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公开(公告)号：US06673834B2
公开(公告)日：2004-01-06
申请号：US10300963
申请日：2002-11-21
申请人： Michael Kurz , Matthias Herrmann , Luigi Toti , Laszlo Vertesy
发明人： Michael Kurz , Matthias Herrmann , Luigi Toti , Laszlo Vertesy
IPC分类号： A61K31336
CPC分类号： C12R1/645 , C07D303/34 , C12P17/02
摘要： Compounds of the formula I are suitable for producing pharmaceuticals for the prophylaxis and therapy of diseases in which high blood platelet aggregations occur.
摘要翻译： 式I化合物适用于生产用于预防和治疗出现高血小板聚集的疾病的药物。
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2.发明授权Coniosulfides and their derivatives, processes for preparing them, and their use as pharmaceuticals 失效连环硫化物及其衍生物，制备方法及其作为药物的用途公开(公告)号：US06927236B2
公开(公告)日：2005-08-09
申请号：US10247102
申请日：2002-09-19
申请人： Laszlo Vertesy , Klaus Ehrlich , Michael Kurz , Marian Paul Segeth , Luigi Toti
发明人： Laszlo Vertesy , Klaus Ehrlich , Michael Kurz , Marian Paul Segeth , Luigi Toti
IPC分类号： A61K31/4015 , A61K38/00 , C07K5/06 , C07K5/083 , C12P11/00 , C12P13/00 , C12P13/02 , A01N37/00 , A01N37/12 , A01N37/44 , A61K31/195 , A61K31/20
CPC分类号： C12P13/001 , A61K31/4015 , A61K38/00 , C07K5/06026 , C07K5/0806 , C12P11/00 , C12P13/02
摘要： The present invention relates to compounds of the formula which are formed during fermentation by the microorganism Coniochaeta ellipsoidea Udagawa, DSM 13856, or by one of its mutations and/or variants, and chemically derivatized if appropriate. The invention furthermore relates to a process for preparing compounds of the formula (I), and to their use as pharmaceuticals. In addition, the invention relates to the use of a compound of the formula (VI) for producing a pharmaceutical for the treatment and prophylaxis of degenerative neuropathics or of Alzheimer's disease.
摘要翻译： 本发明涉及在发酵过程中通过微生物虹节藻（Rhodobsoidea Udagawa），DSM 13856或其突变和/或变体之一形成的下式的化合物，并且如果合适的话化学衍生化。 本发明还涉及制备式（I）化合物的方法及其作为药物的用途。 此外，本发明涉及式（VI）化合物在制备用于治疗和预防退行性神经病学或阿尔茨海默病的药物中的用途。
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3.发明授权2-Phenylbenzofuran derivatives, a process for preparing them, and their use 有权2-苯基苯并呋喃衍生物，其制备方法及其应用公开(公告)号：US07148254B2
公开(公告)日：2006-12-12
申请号：US10972546
申请日：2004-10-25
申请人： Laszlo Vertesy , Michael Kurz , Astrid Markus-Erb , Luigi Toti
发明人： Laszlo Vertesy , Michael Kurz , Astrid Markus-Erb , Luigi Toti
IPC分类号： A61K31/34 , C07D307/86 , C12P17/04 , C12N1/18
CPC分类号： C12R1/66 , C07D307/86 , C12P17/04
摘要： The present invention relates to 2-phenylbenzofurans of formula (I) which are formed, during fermentation, by the microorganism Aspergillus flavipes ST003878 (DSM 15290), to a process for preparing them and to their use as pharmaceuticals for the treatment and/or prophylaxis of bacterial infectious diseases or mycoses.
摘要翻译： 本发明涉及式（I）的2-苯基苯并呋喃，其在发酵过程中由微生物黄曲霉ST003878（DSM15290）制成，涉及其制备方法及其作为药物用于治疗和/或预防的用途 的细菌感染性疾病或真菌病。
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公开(公告)号：US07253206B2
公开(公告)日：2007-08-07
申请号：US10367545
申请日：2003-02-14
申请人： Laszlo Vertesy , Michael Kurz , Ziyu Li , Luigi Toti
发明人： Laszlo Vertesy , Michael Kurz , Ziyu Li , Luigi Toti
CPC分类号： C07D307/92 , C12P7/22 , C12P17/04 , C12R1/80
摘要： The present invention provides novel phenalenone derivatives of formula (I) which are formed by the microorganism Penicillium herquei Bainer & Sartory, DSM 14142, during fermentation. A process for their preparation, their use as pharmaceutical compositions, and their use for the treatment or prophylaxis of bacterial infections, mycoses, oncoses and rheumatic diseases are also disclosed and claimed
摘要翻译： 本发明提供在发酵过程中由微生物青霉菌Bainer＆Sartory DSM 14142形成的新颖的式（I）的phenalenone衍生物。 其制备方法，它们作为药物组合物的用途及其用于治疗或预防细菌感染，真菌病，肿瘤和风湿性疾病的用途也被公开和要求保护
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5.发明申请2-Phenylbenzofuran derivatives, a process for preparing them, and their use 有权2-苯基苯并呋喃衍生物，其制备方法及其应用公开(公告)号：US20050137254A1
公开(公告)日：2005-06-23
申请号：US10972546
申请日：2004-10-25
申请人： Laszlo Vertesy , Michael Kurz , Astrid Markus-Erb , Luigi Toti
发明人： Laszlo Vertesy , Michael Kurz , Astrid Markus-Erb , Luigi Toti
IPC分类号： C07D307/86 , C12P17/04 , A61K31/343 , C12N1/16
CPC分类号： C12R1/66 , C07D307/86 , C12P17/04
摘要： The present invention relates to 2-phenylbenzofurans of formula (I) which are formed, during fermentation, by the microorganism Aspergillus flavipes ST003878 (DSM 15290), to a process for preparing them and to their use as pharmaceuticals for the treatment and/or prophylaxis of bacterial infectious diseases or mycoses.
摘要翻译： 本发明涉及式（I）的2-苯基苯并呋喃，其在发酵过程中由微生物黄曲霉ST003878（DSM15290）制成，涉及其制备方法及其作为药物用于治疗和/或预防的用途 的细菌感染性疾病或真菌病。
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6.发明授权Coniosetin and derivatives thereof, process for the preparation and the use thereof 有权洋葱素及其衍生物，其制备方法和用途公开(公告)号：US06599930B2
公开(公告)日：2003-07-29
申请号：US10003413
申请日：2001-12-06
申请人： Laszlo Vertesy , Martin Knauf , Astrid Markus-Erb , Luigi Toti , Marie-Cecile Raynal-Wetzel , Florence Fassy
发明人： Laszlo Vertesy , Martin Knauf , Astrid Markus-Erb , Luigi Toti , Marie-Cecile Raynal-Wetzel , Florence Fassy
IPC分类号： A61K3142
CPC分类号： C07D207/44
摘要： The present invention relates to novel active substances (coniosetin and coniosetin derivatives) of the formula I which are produced by the microorganism Coniochaeta ellipsoidea Udagawa (DSM 13856) during fermentation, wherein R, R2, R3, R4, R5, X, X2, X3 and X4 have the meanings stated in the specification, to chemical derivatives of coniosetin, to a process for their preparation and to their use as pharmaceuticals.
摘要翻译： 本发明涉及在发酵过程中由微生物Coniochaeta ellipsoidea Udagawa（DSM 13856）生产的式I的新型活性物质（coniosetin和conisonetin衍生物），其中R，R2，R3，R4，R5，X，X2，X3和 X4具有说明书中所述的含义，对于曲妥单抗的化学衍生物，其制备方法及其作为药物的用途。
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7.发明申请Coniosulfides and their derivatives, processes for preparing them, and their use as pharmaceuticals 审中-公开连环硫化物及其衍生物，制备方法及其作为药物的用途公开(公告)号：US20050209308A1
公开(公告)日：2005-09-22
申请号：US11132016
申请日：2005-05-18
申请人： Laszlo Vertesy , Klaus Ehrlich , Marian Segeth , Luigi Toti
发明人： Laszlo Vertesy , Klaus Ehrlich , Marian Segeth , Luigi Toti
CPC分类号： C12P13/001 , A61K31/4015 , A61K38/00 , C07K5/06026 , C07K5/0806 , C12P11/00 , C12P13/02
摘要： Coniosulfides and their derivatives, processes for preparing them, and their use as pharmaceuticals. The present invention relates to the use of a compound of the formula (VI) for producing a pharmaceutical for the treatment and prophylaxis of degenerative neuropathics or of Alzheimer's disease.
摘要翻译： 连环硫化物及其衍生物，制备方法及其作为药物的用途。 本发明涉及式（VI）化合物在制备用于治疗和预防退行性神经病学或阿尔茨海默病的药物中的用途。
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8.发明授权Percyquinnin, a process for its production and its use as a pharmaceutical 有权Percyquinnin，其生产过程及其作为药物的使用公开(公告)号：US06596518B2
公开(公告)日：2003-07-22
申请号：US09826866
申请日：2001-04-06
申请人： Cordula Hopmann , Michael Kurz , Guenter Mueller , Luigi Toti
发明人： Cordula Hopmann , Michael Kurz , Guenter Mueller , Luigi Toti
IPC分类号： C12P1702
CPC分类号： C12R1/645 , C07D305/14 , C12P17/02
摘要： The present invention relates to a compound named Percyquinnin that is obtainable by cultivating a basidiomycetes Stereum complicatum (DSM 13303), and to its pharmaceutically acceptable salts. The present invention further relates to a process for the production of Percyquinnin and to the use of Percyquinnin and its pharmaceutically acceptable salts as pharmaceuticals, in particular to their use as inhibitors of lipase.
摘要翻译： 本发明涉及可通过培养担子菌（Stereum complicatum）（DSM 13303）获得的称为Percyquinnin的化合物及其药学上可接受的盐。 本发明进一步涉及一种生产珀金喹素的方法，以及使用过氧喹啉及其药学上可接受的盐作为药物，特别是其作为脂肪酶抑制剂的用途。
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9.发明授权Spirobenzofuran lactams and their derivatives, processes for their preparation and use thereof 有权螺吡喃并呋喃内酰胺及其衍生物，其制备方法和用途公开(公告)号：US07160917B2
公开(公告)日：2007-01-09
申请号：US10732702
申请日：2003-12-10
申请人： Claudia Eder , Michael Kurz , Luigi Toti
发明人： Claudia Eder , Michael Kurz , Luigi Toti
IPC分类号： A61K31/4035 , C07D209/44
CPC分类号： C07D493/04 , C12P17/188 , C12R1/00
摘要： The present invention relates to spirobenzofuran lactam derivatives of the formula I which are formed during fermentation by the microorganism Stachybotris atra ST002348, DSM 14952, processes for their preparation, their use as pharmaceuticals, and the microorganism Stachybotris atra ST002348, DSM 14952.
摘要翻译： 本发明涉及在微生物Stachybotris atra ST002348，DSM 14952的发酵过程中形成的式I的螺苯并呋喃内酰胺衍生物，其制备方法，它们作为药物的用途，以及微生物Stachybotris atra ST002348，DSM14952。
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10.发明授权公开(公告)号：US06794408B2
公开(公告)日：2004-09-21
申请号：US10351773
申请日：2003-01-27
申请人： Claudia Eder , Michael Kurz , Luigi Toti
发明人： Claudia Eder , Michael Kurz , Luigi Toti
IPC分类号： A61K3134
CPC分类号： C07D307/77 , C12P17/04 , C12R1/645
摘要： The present invention provides novel drechsleranol compounds of formula (I) which are formed by the microorganism Drechslera australlensis, ST 003360, DSM 14093, or a fungus ST 004112, DSM 14524, during fermentation. A process for their preparation, pharmaceutical compositions containing said drechsleranols their use for the treatment and/or prophylaxis of degenerative neuropathies, such as, Alzheimeu's disease, or psychiatric disorders, such as depression, sleep disturbance or seasonal affective disorder, and their use as chelating agents or antioxidants are also disclosed and claimed.
摘要翻译： 本发明提供了在发酵期间由微生物Drechslera australlensis，ST 003360，DSM14093或真菌ST 004112，DSM14524形成的式（I）的新颖的德劳克醇化合物。 它们的制备方法，含有所述的drechsleranols的药物组合物，它们用于治疗和/或预防退行性神经病，例如阿尔茨海默病，或精神疾病如抑郁症，睡眠障碍或季节性情感障碍，以及它们作为螯合剂的用途 还公开并要求保护剂或抗氧化剂。
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