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公开(公告)号：US07781728B2
公开(公告)日：2010-08-24
申请号：US12125013
申请日：2008-05-21
申请人： Michael W. Senko , Viatcheslav V. Kovtoun , Paul R. Atherton , Jean Jacques Dunyach , Eloy R. Wouters , Maurizio Splendore , William Siebert
发明人： Michael W. Senko , Viatcheslav V. Kovtoun , Paul R. Atherton , Jean Jacques Dunyach , Eloy R. Wouters , Maurizio Splendore , William Siebert
CPC分类号： H01J49/065 , H01J3/14 , H01J49/066
摘要： A device for transporting and focusing ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from a plurality of longitudinally spaced apart electrodes to which oscillatory (e.g., radio-frequency) voltages are applied. In order to create a tapered field that focuses ions to a narrow beam near the device exit, the inter-electrode spacing or the oscillatory voltage amplitude is increased in the direction of ion travel.
摘要翻译： 用于在质谱仪的低真空或大气压区域中输送和聚焦离子的装置由多个纵向间隔开的电极构成，施加振荡（例如，射频）电压。 为了创建将离子聚焦到设备出口附近的窄波束的锥形场，电离间隔或振荡电压振幅在离子行进方向上增加。
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公开(公告)号：US20090045062A1
公开(公告)日：2009-02-19
申请号：US12125013
申请日：2008-05-21
申请人： Michael W. Senko , Viatcheslav V. Kovtoun , Paul R. Atherton , Jean Jacques Dunyach , Eloy R. Wouters , Maurizio Splendore , William Siebert
发明人： Michael W. Senko , Viatcheslav V. Kovtoun , Paul R. Atherton , Jean Jacques Dunyach , Eloy R. Wouters , Maurizio Splendore , William Siebert
CPC分类号： H01J49/065 , H01J3/14 , H01J49/066
摘要： A device for transporting and focusing ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from a plurality of longitudinally spaced apart electrodes to which oscillatory (e.g., radio-frequency) voltages are applied. In order to create a tapered field that focuses ions to a narrow beam near the device exit, the inter-electrode spacing or the oscillatory voltage amplitude is increased in the direction of ion travel.
摘要翻译： 用于在质谱仪的低真空或大气压区域中输送和聚焦离子的装置由多个纵向间隔开的电极构成，施加振荡（例如，射频）电压。 为了创建将离子聚焦到设备出口附近的窄波束的锥形场，电离间隔或振荡电压振幅在离子行进方向上增加。
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3.发明授权公开(公告)号：US08546753B2
公开(公告)日：2013-10-01
申请号：US13550369
申请日：2012-07-16
IPC分类号： H01J49/00
CPC分类号： H01J49/167 , H01J49/068
摘要： An electrospray ion source apparatus comprises: a plurality of emitter capillaries, each comprising an internal bore for transporting a portion of a liquid sample from a source, an electrode portion for providing a first applied electric potential and an emitter tip for emitting a cloud of charged particles generated from the liquid sample portion; a counter electrode for providing a second applied electric potential different from the first applied electric potential; and at least one shield electrode disposed at least partially between the counter electrode and the emitter tip of at least one of the emitter capillaries for providing a third applied electric potential intermediate to the first and second applied electric potentials, wherein the at least one shield electrode is configured such that provision of the third applied electric potential to the at least one shield electrode minimizes electric field interference effects between the plurality of emitter capillaries.
摘要翻译： 电喷雾离子源设备包括：多个发射器毛细管，每个发射器毛细管包括用于从源极输送液体样品的一部分的内孔，用于提供第一施加电位的电极部分和用于发射带电的云的发射器尖端 从液体样品部分产生的颗粒; 用于提供不同于第一施加电位的第二施加电位的对电极; 以及至少一个屏蔽电极，至少部分地设置在所述发射极毛细管中的至少一个的所述对电极和所述发射极尖之间，用于向所述第一和第二施加电位提供中间的第三施加电位，其中所述至少一个屏蔽电极 被配置为使得向至少一个屏蔽电极提供第三施加电位使得多个发射器毛细管之间的电场干扰效应最小化。
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4.发明授权公开(公告)号：US08237115B2
公开(公告)日：2012-08-07
申请号：US12642617
申请日：2009-12-18
IPC分类号： H01J49/00
CPC分类号： H01J49/167 , H01J49/068
摘要： An electrospray ion source apparatus comprises: a plurality of emitter capillaries, each comprising an internal bore for transporting a portion of a liquid sample from a source, an electrode portion for providing a first applied electric potential and an emitter tip for emitting charged particles generated from the liquid sample portion; a counter electrode for providing a second applied electric potential different from the first applied electric potential; and at least one shield electrode disposed at least partially between the counter electrode and the emitter tip of at least one of the emitter capillaries for providing a third applied electric potential intermediate to the first and second applied electric potentials, wherein the at least one shield electrode is configured such that provision of the third applied electric potential to the at least one shield electrode provides a uniformity of emission of charged particles from the plurality of emitter tips.
摘要翻译： 电喷雾离子源装置包括：多个发射器毛细管，每个发射器毛细管包括用于从源极输送液体样品的一部分的内孔，用于提供第一施加电位的电极部分和用于发射由 液体样品部分; 用于提供不同于第一施加电位的第二施加电位的对电极; 以及至少一个屏蔽电极，至少部分地设置在所述发射极毛细管中的至少一个的所述对电极和所述发射极尖之间，用于向所述第一和第二施加电位提供中间的第三施加电位，其中所述至少一个屏蔽电极 配置成使得向至少一个屏蔽电极提供第三施加电位提供了从多个发射极尖端发射带电粒子的均匀性。
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公开(公告)号：US07952070B2
公开(公告)日：2011-05-31
申请号：US12352262
申请日：2009-01-12
CPC分类号： H01J49/063
摘要： A method and apparatus of combining two independent multipoles in an interlaced fashion to form a resultant multipole structure is introduced. Such an arrangement enables ions from two separate sources to be merged along a predetermined longitudinal direction but also enables in the reverse path, predetermined portions of ions from a single source to be directed along one or more ion channel paths to also enable, for example, simultaneous collection by a Time of Flight (TOF) mass analyzer and an ion trap.
摘要翻译： 介绍了以隔行方式组合两个独立多极体以形成结果多极结构的方法和装置。 这种布置使得来自两个分离的源的离子可以沿着预定的纵向方向合并，但是也可以在相反的路径中实现来自单个源的离子的预定部分沿着一个或多个离子通道路径引导， 通过飞行时间（TOF）质量分析仪和离子阱同时收集。
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公开(公告)号：US07514673B2
公开(公告)日：2009-04-07
申请号：US11764100
申请日：2007-06-15
CPC分类号： H01J3/14 , H01J49/065
摘要： A device for transporting and focusing ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from a plurality of longitudinally spaced apart electrodes to which oscillatory (e.g., radio-frequency) voltages are applied. In order to create a tapered field that focuses ions to a narrow beam near the device exit, the inter-electrode spacing or the oscillatory voltage amplitude is increased in the direction of ion travel.
摘要翻译： 用于在质谱仪的低真空或大气压区域中输送和聚焦离子的装置由多个纵向间隔开的电极构成，施加振荡（例如，射频）电压。 为了创建将离子聚焦到设备出口附近的窄波束的锥形场，电离间隔或振荡电压振幅在离子行进方向上增加。
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公开(公告)号：US07034294B2
公开(公告)日：2006-04-25
申请号：US10922636
申请日：2004-08-19
IPC分类号： H01J49/42
CPC分类号： H01J49/423
摘要： A three section linear or two-dimensional (2D) quadrupole ion trap as a high performance mass spectrometer is described. Mass analysis is performed by ejecting ions radically out slots formed in at least two of the rods using the mass selective instability mode of operation. The slot geometry is optimized to enable ions of different mass ranges to be scanned out of differently dimensioned slots. Multiple detectors arranged to receive ejected ions in multiple directions provide the ability to simultaneously or sequentially scan or perform mass analysis of ions of different natures.
摘要翻译： 描述了作为高性能质谱仪的三段线性或二维（2D）四极离子阱。 通过使用质量选择不稳定操作模式将离子从基本上排出形成在至少两个杆中的槽中来进行质量分析。 优化槽槽几何形状，使不同质量范围的离子从不同尺寸的槽中扫描。 布置成在多个方向上接收喷射离子的多个检测器提供同时或顺序地扫描或执行不同性质的离子的质量分析的能力。
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公开(公告)号：US20080308721A1
公开(公告)日：2008-12-18
申请号：US11764100
申请日：2007-06-15
CPC分类号： H01J3/14 , H01J49/065
摘要： A device for transporting and focusing ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from a plurality of longitudinally spaced apart electrodes to which oscillatory (e.g., radio-frequency) voltages are applied. In order to create a tapered field that focuses ions to a narrow beam near the device exit, the inter-electrode spacing or the oscillatory voltage amplitude is increased in the direction of ion travel.
摘要翻译： 用于在质谱仪的低真空或大气压区域中输送和聚焦离子的装置由多个纵向间隔开的电极构成，施加振荡（例如，射频）电压。 为了创建将离子聚焦到设备出口附近的窄波束的锥形场，电离间隔或振荡电压振幅在离子行进方向上增加。
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公开(公告)号：US08785847B2
公开(公告)日：2014-07-22
申请号：US13396982
申请日：2012-02-15
CPC分类号： H01J49/063 , H01J49/062
摘要： A mass spectrometer having an ion guide with an axial field is described. The ion guide includes electrodes with longitudinally extending gaps and inserts configured to be proximate to the gaps.
摘要翻译： 描述了具有轴向场的离子导向器的质谱仪。 离子导向器包括具有纵向延伸的间隙的电极和构造成靠近间隙的插入件。
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10.发明授权Reduction of chemical noise in a MALDI mass spectrometer by in-trap photodissociation of matrix cluster ions 失效通过基质簇离子的陷阱光解作用减少MALDI质谱仪中的化学噪声公开(公告)号：US07351955B2
公开(公告)日：2008-04-01
申请号：US11233825
申请日：2005-09-09
IPC分类号： H01J49/00
CPC分类号： H01J49/164 , H01J49/0059
摘要： A MALDI mass spectrometer includes a radiation source, such as a gas or solid state laser, that emits a beam of radiation (typically in the UV or IR wavelengths) directed along the central axis of a linear ion trap in which analyte ions and matrix cluster ions are confined. The radiation beam has a wavelength that is strongly absorbed by the matrix cluster ions. The absorption of radiation by the matrix cluster ions produces dissociation of the matrix cluster ion into fragments having mass-to-charge ratios that lie below a mass-to-charge ratio range of interest. Thus, chemical noise associated with matrix cluster ions is reduced or eliminated.
摘要翻译： MALDI质谱仪包括辐射源，例如气体或固体激光器，其发射沿着线性离子阱的中心轴引导的辐射束（通常在UV或IR波长），其中分析物离子和基质簇 离子被限制。 辐射束具有被基质簇离子强烈吸收的波长。 基质簇离子对辐射的吸收会导致基质簇离子离解成具有低于感兴趣的质荷比范围的质荷比的片段。 因此，减少或消除与基质簇离子相关的化学噪声。
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