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    Apparatus and methods for preparing identification features including pharmaceutical applications
    4.
    发明申请
    Apparatus and methods for preparing identification features including pharmaceutical applications 审中-公开
    用于制备识别特征的装置和方法，包括药物应用

    公开(公告)号：US20100294147A1

    公开(公告)日：2010-11-25

    申请号：US11305327

    申请日：2005-12-19

    申请人： Cedric Loiret-Bernal ,  Bjoern Rosner ,  Sylvain Cruchon-Dupeyrat ,  John E. Bussan ,  Michael Nelson

    发明人： Cedric Loiret-Bernal ,  Bjoern Rosner ,  Sylvain Cruchon-Dupeyrat ,  John E. Bussan ,  Michael Nelson

    IPC分类号： B41F17/36

    CPC分类号： B41F19/068 ,  B41F17/36

    摘要： Semi-automated or automated manufacturing of micro- or nanostructured identification features on objects and compositions, and especially pharmaceutical compositions. In particular, a motorized stamping apparatus capable of precise hot embossing with or without closed-loop control of the loading; a modular stamp head for a high-throughput parallel stamping apparatus that comprise an array of compact, error-tolerant, individually temperature-controllable stamping elements; inexpensive stamp holders for said elements, as well as associated methods. The inventive features do not reside in the method of making the stamps.

    摘要翻译： 在物体和组合物上，特别是药物组合物的半自动或自动化制造微结构或纳米结构的识别特征。 特别是一种电动冲压装置，能够精确地加热或不加负荷闭环控制的热压花; 用于高通量并行冲压装置的模块化压头，其包括紧凑的，容错的，单独的温度可控的冲压元件阵列; 用于所述元件的廉价邮票持有者以及相关方法。 本发明的特征不在于制作邮票的方法。

    APPARATUS AND METHODS FOR PREPARING IDENTIFICATION FEATURES INCLUDING PHARMACEUTICAL APPLICATIONS
    5.
    发明申请
    APPARATUS AND METHODS FOR PREPARING IDENTIFICATION FEATURES INCLUDING PHARMACEUTICAL APPLICATIONS 审中-公开
    用于准备鉴定特征的装置和方法，包括药物应用

    公开(公告)号：US20120272845A1

    公开(公告)日：2012-11-01

    申请号：US13539259

    申请日：2012-06-29

    申请人： Cedric Loiret-Bernal ,  Bjoern Rosner ,  Sylvain Cruchon-Dupeyrat ,  John E. Bussan ,  Michael Nelson

    发明人： Cedric Loiret-Bernal ,  Bjoern Rosner ,  Sylvain Cruchon-Dupeyrat ,  John E. Bussan ,  Michael Nelson

    IPC分类号： B44B5/00

    CPC分类号： B41F19/068 ,  B41F17/36

    摘要： Semi-automated or automated manufacturing of micro- or nanostructured identification features on objects and compositions, and especially pharmaceutical compositions. In particular, a motorized stamping apparatus capable of precise hot embossing with or without closed-loop control of the loading; a modular stamp head for a high-throughput parallel stamping apparatus that comprise an array of compact, error-tolerant, individually temperature-controllable stamping elements; inexpensive stamp holders for said elements, as well as associated methods. The inventive features do not reside in the method of making the stamps.

    摘要翻译： 在物体和组合物上，特别是药物组合物的半自动或自动化制造微结构或纳米结构的识别特征。 特别是一种电动冲压装置，能够精确地加热或不加负荷闭环控制的热压花; 用于高通量并行冲压装置的模块化压头，其包括紧凑的，容错的，单独的温度可控的冲压元件阵列; 用于所述元件的廉价邮票持有者以及相关方法。 本发明的特征不在于制作邮票的方法。

    High throughput inspecting
    6.
    发明申请
    High throughput inspecting 审中-公开
    高通量检测

    公开(公告)号：US20100294927A1

    公开(公告)日：2010-11-25

    申请号：US11519199

    申请日：2006-09-12

    申请人： Michael Nelson ,  Sylvain Cruchon-Dupeyrat ,  Bjoern Rosner ,  Cedric Loiret-Bernal

    发明人： Michael Nelson ,  Sylvain Cruchon-Dupeyrat ,  Bjoern Rosner ,  Cedric Loiret-Bernal

    IPC分类号： G01N23/00 ,  A61K9/44 ,  G06F19/00 ,  G01N1/02

    CPC分类号： A61K9/2072 ,  G06Q10/08 ,  G06Q50/22

    摘要： The various embodiments provide methods and apparatus high-throughput reading and decoding of information-encoding features (especially identification features) on pharmaceutical compositions for the purpose of e.g. counterfeiting detection and inventory tracking/tracing. A preferred embodiment provides high-throughput imaging of regular arrays of pharmaceutical tablets with a scanning electron microscope. Another preferred embodiment provides video-rate scanning probe imaging of pharmaceutical compositions and especially atomic force microscopy imaging thereof.

    摘要翻译： 各种实施例提供了用于例如药物组合物的信息编码特征（特别是识别特征）的高通量读取和解码方法和装置。 伪造检测和库存跟踪/跟踪。 优选的实施方案提供了用扫描电子显微镜对药物片剂的规则阵列的高通量成像。 另一个优选实施例提供药物组合物的视频速率扫描探针成像，特别是其原子力显微镜成像。

    COMPACT NANOFABRICATION APPARATUS
    7.
    发明申请
    COMPACT NANOFABRICATION APPARATUS 审中-公开
    紧凑的纳米装置

    公开(公告)号：US20090023607A1

    公开(公告)日：2009-01-22

    申请号：US12116908

    申请日：2008-05-07

    申请人： Sergey V. Rozhok ,  Michael Nelson ,  Nabil A. Amro ,  Joseph S. Fragala ,  Raymond Roger Shile ,  John Edward Bussan ,  Dirk N. vanMerkestyn

    发明人： Sergey V. Rozhok ,  Michael Nelson ,  Nabil A. Amro ,  Joseph S. Fragala ,  Raymond Roger Shile ,  John Edward Bussan ,  Dirk N. vanMerkestyn

    IPC分类号： C40B50/14 ,  C40B60/14

    CPC分类号： G03F7/0002 ,  G01Q80/00 ,  G03F7/70383 ,  G03F9/00

    摘要： An apparatus for use in fabricating structures and depositing materials from tips to surfaces for patterning in direct-write mode, providing ability to travel macroscopic distances and yet provide for nanoscale patterning. Useful in small scale fabrication and nanolithography. The instrument can be compact and used on a laboratory bench or desktop. An apparatus comprising: at least one multi-axis assembly comprising a plurality of nanopositioning stages, at least one pen assembly, wherein the pen assembly and the multi-axis assembly are adapted for delivery of material from the pen assembly to a substrate which is positioned by the multi-axis assembly, at least one viewing assembly, at least one controller. Nanopositioning by piezoelectric methods and devices and motors is particularly useful. The apparatus can include integrated environmental chambers and housings, as well as ink reservoirs for materials to be delivered. The viewing assembly can be a microscope with a long working distance. Particularly useful for fabrication of bioarrays or microarrays. The multi-axis assembly can be a five-axis assembly. Software can facilitate efficient usage.

    摘要翻译： 一种用于制造结构并从尖端到表面沉积材料的装置，用于以直写式模式进行图案化，提供行进宏观距离并提供纳米尺度图案化的能力。 适用于小规模制造和纳米光刻。 该仪器可以紧凑，并在实验台或台式机上使用。 一种装置，包括：至少一个多轴组件，其包括多个纳米定位阶段，至少一个笔组件，其中所述笔组件和所述多轴组件适于将材料从所述笔组件传送到定位的衬底 通过多轴组件，至少一个观察组件，至少一个控制器。 通过压电方法和装置和电动机的定位是特别有用的。 该设备可以包括集成的环境室和壳体，以及用于要输送的材料的油墨储存器。 观察组件可以是具有长工作距离的显微镜。 特别适用于制造生物芯片或微阵列。 多轴组件可以是五轴组件。 软件可以促进有效的使用。

    COMPACT NANOFABRICATION APPARATUS
    8.
    发明申请
    COMPACT NANOFABRICATION APPARATUS 审中-公开
    紧凑的纳米装置

    公开(公告)号：US20110195850A1

    公开(公告)日：2011-08-11

    申请号：US13088284

    申请日：2011-04-15

    申请人： Sergey V. ROZHOK ,  Michael Nelson ,  Nabil A. Amro ,  Joseph S. Fragala ,  Raymond Roger Shile ,  John Edward Bussan ,  Dirk N. vanMerkestyn

    发明人： Sergey V. ROZHOK ,  Michael Nelson ,  Nabil A. Amro ,  Joseph S. Fragala ,  Raymond Roger Shile ,  John Edward Bussan ,  Dirk N. vanMerkestyn

    IPC分类号： C40B30/00 ,  C40B50/14

    CPC分类号： G03F7/0002 ,  G01Q80/00 ,  G03F7/70383 ,  G03F9/00

    摘要： An apparatus for use in fabricating structures and depositing materials from tips to surfaces for patterning in direct-write mode, providing ability to travel macroscopic distances and yet provide for nanoscale patterning. Useful in small scale fabrication and nanolithography. The instrument can be compact and used on a laboratory bench or desktop. An apparatus comprising: at least one multi-axis assembly comprising a plurality of nanopositioning stages, at least one pen assembly, wherein the pen assembly and the multi-axis assembly are adapted for delivery of material from the pen assembly to a substrate which is positioned by the multi-axis assembly, at least one viewing assembly, at least one controller. Nanopositioning by piezoelectric methods and devices and motors is particularly useful. The apparatus can include integrated environmental chambers and housings, as well as ink reservoirs for materials to be delivered. The viewing assembly can be a microscope with a long working distance. Particularly useful for fabrication of bioarrays or microarrays. The multi-axis assembly can be a five-axis assembly. Software can facilitate efficient usage.

    摘要翻译： 一种用于制造结构并从尖端到表面沉积材料的装置，用于以直写式模式进行图案化，提供行进宏观距离并提供纳米尺度图案化的能力。 适用于小规模制造和纳米光刻。 该仪器可以紧凑，并在实验台或台式机上使用。 一种装置，包括：至少一个多轴组件，其包括多个纳米定位阶段，至少一个笔组件，其中所述笔组件和所述多轴组件适于将材料从所述笔组件传送到定位的衬底 通过多轴组件，至少一个观察组件，至少一个控制器。 通过压电方法和装置和电动机的定位是特别有用的。 该设备可以包括集成的环境室和壳体，以及用于要输送的材料的油墨储存器。 观察组件可以是具有长工作距离的显微镜。 特别适用于制造生物芯片或微阵列。 多轴组件可以是五轴组件。 软件可以促进有效的使用。