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公开(公告)号：US20110015241A1
公开(公告)日：2011-01-20
申请号：US12301978
申请日：2007-05-25
IPC分类号： A61K31/422 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to substituted heterocycles, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
摘要翻译： 本发明涉及取代的杂环，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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公开(公告)号：US08263624B2
公开(公告)日：2012-09-11
申请号：US12302503
申请日：2007-05-25
申请人： Michael Härter , Tobias Wunberg , Swen Allerheiligen , Marcus Bauser , Ulrich Rester , Stefan Heitmeier
发明人： Michael Härter , Tobias Wunberg , Swen Allerheiligen , Marcus Bauser , Ulrich Rester , Stefan Heitmeier
IPC分类号： A61K31/44 , A61K31/422 , A61K31/4523 , A61K31/4164 , A61K31/506 , A61K31/5377 , A61K31/5355 , C07D231/12 , C07D401/04 , C07D413/14 , C07D417/12 , C07D419/14
CPC分类号： C07D409/14 , C07D231/12 , C07D413/14
摘要： The invention relates to aryl-substituted heterocycles, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
摘要翻译： 本发明涉及芳基取代的杂环，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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公开(公告)号：US20130040946A1
公开(公告)日：2013-02-14
申请号：US13625086
申请日：2012-09-24
申请人： Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
发明人： Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
IPC分类号： A61K31/519 , C12N5/0775 , A61P7/00 , C12N5/0789 , C07D487/04 , A61K31/5377
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to substituted imidazo- and triazolopyrimidines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of haematological disorders, preferably of leucopenias and neutropenias.
摘要翻译： 本发明涉及取代的咪唑并 - 三唑并嘧啶类及其制备方法及其制备用于治疗和/或预防疾病，特别是血液病，优选白细胞减少和中性粒细胞减少症的药物的用途。
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公开(公告)号：US08273752B2
公开(公告)日：2012-09-25
申请号：US12529711
申请日：2008-03-04
申请人： Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
发明人： Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to substituted imidazo- and triazolopyrimidines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of haematological disorders, preferably of leucopenias and neutropenias.
摘要翻译： 本发明涉及取代的咪唑并 - 三唑并嘧啶类及其制备方法及其制备用于治疗和/或预防疾病，特别是血液病，优选白细胞减少和中性粒细胞减少症的药物的用途。
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公开(公告)号：US20100184740A1
公开(公告)日：2010-07-22
申请号：US12665729
申请日：2008-06-07
申请人： Swen Allerheiligen , Marcus Bauser , Dirk Heimbach , Stefan Heitmeier , Mark Jean Gnoth , Christoph Gerdes , Georges Von Degenfeld , Susanne Röhrig , Ulrich Rester , Elke Dittrich-Wengenroth , Uwe Saatman , Adrian Tersteegen
发明人： Swen Allerheiligen , Marcus Bauser , Dirk Heimbach , Stefan Heitmeier , Mark Jean Gnoth , Christoph Gerdes , Georges Von Degenfeld , Susanne Röhrig , Ulrich Rester , Elke Dittrich-Wengenroth , Uwe Saatman , Adrian Tersteegen
IPC分类号： A61K31/4439 , C07D413/14 , A61K31/5377 , A61K31/496 , C07D417/14 , A61K31/541 , A61K31/553 , A61P7/02 , A61P7/00 , A61P9/12 , A61P29/00
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
摘要翻译： 本发明涉及新的取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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公开(公告)号：US09051323B2
公开(公告)日：2015-06-09
申请号：US13625086
申请日：2012-09-24
申请人： Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
发明人： Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to substituted imidazo- and triazolopyrimidines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of haematological disorders, preferably of leucopenias and neutropenias.
摘要翻译： 本发明涉及取代的咪唑并 - 三唑并嘧啶类及其制备方法及其制备用于治疗和/或预防疾病，特别是血液病，优选白细胞减少和中性粒细胞减少症的药物的用途。
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公开(公告)号：US08476267B2
公开(公告)日：2013-07-02
申请号：US12668633
申请日：2008-06-28
申请人： Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
发明人： Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
IPC分类号： A61K31/535
CPC分类号： C07D487/04 , C12N5/0647
摘要： The invention relates to substituted imidazo-, pyrazolopyrazines and imidazotriazines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of hematological disorders, preferably of leukopenias and neutropenias.
摘要翻译： 本发明涉及取代的咪唑并，吡唑并吡嗪和咪唑并嗪及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是血液病症，优选白细胞减少症和中性粒细胞减少症的药物的用途。
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公开(公告)号：US08383822B2
公开(公告)日：2013-02-26
申请号：US12665729
申请日：2008-06-07
申请人： Swen Allerheiligen , Marcus Bauser , Dirk Heimbach , Stefan Heitmeier , Mark Jean Gnoth , Christoph Gerdes , Georges Von Degenfeld , Susanne Röhrig , Ulrich Rester , Elke Dittrich-Wengenroth , Uwe Saatmann , Adrian Tersteegen , Joachim Krüger , Holger Paulsen
发明人： Swen Allerheiligen , Marcus Bauser , Dirk Heimbach , Stefan Heitmeier , Mark Jean Gnoth , Christoph Gerdes , Georges Von Degenfeld , Susanne Röhrig , Ulrich Rester , Elke Dittrich-Wengenroth , Uwe Saatmann , Adrian Tersteegen , Joachim Krüger , Holger Paulsen
IPC分类号： A61K31/44 , C07D413/00
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
摘要翻译： 本发明涉及新的取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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公开(公告)号：US20110053929A1
公开(公告)日：2011-03-03
申请号：US12668633
申请日：2008-06-28
申请人： Stephan Siegel , Andreas Wilman , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
发明人： Stephan Siegel , Andreas Wilman , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Adrian Tersteegen , Michael Gerisch
IPC分类号： A61K31/4985 , C07D487/04 , A61K31/5377 , A61P7/00 , C12N5/0789
CPC分类号： C07D487/04 , C12N5/0647
摘要： The invention relates to substituted imidazo-, pyrazolopyrazines and imidazotriazines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of hematological disorders, preferably of leukopenias and neutropenias.
摘要翻译： 本发明涉及取代的咪唑并，吡唑并吡嗪和咪唑并嗪及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是血液病症，优选白细胞减少症和中性粒细胞减少症的药物的用途。
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公开(公告)号：US20100113441A1
公开(公告)日：2010-05-06
申请号：US12529711
申请日：2008-03-04
申请人： Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
发明人： Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
IPC分类号： A61K31/519 , C12N5/00 , A61K31/5377 , C07D487/04 , A61P9/00
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to substituted imidazopyrimidines and triazolopyrimidines, to methods for the production thereof, and to the use of same for producing medicaments for the treatment and/or prophylaxis of diseases, especially haematological diseases, preferably leucopenia and neutropenia.
摘要翻译： 本发明涉及取代的咪唑并嘧啶和三唑并嘧啶，其制备方法及其用途，用于制备用于治疗和/或预防疾病，特别是血液病，优选白细胞减少和中性白细胞减少症的药物。
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