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    SYSTEM AND METHOD FOR TRANSVASCULARLY STIMULATING CONTENTS OF THE CAROTID SHEATH
    1.
    发明申请
    SYSTEM AND METHOD FOR TRANSVASCULARLY STIMULATING CONTENTS OF THE CAROTID SHEATH 有权
    用于血管内皮细胞刺激的系统和方法

    公开(公告)号：US20100023088A1

    公开(公告)日：2010-01-28

    申请号：US12413495

    申请日：2009-03-27

    申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

    发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

    IPC分类号： A61N1/36 ,  A61N7/00

    CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

    摘要： Methods and systems are disclosed for stimulating contents of the carotid sheath using an intravascular pulse generator and lead. The lead carries an energy delivery device such as an electrode, which is anchor within the portion of the internal jugular vein that is disposed within the carotid sheath. The energy delivery device is energized to transvenously direct energy to target contents of the carotid sheath external to the internal jugular vein. Such target contents may include nervous system elements associated with the carotid sinus baroreceptors, the carotid sinus nerve and associated nerve branches, and or the vagus nerve and associated nerve branches. The system may be used to control blood pressure and/or to lower heart rate and may be suitable for treatment of hypertension, heart failure, or other conditions.

    摘要翻译： 公开了使用血管内脉冲发生器和引线刺激颈动脉鞘的内容物的方法和系统。 引线携带能量递送装置，例如电极，其锚定在设置在颈动脉鞘内的颈内静脉的部分内。 能量递送装置被通电以将能量传递给颈内静脉外部的颈动脉鞘的目标物质。 这样的目标物质可以包括与颈动脉窦压力感受器，颈动脉窦神经和相关神经分支相关的神经系统元件，或迷走神经和相关联的神经分支。 该系统可用于控制血压和/或降低心率，并且可适用于治疗高血压，心力衰竭或其它病症。

    TRANSVASCULAR ELECTRODE SYSTEM AND METHOD
    2.
    发明申请
    TRANSVASCULAR ELECTRODE SYSTEM AND METHOD 有权
    透射电极系统及方法

    公开(公告)号：US20120221014A1

    公开(公告)日：2012-08-30

    申请号：US13286217

    申请日：2011-11-01

    申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

    发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

    IPC分类号： A61N1/05 ,  A61B19/00

    CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

    摘要： A transvascular electrode system includes an expandable electrode-carrying anchor. The anchor is intravascularly advanced in a compressed position to a first site in a blood vessel. A first portion of the anchor expands to position an electrode against the vessel wall, while a second portion remains is compressed. Mapping is performed by delivering stimulation energy from the electrode and measuring the response (e.g. blood pressure, heart rate, and/or related parameters). The first portion is at least partially collapsed and the electrode system is moved to a second site. The first portion is expanded to position the electrode into against the vessel wall, while the second portion remains compressed. Additional mapping is performed. The process is repeated until the anchor electrode position is optimized, at which point the second portion of the anchor is expanded to chronically retain the electrode in the vessel.

    摘要翻译： 经血管电极系统包括可扩张电极承载锚。 锚固体在压缩位置中血管内前进到血管中的第一部位。 锚的第一部分膨胀以将电极定位在血管壁上，而第二部分保留被压缩。 通过从电极传递刺激能量并测量反应（例如血压，心率和/或相关参数）来进行测绘。 第一部分至少部分地折叠并且电极系统移动到第二部位。 第一部分被扩展以将电极定位在血管壁上，而第二部分保持压缩。 执行附加映射。 重复该过程直到锚定位置被优化，此时锚固体的第二部分被膨胀以将电极长期地保持在容器中。

    SYSTEM AND METHOD FOR TRANSVASCULARLY STIMULATING CONTENTS OF THE CAROTID SHEATH
    4.
    发明申请
    SYSTEM AND METHOD FOR TRANSVASCULARLY STIMULATING CONTENTS OF THE CAROTID SHEATH 有权
    用于血管内皮细胞刺激的系统和方法

    公开(公告)号：US20110166482A1

    公开(公告)日：2011-07-07

    申请号：US13042350

    申请日：2011-03-07

    申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

    发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

    IPC分类号： A61N1/36 ,  A61N7/00

    CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

    摘要： Methods and systems are disclosed for stimulating contents of the carotid sheath using an intravascular pulse generator and lead. The lead carries an energy delivery device such as an electrode, which is anchor within the portion of the internal jugular vein that is disposed within the carotid sheath. The energy delivery device is energized to transvenously direct energy to target contents of the carotid sheath external to the internal jugular vein. Such target contents may include nervous system elements associated with the carotid sinus baroreceptors, the carotid sinus nerve and associated nerve branches, and or the vagus nerve and associated nerve branches. The system may be used to control blood pressure and/or to lower heart rate and may be suitable for treatment of hypertension, heart failure, or other conditions.

    摘要翻译： 公开了使用血管内脉冲发生器和引线刺激颈动脉鞘的内容物的方法和系统。 引线携带能量递送装置，例如电极，其锚定在设置在颈动脉鞘内的颈内静脉的部分内。 能量递送装置被通电以将能量传递给颈内静脉外部的颈动脉鞘的目标物质。 这样的目标物质可以包括与颈动脉窦压力感受器，颈动脉窦神经和相关神经分支相关的神经系统元件，或迷走神经和相关联的神经分支。 该系统可用于控制血压和/或降低心率，并且可适用于治疗高血压，心力衰竭或其它病症。

    System and method for transvascularly stimulating contents of the carotid sheath
    5.
    发明授权
    System and method for transvascularly stimulating contents of the carotid sheath 有权
    用于血管内刺激颈动脉内皮的系统和方法

    公开(公告)号：US07925352B2

    公开(公告)日：2011-04-12

    申请号：US12413495

    申请日：2009-03-27

    申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

    发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

    IPC分类号： A61N1/00

    CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

    摘要： Methods and systems are disclosed for stimulating contents of the carotid sheath using an intravascular pulse generator and lead. The lead carries an energy delivery device such as an electrode, which is anchor within the portion of the internal jugular vein that is disposed within the carotid sheath. The energy delivery device is energized to transvenously direct energy to target contents of the carotid sheath external to the internal jugular vein. Such target contents may include nervous system elements associated with the carotid sinus baroreceptors, the carotid sinus nerve and associated nerve branches, and or the vagus nerve and associated nerve branches. The system may be used to control blood pressure and/or to lower heart rate and may be suitable for treatment of hypertension, heart failure, or other conditions.

    摘要翻译： 公开了使用血管内脉冲发生器和引线刺激颈动脉鞘的内容物的方法和系统。 引线携带能量递送装置，例如电极，其锚定在设置在颈动脉鞘内的颈内静脉的部分内。 能量递送装置被通电以将能量传递给颈内静脉外部的颈动脉鞘的目标物质。 这样的目标物质可以包括与颈动脉窦压力感受器，颈动脉窦神经和相关神经分支相关的神经系统元件，或迷走神经和相关联的神经分支。 该系统可用于控制血压和/或降低心率，并且可适用于治疗高血压，心力衰竭或其它病症。

    Transvascular electrode system and method
    6.
    发明授权
    Transvascular electrode system and method 有权
    血管电极系统及方法

    公开(公告)号：US08428730B2

    公开(公告)日：2013-04-23

    申请号：US13286217

    申请日：2011-11-01

    申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

    发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

    IPC分类号： A61N1/00

    CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

    摘要： A transvascular electrode system includes an expandable electrode-carrying anchor. The anchor is intravascularly advanced in a compressed position to a first site in a blood vessel. A first portion of the anchor expands to position an electrode against the vessel wall, while a second portion remains is compressed. Mapping is performed by delivering stimulation energy from the electrode and measuring the response (e.g. blood pressure, heart rate, and/or related parameters). The first portion is at least partially collapsed and the electrode system is moved to a second site. The first portion is expanded to position the electrode into against the vessel wall, while the second portion remains compressed. Additional mapping is performed. The process is repeated until the anchor electrode position is optimized, at which point the second portion of the anchor is expanded to chronically retain the electrode in the vessel.

    摘要翻译： 经血管电极系统包括可扩张电极承载锚。 锚固体在压缩位置中血管内前进到血管中的第一部位。 锚的第一部分膨胀以将电极定位在血管壁上，而第二部分保留被压缩。 通过从电极传递刺激能量并测量反应（例如血压，心率和/或相关参数）来进行测绘。 第一部分至少部分地折叠并且电极系统移动到第二部位。 第一部分被扩展以将电极定位在血管壁上，而第二部分保持压缩。 执行附加映射。 重复该过程直到锚定位置被优化，此时锚固体的第二部分被膨胀以将电极长期地保持在容器中。

    System and method for transvascularly stimulating contents of the carotid sheath
    7.
    发明授权
    System and method for transvascularly stimulating contents of the carotid sheath 有权
    用于血管内刺激颈动脉内皮的系统和方法

    公开(公告)号：US08369954B2

    公开(公告)日：2013-02-05

    申请号：US13042350

    申请日：2011-03-07

    申请人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

    发明人： Richard S. Stack ,  Michael S. Williams ,  Daniel W. Fifer ,  Richard A. Glenn ,  Geoffrey A. Orth ,  Lynn Elliott ,  Colleen Stack N'diaye

    IPC分类号： A61N1/00

    CPC分类号： A61N1/05 ,  A61N1/0558 ,  A61N1/36114 ,  A61N1/36117 ,  A61N2007/0043

    摘要： Methods and systems are disclosed for stimulating contents of the carotid sheath using an intravascular pulse generator and lead. The lead carries an energy delivery device such as an electrode, which is anchor within the portion of the internal jugular vein that is disposed within the carotid sheath. The energy delivery device is energized to transvenously direct energy to target contents of the carotid sheath external to the internal jugular vein. Such target contents may include nervous system elements associated with the carotid sinus baroreceptors, the carotid sinus nerve and associated nerve branches, and or the vagus nerve and associated nerve branches. The system may be used to control blood pressure and/or to lower heart rate and may be suitable for treatment of hypertension, heart failure, or other conditions.

    摘要翻译： 公开了使用血管内脉冲发生器和引线刺激颈动脉鞘的内容物的方法和系统。 引线携带能量递送装置，例如电极，其锚定在设置在颈动脉鞘内的颈内静脉的部分内。 能量递送装置被通电以将能量传递给颈内静脉外部的颈动脉鞘的目标物质。 这样的目标物质可以包括与颈动脉窦压力感受器，颈动脉窦神经和相关神经分支相关的神经系统元件，或迷走神经和相关联的神经分支。 该系统可用于控制血压和/或降低心率，并且可适用于治疗高血压，心力衰竭或其它病症。