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公开(公告)号：US07507706B1
公开(公告)日：2009-03-24
申请号：US09868123
申请日：1999-12-13
申请人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew J. Whitters , Clive Wood , Marsha Wills-Karp
发明人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew J. Whitters , Clive Wood , Marsha Wills-Karp
CPC分类号： C07K14/7155 , A61K38/00 , A61K2039/505 , C07K2319/02
摘要： Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed. Methods of medical treatment using such molecules and antagonists of the IL-13/IL-13R interaction are also provided.
摘要翻译： 公开了编码IL-13受体的多核苷酸及其片段。 还公开了IL-13受体蛋白质，其生产方法，IL-13及其受体的结合抑制剂及其鉴定方法。 还提供了使用这种分子和IL-13 / IL-13R相互作用的拮抗剂的药物治疗方法。
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2.发明授权Antibodies to human IL-13bc and methods of their use in inhibiting IL-13 binding 失效人IL-13bc的抗体及其用于抑制IL-13结合的方法公开(公告)号：US07078494B1
公开(公告)日：2006-07-18
申请号：US09714792
申请日：2000-11-16
申请人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
发明人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
CPC分类号： C07K16/244
摘要： Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed.
摘要翻译： 公开了编码IL-13受体的多核苷酸及其片段。 还公开了IL-13受体蛋白质，其生产方法，IL-13及其受体的结合抑制剂及其鉴定方法。
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3.发明授权Methods of inhibiting binding and treating Ig-mediated responses with IL-13 receptor 失效抑制IL-13受体结合和治疗Ig介导的应答的方法公开(公告)号：US06248714B1
公开(公告)日：2001-06-19
申请号：US08846340
申请日：1997-04-30
申请人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
发明人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
IPC分类号： A61K3800
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00 , C07K2319/30 , Y10S514/826 , Y10S514/885
摘要： IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor methods of mediating-Ig-responses and methods for their identification are also disclosed.
摘要翻译： 还公开了IL-13受体蛋白质，其生产方法，IL-13的结合抑制剂及其介导-Ig-应答的受体方法及其鉴定方法。
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公开(公告)号：US5710023A
公开(公告)日：1998-01-20
申请号：US609572
申请日：1996-03-01
申请人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
发明人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
IPC分类号： A61K38/00 , C07K14/715 , C12N15/12 , C07K14/52 , C12N15/85
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00 , C07K2319/30 , Y10S514/826 , Y10S514/885
摘要： Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed.
摘要翻译： 公开了编码IL-13受体的多核苷酸及其片段。 还公开了IL-13受体蛋白质，其生产方法，IL-13及其受体的结合抑制剂及其鉴定方法。
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公开(公告)号：US20100086516A1
公开(公告)日：2010-04-08
申请号：US12408458
申请日：2009-03-20
申请人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew J. Whitters , Clive Wood , Marsha Wills-Karp
发明人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew J. Whitters , Clive Wood , Marsha Wills-Karp
IPC分类号： A61K38/20 , A61K39/395 , C12P21/06 , C12N5/00 , G01N33/566 , C07K14/54 , C07K16/24 , C07H21/04
CPC分类号： G01N33/6863 , G01N2333/54
摘要： Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed. Methods of medical treatment using such molecules and antagonists of the IL-13/IL-13R interaction are also provided.
摘要翻译： 公开了编码IL-13受体的多核苷酸及其片段。 还公开了IL-13受体蛋白质，其生产方法，IL-13及其受体的结合抑制剂及其鉴定方法。 还提供了使用这种分子和IL-13 / IL-13R相互作用的拮抗剂的药物治疗方法。
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6.发明授权Methods of using antibodies to human IL-13bc for inhibiting IL-13 binding 失效使用人IL-13bc抗体抑制IL-13结合的方法公开(公告)号：US07674591B2
公开(公告)日：2010-03-09
申请号：US11362028
申请日：2006-02-27
申请人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
发明人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
IPC分类号： G01N33/567 , A61K39/395 , C07K14/715 , C12P21/06
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00 , C07K2319/30 , Y10S514/826 , Y10S514/885
摘要： Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed.
摘要翻译： 公开了编码IL-13受体的多核苷酸及其片段。 还公开了IL-13受体蛋白质，其生产方法，IL-13及其受体的结合抑制剂及其鉴定方法。
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公开(公告)号：US07553487B2
公开(公告)日：2009-06-30
申请号：US10989313
申请日：2004-11-15
申请人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew J. Whitters , Clive Wood , Marsha Wills-Karp
发明人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew J. Whitters , Clive Wood , Marsha Wills-Karp
CPC分类号： G01N33/6863 , G01N2333/54
摘要： The present invention is directed to methods for treating asthma.
摘要翻译： 本发明涉及治疗哮喘的方法。
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8.发明授权公开(公告)号：US07282206B2
公开(公告)日：2007-10-16
申请号：US10671034
申请日：2003-09-25
申请人： Thomas A. Wynn , Monica G. Chiaramonte , Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew J. Whitters , Clive Wood
发明人： Thomas A. Wynn , Monica G. Chiaramonte , Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew J. Whitters , Clive Wood
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00 , Y02A50/423 , Y10S514/826
摘要： Methods are provided for treating or inhibiting the formation of tissue fibrosis using IL-13 antagonists, including without limitation soluble forms of the IL-13 receptor.
摘要翻译： 提供了使用IL-13拮抗剂治疗或抑制组织纤维化形成的方法，包括但不限于IL-13受体的可溶形式。
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公开(公告)号：US20060177902A1
公开(公告)日：2006-08-10
申请号：US11362028
申请日：2006-02-27
申请人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
发明人： Mary Collins , Debra Donaldson , Lori Fitz , Tamlyn Neben , Matthew Whitters , Clive Wood
IPC分类号： A61K38/17 , C07K14/715 , C07H21/04 , C12P21/06
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00 , C07K2319/30 , Y10S514/826 , Y10S514/885
摘要： Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed.
摘要翻译： 公开了编码IL-13受体的多核苷酸及其片段。 还公开了IL-13受体蛋白质，其生产方法，IL-13及其受体的结合抑制剂及其鉴定方法。
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公开(公告)号：US20060073148A1
公开(公告)日：2006-04-06
申请号：US11155843
申请日：2005-06-17
申请人： Lioudmila Tchistiakova , Marion Kasaian , Debra Donaldson , Xiang-Yang Tan , Davinder Gill , Macy Jin , Bruce Jacobson , Samuel Goldman , John Knopf , Angela Widom
发明人： Lioudmila Tchistiakova , Marion Kasaian , Debra Donaldson , Xiang-Yang Tan , Davinder Gill , Macy Jin , Bruce Jacobson , Samuel Goldman , John Knopf , Angela Widom
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/24 , C12N5/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
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