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    Realtime ultrasonic imaging of perfusion using ultrasonic contrast agents
    3.
    发明授权
    Realtime ultrasonic imaging of perfusion using ultrasonic contrast agents 失效
    使用超声造影剂实时灌注超声成像

    公开(公告)号：US06171246B2

    公开(公告)日：2001-01-09

    申请号：US09302063

    申请日：1999-04-29

    申请人： Michalakis Averkiou ,  Jeffry E. Powers ,  Matthew Bruce ,  Danny M. Skyba

    发明人： Michalakis Averkiou ,  Jeffry E. Powers ,  Matthew Bruce ,  Danny M. Skyba

    IPC分类号： A61B814

    CPC分类号： A61B8/481 ,  A61B8/543 ,  G01S7/52038 ,  G01S7/52039 ,  G01S15/8981

    摘要： Perfusion of tissue such as the myocardium by a microbubble contrast agent is imaged in realtime by a multiple pulse technique which uses low power transmit pulses which are sufficient to elicit a harmonic response from the microbubbles but are not high enough in power to cause substantial destruction to the microbubbles. In a preferred embodiment the realtime microbubble image sequence is displayed in color, overlaid with a grayscale image of the surrounding tissue in the region being imaged.

    摘要翻译： 通过微泡造影剂对诸如心肌的组织灌注通过多脉冲技术实时成像，所述多脉冲技术使用足以引起来自微泡的谐波响应的低功率发射脉冲，但是不足以引起大量破坏 微泡。 在优选实施例中，实时微泡图像序列以彩色显示，并与被成像区域中的周围组织的灰度图像重叠。

    Ultrasonic Diagnostic Imaging System and Method for Detecting Lesions of the Liver
    8.
    发明申请
    Ultrasonic Diagnostic Imaging System and Method for Detecting Lesions of the Liver 审中-公开
    超声诊断成像系统及检测肝脏病变的方法

    公开(公告)号：US20090124907A1

    公开(公告)日：2009-05-14

    申请号：US11816424

    申请日：2006-02-16

    申请人： Matthew Bruce ,  Jeffry E. Powers ,  Rohit Garg ,  Dan Skyba ,  Michalakis Averkiou

    发明人： Matthew Bruce ,  Jeffry E. Powers ,  Rohit Garg ,  Dan Skyba ,  Michalakis Averkiou

    IPC分类号： A61B8/14

    CPC分类号： A61B8/481 ,  A61B5/7264 ,  A61B8/085

    摘要： Significant liver growths such as HCC lesions are detected during a contrast agent ultrasound exam by their early reception of contrast and brightening following a bolus injection, as compared with surrounding normal tissue and benign growths. A pixel classifier looks for and identifies pixel or voxel regions where this early wash-in of contrast occurs and denotes these pixel or voxel locations in a parametric image. The pixel classifier analyzes pixel or voxel values from a sequence of images and identifies suspicious regions in an image by uniquely coding the points in a parametric liver image where early wash-in occurs.

    摘要翻译： 与周围的正常组织和良性生长相比，在造影剂超声检查期间，通过早期接受对比剂和强化注射之后，检测到HCC损伤等显着的肝脏生长。 像素分类器寻找并识别像素或体素区域，其中出现对比度的早期洗涤，并且在参数图像中表示这些像素或体素位置。 像素分类器分析来自图像序列的像素或体元值，并且通过唯一地编码出现早期洗涤的参数肝脏图像中的点来识别图像中的可疑区域。

    Combination Imaging and Therapy Transducer With Therapy Transducer Amplifier
    10.
    发明申请
    Combination Imaging and Therapy Transducer With Therapy Transducer Amplifier 有权
    组合成像和治疗传感器与治疗传感器放大器

    公开(公告)号：US20080228075A1

    公开(公告)日：2008-09-18

    申请号：US12064309

    申请日：2006-08-25

    申请人： John Fraser ,  Jeffry E. Powers ,  Michalakis Averkiou

    发明人： John Fraser ,  Jeffry E. Powers ,  Michalakis Averkiou

    IPC分类号： A61B8/00

    CPC分类号： A61B17/22004 ,  A61B8/0833 ,  A61B8/14 ,  A61B8/4405 ,  A61B8/481 ,  A61B17/2256 ,  A61B2017/22028 ,  A61B2090/378 ,  G01S15/8918 ,  G01S15/8977

    摘要： A combined ultrasound imaging and therapy transducer (10) includes a linear array of imaging transducer elements (14). First and second linear arrays of therapy transducer elements (18, 20) extend longitudinally along respective first and second sides of the imaging transducer elements and are canted inwardly toward each other. The imaging and therapy transducer is used with an ultrasound imaging system to locate clots in a region of interest. After the region of interest has been perfused with a microbubble contrast agent, the therapy transducer elements are driven by an amplifier located in the transducer to dissolve the clot. The use of the imaging transducer elements and the therapy transducer elements can be interleaved so that the therapy can be conditioned on an ultrasound image showing substantial destruction of the contrast agent microbubbles, re-perfusion of microbubbles in the region of interest, or the continued presence of the clot.

    摘要翻译： 组合的超声成像和治疗换能器（10）包括成像换能器元件（14）的线性阵列。 治疗换能器元件（18,20）的第一和第二线性阵列沿着成像换能器元件的相应的第一和第二侧纵向延伸并且向内朝向彼此倾斜。 成像和治疗传感器与超声成像系统一起使用以定位感兴趣区域中的凝块。 在用微泡造影剂灌注感兴趣区域之后，治疗换能器元件由位于换能器中的放大器驱动以溶解凝块。 可以使用成像换能器元件和治疗换能器元件进行交织，使得治疗可以对超声图像进行调节，该超声图像显示造影剂微泡的显着破坏，感兴趣区域中微泡的再次灌注，或持续存在 的凝块。