公开(公告)号：US20120172692A1

公开(公告)日：2012-07-05

申请号：US12985224

申请日：2011-01-05

申请人： Janet Tamada ,  Michael J. Tierney ,  Ramakrishna Madabhushi ,  Arvind N. Jina

发明人： Janet Tamada ,  Michael J. Tierney ,  Ramakrishna Madabhushi ,  Arvind N. Jina

IPC分类号： A61B5/1486

CPC分类号： A61B5/14514 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/685

摘要： An analyte monitor having a plurality of fluid paths, each fluid path having a distal opening adapted to be disposed on one side of a stratum corneum layer of a user's skin, a proximal opening adapted to be disposed on another side of the stratum corneum layer and an interior space extending between the distal and proximal openings; a sensing zone in fluid communication with the proximal openings of the fluid paths; sensing fluid extending from the sensing zone into substantially the entire interior space of the fluid paths; and an analyte sensor adapted to detect a concentration of analyte in the sensing fluid within the sensing zone, wherein at least one of the sensing fluid and the analyte sensor comprises a catalyst for mutarotation of glucose. The invention also includes a method of using the monitor.

摘要翻译： 一种具有多个流体路径的分析物监测器，每个流体路径具有适于设置在使用者皮肤的角质层的一侧上的远端开口，适于设置在角质层的另一侧上的近侧开口，以及 在远端和近端开口之间延伸的内部空间; 与流体路径的近端开口流体连通的感测区域; 从所述感测区域延伸到所述流体路径的基本上整个内部空间中的感测流体; 以及分析物传感器，其适于检测所述感测区域内的所述感测流体中的分析物的浓度，其中所述感测流体和所述分析物传感器中的至少一个包括用于葡萄糖变异的催化剂。 本发明还包括使用监视器的方法。

公开(公告)号：US20110137322A1

公开(公告)日：2011-06-09

申请号：US12959704

申请日：2010-12-03

申请人： Frederic H. Moll ,  David J. Rosa ,  Andris D. Ramans ,  Steven J. Blumenkranz ,  Gary S. Guthart ,  Gunter D. Niemeyer ,  William C. Nowlin ,  J. Kenneth Salisbury, JR. ,  Michael J. Tierney

发明人： Frederic H. Moll ,  David J. Rosa ,  Andris D. Ramans ,  Steven J. Blumenkranz ,  Gary S. Guthart ,  Gunter D. Niemeyer ,  William C. Nowlin ,  J. Kenneth Salisbury, JR. ,  Michael J. Tierney

IPC分类号： A61B19/00

CPC分类号： A61B19/2203 ,  A61B34/30 ,  A61B34/35 ,  A61B34/37 ,  A61B34/76 ,  A61B90/361 ,  A61B2017/00199 ,  A61B2034/305 ,  A61B2034/742 ,  A61B2090/506 ,  G06F19/00 ,  G09B23/285

摘要： Improved robotic surgical systems, devices, and methods include selectably associatable master/slave pairs, often having more manipulator arms than will be moved simultaneously by the two hands of a surgeon. Four manipulator arms can support an image capture device, a left hand tissue manipulation tool, a right hand tissue manipulation tool, and a fourth surgical instrument, particularly for stabilizing, retracting, tool change, or other functions benefiting from intermittent movement. The four or more arms may sequentially be controlled by left and right master input control devices. The fourth arm may be used to support another image capture device, and control of some or all of the arms may be transferred back-and-forth between the operator and an assistant. Two or more robotic systems each having master controls and slave manipulators may be coupled to enable cooperative surgery between two or more operators.

摘要翻译： 改进的机器人手术系统，装置和方法包括可选择地可关联的主/从对，通常具有比外科医生的两只手同时移动的更多的操纵臂。 四个操纵臂可以支撑图像捕获装置，左手组织操作工具，右手组织操作工具和第四手术器械，特别是用于稳定，缩回，换刀或受益于间歇运动的其他功能。 四个或更多个臂可以顺序地由左和右主输入控制装置控制。 第四臂可以用于支持另一图像捕获装置，并且可以在操作者和助手之间来回传送一些或所有臂的控制。 可以耦合两个或更多个具有主控制器和从动操纵器的机器人系统，以实现两个或多个操作者之间的协作手术。

公开(公告)号：US20100049021A1

公开(公告)日：2010-02-25

申请号：US12545008

申请日：2009-08-20

申请人： Arvind N. Jina ,  Ashok Parmar ,  Beelee Chua ,  Janet Tamada ,  Jonathan Lee ,  Michael J. Tierney ,  Navneet Kaur ,  Paul Magginetti ,  Shashi P. Desai

发明人： Arvind N. Jina ,  Ashok Parmar ,  Beelee Chua ,  Janet Tamada ,  Jonathan Lee ,  Michael J. Tierney ,  Navneet Kaur ,  Paul Magginetti ,  Shashi P. Desai

IPC分类号： A61B5/1468

CPC分类号： A61B5/14532 ,  A61B5/14514 ,  A61B5/14865 ,  A61B2560/0223

摘要： One aspect of the invention provides an analyte monitor including a sensing volume, an analyte extraction area in contact with the sensing volume adapted to extract an analyte into the sensing volume, and an analyte sensor adapted to detect a concentration of analyte in the sensing volume. The sensing volume is defined by a first face, a second face opposite to the first face, and a thickness equal to the distance between the two faces. The surface area of the first face is about equal to the surface area of the second face and the extraction area is about equal to the surface area of the first and second face of the sensing volume. The analyte sensor includes a working electrode in contact with the sensing volume, the working electrode having a surface area at least as large as the analyte extraction area, and a second electrode in fluid communication with the sensing volume.

摘要翻译： 本发明的一个方面提供一种分析物监测器，其包括感测体积，与适于将分析物提取到感测体积中的感测体接触的分析物提取区域，以及适于检测感测体积中的分析物浓度的分析物传感器。 感测体积由第一面，与第一面相反的第二面和厚度等于两个面之间的距离限定。 第一面的表面积约等于第二面的表面积，并且提取面积大约等于感测体积的第一和第二面的表面积。 分析物传感器包括与感测体积接触的工作电极，工作电极具有至少与分析物提取区域一样大的表面积，以及与感测体积流体连通的第二电极。

公开(公告)号：US20090234371A1

公开(公告)日：2009-09-17

申请号：US12407101

申请日：2009-03-19

申请人： Michael J. Tierney ,  Thomas G. Cooper ,  Chris A. Julian ,  Stephen J. Blumenkranz ,  Gary S. Guthart ,  Robert G. Younge

发明人： Michael J. Tierney ,  Thomas G. Cooper ,  Chris A. Julian ,  Stephen J. Blumenkranz ,  Gary S. Guthart ,  Robert G. Younge

IPC分类号： A61B19/00

CPC分类号： A61B34/30 ,  A61B17/00234 ,  A61B18/1445 ,  A61B34/35 ,  A61B34/37 ,  A61B34/71 ,  A61B34/76 ,  A61B46/13 ,  A61B90/361 ,  A61B90/90 ,  A61B90/98 ,  A61B2017/00477 ,  A61B2017/00482 ,  A61B2034/305 ,  A61B2090/0803 ,  A61B2090/0818 ,  A61B2090/506 ,  G06Q30/02 ,  H01H36/0046 ,  H01H85/0056 ,  Y10S901/41 ,  Y10T74/20305 ,  Y10T74/20311

摘要： Robotic surgical tools, systems, and methods for preparing for and performing robotic surgery include a memory mounted on the tool. The memory can perform a number of functions when the tool is loaded on the tool manipulator: first, the memory can provide a signal verifying that the tool is compatible with that particular robotic system. Secondly, the tool memory may identify the tool-type to the robotic system so that the robotic system can reconfigure its programming. Thirdly, the memory of the tool may indicate tool-specific information, including measured calibration offsets indicating misalignment of the tool drive system, tool life data, or the like. This information may be stored in a read only memory (ROM), or in a nonvolatile memory which can be written to only a single time. The invention further provides improved engagement structures for coupling robotic surgical tools with manipulator structures.

公开(公告)号：US07189341B2

公开(公告)日：2007-03-13

申请号：US10692761

申请日：2003-10-24

申请人： Huawen Li ,  Michael J. Tierney

发明人： Huawen Li ,  Michael J. Tierney

IPC分类号： H01B1/22 ,  C25B11/04 ,  G01N27/327

CPC分类号： C09D11/52 ,  C09D11/101 ,  C09D11/30 ,  G01N27/3271

摘要： The invention is directed to conductive polymer compositions, catalytic ink compositions (e.g., for use in screen-printing), electrodes produced by deposition of an ink composition, as well as methods of making, and methods of using such compositions and electrodes. An exemplary ink material comprises a metal catalyst (e.g., platinum black and/or platinum-on-carbon), graphite as a conducting material, a polymer binding material, and an organic solvent. In one aspect, the polymer binding material comprises a polymer binder blend comprising first and second polymers, wherein the first polymer has a glass transition temperature higher than the second polymer. In a second aspect, the polymer binding material comprises a hydrophilic acrylic polymer, copolymer, or terpolymer. The conductive polymer compositions of the present invention may be used, for example, to make electrochemical sensors. Such sensors may be used, for example, in a variety of devices to monitor analyte amount or concentrations in subjects.

公开(公告)号：US07018568B2

公开(公告)日：2006-03-28

申请号：US10327506

申请日：2002-12-19

申请人： Michael J. Tierney

发明人： Michael J. Tierney

IPC分类号： H01B1/22

CPC分类号： C09D11/52 ,  C08K3/04 ,  C08K3/08 ,  C09D11/101 ,  C09D11/30

摘要： The invention is directed to conductive polymer compositions, catalytic ink compositions (e.g., for use in screen-printing), electrodes produced by deposition of an ink composition, methods of making, and methods of using thereof. An exemplary ink material comprises platinum black and/or platinum-on-carbon as the catalyst, graphite as a conducting material, a polymer binding material, and an organic solvent. The polymer binding material is typically a copolymer of hydrophilic and hydrophobic monomers. The conductive polymer compositions of the present invention can be used, for example, to make electrochemical sensors. Such sensors can be used in a variety of analyte monitoring devices to monitor analyte amount or concentrations in subjects, for example, glucose monitoring devices to monitor glucose levels in subjects with diabetes.

公开(公告)号：US06885883B2

公开(公告)日：2005-04-26

申请号：US09859218

申请日：2001-05-14

申请人： Norman A. Parris ,  Russell O. Potts ,  Michael J. Tierney ,  Christopher Uhegbu

发明人： Norman A. Parris ,  Russell O. Potts ,  Michael J. Tierney ,  Christopher Uhegbu

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/14532 ,  A61B5/14514 ,  A61B5/1486

摘要： The present invention relates to a predictive-kinetic method for use with data processing of a sensor-generated signal, as well as, microprocessors and monitoring systems employing such a predictive-kinetic method. Data from a transient region of a signal is used with suitable models and curve-fitting methods to predict the signal that would be measured for the system at the completion of the reaction. The values resulting from data processing of sensor response using the methods of the present invention are less sensitive to measurement variables.

摘要翻译： 本发明涉及一种用于传感器生成信号的数据处理的预测动力学方法，以及采用这种预测动力学方法的微处理器和监视系统。 来自信号的瞬态区域的数据与合适的模型和曲线拟合方法一起使用以预测在反应完成时将对系统测量的信号。 使用本发明的方法的传感器响应的数据处理产生的值对测量变量较不敏感。

公开(公告)号：US06736777B2

公开(公告)日：2004-05-18

申请号：US10353734

申请日：2003-01-29

申请人： Lynn Kim ,  Norman A. Parris ,  Russell O. Potts ,  Michael J. Tierney

发明人： Lynn Kim ,  Norman A. Parris ,  Russell O. Potts ,  Michael J. Tierney

IPC分类号： A61B500

CPC分类号： A61B5/14514 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/1495 ,  A61N1/30

摘要： The present invention relates generally to a sensor for use in monitoring the amount or concentration of target chemical analytes present in a biological system. For example, the invention relates to a sensor for measuring the amount or concentration of one or more analytes in a transdermally extracted sample. In one embodiment, the invention includes a sensor element comprising, a sensing electrode that reacts electrochemically with hydrogen peroxide to provide a detectable signal, wherein the sensing electrode comprises a platinum-group metal.

摘要翻译： 本发明一般涉及用于监测存在于生物系统中的目标化学分析物的量或浓度的传感器。 例如，本发明涉及用于测量经皮提取样品中一种或多种分析物的量或浓度的传感器。 在一个实施方案中，本发明包括传感器元件，其包括感测电极，其与电化学反应与过氧化氢反应以提供可检测信号，其中感测电极包含铂族金属。

公开(公告)号：US06633772B2

公开(公告)日：2003-10-14

申请号：US09927583

申请日：2001-08-10

申请人： Russell Ford ,  Matthew J. Lesho ,  Russell O. Potts ,  Michael J. Tierney ,  Charles W. Wei

发明人： Russell Ford ,  Matthew J. Lesho ,  Russell O. Potts ,  Michael J. Tierney ,  Charles W. Wei

IPC分类号： A61B500

CPC分类号： G16H10/40 ,  G06F19/00 ,  G06F19/3456 ,  G16H10/60 ,  G16H40/63 ,  Y10S707/99945 ,  Y10S707/99948

摘要： The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.

摘要翻译： 本发明涉及配制分析物数据数据库的方法，数据库本身及其操作方法。 一方面，本发明包括分析物数据点，派生数据和数据属性数据库的配方，其包括使用能够频繁地监测分析物浓度或量的分析物监测装置收集的数据点。 这样的数据点可以包括获取的数据（例如，对应于由所述分析物监测装置测量的分析物浓度或量的值）。 然后将这些数据点与一个或多个相关数据属性相关联。 可以操作生成的数据库以确定数据库的组件之间的关系。

公开(公告)号：US06594514B2

公开(公告)日：2003-07-15

申请号：US10026086

申请日：2001-12-20

申请人： Bret Berner ,  Chia-Ming Chiang ,  Michael D. Garrison ,  Janan Jona ,  Russell O. Potts ,  Janet A. Tamada ,  Michael J. Tierney

发明人： Bret Berner ,  Chia-Ming Chiang ,  Michael D. Garrison ,  Janan Jona ,  Russell O. Potts ,  Janet A. Tamada ,  Michael J. Tierney

IPC分类号： A16B505

CPC分类号： A61B5/1486 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150091 ,  A61B5/157 ,  A61N1/30 ,  C12Q1/006

摘要： Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.