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    Microprojection Array Immunization Patch and Method
    1.
    发明申请
    Microprojection Array Immunization Patch and Method 审中-公开
    微喷射阵列免疫贴片和方法

    公开(公告)号：US20090143724A1

    公开(公告)日：2009-06-04

    申请号：US12367318

    申请日：2009-02-06

    申请人： Michel J.N. Cormier ,  James A. Matriano ,  Peter E. Daddona ,  Juanita A. Johnson ,  Wendy A. Young

    发明人： Michel J.N. Cormier ,  James A. Matriano ,  Peter E. Daddona ,  Juanita A. Johnson ,  Wendy A. Young

    IPC分类号： A61M37/00

    CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61K9/0021 ,  A61M2037/0046 ,  A61M2037/0061 ,  Y02A50/401

    摘要： Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, and methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.

    摘要翻译： 公开了具有微喷射阵列（10）的皮肤贴片（20），含有抗原剂和免疫应答增强佐剂的储液器（18）及其使用方法来接种动物（例如人）。 在优选实施例中，微喷射阵列（10）由光刻和微冲压钛箔（14）组成。 微注射物（12）用含有疫苗抗原和佐剂（例如葡糖胺基胞壁酰二肽）的液体制剂包衣，干燥并施用于使用冲击施加器接种疫苗的皮肤。 微突出物（12）产生通过角质层的浅表通路以促进抗原剂和佐剂的渗透。 可以控制抗原剂量和穿透深度。 该技术广泛适用于各种各样的治疗性疫苗，以提高功效和使用方便。

    Transdermal Electrotransport Delivery Device Including an Antimicrobial Compatible Reservoir Composition
    6.
    发明申请
    Transdermal Electrotransport Delivery Device Including an Antimicrobial Compatible Reservoir Composition 审中-公开
    透皮电传递装置，包括抗微生物兼容的储层组成

    公开(公告)号：US20100152242A1

    公开(公告)日：2010-06-17

    申请号：US12711608

    申请日：2010-02-24

    申请人： Wendy A. Young ,  Michel J.N. Cormier

    发明人： Wendy A. Young ,  Michel J.N. Cormier

    IPC分类号： A61K31/4468 ,  A61P25/04

    CPC分类号： A61N1/30

    摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.

    摘要翻译： 具有电连接到阳极和阴极的阳极，阴极和电源的透皮电运输药物递送装置。 阳极和阴极中的至少一个包括电极和由包含聚合物材料的外壳和与外壳接触的水性介质的容器。 水性介质包括（i）药物或电解质盐或其混合物，（ii）丙二醇，和（iii）足以抑制水性介质中微生物生长的量的抗微生物剂。 丙二醇防止抗微生物剂被用于构建输送装置的其它材料吸附。 还提供了一种制备透皮电转运药物递送装置的方法。

    Reduction of skin irritation during electrotransport delivery
    7.
    发明授权
    Reduction of skin irritation during electrotransport delivery 失效
    电运输期间减少皮肤刺激

    公开(公告)号：US5865792A

    公开(公告)日：1999-02-02

    申请号：US895096

    申请日：1997-07-16

    申请人： Philip W. Ledger ,  Michel J.N. Cormier ,  Patricia S. Campbell

    发明人： Philip W. Ledger ,  Michel J.N. Cormier ,  Patricia S. Campbell

    IPC分类号： A61N1/30 ,  A61N1/32

    CPC分类号： A61N1/0432 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/325 ,  A61N1/0436 ,  A61N1/0444

    摘要： The invention is directed to a composition and product for use in an electrotransport device. The composition includes an ionized drug, an anti-inflammatory agent and a solvent. Preferably, the anti-inflammatory agent is hydrocortisone or esters thereof, and the solvent is an alcohol, a glycol, a glycerol, a cyclodextrin, a nonionic surfactant or mixtures thereof. The composition preferably further includes a gel matrix that is a swellable, hydrophilic polymer, a water soluble hydrophilic polymer or a solid polymer. A hydrophobic polymer and/or additives may also be included.

    摘要翻译： 本发明涉及一种用于电输送装置的组合物和产品。 组合物包括电离药物，抗炎剂和溶剂。 优选地，抗炎剂是氢化可的松或其酯，溶剂是醇，二醇，甘油，环糊精，非离子表面活性剂或其混合物。 组合物优选还包括可溶胀亲水性聚合物，水溶性亲水聚合物或固体聚合物的凝胶基质。 还可以包括疏水性聚合物和/或添加剂。

    Method and apparatus for coating skin piercing microprojections
    9.
    发明授权
    Method and apparatus for coating skin piercing microprojections 有权
    皮肤穿刺微粒涂层的方法和装置

    公开(公告)号：US07435299B2

    公开(公告)日：2008-10-14

    申请号：US10984510

    申请日：2004-11-09

    申请人： Joseph C. Trautman ,  Cedric T. Wright ,  Michel J.N. Cormier

    发明人： Joseph C. Trautman ,  Cedric T. Wright ,  Michel J.N. Cormier

    IPC分类号： B05C1/08 ,  B05C1/00

    CPC分类号： A61K9/0021 ,  A61B17/205 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0053 ,  B05D1/18 ,  B05D1/28

    摘要： An apparatus and method are provided for selectively applying an agent-containing liquid coating to extremely tiny skin piercing microprojections (10). The coating solution is applied to the skin piercing microprojections (10) using a coating technique which selectively coats only the skin piercing microprojections (10) and not the substrate (12) from which the microprojections (10) extend, and then dried. The coating method includes providing an agent-containing coating liquid and conveying the liquid to a liquid holding surface having a coating transfer region. The depth of the coating liquid at the coating transfer region is precisely controlled. The microprojections are then immersed to a predetermined level in the coating liquid. The liquid that coats the microprojections (10) is then dried to form a solid agent-containing coating on the microprojections (10).

    摘要翻译： 提供了一种用于选择性地将含药剂的液体涂层施加到极微小的皮肤刺穿微突出物（10）上的装置和方法。 使用涂覆技术将涂布溶液施加到皮肤刺穿微突出物（10）上，涂覆技术仅选择性地涂覆皮肤刺穿微突出物（10）而不是微突出物（10）延伸的基底（12），然后干燥。 涂布方法包括提供含药剂的涂布液体并将液体输送到具有涂覆转移区域的液体保持表面。 涂层转移区域的涂布液的深度被精确地控制。 然后将微注入物浸入涂布液中的预定水平。 然后将涂覆微喷射体（10）的液体干燥，以在微喷射体（10）上形成含固体剂的涂层。