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公开(公告)号：US20100294844A1
公开(公告)日：2010-11-25
申请号：US11109877
申请日：2005-04-20
申请人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
发明人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
CPC分类号： B30B15/065 , B30B15/34 , G06K19/06028
摘要： Methods for providing pharmaceutical compositions and objects with identification regions and identification features which are difficult to detect. Microlithography, nanolithography, and stamping methods are used. The identification features can be positive protrusions or negative indentations with respect to the surface. The identification regions can comprise bar codes and holograms. DPN printing or other lithographies such as electron beam lithography, optical lithography, or nanoimprint lithography can be used to prepare stamps, which are then used to prepare the identification features. Redundant patterns can be formed. The invention is useful for counterfeit prevention. An apparatus for stamping the identification features is also described.
摘要翻译： 用于提供药物组合物和物体具有难以检测的识别区域和识别特征的方法。 使用微光刻，纳米光刻和冲压方法。 识别特征可以是相对于表面的正突起或负凹痕。 识别区域可以包括条形码和全息图。 可以使用DPN印刷或诸如电子束光刻，光刻或纳米压印光刻的其它平版印刷术来制备标记，然后将其用于制备识别特征。 可以形成冗余图案。 本发明可用于防伪。 还描述了用于冲压识别特征的装置。
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2.发明申请Apparatus and methods for preparing identification features including pharmaceutical applications 审中-公开用于制备识别特征的装置和方法，包括药物应用公开(公告)号：US20100294147A1
公开(公告)日：2010-11-25
申请号：US11305327
申请日：2005-12-19
申请人： Cedric Loiret-Bernal , Bjoern Rosner , Sylvain Cruchon-Dupeyrat , John E. Bussan , Michael Nelson
发明人： Cedric Loiret-Bernal , Bjoern Rosner , Sylvain Cruchon-Dupeyrat , John E. Bussan , Michael Nelson
IPC分类号： B41F17/36
CPC分类号： B41F19/068 , B41F17/36
摘要： Semi-automated or automated manufacturing of micro- or nanostructured identification features on objects and compositions, and especially pharmaceutical compositions. In particular, a motorized stamping apparatus capable of precise hot embossing with or without closed-loop control of the loading; a modular stamp head for a high-throughput parallel stamping apparatus that comprise an array of compact, error-tolerant, individually temperature-controllable stamping elements; inexpensive stamp holders for said elements, as well as associated methods. The inventive features do not reside in the method of making the stamps.
摘要翻译： 在物体和组合物上，特别是药物组合物的半自动或自动化制造微结构或纳米结构的识别特征。 特别是一种电动冲压装置，能够精确地加热或不加负荷闭环控制的热压花; 用于高通量并行冲压装置的模块化压头，其包括紧凑的，容错的，单独的温度可控的冲压元件阵列; 用于所述元件的廉价邮票持有者以及相关方法。 本发明的特征不在于制作邮票的方法。
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3.发明申请APPARATUS AND METHODS FOR PREPARING IDENTIFICATION FEATURES INCLUDING PHARMACEUTICAL APPLICATIONS 审中-公开用于准备鉴定特征的装置和方法，包括药物应用公开(公告)号：US20120272845A1
公开(公告)日：2012-11-01
申请号：US13539259
申请日：2012-06-29
申请人： Cedric Loiret-Bernal , Bjoern Rosner , Sylvain Cruchon-Dupeyrat , John E. Bussan , Michael Nelson
发明人： Cedric Loiret-Bernal , Bjoern Rosner , Sylvain Cruchon-Dupeyrat , John E. Bussan , Michael Nelson
IPC分类号： B44B5/00
CPC分类号： B41F19/068 , B41F17/36
摘要： Semi-automated or automated manufacturing of micro- or nanostructured identification features on objects and compositions, and especially pharmaceutical compositions. In particular, a motorized stamping apparatus capable of precise hot embossing with or without closed-loop control of the loading; a modular stamp head for a high-throughput parallel stamping apparatus that comprise an array of compact, error-tolerant, individually temperature-controllable stamping elements; inexpensive stamp holders for said elements, as well as associated methods. The inventive features do not reside in the method of making the stamps.
摘要翻译： 在物体和组合物上，特别是药物组合物的半自动或自动化制造微结构或纳米结构的识别特征。 特别是一种电动冲压装置，能够精确地加热或不加负荷闭环控制的热压花; 用于高通量并行冲压装置的模块化压头，其包括紧凑的，容错的，单独的温度可控的冲压元件阵列; 用于所述元件的廉价邮票持有者以及相关方法。 本发明的特征不在于制作邮票的方法。
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公开(公告)号：US20100297190A1
公开(公告)日：2010-11-25
申请号：US12536465
申请日：2009-08-05
申请人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
发明人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
CPC分类号： B30B15/065 , B30B15/34 , G06K19/06028
摘要： Methods for providing pharmaceutical compositions and objects with identification regions and identification features which are difficult to detect. Microlithography, nanolithography, and stamping methods are used. The identification features can be positive protrusions or negative indentations with respect to the surface. The identification regions can comprise bar codes and holograms. DPN printing or other lithographies such as electron beam lithography, optical lithography, or nanoimprint lithography can be used to prepare stamps, which are then used to prepare the identification features. Redundant patterns can be formed. The invention is useful for counterfeit prevention. An apparatus for stamping the identification features is also described.
摘要翻译： 用于提供药物组合物和物体具有难以检测的识别区域和识别特征的方法。 使用微光刻，纳米光刻和冲压方法。 识别特征可以是相对于表面的正突起或负凹痕。 识别区域可以包括条形码和全息图。 可以使用DPN印刷或诸如电子束光刻，光刻或纳米压印光刻的其它平版印刷术来制备标记，然后将其用于制备识别特征。 可以形成冗余图案。 本发明可用于防伪。 还描述了用于冲压识别特征的装置。
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公开(公告)号：US20100294927A1
公开(公告)日：2010-11-25
申请号：US11519199
申请日：2006-09-12
CPC分类号： A61K9/2072 , G06Q10/08 , G06Q50/22
摘要： The various embodiments provide methods and apparatus high-throughput reading and decoding of information-encoding features (especially identification features) on pharmaceutical compositions for the purpose of e.g. counterfeiting detection and inventory tracking/tracing. A preferred embodiment provides high-throughput imaging of regular arrays of pharmaceutical tablets with a scanning electron microscope. Another preferred embodiment provides video-rate scanning probe imaging of pharmaceutical compositions and especially atomic force microscopy imaging thereof.
摘要翻译： 各种实施例提供了用于例如药物组合物的信息编码特征（特别是识别特征）的高通量读取和解码方法和装置。 伪造检测和库存跟踪/跟踪。 优选的实施方案提供了用扫描电子显微镜对药物片剂的规则阵列的高通量成像。 另一个优选实施例提供药物组合物的视频速率扫描探针成像，特别是其原子力显微镜成像。
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公开(公告)号：US08235302B2
公开(公告)日：2012-08-07
申请号：US11109877
申请日：2005-04-20
申请人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
发明人： Cedric Loiret-Bernal , Linette Demers , Bjoern Rosner , Michael Nelson , Ray Eby , Joseph S. Fragala , Raymond Roger Shile , Hua Zhang , John Edward Bussan , Sylvain Cruchon-Dupeyrat
CPC分类号： B30B15/065 , B30B15/34 , G06K19/06028
摘要： Methods for providing pharmaceutical compositions and objects with identification regions and identification features which are difficult to detect. Microlithography, nanolithography, and stamping methods are used. The identification features can be positive protrusions or negative indentations with respect to the surface. The identification regions can comprise bar codes and holograms. DPN printing or other lithographies such as electron beam lithography, optical lithography, or nanoimprint lithography can be used to prepare stamps, which are then used to prepare the identification features. Redundant patterns can be formed. The invention is useful for counterfeit prevention. An apparatus for stamping the identification features is also described.
摘要翻译： 用于提供药物组合物和物体具有难以检测的识别区域和识别特征的方法。 使用微光刻，纳米光刻和冲压方法。 识别特征可以是相对于表面的正突起或负凹痕。 识别区域可以包括条形码和全息图。 可以使用DPN印刷或诸如电子束光刻，光刻或纳米压印光刻的其它平版印刷术来制备标记，然后将其用于制备识别特征。 可以形成冗余图案。 本发明可用于防伪。 还描述了用于冲压识别特征的装置。
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7.发明申请Stamps with micrometer-and nanometer-scale features and methods of fabrication thereof 有权具有微米和纳米尺度特征的印模及其制造方法公开(公告)号：US20100294146A1
公开(公告)日：2010-11-25
申请号：US11305326
申请日：2005-12-19
申请人： Joseph S. Fragala , Cedric Loiret-Bernal , Hua Zhang , Raymond Roger Shile , Bjoern Rosner , Sylvain Cruchon-Dupeyrat
发明人： Joseph S. Fragala , Cedric Loiret-Bernal , Hua Zhang , Raymond Roger Shile , Bjoern Rosner , Sylvain Cruchon-Dupeyrat
IPC分类号： B44B5/02
摘要： Stamps and methods of making stamps for applications in anti-counterfeiting and authentication. The stamps are relatively small in size and feature nanoscale and microscale identification regions and features. High throughput manufacturing and high resolution methods are used to make the stamps including electron beam lithography and optical lithography. Anti-fouling coatings can be applied.
摘要翻译： 邮票和制作邮票的方法，用于防伪和认证。 邮票的尺寸相对较小，具有纳米尺度和微尺度识别区域和特征。 使用高通量制造和高分辨率方法来制作邮票，包括电子束光刻和光刻。 可以应用防污涂料。
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8.发明授权Stamps with micrometer-and nanometer-scale features and methods of fabrication thereof 有权具有微米和纳米尺度特征的印模及其制造方法公开(公告)号：US08387529B2
公开(公告)日：2013-03-05
申请号：US13286954
申请日：2011-11-01
申请人： Joseph S. Fragala , Cedric Loiret-Bernal , Hua Zhang , Raymond Roger Shile , Bjoern Rosner , Sylvain Cruchon-Dupeyrat
发明人： Joseph S. Fragala , Cedric Loiret-Bernal , Hua Zhang , Raymond Roger Shile , Bjoern Rosner , Sylvain Cruchon-Dupeyrat
IPC分类号： B41C1/00
摘要： Stamps and methods of making stamps for applications in anti-counterfeiting and authentication. The stamps are relatively small in size and feature nanoscale and microscale identification regions and features. High throughput manufacturing and high resolution methods are used to make the stamps including electron beam lithography and optical lithography. Anti-fouling coatings can be applied.
摘要翻译： 邮票和制作邮票的方法，用于防伪和认证。 邮票的尺寸相对较小，具有纳米尺度和微尺度识别区域和特征。 使用高通量制造和高分辨率方法来制作邮票，包括电子束光刻和光刻。 可以应用防污涂料。
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9.发明授权Stamps with micrometer- and nanometer-scale features and methods of fabrication thereof 有权具有微米级和纳米尺度特征的印模及其制造方法公开(公告)号：US08069782B2
公开(公告)日：2011-12-06
申请号：US11305326
申请日：2005-12-19
申请人： Joseph S. Fragala , Cedric Loiret-Bernal , Hua Zhang , Raymond Roger Shile , Bjoern Rosner , Sylvain Cruchon-Dupeyrat
发明人： Joseph S. Fragala , Cedric Loiret-Bernal , Hua Zhang , Raymond Roger Shile , Bjoern Rosner , Sylvain Cruchon-Dupeyrat
IPC分类号： B41F17/36
摘要： Stamps and methods of making stamps for applications in anti-counterfeiting and authentication. The stamps are relatively small in size and feature nanoscale and microscale identification regions and features. High throughput manufacturing and high resolution methods are used to make the stamps including electron beam lithography and optical lithography. Anti-fouling coatings can be applied.
摘要翻译： 邮票和制作邮票的方法，用于防伪和认证。 邮票的尺寸相对较小，具有纳米尺度和微尺度识别区域和特征。 使用高通量制造和高分辨率方法来制作邮票，包括电子束光刻和光刻。 可以应用防污涂料。
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10.发明申请STAMPS WITH MICROMETER-AND NANOMETER-SCALE FEATURES AND METHODS OF FABRICATION THEREOF 有权具有微型和纳米尺度特征的标准及其制造方法公开(公告)号：US20120052415A1
公开(公告)日：2012-03-01
申请号：US13286954
申请日：2011-11-01
申请人： Joseph S. Fragala , Cedric Loiret-Bernal , Hua Zhang , Raymond Roger Shile , Bjoern Rosner , Sylvain Cruchon-Dupeyrat
发明人： Joseph S. Fragala , Cedric Loiret-Bernal , Hua Zhang , Raymond Roger Shile , Bjoern Rosner , Sylvain Cruchon-Dupeyrat
摘要： Stamps and methods of making stamps for applications in anti-counterfeiting and authentication. The stamps are relatively small in size and feature nanoscale and microscale identification regions and features. High throughput manufacturing and high resolution methods are used to make the stamps including electron beam lithography and optical lithography. Anti-fouling coatings can be applied.
摘要翻译： 邮票和制作邮票的方法，用于防伪和认证。 邮票的尺寸相对较小，具有纳米尺度和微尺度识别区域和特征。 使用高通量制造和高分辨率方法来制作邮票，包括电子束光刻和光刻。 可以应用防污涂料。
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