised upon full advancement of the piston, so as to de-pressurize the device after delivery of an injection.
摘要翻译： 无针注射装置，其中使用气瓶或其他加压气体源来推进活塞并强制地通过注射口排出可注射流体。 当使用气体盒时，气体盒可以从初始位置移动到释放气体的致动位置以驱动喷射，并且可以采用反冲抑制器来防止气体盒回到初始位置 。 气瓶密封件可以设置在气体盒上并且可与气体盒一起移动，以将气体盒密封在气体盒壳体的内壁上。 无针注射装置也可以被配置为使得在活塞完全前进时密封受到影响，以便在输送注射之后对装置进行减压。
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7.发明授权Intradermal injection system for injecting DNA-based injectables into humans 有权用于将DNA基注射液注射入人体内的注射系统公开(公告)号：US06752780B2
公开(公告)日：2004-06-22
申请号：US10001856
申请日：2001-11-19
IPC分类号： A61M530
CPC分类号： A61M5/30
摘要： A system for injecting DNA-based medications into humans is provided by the present invention. The system includes a needle-free injector with an injection orifice of approximately 0.004 inches for supplying DNA-based medication at an initial pressure of from 3900 to 4300 psi, and then immediately declining to a level of about 2800 to 3800 psi, and then immediately cutting off pressure to terminate the injection. The injector includes an annular adapter for spacing the injection orifice from the skin of the patient. The adapter includes an abutment against which the injector is disposed so that the orifice is spaced approximately 0.76-1.0 inch from the skin of the patient, the adapter having an inner diameter at the distal end of approximately 0.50-0.70 inches.
摘要翻译： 本发明提供了一种将基于DNA的药物注入人体的系统。 该系统包括具有大约0.004英寸的注射孔的无针注射器，用于在3900至4300psi的初始压力下提供基于DNA的药物，然后立即下降至约2800至3800psi的水平，然后立即 切断压力以终止注射。 注射器包括用于将注射孔与患者皮肤间隔开的环形适配器。 适配器包括抵靠件，注射器设置在支座上，使得孔口与患者皮肤间隔大约0.76-1.0英寸，适配器的远端的内径大约为0.50-0.70英寸。
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公开(公告)号：US06383168B1
公开(公告)日：2002-05-07
申请号：US09539731
申请日：2000-03-30
申请人： Sergio Landau , James M. Bonicatto
发明人： Sergio Landau , James M. Bonicatto
IPC分类号： A61M530
CPC分类号： A61M5/30 , A61M5/2053 , A61M5/2459 , A61M2005/2462 , A61M2005/3104 , A61M2005/3106 , A61M2005/3128 , A61M2005/3132
摘要： In accordance with an embodiment of the invention, a needleless injection apparatus includes a cartridge having a plunger disposed at a rearward end. The cartridge includes an inner portion with a throat at a forward portion and a displaceable outlet valve initially disposed within the cartridge throat. The cartridge further includes a generally outwardly facing surface and a system for selectively providing driving force to drive the plunger in a forward direction. The apparatus also includes a nozzle for receiving the cartridge, the nozzle defining a rearward, cartridge-receiving portion, and having a forward portion terminating in and defining a valve abutment surface with a plurality of channels and an injection orifice. The forward portion of the nozzle being configured to receive the valve when the valve is displaced to a forwardly disposed position such that the valve is disposed against the valve abutment surface, and so that the inner portion of the cartridge has fluid access to the orifice via the channels. The nozzle further includes a generally inwardly facing surface that abuts the cartridge surface, and a seal disposed between the outwardly facing surface of the cartridge and the inwardly facing surface of the nozzle for at least reducing leakage of injectate therebetween.
摘要翻译： 根据本发明的实施例，无针注射装置包括具有设置在后端的柱塞的药筒。 盒包括在前部具有喉部的内部部分和最初设置在筒状喉部内的可移位的出口阀。 该墨盒还包括大致向外的表面和用于选择性地提供驱动力以向前驱动柱塞的系统。 该设备还包括用于接收盒的喷嘴，喷嘴限定向后的盒接收部分，并且具有终止于并限定具有多个通道的阀邻接表面的前部以及喷射孔。 喷嘴的前部构造成当阀被移动到向前布置的位置时接纳阀，使得阀抵靠阀邻接表面设置，并且使得筒的内部部分具有流体通过孔口的流体通路 渠道。 喷嘴还包括一个大致向内的表面，该表面邻近墨盒表面，以及密封件，其设置在墨盒的面向外的表面和喷嘴的向内的表面之间，用于至少减少其间的注射器的泄漏。
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