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公开(公告)号：US09523637B2
公开(公告)日：2016-12-20
申请号：US13553381
申请日：2012-07-19
IPC分类号： G01N29/02 , G01N21/3504 , G01N21/17
CPC分类号： G01N21/3504 , G01N2021/1704
摘要： A method of using photoacoustic spectroscopy to determine chemical information about an analyte includes the steps of emitting a light ray for interaction with a sample of an analyte; transmitting the light ray through a fill fluid disposed in a detection cell, the fill fluid having molecules substantially similar to molecules of the analyte to absorb the light ray; producing a thermal wave and oscillation in the fill fluid proportional to an intensity of the light ray; including a pressure oscillation in the fill fluid by the thermal wave; and detecting the pressure oscillation by a microphone to determine information about the analyte sample.
摘要翻译： 使用光声光谱法确定关于分析物的化学信息的方法包括以下步骤：发射用于与分析物的样品相互作用的光线; 透射通过设置在检测单元中的填充流体的光线，所述填充流体具有基本上类似于分析物分子的分子以吸收光线; 产生与光线强度成比例的填充流体中的热波和振荡; 包括通过热波在填充流体中的压力振荡; 并且通过麦克风检测压力振荡以确定关于分析物样品的信息。
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公开(公告)号：US08240189B2
公开(公告)日：2012-08-14
申请号：US11576359
申请日：2005-10-04
IPC分类号： G01N21/17
CPC分类号： G01N21/3504 , G01N2021/1704
摘要： A method of using photoacoustic spectroscopy to determine chemical information about an analyte includes the steps of emitting a light ray for interaction with a sample of an analyte; transmitting the light ray through a fill fluid disposed in a detection cell, the fill fluid having molecules substantially similar to molecules of the analyte to absorb the light ray; producing a thermal wave and oscillation in the fill fluid proportional to an intensity of the light ray; including a pressure oscillation in the fill fluid by the thermal wave; and detecting the pressure oscillation by a microphone to determine information about the analyte sample.
摘要翻译： 使用光声光谱法确定关于分析物的化学信息的方法包括以下步骤：发射用于与分析物的样品相互作用的光线; 透射通过设置在检测单元中的填充流体的光线，所述填充流体具有基本上类似于分析物分子的分子以吸收光线; 产生与光线强度成比例的填充流体中的热波和振荡; 包括通过热波在填充流体中的压力振荡; 并且通过麦克风检测压力振荡以确定关于分析物样品的信息。
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3.发明申请公开(公告)号：US20090219539A1
公开(公告)日：2009-09-03
申请号：US12094465
申请日：2006-03-10
申请人： Michael L. Myrick , Robert P. Freese , Ryan J. Priore , John C. Blackburn , Jonathan H. James , David L. Perkins
发明人： Michael L. Myrick , Robert P. Freese , Ryan J. Priore , John C. Blackburn , Jonathan H. James , David L. Perkins
IPC分类号： G01N21/55
CPC分类号： G01N21/4738 , G01N21/31 , G01N21/9508
摘要： A method of real-time processing and monitoring comprises the steps of blending a material of interest (e.g., an active pharmaceutical material), with a secondary material, (e.g., an excipient), illuminating the blended materials with light, reflecting light carrying information about the blended materials through at least one multivariate optical element (148) and detecting said light with a first detector (152), detecting a deflected portion of the information carrying light with a second detector (156), and determining in real-time at least one selected property of the blended materials based on the detector outputs.
摘要翻译： 实时处理和监测的方法包括将感兴趣的材料（例如，活性药物材料）与辅助材料（例如赋形剂）混合，用光照射混合的材料的步骤，反射携带光的信息 关于通过至少一个多元光学元件（148）的混合材料，并用第一检测器（152）检测所述光，利用第二检测器（156）检测携带光的信息的偏转部分，并且实时地确定 基于检测器输出的混合材料的至少一个选定的性质。
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4.发明申请公开(公告)号：US20090219538A1
公开(公告)日：2009-09-03
申请号：US12094460
申请日：2006-03-10
申请人： Michael L. Myrick , Robert P. Freese , Ryan J. Priore , John C. Blackburn , Jonathan H. James , David L. Perkins
发明人： Michael L. Myrick , Robert P. Freese , Ryan J. Priore , John C. Blackburn , Jonathan H. James , David L. Perkins
IPC分类号： G01N21/55
CPC分类号： G01N21/4738 , G01N21/31 , G01N21/9508
摘要： A method of high-speed processing and monitoring of a product, such as a pharmaceutical powder or tablet, comprises: moving the product (C) past an inspection station; illuminating at least a portion of the product with light; spectrally filtering a first portion of light carrying information about the product, o.g., transmitted or reflected light, by passing said first portion through at least one multivariate optical element (148) and detecting said filtered light with a first detector (152), —detecting a deflected second portion of said light with a second detector (156); and determining at least one selected property of the product based on the detector outputs.
摘要翻译： 产品如药物粉末或片剂的高速处理和监测方法包括：将产品（C）移动通过检查站; 用光照射产品的至少一部分; 通过使所述第一部分穿过至少一个多元光学元件（148）并且用第一检测器（152）检测所述滤波光，对通过所述产品，传播或反射光的信息的第一部分进行光谱滤波， - 检测 所述光的偏转的第二部分具有第二检测器（156）; 以及基于所述检测器输出确定所述产品的至少一个所选属性。
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5.发明授权公开(公告)号：US08358418B2
公开(公告)日：2013-01-22
申请号：US12094465
申请日：2006-03-10
申请人： Michael L. Myrick , Robert P. Freese , Ryan J. Priore , John C. Blackburn , Jonathan H. James , David L. Perkins
发明人： Michael L. Myrick , Robert P. Freese , Ryan J. Priore , John C. Blackburn , Jonathan H. James , David L. Perkins
IPC分类号： G01N21/55
CPC分类号： G01N21/4738 , G01N21/31 , G01N21/9508
摘要： A method of real-time processing and monitoring comprises the steps of blending a material of interest (e.g., an active pharmaceutical material), with a secondary material, (e.g., an excipient), illuminating the blended materials with light, reflecting light carrying information about the blended materials through at least one multivariate optical element (148) and detecting said light with a first detector (152), detecting a deflected portion of the information carrying light with a second detector (156), and determining in real-time at least one selected property of the blended materials based on the detector outputs.
摘要翻译： 实时处理和监测的方法包括将感兴趣的材料（例如，活性药物材料）与辅助材料（例如赋形剂）混合，用光照射混合的材料的步骤，反射携带光的信息 关于通过至少一个多元光学元件（148）的混合材料，并用第一检测器（152）检测所述光，利用第二检测器（156）检测携带光的信息的偏转部分，并且实时地确定 基于检测器输出的混合材料的至少一个选定的性质。
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公开(公告)号：US20120279281A1
公开(公告)日：2012-11-08
申请号：US13553381
申请日：2012-07-19
CPC分类号： G01N21/3504 , G01N2021/1704
摘要： A method of using photoacoustic spectroscopy to determine chemical information about an analyte includes the steps of emitting a light ray for interaction with a sample of an analyte; transmitting the light ray through a fill fluid disposed in a detection cell, the fill fluid having molecules substantially similar to molecules of the analyte to absorb the light ray; producing a thermal wave and oscillation in the fill fluid proportional to an intensity of the light ray; including a pressure oscillation in the fill fluid by the thermal wave; and detecting the pressure oscillation by a microphone to determine information about the analyte sample.
摘要翻译： 使用光声光谱法确定关于分析物的化学信息的方法包括以下步骤：发射用于与分析物的样品相互作用的光线; 透射通过设置在检测单元中的填充流体的光线，所述填充流体具有基本上类似于分析物分子的分子以吸收光线; 产生与光线强度成比例的填充流体中的热波和振荡; 包括通过热波在填充流体中的压力振荡; 并且通过麦克风检测压力振荡以确定关于分析物样品的信息。
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7.发明授权Method of high-speed monitoring based on the use of multivariate optical elements 有权基于多元光学元件使用的高速监测方法公开(公告)号：US08208147B2
公开(公告)日：2012-06-26
申请号：US12094460
申请日：2006-03-10
申请人： Michael L. Myrick , Robert P. Freese , Ryan J. Priore , John C. Blackburn , Jonathan H. James , David L. Perkins
发明人： Michael L. Myrick , Robert P. Freese , Ryan J. Priore , John C. Blackburn , Jonathan H. James , David L. Perkins
IPC分类号： G01N21/55
CPC分类号： G01N21/4738 , G01N21/31 , G01N21/9508
摘要： A method of high-speed processing and monitoring of a product, such as a pharmaceutical powder or tablet, comprises: moving the product (C) past an inspection station; illuminating at least a portion of the product with light; spectrally filtering a first portion of light carrying information about the product, o.g., transmitted or reflected light, by passing said first portion through at least one multivariate optical element (148) and detecting said filtered light with a first detector (152), —detecting a deflected second portion of said light with a second detector (156); and determining at least one selected property of the product based on the detector outputs.
摘要翻译： 产品如药物粉末或片剂的高速处理和监测方法包括：将产品（C）移动通过检查站; 用光照射产品的至少一部分; 通过使所述第一部分穿过至少一个多元光学元件（148）并且用第一检测器（152）检测所述滤波光，对通过所述产品，传播或反射光的信息的第一部分进行光谱滤波， - 检测 所述光的偏转的第二部分具有第二检测器（156）; 以及基于所述检测器输出确定所述产品的至少一个所选属性。
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公开(公告)号：US20080276687A1
公开(公告)日：2008-11-13
申请号：US11576359
申请日：2005-10-04
IPC分类号： G01N21/00
CPC分类号： G01N21/3504 , G01N2021/1704
摘要： A method of using photoacoustic spectroscopy to determine chemical information about an analyte includes the steps of emitting a light ray for interaction with a sample of an analyte; transmitting the light ray through a fill fluid disposed in a detection cell, the fill fluid having molecules substantially similar to molecules of the analyte to absorb the light ray; producing a thermal wave and oscillation in the fill fluid proportional to an intensity of the light ray; including a pressure oscillation in the fill fluid by the thermal wave; and detecting the pressure oscillation by a microphone to determine information about the analyte sample
摘要翻译： 使用光声光谱法确定关于分析物的化学信息的方法包括以下步骤：发射用于与分析物的样品相互作用的光线; 透射通过设置在检测单元中的填充流体的光线，所述填充流体具有基本上类似于分析物分子的分子以吸收光线; 产生与光线强度成比例的填充流体中的热波和振荡; 包括通过热波在填充流体中的压力振荡; 并且通过麦克风检测压力振荡以确定关于分析物样品的信息
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公开(公告)号：US09170154B2
公开(公告)日：2015-10-27
申请号：US12295631
申请日：2007-06-26
CPC分类号： G01J3/28 , G01J3/02 , G01J3/0291 , G01J3/10 , G01J2003/1213 , G01J2003/2866 , G01N2201/129
摘要： A method of classifying information in an optical analysis system includes obtaining calibration data defining a plurality of data points, each data point representing values for two or more detectors when sampling a material used to construct a multivariate optical element. Based on the calibration data, one or more validation models can be developed to indicate one or more ranges of expected results. Validation data comprising the models can be used to compare data points representing values for two or more detectors when performing a measurement of a material to determine if the data points fall within an expected range. Classification data can be generated based on the comparison and, in some embodiments, one or more indicators, such as a confidence level in a measurement, can be provided.
摘要翻译： 在光学分析系统中对信息进行分类的方法包括：获取定义多个数据点的校准数据，当对用于构造多变量光学元件的材料进行采样时，每个数据点表示两个或更多个检测器的值。 基于校准数据，可以开发一个或多个验证模型来指示预期结果的一个或多个范围。 包括模型的验证数据可以用于比较在进行材料测量时确定两个或多个检测器的值的数据点，以确定数据点是否落在预期范围内。 可以基于比较来生成分类数据，并且在一些实施例中，可以提供一个或多个指标，例如测量中的置信水平。
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10.发明授权Optical analysis system and methods for operating multivariate optical elements in a normal incidence orientation 有权用于在正常入射方向操作多元光学元件的光学分析系统和方法公开(公告)号：US08049881B2
公开(公告)日：2011-11-01
申请号：US12094469
申请日：2006-11-27
IPC分类号： G01J3/40
CPC分类号： G01J3/08 , A61K8/046 , A61K8/25 , A61K8/26 , A61K8/44 , A61Q11/00 , G01J3/02 , G01J3/0205 , G01J3/021 , G01J3/0232 , G01J3/0291 , G01J3/28 , G01N21/274 , G01N21/31
摘要： A method of arranging and utilizing a multivariate optical computing and analysis system includes transmitting light from a light source; reflecting the light from the sample; directing a portion of the light reflected from the sample with a beamsplitter; and arranging an optical filter mechanism in a normal incidence orientation to receive the light reflected from the sample, the optical filter mechanism configured to filter and measure data carried by the light reflected from the sample.
摘要翻译： 一种布置和利用多变量光学计算和分析系统的方法，包括从光源发射光; 反映样品的光; 用分束器引导从样品反射的一部分光; 以及将法兰入射方向的滤光器机构布置成接收从样品反射的光，所述滤光器机构被配置为过滤和测量由样品反射的光携带的数据。
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