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12 条记录 (耗时 0.031 秒)

    Microprojection Array Immunization Patch and Method
    2.
    发明申请
    Microprojection Array Immunization Patch and Method 审中-公开
    微喷射阵列免疫贴片和方法

    公开(公告)号：US20090143724A1

    公开(公告)日：2009-06-04

    申请号：US12367318

    申请日：2009-02-06

    申请人： Michel J.N. Cormier ,  James A. Matriano ,  Peter E. Daddona ,  Juanita A. Johnson ,  Wendy A. Young

    发明人： Michel J.N. Cormier ,  James A. Matriano ,  Peter E. Daddona ,  Juanita A. Johnson ,  Wendy A. Young

    IPC分类号： A61M37/00

    CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61K9/0021 ,  A61M2037/0046 ,  A61M2037/0061 ,  Y02A50/401

    摘要： Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, and methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.

    摘要翻译： 公开了具有微喷射阵列（10）的皮肤贴片（20），含有抗原剂和免疫应答增强佐剂的储液器（18）及其使用方法来接种动物（例如人）。 在优选实施例中，微喷射阵列（10）由光刻和微冲压钛箔（14）组成。 微注射物（12）用含有疫苗抗原和佐剂（例如葡糖胺基胞壁酰二肽）的液体制剂包衣，干燥并施用于使用冲击施加器接种疫苗的皮肤。 微突出物（12）产生通过角质层的浅表通路以促进抗原剂和佐剂的渗透。 可以控制抗原剂量和穿透深度。 该技术广泛适用于各种各样的治疗性疫苗，以提高功效和使用方便。

    Transdermal Electrotransport Delivery Device Including an Antimicrobial Compatible Reservoir Composition
    4.
    发明申请
    Transdermal Electrotransport Delivery Device Including an Antimicrobial Compatible Reservoir Composition 审中-公开
    透皮电传递装置，包括抗微生物兼容的储层组成

    公开(公告)号：US20100152242A1

    公开(公告)日：2010-06-17

    申请号：US12711608

    申请日：2010-02-24

    申请人： Wendy A. Young ,  Michel J.N. Cormier

    发明人： Wendy A. Young ,  Michel J.N. Cormier

    IPC分类号： A61K31/4468 ,  A61P25/04

    CPC分类号： A61N1/30

    摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.

    摘要翻译： 具有电连接到阳极和阴极的阳极，阴极和电源的透皮电运输药物递送装置。 阳极和阴极中的至少一个包括电极和由包含聚合物材料的外壳和与外壳接触的水性介质的容器。 水性介质包括（i）药物或电解质盐或其混合物，（ii）丙二醇，和（iii）足以抑制水性介质中微生物生长的量的抗微生物剂。 丙二醇防止抗微生物剂被用于构建输送装置的其它材料吸附。 还提供了一种制备透皮电转运药物递送装置的方法。

    Transdermal drug delivery devices having coated microprotrusions
    5.
    发明授权
    Transdermal drug delivery devices having coated microprotrusions 有权
    透皮药物递送装置具有包被的微突起

    公开(公告)号：US08663155B2

    公开(公告)日：2014-03-04

    申请号：US11347779

    申请日：2006-02-02

    申请人： Michel J. N. Cormier ,  Wendy A. Young ,  Kofi Nyam ,  Peter E. Daddona ,  Wei-Qi Lin

    发明人： Michel J. N. Cormier ,  Wendy A. Young ,  Kofi Nyam ,  Peter E. Daddona ,  Wei-Qi Lin

    IPC分类号： A61M37/00

    CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061

    摘要： A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.

    摘要翻译： 提供了用于经皮透皮递送有效药理活性剂的装置（12）和方法。 将试剂溶解在水中以形成具有适当粘度的水性涂料溶液，以涂覆极微小的皮肤刺穿元件（10）。 使用已知的涂覆技术将涂布溶液施加到皮肤刺穿元件（10）上，然后干燥。 将装置（12）施加到活动物（例如人）的皮肤上，导致微突起（10）刺穿角质层并将治疗有效剂量的药剂递送至动物。

    Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition
    7.
    发明授权
    Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition 有权

    公开(公告)号：US07761147B2

    公开(公告)日：2010-07-20

    申请号：US11084628

    申请日：2005-03-18

    申请人： Wendy A. Young ,  Michel J. N. Cormier

    发明人： Wendy A. Young ,  Michel J. N. Cormier

    IPC分类号： A61N1/30 ,  A61K9/22

    CPC分类号： A61N1/30

    摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.

    Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition
    10.
    发明授权
    Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition 有权
    透皮电运输装置包括抗微生物相容的储存器组合物

    公开(公告)号：US07801599B2

    公开(公告)日：2010-09-21

    申请号：US11556413

    申请日：2006-11-03

    申请人： Wendy A. Young ,  Michel J. Cormier

    发明人： Wendy A. Young ,  Michel J. Cormier

    IPC分类号： A61N1/30

    CPC分类号： A61N1/30

    摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.

    摘要翻译： 具有电连接到阳极和阴极的阳极，阴极和电源的透皮电运输药物递送装置。 阳极和阴极中的至少一个包括电极和由包含聚合物材料的外壳和与外壳接触的水性介质的容器。 水性介质包括（i）药物或电解质盐或其混合物，（ii）丙二醇，和（iii）足以抑制水性介质中微生物生长的量的抗微生物剂。 丙二醇防止抗微生物剂被用于构建输送装置的其它材料吸附。 还提供了一种制备透皮电转运药物递送装置的方法。