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公开(公告)号:US09012602B2
公开(公告)日:2015-04-21
申请号:US13245349
申请日:2011-09-26
IPC分类号: C07K14/52
CPC分类号: C07K14/523 , C07K14/521 , C07K2319/00 , C07K2319/30 , Y10S530/866
摘要: Isolated polynucleotides encoding Macaca fascicularis CCL17 (CynoCCL17), polypeptides obtainable from expression of these polynucleotides, recombinant cells, and methods of use are disclosed.
摘要翻译: 公开了编码猕猴藻CCL17(CynoCCL17)的分离的多核苷酸,可从这些多核苷酸的表达获得的多肽,重组细胞和使用方法。
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公开(公告)号:US20120082622A1
公开(公告)日:2012-04-05
申请号:US13245349
申请日:2011-09-26
IPC分类号: A61K49/00 , C12N15/63 , C07K14/47 , C12P21/02 , C12N5/10 , G01N33/566 , C12N1/21 , C12N1/15 , C12N1/19 , C12N15/12 , C07K16/18
CPC分类号: C07K14/523 , C07K14/521 , C07K2319/00 , C07K2319/30 , Y10S530/866
摘要: Isolated polynucleotides encoding Macaca fascicularis CCL17 (CynoCCL17), polypeptides obtainable from expression of these polynucleotides, recombinant cells, and methods of use are disclosed.
摘要翻译: 公开了编码猕猴藻CCL17(CynoCCL17)的分离的多核苷酸,可从这些多核苷酸的表达获得的多肽,重组细胞和使用方法。
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公开(公告)号:US20090291455A1
公开(公告)日:2009-11-26
申请号:US12469770
申请日:2009-05-21
CPC分类号: C07K14/7155 , G01N33/5088 , G01N33/6863
摘要: Isolated polynucleotides encoding cynomolgus monkey gp80, polypeptides obtainable from expression of these polynucleotides, compositions, recombinant cells, methods of making and using these polynucleotides, polypeptides, and compositions are useful in development of human therapeutics.
摘要翻译: 编码食蟹猴gp80的分离的多核苷酸,可从这些多核苷酸的表达获得的多肽,组合物,重组细胞,制备和使用这些多核苷酸,多肽和组合物的方法可用于人类治疗学的开发。
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公开(公告)号:US08338171B2
公开(公告)日:2012-12-25
申请号:US12855214
申请日:2010-08-12
CPC分类号: G01N33/5088 , C07K14/70596 , G01N33/502 , G01N2333/70596
摘要: Polynucleotide sequences encoding a baboon homolog of human CD147 and polypeptides obtainable form the polynucleotides and uses are disclosed.
摘要翻译: 公开了编码人CD147的狒狒同系物的多核苷酸序列和可从多核苷酸和用途获得的多肽。
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公开(公告)号:US07931905B2
公开(公告)日:2011-04-26
申请号:US12469770
申请日:2009-05-21
IPC分类号: A61K39/00 , A61K39/395 , C07K14/00
CPC分类号: C07K14/7155 , G01N33/5088 , G01N33/6863
摘要: Isolated polynucleotides encoding cynomolgus monkey gp80, polypeptides obtainable from expression of these polynucleotides, compositions, recombinant cells, methods of making and using these polynucleotides, polypeptides, and compositions are useful in development of human therapeutics.
摘要翻译: 编码食蟹猴gp80的分离的多核苷酸,可从这些多核苷酸的表达获得的多肽,组合物,重组细胞,制备和使用这些多核苷酸,多肽和组合物的方法可用于人类治疗学的开发。
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公开(公告)号:US20110052499A1
公开(公告)日:2011-03-03
申请号:US12855214
申请日:2010-08-12
IPC分类号: A61K49/00 , C07H21/04 , C12N15/63 , C12N5/10 , C07K14/47 , C12P21/02 , C07K16/18 , G01N33/53 , C12N1/21
CPC分类号: G01N33/5088 , C07K14/70596 , G01N33/502 , G01N2333/70596
摘要: Polynucleotide sequences encoding a baboon homolog of human CD147 and polypeptides obtainable form the polynucleotides and uses are disclosed.
摘要翻译: 公开了编码人CD147的狒狒同系物的多核苷酸序列和可由多核苷酸和用途获得的多肽。
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公开(公告)号:US07879978B2
公开(公告)日:2011-02-01
申请号:US12415095
申请日:2009-03-31
申请人: Adam Cotty , Natalie Fursov , Michael Naso
发明人: Adam Cotty , Natalie Fursov , Michael Naso
CPC分类号: C07K16/2896 , C07K14/47 , G01N33/505 , G01N33/5088 , G01N33/56972 , G01N2500/04
摘要: Isolated polynucleotides encoding Macaca fascicularis ST2L (Cyno ST2L), polypeptides obtainable from expression of these polynucleotides, recombinant cells, and methods of use are disclosed.
摘要翻译: 公开了编码猕猴属ST2L(Cyno ST2L)的分离的多核苷酸,可从这些多核苷酸的表达获得的多肽,重组细胞和使用方法。
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公开(公告)号:US20090232734A1
公开(公告)日:2009-09-17
申请号:US12412957
申请日:2009-03-27
申请人: G. Mark Anderson , Bernard Scallon , Michael Naso , Ann Cai , Cam Ngo
发明人: G. Mark Anderson , Bernard Scallon , Michael Naso , Ann Cai , Cam Ngo
IPC分类号: C07K16/30 , A61K39/395 , C07K16/46 , A61K51/10 , C12N15/13 , C12N15/85 , C12N5/16 , C12P21/08 , A01K67/027 , C12N5/06 , A61P35/04
CPC分类号: C07K16/36 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要: Isolated anti-tissue factor antibodies, immunoglobulins, cleavage products and other specified portions and variants thereof having enhanced ADCC activity, as well as anti-tissue factor antibody compositions, encoding or complementary nucleic acids, vectors, host cells, compositions, formulations, devices, transgenic animals, transgenic plants, and methods of making and using thereof. The antibodies of the invention bind human tissue factor and demonstrate enhanced ADCC activity. Accordingly, the antibodies can be used in a variety of methods for diagnosing, treating, and/or preventing diseases involving tissue factor, where enhanced ADCC activity is desirable such as cancer.
摘要翻译: 分离的抗组织因子抗体,免疫球蛋白,切割产物和其具有增强的ADCC活性的其它指定部分和变体,以及抗组织因子抗体组合物,编码或互补核酸,载体,宿主细胞,组合物,制剂,装置, 转基因动物,转基因植物及其制备和使用方法。 本发明的抗体结合人组织因子并表现出增强的ADCC活性。 因此,抗体可用于各种诊断,治疗和/或预防涉及组织因子的疾病的方法,其中期望增加ADCC活性,例如癌症。
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公开(公告)号:US08293882B2
公开(公告)日:2012-10-23
申请号:US12412957
申请日:2009-03-27
申请人: G. Mark Anderson , Bernard Scallon , Michael Naso , Ann Cai , Cam Ngo
发明人: G. Mark Anderson , Bernard Scallon , Michael Naso , Ann Cai , Cam Ngo
IPC分类号: C07H21/04
CPC分类号: C07K16/36 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要: Isolated anti-tissue factor antibodies, immunoglobulins, cleavage products and other specified portions and variants thereof having enhanced ADCC activity, as well as anti-tissue factor antibody compositions, encoding or complementary nucleic acids, vectors, host cells, compositions, formulations, devices, transgenic animals, transgenic plants, and methods of making and using thereof. The antibodies of the invention bind human tissue factor and demonstrate enhanced ADCC activity. Accordingly, the antibodies can be used in a variety of methods for diagnosing, treating, and/or preventing diseases involving tissue factor, where enhanced ADCC activity is desirable such as cancer.
摘要翻译: 分离的抗组织因子抗体,免疫球蛋白,切割产物和其具有增强的ADCC活性的其它指定部分和变体,以及抗组织因子抗体组合物,编码或互补核酸,载体,宿主细胞,组合物,制剂,装置, 转基因动物,转基因植物及其制备和使用方法。 本发明的抗体结合人组织因子并表现出增强的ADCC活性。 因此,抗体可用于各种诊断,治疗和/或预防涉及组织因子的疾病的方法,其中期望增加ADCC活性,例如癌症。
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公开(公告)号:US20110236390A1
公开(公告)日:2011-09-29
申请号:US12915445
申请日:2010-10-29
申请人: Juan Carlos Almagro , Daniela Della Ducata , Merle Elloso , Jinquan Luo , Thomas Malia , Michael Naso , Galina Obmolova , Robert Rauchenberger , Mark Rutz , Raymond Sweet , Susann Taudte , Bingyuan Wu , Sheng-Jiun Wu
发明人: Juan Carlos Almagro , Daniela Della Ducata , Merle Elloso , Jinquan Luo , Thomas Malia , Michael Naso , Galina Obmolova , Robert Rauchenberger , Mark Rutz , Raymond Sweet , Susann Taudte , Bingyuan Wu , Sheng-Jiun Wu
IPC分类号: A61K39/395 , C12N15/63 , C12N5/10 , C07K16/24 , C12N1/00 , C07H21/00 , C07K1/107 , A61P29/00 , A61P11/00 , A61P17/06 , A61P11/06 , A61P19/02
CPC分类号: C07K16/244 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要: Interleukin-17A (IL-17A) antibody antagonists, polynucleotides encoding IL-17A antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译: 公开了白细胞介素-177(IL-17A)抗体拮抗剂,编码IL-17A抗体拮抗剂或其片段的多核苷酸,以及制备和使用前述物质的方法。
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