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1.发明授权Methods and compositions for modulating T helper (Th) cell development and function 失效调节T辅助细胞（Th）细胞发育和功能的方法和组合物公开(公告)号：US07314623B2
公开(公告)日：2008-01-01
申请号：US10620169
申请日：2003-07-15
IPC分类号： A61K39/00 , A61K39/395 , A61K38/17
CPC分类号： C12N5/0636 , A61K38/00 , A61K2039/505 , A61K2039/57 , C07K14/54 , C07K14/7155 , C12N2501/23
摘要： Methods and compositions for modulating T helper (Th) cell development and function using modulators of IL-21, e.g., human IL-21, activity or level.
摘要翻译： 使用IL-21调节剂（例如人IL-21，活性或水平）调节T辅助细胞（Th）细胞发育和功能的方法和组合物。
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2.发明授权Methods and compositions for modulating T helper (TH) cell development and function 失效用于调节T辅助细胞（TH）细胞发育和功能的方法和组合物公开(公告)号：US07731946B2
公开(公告)日：2010-06-08
申请号：US11938618
申请日：2007-11-12
CPC分类号： C12N5/0636 , A61K38/00 , A61K2039/505 , A61K2039/57 , C07K14/54 , C07K14/7155 , C12N2501/23
摘要： Methods and compositions for modulating T helper (Th) cell development and function using modulators of IL-21, e.g., human IL-21, activity or level.
摘要翻译： 使用IL-21调节剂（例如人IL-21，活性或水平）调节T辅助细胞（Th）细胞发育和功能的方法和组合物。
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公开(公告)号：US20060039902A1
公开(公告)日：2006-02-23
申请号：US11197488
申请日：2005-08-05
申请人： Deborah Young , Mary Collins , Kyriaki Dunussi-Joannopoulos , Richard O'Hara , Marion Kasaian , Matthew Whitters
发明人： Deborah Young , Mary Collins , Kyriaki Dunussi-Joannopoulos , Richard O'Hara , Marion Kasaian , Matthew Whitters
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0368 , A61K38/1793 , A61K49/0008 , A61K2039/505 , C07K14/7155 , C07K2319/30 , G01N33/6869 , G01N33/6893 , G01N2500/02 , G01N2800/245
摘要： Methods and compositions for inhibiting interleukin-21 (IL-21)/IL-21 receptor (MU-1) activity using antagonists of IL-21 or IL-21 receptor (“IL-21R” or “MU-1”), are disclosed. IL-21/IL-21R antagonists can be used to induce immune suppression in vivo, e.g., for treating, ameliorating or preventing autoimmune or inflammatory disorders, including, e.g., inflammatory bowel disease (IBD), rheumatoid arthritis (RA), transplant/graft rejection, psoriasis, asthma, fibrosis, and systemic lupus erythematosus (SLE).
摘要翻译： 使用IL-21或IL-21受体（“IL-21R”或“MU-1”）拮抗剂抑制白细胞介素-21（IL-21）/ IL-21受体（MU-1）活性的方法和组合物 披露 IL-21 / IL-21R拮抗剂可用于诱导体内的免疫抑制，例如用于治疗，改善或预防自身免疫性或炎症性疾病，包括例如炎症性肠病（IBD），类风湿性关节炎（RA），移植/ 移植物排斥，牛皮癣，哮喘，纤维化和系统性红斑狼疮（SLE）。
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4.发明申请GITR ligand and GITR ligand-related molecules and antibodies and uses thereof 有权GITR配体和GITR配体相关分子和抗体及其用途公开(公告)号：US20050014224A1
公开(公告)日：2005-01-20
申请号：US10853032
申请日：2004-05-24
申请人： Mary Collins , Ethan Shevach , Rebecca McHugh , Matthew Whitters , Deborah Young , Michael Byrne , Padmalatha Reddy , Geoffrey Stephens , Beatriz Carreno
发明人： Mary Collins , Ethan Shevach , Rebecca McHugh , Matthew Whitters , Deborah Young , Michael Byrne , Padmalatha Reddy , Geoffrey Stephens , Beatriz Carreno
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C07K14/525 , C07K16/24 , C07K16/28 , G01N33/566 , C12P21/02 , C07K14/705 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/2866 , C07K2317/73 , G01N33/566
摘要： The present invention provides novel isolated and purified polynucleotides and polypeptides related to a novel ligand for glucocorticoid-induced TNF receptor (GITR). The invention also provides antibodies to the GITR ligand (GITRL). The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating disorders arising from disregulation of the immune system (e.g., autoimmune disorders, inflammatory diseases, and transplant rejection, and cancers and infectious diseases) using GITRL and/or modulators of GITRL. The present invention is further directed to novel therapeutics and therapeutic targets and to methods of screening and assessing test compounds for the intervention (treatment) and prevention of said disorders arising from disregulation of the immune system, as related to GITRL and GITR.
摘要翻译： 本发明提供了与糖皮质激素诱导的TNF受体（GITR）的新型配体相关的新型分离和纯化的多核苷酸和多肽。 本发明还提供了对GITR配体（GITRL）的抗体。 本发明还涉及使用GITRL诊断，预后，监测免疫系统失调引起的疾病（例如，自身免疫疾病，炎性疾病和移植排斥，以及癌症和感染性疾病）的新方法 和/或GITRL的调节剂。 本发明还涉及新的治疗学和治疗靶标，以及与GITRL和GITR有关的筛选和评估试验化合物用于干预（治疗）和预防由免疫系统失调引起的所述疾病的方法。
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公开(公告)号：US07910105B2
公开(公告)日：2011-03-22
申请号：US11402885
申请日：2006-04-13
IPC分类号： A61K39/395 , A61K38/20
CPC分类号： G01N33/6869 , A61K33/24 , A61K38/13 , A61K38/1793 , A61K38/20 , A61K45/06 , A61K2039/505 , C07K14/7155 , C07K16/244 , C07K16/2866 , C07K2319/30 , G01N2800/00 , Y02A50/423 , A61K2300/00
摘要： The present invention provides methods of screening for compositions useful for treating, ameliorating, or preventing fibrosis and/or fibrosis-associated conditions by measuring changes in the level(s) of IL-21 and/or IL-21 receptor (IL-21R) (e.g., the level of expression of IL-21 and/or IL-21R protein and/or mRNA, the level of activity of IL-21 and/or IL-21R, the level of interaction of IL-21 with IL-21R). The invention further provides antagonists of IL-21 or IL-21R for the treatment of fibrosis and/or fibrosis-associated conditions. Further provided herein are methods of diagnosing, prognosing, and monitoring the progress (e.g., the course of treatment) of fibrosis and/or fibrosis-associated conditions by measuring the level of IL-21 and/or IL-21R (i.e., the level of activity of IL-21 and/or IL-21R, the level of expression of IL-21 and/or IL-21R (e.g., the level of IL-21 and/or IL-21R gene products), and/or the level of interaction of IL-21 with IL-21R).
摘要翻译： 本发明提供了通过测量IL-21和/或IL-21受体（IL-21R）水平的变化来筛选用于治疗，改善或预防纤维化和/或纤维化相关病症的组合物的方法， （例如，IL-21和/或IL-21R蛋白和/或mRNA的表达水平，IL-21和/或IL-21R的活性水平，IL-21与IL-21R的相互作用水平 ）。 本发明还提供了用于治疗纤维化和/或纤维化相关病症的IL-21或IL-21R拮抗剂。 本文还提供了通过测量IL-21和/或IL-21R的水平来诊断，预测和监测纤维化和/或纤维化相关病症的进展（例如，治疗过程）的方法（即，水平 的IL-21和/或IL-21R的活性，IL-21和/或IL-21R的表达水平（例如IL-21和/或IL-21R基因产物的水平）和/或 IL-21与IL-21R的相互作用水平）。
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公开(公告)号：US20110142833A1
公开(公告)日：2011-06-16
申请号：US13030840
申请日：2011-02-18
CPC分类号： G01N33/6869 , A61K33/24 , A61K38/13 , A61K38/1793 , A61K38/20 , A61K45/06 , A61K2039/505 , C07K14/7155 , C07K16/244 , C07K16/2866 , C07K2319/30 , G01N2800/00 , Y02A50/423 , A61K2300/00
摘要： The present invention provides methods of screening for compositions useful for treating, ameliorating, or preventing fibrosis and/or fibrosis-associated conditions by measuring changes in the level(s) of IL-21 and/or IL-21 receptor (IL-21R) (e.g., the level of expression of IL-21 and/or IL-21R protein and/or mRNA, the level of activity of IL-21 and/or IL-21R, the level of interaction of IL-21 with IL-21R). The invention further provides antagonists of IL-21 or IL-21R for the treatment of fibrosis and/or fibrosis-associated conditions. Further provided herein are methods of diagnosing, prognosing, and monitoring the progress (e.g., the course of treatment) of fibrosis and/or fibrosis-associated conditions by measuring the level of IL-21 and/or IL-21R (i.e., the level of activity of IL-21 and/or IL-21R, the level of expression of IL-21 and/or IL-21R (e.g., the level of IL-21 and/or IL-21R gene products), and/or the level of interaction of IL-21 with IL-21R).
摘要翻译： 本发明提供了通过测量IL-21和/或IL-21受体（IL-21R）水平的变化来筛选用于治疗，改善或预防纤维化和/或纤维化相关病症的组合物的方法， （例如，IL-21和/或IL-21R蛋白和/或mRNA的表达水平，IL-21和/或IL-21R的活性水平，IL-21与IL-21R的相互作用水平 ）。 本发明还提供了用于治疗纤维化和/或纤维化相关病症的IL-21或IL-21R拮抗剂。 本文还提供了通过测量IL-21和/或IL-21R的水平来诊断，预测和监测纤维化和/或纤维化相关病症的进展（例如，治疗过程）的方法（即，水平 的IL-21和/或IL-21R的活性，IL-21和/或IL-21R的表达水平（例如IL-21和/或IL-21R基因产物的水平）和/或 IL-21与IL-21R的相互作用水平）。
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7.发明授权Methods of inhibiting binding and treating Ig-mediated responses with IL-13 receptor 失效抑制IL-13受体结合和治疗Ig介导的应答的方法公开(公告)号：US06248714B1
公开(公告)日：2001-06-19
申请号：US08846340
申请日：1997-04-30
申请人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
发明人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
IPC分类号： A61K3800
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00 , C07K2319/30 , Y10S514/826 , Y10S514/885
摘要： IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor methods of mediating-Ig-responses and methods for their identification are also disclosed.
摘要翻译： 还公开了IL-13受体蛋白质，其生产方法，IL-13的结合抑制剂及其介导-Ig-应答的受体方法及其鉴定方法。
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公开(公告)号：US5710023A
公开(公告)日：1998-01-20
申请号：US609572
申请日：1996-03-01
申请人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
发明人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
IPC分类号： A61K38/00 , C07K14/715 , C12N15/12 , C07K14/52 , C12N15/85
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00 , C07K2319/30 , Y10S514/826 , Y10S514/885
摘要： Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed.
摘要翻译： 公开了编码IL-13受体的多核苷酸及其片段。 还公开了IL-13受体蛋白质，其生产方法，IL-13及其受体的结合抑制剂及其鉴定方法。
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9.发明授权Antibodies to human IL-13bc and methods of their use in inhibiting IL-13 binding 失效人IL-13bc的抗体及其用于抑制IL-13结合的方法公开(公告)号：US07078494B1
公开(公告)日：2006-07-18
申请号：US09714792
申请日：2000-11-16
申请人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
发明人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
CPC分类号： C07K16/244
摘要： Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed.
摘要翻译： 公开了编码IL-13受体的多核苷酸及其片段。 还公开了IL-13受体蛋白质，其生产方法，IL-13及其受体的结合抑制剂及其鉴定方法。
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10.发明授权Methods of using antibodies to human IL-13bc for inhibiting IL-13 binding 失效使用人IL-13bc抗体抑制IL-13结合的方法公开(公告)号：US07674591B2
公开(公告)日：2010-03-09
申请号：US11362028
申请日：2006-02-27
申请人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
发明人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
IPC分类号： G01N33/567 , A61K39/395 , C07K14/715 , C12P21/06
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00 , C07K2319/30 , Y10S514/826 , Y10S514/885
摘要： Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed.
摘要翻译： 公开了编码IL-13受体的多核苷酸及其片段。 还公开了IL-13受体蛋白质，其生产方法，IL-13及其受体的结合抑制剂及其鉴定方法。
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