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    Lung Cancer Biomarkers and Uses Thereof
    3.
    发明申请
    Lung Cancer Biomarkers and Uses Thereof 审中-公开
    肺癌生物标志物及其用途

    公开(公告)号：US20120101002A1

    公开(公告)日：2012-04-26

    申请号：US13279990

    申请日：2011-10-24

    申请人： Michael Riel-Mehan ,  Alex A.E. Stewart ,  Rachel M. Ostroff ,  Stephen Alaric Williams ,  Edward N. Brody

    发明人： Michael Riel-Mehan ,  Alex A.E. Stewart ,  Rachel M. Ostroff ,  Stephen Alaric Williams ,  Edward N. Brody

    IPC分类号： C40B30/04 ,  G06F19/24 ,  C40B40/10

    CPC分类号： G01N33/6893 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/16 ,  G01N33/57423 ,  G16B20/00 ,  G16B25/00 ,  G16B40/00 ,  G16B99/00

    摘要： The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of non-small cell lung cancer and general cancer. In one aspect, methods are provided for diagnosing non-small cell lung cancer, where the methods include detecting, in a sample, at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 1, wherein an individual is classified as having lung cancer, or the likelihood of having lung cancer is determined, based on the at least one biomarker value. In another aspect, methods are provided for diagnosing cancer, where the methods include detecting, in a sample, at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 19, wherein an individual is classified as having cancer, or the likelihood of having cancer is determined, based on the at least one biomarker value.

    摘要翻译： 本公开包括用于非小细胞肺癌和一般癌症的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。 在一个方面，提供了用于诊断非小细胞肺癌的方法，其中所述方法包括在样品中检测对应于选自表1中提供的生物标志物的至少一种生物标志物的至少一种生物标志物值，其中个体为 基于所述至少一种生物标志物值，确定分类为具有肺癌或确定患有肺癌的可能性。 在另一方面，提供了用于诊断癌症的方法，其中所述方法包括在样品中检测对应于选自表19中提供的生物标志物的至少一种生物标志物的至少一种生物标志物值，其中个体被分类为具有癌症， 或者基于所述至少一种生物标志物值确定患有癌症的可能性。

    Mesothelioma Biomarkers and Uses Thereof
    5.
    发明申请
    Mesothelioma Biomarkers and Uses Thereof 审中-公开
    间皮瘤生物标志物及其用途

    公开(公告)号：US20120077695A1

    公开(公告)日：2012-03-29

    申请号：US13246388

    申请日：2011-09-27

    申请人： Rachel M. Ostroff ,  Alex A.E. Stewart ,  Stephen Alaric Williams ,  Edward N. Brody ,  Malti Nikrad ,  Michael Riel-Mehan

    发明人： Rachel M. Ostroff ,  Alex A.E. Stewart ,  Stephen Alaric Williams ,  Edward N. Brody ,  Malti Nikrad ,  Michael Riel-Mehan

    IPC分类号： C40B30/04 ,  C40B40/10

    CPC分类号： C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N2800/50

    摘要： The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer. In one aspect, methods are provided for diagnosing mesothelioma where the methods include detecting, in a biological sample, at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 1, wherein an individual is classified as having mesothelioma, or the likelihood of an individual having mesothelioma is determined, based on the at least one biomarker value. In another aspect, methods are provided for diagnosing cancer generally where the methods include detecting, in a biological sample at least one biomarker value corresponding to at least one biomarker selected from the biomarkers provided in Table 17, wherein an individual is classified as having cancer generally, or the likelihood of an individual having cancer is determined, based on the at least one biomarker value.

    摘要翻译： 本公开包括用于癌症的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。 在一个方面，提供了用于诊断间皮瘤的方法，其中所述方法包括在生物样品中检测对应于选自表1中提供的生物标志物的至少一种生物标志物的至少一种生物标记值，其中个体被分类为具有间皮瘤， 或者基于所述至少一种生物标志物值确定个体具有间皮瘤的可能性。 在另一方面，提供了用于诊断癌症的方法，其中所述方法包括在生物样品中检测对应于选自表17中提供的生物标志物的至少一种生物标志物的至少一种生物标记值，其中个体被分类为具有癌症 或者确定个体患有癌症的可能性，基于至少一种生物标志物值。

    Lung Cancer Biomarkers and Uses Thereof
    7.
    发明申请
    Lung Cancer Biomarkers and Uses Thereof 审中-公开
    肺癌生物标志物及其用途

    公开(公告)号：US20100070191A1

    公开(公告)日：2010-03-18

    申请号：US12556480

    申请日：2009-09-09

    申请人： Larry Gold ,  Marty Stanton ,  Edward N. Brody ,  Rachel M. Ostroff ,  Dominic Zichi ,  Alex A.E. Stewart

    发明人： Larry Gold ,  Marty Stanton ,  Edward N. Brody ,  Rachel M. Ostroff ,  Dominic Zichi ,  Alex A.E. Stewart

    IPC分类号： G01N33/574 ,  C12Q1/02 ,  G06F19/00

    CPC分类号： G01N33/57423

    摘要： The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, Col. 2, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.

    摘要翻译： 本申请包括用于肺癌的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。 在一个方面，该应用提供可以单独使用或以各种组合使用以诊断肺癌或允许肺结节的鉴别诊断为良性或恶性的生物标志物。 在另一方面，提供了用于诊断个体中的肺癌的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自表1中提供的生物标志物组的至少一种生物标志物的生物标记值 ，第2栏，其中基于所述至少一种生物标记值，将个体分类为具有肺癌或确定患有肺癌的个体的可能性。