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公开(公告)号：US07608089B2
公开(公告)日：2009-10-27
申请号：US11022189
申请日：2004-12-22
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/12154 , A61B2017/00477 , A61B2017/12054 , A61B2017/12063 , A61B2017/12095
摘要： An assembly for occluding a vascular site (e.g., an aneurysm) of a human or veterinary patient includes a vaso-occlusive member, a pusher member having a distal end and a severable junction located proximal to the distal end, and a pivotable coupling that couples the pusher member to the occlusive member. A delivery catheter can be used to deliver the vaso-occlusive member to the vascular site. A method of using the assembly to occlude an aneurysm having an aneurysmal sac and an aneurysmal neck, includes locating the catheter within the aneurysmal neck, and manipulating the pusher member to place the vaso-occlusive member within the aneurysmal sac. The method further includes severing the severable junction to detach the vaso-occlusive member from the pusher member. As a result, an axial force is applied by the vaso-occlusive member in a proximal direction, which buckles the pivotable coupling to laterally deflect the axial force. The lateral deflection of the axial force caused by the buckling of the pivotable coupling prevents the catheter from being displaced from the aneurysmal neck by the axial force.
摘要翻译： 用于闭塞人或兽医患者的血管部位（例如，动脉瘤）的组件包括血管闭塞构件，具有远端的推动器构件和位于远端附近的可分离接合部以及可枢转联接件 推动器构件到闭塞构件。 输送导管可用于将血管闭塞成员递送至血管部位。 一种使用组件闭塞具有动脉瘤囊和动脉瘤颈部的动脉瘤的方法，包括将导管定位在动脉瘤颈内，以及操纵推动器构件以将血管闭塞构件置于动脉瘤囊内。 该方法还包括切断可分开的连接处以将血管闭塞构件与推动器构件分离。 结果，轴向力由近端方向由血管闭塞构件施加，该近侧方向使可枢转联接器弯曲以横向偏转轴向力。 由可枢转联轴器的弯曲引起的轴向力的横向偏转防止导管通过轴向力从动脉瘤颈部移位。
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2.发明授权Method of intravascularly delivering stimulation leads into direct contact with tissue 失效血管内传递刺激的方法导致与组织直接接触公开(公告)号：US08060207B2
公开(公告)日：2011-11-15
申请号：US10744853
申请日：2003-12-22
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534
摘要： A method of treating a disorder in a patient is provided. The method comprises delivering a stimulation lead within a blood vessel, intralumenally puncturing a wall of the blood vessel to create an exit point, and then introducing the stimulation lead through the exit point into direct contact with tissue the stimulation of which treats the disorder. Optionally, the method comprises implanting a source of stimulation within the patient's body, and then electrically coupling the proximal end of the stimulation lead to the implanted stimulation source. Using the stimulation lead, the tissue can then be stimulated in order to treat the disorder.
摘要翻译： 提供了一种治疗患者疾病的方法。 该方法包括在血管内递送刺激引线，腔内穿刺血管的壁以产生出口点，然后将刺激引线通过出口点直接接触组织，其刺激治疗病症。 可选地，该方法包括将刺激源植入患者体内，然后将刺激引线的近端电耦合到植入的刺激源。 使用刺激铅，然后可以刺激组织以治疗该疾病。
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公开(公告)号：US20100042133A1
公开(公告)日：2010-02-18
申请号：US12605175
申请日：2009-10-23
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/12154 , A61B2017/00477 , A61B2017/12054 , A61B2017/12063 , A61B2017/12095
摘要： An assembly for occluding a vascular site (e.g., an aneurysm) of a human or veterinary patient includes a vaso-occlusive member, a pusher member having a distal end and a severable junction located proximal to the distal end, and a pivotable coupling that couples the pusher member to the occlusive member. A delivery catheter can be used to deliver the vaso-occlusive member to the vascular site. A method of using the assembly to occlude an aneurysm having an aneurysmal sac and an aneurysmal neck, includes locating the catheter within the aneurysmal neck, and manipulating the pusher member to place the vaso-occlusive member within the aneurysmal sac. The method further includes severing the severable junction to detach the vaso-occlusive member from the pusher member. As a result, an axial force is applied by the vaso-occlusive member in a proximal direction, which buckles the pivotable coupling to laterally deflect the axial force. The lateral deflection of the axial force caused by the buckling of the pivotable coupling prevents the catheter from being displaced from the aneurysmal neck by the axial force.
摘要翻译： 用于闭塞人或兽医患者的血管部位（例如，动脉瘤）的组件包括血管闭塞构件，具有远端的推动器构件和位于远端附近的可分离接合部以及可枢转联接件 推动器构件到闭塞构件。 输送导管可用于将血管闭塞成员递送至血管部位。 一种使用组件闭塞具有动脉瘤囊和动脉瘤颈部的动脉瘤的方法，包括将导管定位在动脉瘤颈内，以及操纵推动器构件以将血管闭塞构件置于动脉瘤囊内。 该方法还包括切断可分开的连接处以将血管闭塞构件与推动器构件分离。 结果，轴向力由近端方向由血管闭塞构件施加，该近侧方向使可枢转联接器弯曲以横向偏转轴向力。 由可枢转联轴器的弯曲引起的轴向力的横向偏转防止导管通过轴向力从动脉瘤颈部移位。
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4.发明授权公开(公告)号：US08731674B2
公开(公告)日：2014-05-20
申请号：US13347434
申请日：2012-01-10
IPC分类号： A61N1/05
CPC分类号： A61N1/36082 , A61N1/36103
摘要： A method of treating a neurological disorder comprises introducing an electrical stimulation lead within a patient's head, locating the stimulation lead within the 4th ventricle of the patient's head, and placing the stimulation lead adjacent the fastigium nucleus of the patient's brain. The method may further comprise stimulating the fastigium nucleus with the stimulation lead to treat the neurological disorder, for example, by increasing the flow of blood within the patient's brain.
摘要翻译： 治疗神经障碍的方法包括在患者头部内引入电刺激引线，将刺激引线置于患者头部的第四脑室内，并将刺激引线放置在患者大脑的快速核附近。 该方法可以进一步包括用刺激引线刺激快镰核，以治疗神经障碍，例如通过增加患者脑内血液的流动。
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公开(公告)号：US20120310270A1
公开(公告)日：2012-12-06
申请号：US13586280
申请日：2012-08-15
申请人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
发明人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
IPC分类号： A61M29/00
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/1214 , A61B17/12168 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12063
摘要： In one embodiment, a neck bridge for bridging the neck of an aneurysm includes a junction region, a number of radially extending array elements attached to the junction region, and a cover attached to one or both of the junction region and an array element. The array elements are configured to be positioned within the aneurysm after the neck bridge is deployed from a delivery device. In a second embodiment, the neck bridge includes a junction region and a braided or mesh-like structure secured to the junction region. The braided or mesh-like structure is made from an elastic material.
摘要翻译： 在一个实施例中，用于桥接动脉瘤颈部的颈桥包括连接区域，连接到接合区域的多个径向延伸的阵列元件以及附接到接合区域和阵列元件中的一个或两者的盖。 阵列元件构造成在颈桥从输送装置部署之后定位在动脉瘤内。 在第二实施例中，颈桥包括固定到接合区域的连接区域和编织或网状结构。 编织或网状结构由弹性材料制成。
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公开(公告)号：US20120191003A1
公开(公告)日：2012-07-26
申请号：US13437214
申请日：2012-04-02
IPC分类号： A61B5/05
CPC分类号： A61N1/0551 , A61B5/04001 , A61B5/0488 , A61B5/1107 , A61B5/4519 , A61B5/4893 , A61B17/149 , A61B17/1671 , A61B17/1757 , A61B17/320016 , A61B17/7092 , A61B17/8897 , A61B2017/32006 , A61B2562/0261 , A61B2562/046
摘要： Described herein are bimanually controlled neural localization devices capable of determining if a nerve is nearby a region of the device. In general, the device may include at least two electrodes including an anode in electrical communication with a anodal conductor and a cathode in electrical communication with a cathodal conductor. The device may further include a flexible elongate body, wherein the flexible elongate body has an axial length, a width and a thickness, wherein the axial length is greater than the width, and the width is greater than the thickness and is greater than a width of the at least two electrodes. The at least two electrodes may be disposed substantially in-line and centered along the length of the elongate body. In some embodiments, the device may further include a guidewire coupler at the distal end region of the elongate body.
摘要翻译： 这里描述的是能够确定神经是否在装置的区域附近的双手控制的神经定位装置。 通常，该装置可以包括至少两个电极，包括与阳极导体电连通的阳极和与阴极导体电连通的阴极。 该装置还可以包括柔性细长主体，其中柔性细长主体具有轴向长度，宽度和厚度，其中轴向长度大于宽度，并且宽度大于厚度并且大于宽度 的至少两个电极。 所述至少两个电极可以沿着细长主体的长度基本上一直排列并居中。 在一些实施例中，该装置还可包括在细长主体的远端区域处的导丝联接器。
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公开(公告)号：US08206346B2
公开(公告)日：2012-06-26
申请号：US12838934
申请日：2010-07-19
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61M25/0141 , A61M25/0147 , A61M2025/0163 , A61M2025/105 , A61M2025/1086
摘要： A targeted drug delivery device is provided. The device comprises an elongated member with proximal and distal ends, a plurality of infusion ports associated with the distal end of the elongated member, and a selector mechanism for selectively placing an introducer port into fluid communication with at least one infusion port. A method for treating tissue is also provided. The method comprises introducing a medical device into the tissue, selecting a region of the tissue to treat, positioning the medical device in proximity to the region, and introducing a medicament through the device to treat only that region.
摘要翻译： 提供了靶向药物递送装置。 该装置包括具有近端和远端的细长构件，与细长构件的远端相关联的多个输注端口以及用于选择性地将引导器端口与至少一个输注端口流体连通的选择器机构。 还提供了一种治疗组织的方法。 该方法包括将医疗装置引入组织中，选择组织的区域以治疗，将医疗装置定位在该区域附近，以及通过该装置引入药物以仅治疗该区域。
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8.发明授权公开(公告)号：US08172862B2
公开(公告)日：2012-05-08
申请号：US12723575
申请日：2010-03-12
IPC分类号： A61B17/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/1205 , A61B2017/12063
摘要： This is a medical device for forming an embolism within the vasculature of a patient. More particularly, it concerns an occlusion device comprising an inner core covered with a polymer. The medical device encourages cellular attachment and growth while maintaining favorable handling, deployment and visualization characteristics.
摘要翻译： 这是用于在患者的脉管系统内形成栓塞的医疗装置。 更具体地说，它涉及包含被聚合物覆盖的内核的闭塞装置。 医疗设备鼓励细胞附着和生长，同时保持良好的处理，部署和可视化特征。
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公开(公告)号：US08128614B2
公开(公告)日：2012-03-06
申请号：US12353112
申请日：2009-01-13
IPC分类号： A61M25/01
CPC分类号： A61M25/0662 , A61M25/10 , A61M2025/0006 , A61M2025/0293 , A61M2025/0681 , A61M2025/09125 , A61M2025/1063
摘要： An apparatus for accessing a site within a body includes a cannula and an elongate member. The cannula has a proximal end, a distal end, and a lumen extending therebetween. The elongate member has a distal end configured for insertion into the lumen, wherein the distal end of the elongate member is attachable to and releasable from the distal end of the cannula. A method for accessing a site within a body includes inserting a distal end of an elongate member into a lumen of a cannula, detachably attaching the distal end of the elongate member to the cannula, and steering a distal end of the cannula to a desired site using the elongate member.
摘要翻译： 用于进入体内部位的装置包括套管和细长构件。 套管具有近端，远端和在其间延伸的内腔。 细长构件具有构造成用于插入内腔的远端，其中细长构件的远端可附接到插管的远端并且可从插管的远端释放。 用于访问体内部位的方法包括将细长构件的远端插入套管的内腔，将细长构件的远端可拆卸地连接到套管上，并将套管的远端转向所需位置 使用细长构件。
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公开(公告)号：US20110237982A1
公开(公告)日：2011-09-29
申请号：US13134470
申请日：2011-06-08
申请人： Michael P. Wallace
发明人： Michael P. Wallace
IPC分类号： A61N7/00
CPC分类号： A61B17/22012 , A61B17/2202 , A61B2017/22014 , A61B2017/22082 , A61B2017/22088 , A61B2018/00029
摘要： Apparatus and methods are disclosed for vein and arterial-venous fistulas stenosis and occlusion therapies, including enhancing permeability of the vessel wall using ultrasound energy and delivering a therapeutic agent into the vessel wall. Ultrasound energy may be delivered at frequencies less than 10 MHz and power less than 20 watts using transcutaneous techniques and endovascular methods. Therapeutic agents may be delivered to the treatment area via intravenous and endovascular methods. In some embodiments, ultrasound energy and therapeutic agent application may be combined with angioplasty techniques and with blood flow protection devices. In some other embodiments, a therapeutic agent may be removed from the body after exposure to the vessel wall to minimize a systemic effect of the therapeutic drug.
摘要翻译： 公开了用于静脉和动脉 - 静脉瘘狭窄和闭塞治疗的装置和方法，包括使用超声能量增强血管壁的渗透性并将治疗剂递送到血管壁中。 超声能量可以使用经皮技术和血管内方法在小于10MHz的频率和功率小于20瓦的情况下递送。 治疗剂可通过静脉内和血管内途径递送至治疗区域。 在一些实施例中，超声能量和治疗剂应用可以与血管成形术技术和血液流动保护装置组合。 在一些其它实施方案中，治疗剂可以在暴露于血管壁之后从体内除去，以使治疗药物的全身效应最小化。
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