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公开(公告)号:US07872044B2
公开(公告)日:2011-01-18
申请号:US11975235
申请日:2007-10-18
IPC分类号: A61K31/343 , C07D307/87 , C07F9/28
CPC分类号: C07F9/65517
摘要: The present invention is directed to a compound of Formula (I): or an enantiomer, diastereomer, polymorph or pharmaceutically acceptable salt thereof and methods for preparing said compounds and compositions, intermediates and derivatives thereof, and methods for treating inflammatory or serine protease mediated disorders.
摘要翻译: 本发明涉及式(I)的化合物或其对映体,非对映异构体,多晶型物或其药学上可接受的盐以及制备所述化合物及其组合物,中间体及其衍生物的方法,以及用于治疗炎性或丝氨酸蛋白酶介导的病症的方法 。
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公开(公告)号:US20050176769A1
公开(公告)日:2005-08-11
申请号:US11037938
申请日:2005-01-18
IPC分类号: A61K31/165 , A61K31/381 , A61K31/4436 , A61K31/453 , A61K31/662 , C07F9/30 , C07F9/32 , C07F9/38 , C07F9/40 , C07F9/572 , C07F9/59 , C07F9/60 , C07F9/62 , C07F9/655 , C07F9/6553 , C07F9/6558 , C07F9/6561 , C07F9/6571 , C07D49/02
CPC分类号: C07F9/6561 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/59 , C07F9/60 , C07F9/62 , C07F9/65517 , C07F9/655354 , C07F9/65583 , C07F9/65586 , C07F9/657181
摘要: The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译: 本发明涉及式(I)化合物,这些化合物的制备方法,组合物,中间体及其衍生物,以及治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号:US20080096844A1
公开(公告)日:2008-04-24
申请号:US11975235
申请日:2007-10-18
IPC分类号: A61K31/665 , A61P11/00 , C07F9/02
CPC分类号: C07F9/65517
摘要: The present invention is directed to a compound of Formula (I): or an enantiomer, diastereomer, polymorph or pharmaceutically acceptable salt thereof and methods for preparing said compounds and compositions, intermediates and derivatives thereof, and methods for treating inflammatory or serine protease mediated disorders.
摘要翻译: 本发明涉及式(I)的化合物或其对映体,非对映异构体,多晶型物或其药学上可接受的盐以及制备所述化合物及其组合物,中间体及其衍生物的方法,以及用于治疗炎性或丝氨酸蛋白酶介导的病症的方法 。
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公开(公告)号:US20120022022A1
公开(公告)日:2012-01-26
申请号:US13245208
申请日:2011-09-26
申请人: Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
发明人: Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
CPC分类号: A61K31/381 , A61K31/445 , A61K31/4535 , A61K31/662
摘要: The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译: 本发明涉及式(I)化合物,这些化合物的制备方法,组合物,中间体及其衍生物,以及治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号:US20100048513A1
公开(公告)日:2010-02-25
申请号:US12229089
申请日:2008-08-20
申请人: Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
发明人: Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
IPC分类号: A61K31/381 , A61K31/445 , A61K31/4535 , A61K31/662 , A61P11/00
CPC分类号: A61K31/381 , A61K31/445 , A61K31/4535 , A61K31/662
摘要: The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译: 本发明涉及式(I)化合物,这些化合物的制备方法,组合物,中间体及其衍生物,以及治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号:US20090036409A1
公开(公告)日:2009-02-05
申请号:US12229077
申请日:2008-08-20
申请人: Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence De Garavilla , Bruce E. Maryanoff
发明人: Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence De Garavilla , Bruce E. Maryanoff
IPC分类号: A61K31/662 , C07F1/00 , C07F9/572 , C07F9/576 , C07F9/58 , A61K31/665 , A61K31/675 , C07F9/60 , C07F9/6518 , C07F9/6541 , C07F9/40
CPC分类号: C07F9/6561 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/59 , C07F9/60 , C07F9/62 , C07F9/65517 , C07F9/655354 , C07F9/65583 , C07F9/65586 , C07F9/657181
摘要: The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译: 本发明涉及式(I)化合物,这些化合物的制备方法,组合物,中间体及其衍生物,以及治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号:US07459444B2
公开(公告)日:2008-12-02
申请号:US11037938
申请日:2005-01-18
申请人: Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
发明人: Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
CPC分类号: C07F9/6561 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/59 , C07F9/60 , C07F9/62 , C07F9/65517 , C07F9/655354 , C07F9/65583 , C07F9/65586 , C07F9/657181
摘要: The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译: 本发明涉及式(I)化合物,这些化合物的制备方法,组合物,中间体及其衍生物,以及治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号:US08546358B2
公开(公告)日:2013-10-01
申请号:US13245208
申请日:2011-09-26
申请人: Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
发明人: Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
IPC分类号: A61K31/67
CPC分类号: A61K31/381 , A61K31/445 , A61K31/4535 , A61K31/662
摘要: The present invention is directed to a method for treating or ameliorating asthma in a subject in need thereof comprising administering to the subject a therapeutically effective amount of compound 17:
摘要翻译: 本发明涉及一种用于治疗或改善有需要的受试者的哮喘的方法,包括向受试者施用治疗有效量的化合物17:
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公开(公告)号:US10729072B2
公开(公告)日:2020-08-04
申请号:US16127868
申请日:2018-09-11
申请人: Eugene Powell
发明人: Eugene Powell
摘要: A harvest vacuum assembly includes a vacuum motor coupled to a farming implement. The vacuum motor urges air inwardly through an intake and outwardly through an exhaust when the vacuum motor is turned on. A suction tube is removably coupled to the hydraulic lift on the front end of the farming implement. The suction tube has a suction aperture therein that is directed downwardly toward ground when the suction tube is coupled to the hydraulic lift. Moreover, the suction tube is in fluid communication with the vacuum motor such that the vacuum motor urges air inwardly through the suction aperture. Thus, the suction aperture sucks loose objects on the ground for collection. The exhaust on the vacuum is in fluid communication with a harvester is towed behind the farming implement to transfer the loose objects into the harvester for harvesting.
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公开(公告)号:US08609888B2
公开(公告)日:2013-12-17
申请号:US13550963
申请日:2012-07-17
IPC分类号: A61K31/662 , C07F9/28 , C07F9/30
CPC分类号: C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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