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98 条记录 (耗时 0.031 秒)

    Method of storing frozen microbubble suspensions
    7.
    发明授权
    Method of storing frozen microbubble suspensions 失效
    储存冷冻微泡悬浮液的方法

    公开(公告)号：US5830435A

    公开(公告)日：1998-11-03

    申请号：US909100

    申请日：1997-08-12

    申请人： Feng Yan ,  Michel Schneider ,  Jean Brochot

    发明人： Feng Yan ,  Michel Schneider ,  Jean Brochot

    IPC分类号： A61K49/00 ,  A61K49/22 ,  A61K49/04 ,  A61K9/127

    CPC分类号： A61K49/223

    摘要： Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a tangible membrane. The suspensions, when in liquid form, are injectable and useful as a contrast agents in ultrasonic imaging of blood pool and tissue of living beings. The gas microbubbles are immobilised within the carrier by freezing a suspension of microbubbles with average sizes below 50 .mu.m, preferably below 10 .mu.m and more preferably between 2 .mu.m and 8 .mu.m, to a temperature between -1.degree. C. and -76.degree. C. and maintaining this temperature for prolonged periods of time. The microbubbles may be stabilised by a surfactant such as a lamellar phospholipid or may comprise a membrane made of synthetic or natural polymer or protein. A method of cold storage of microbubble suspensions as well as their use is also disclosed.

    摘要翻译： 公开了固定在包含通常的添加剂和稳定剂的冷冻含水载体液体中的气体微泡的悬浮液，其中载体液体是生理上可接受的，固定化气体微泡是由ev逝包膜或有形膜结合的微泡。 当液体形式时，悬浮液是可注射的，并且可用作血液池和生物组织的超声成像中的造影剂。 将气体微泡固定在载体中，将平均尺寸低于50μm，优选低于10μm，更优选在2μm和8μm之间的微泡悬浮液冷冻至-1℃至-1℃的温度， 76℃，并保持该温度较长时间。 微泡可以通过表面活性剂如片状磷脂来稳定，或者可以包含由合成或天然聚合物或蛋白质制成的膜。 还公开了微泡悬浮液的冷藏方法及其用途。

    Method of echographic imaging using frozen gasbubble suspensions
    8.
    发明授权
    Method of echographic imaging using frozen gasbubble suspensions 失效
    使用冷冻气泡悬浮液的回波成像方法

    公开(公告)号：US5827504A

    公开(公告)日：1998-10-27

    申请号：US909099

    申请日：1997-08-12

    申请人： Feng Yan ,  Michel Schneider ,  Jean Brochot

    发明人： Feng Yan ,  Michel Schneider ,  Jean Brochot

    IPC分类号： A61K49/00 ,  A61K49/22 ,  A61K49/04

    CPC分类号： A61K49/223

    摘要： Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a tangible membrane. The suspensions, when in liquid form, are injectable and useful as a contrast agents in ultrasonic imaging of blood pool and tissue of living beings. The gas microbubbles are immobilised within the carrier by freezing a suspension of microbubbles with average sizes below 50 .mu.m, preferably below 10 .mu.m and more preferably between 2 .mu.m and 8 .mu.m, to a temperature between -1.degree. C. and -76.degree. C. and maintaining this temperature for prolonged periods of time. The microbubbles may be stabilised by a surfactant such as a lamellar phospholipid or may comprise a membrane made of synthetic or natural polymer or protein. A method of cold storage of microbubble suspensions as well as their use is also disclosed.

    摘要翻译： 公开了固定在包含通常的添加剂和稳定剂的冷冻含水载体液体中的气体微泡的悬浮液，其中载体液体是生理上可接受的，固定化气体微泡是由ev逝包膜或有形膜结合的微泡。 当液体形式时，悬浮液是可注射的，并且可用作血液池和生物组织的超声成像中的造影剂。 将气体微泡固定在载体中，将平均尺寸低于50μm，优选低于10μm，更优选在2μm和8μm之间的微泡悬浮液冷冻至-1℃至-1℃的温度， 76℃，并保持该温度较长时间。 微泡可以通过表面活性剂如片状磷脂来稳定，或者可以包含由合成或天然聚合物或蛋白质制成的膜。 还公开了微泡悬浮液的冷藏方法及其用途。

    Stable microbubble suspensions as enhancement agents for ultrasound echography
    9.
    发明授权
    Stable microbubble suspensions as enhancement agents for ultrasound echography 失效
    稳定的微泡悬浮液作为超声波回波成像的增强剂

    公开(公告)号：US5445813A

    公开(公告)日：1995-08-29

    申请号：US134671

    申请日：1993-10-12

    申请人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    发明人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    IPC分类号： A61K47/24 ,  A61B8/08 ,  A61B8/12 ,  A61B8/13 ,  A61K9/127 ,  A61K49/00 ,  A61K49/22 ,  B01F3/04 ,  B01J13/02

    CPC分类号： A61K49/225 ,  A61K49/223

    摘要： Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.

    摘要翻译： 公开了在超声波回波成像中可用作造影剂的水性载体液体中的气体填充微泡的可注射悬浮液。 悬浮液包含两亲性化合物，其中至少一种可以是层状磷脂作为微泡的稳定剂，以防止随时间和压力而塌陷。 载体液体中磷脂的浓度低于0.01％wt，但至少等于或高于磷脂分子仅存在于气体微泡液界面的浓度。 还公开了制备空气或气体填充的微泡的稳定悬浮液的方法。

    Frozen ultrasonic gas suspensions
    10.
    发明授权
    Frozen ultrasonic gas suspensions 失效
    冷冻超声波气体悬浮液

    公开(公告)号：US5961956A

    公开(公告)日：1999-10-05

    申请号：US944408

    申请日：1997-10-06

    申请人： Feng Yan ,  Michel Schneider ,  Jean Brochot

    发明人： Feng Yan ,  Michel Schneider ,  Jean Brochot

    IPC分类号： A61K49/00 ,  A61K49/22 ,  A61K49/04 ,  A61K9/127 ,  A61K9/14

    CPC分类号： A61K49/223

    摘要： Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a tangible membrane. The suspensions, when in liquid form, are injectable and useful as a contrast agents in ultrasonic imaging of blood pool and tissue of living beings. The gas microbubbles are immobilised within the carrier by freezing a suspension of microbubbles with average sizes below 50 .mu.m, preferably below 10 .mu.m and more preferably between 2 .mu.m and 8 .mu.m, to a temperature between -1.degree. C. and -76.degree. C. and maintaining this temperature for prolonged periods of time. The microbubbles may be stabilised by a surfactant such as a lamellar phospholipid or may comprise a membrane made of synthetic or natural polymer or protein. A method of cold storage of microbubble suspensions as well as their use is also disclosed.

    摘要翻译： 公开了固定在包含通常的添加剂和稳定剂的冷冻含水载体液体中的气体微泡的悬浮液，其中载体液体是生理上可接受的，固定化气体微泡是由ev逝包膜或有形膜结合的微泡。 当液体形式时，悬浮液是可注射的，并且可用作血液池和生物组织的超声成像中的造影剂。 将气体微泡固定在载体中，将平均尺寸低于50μm，优选低于10μm，更优选在2μm和8μm之间的微泡悬浮液冷冻至-1℃至-1℃的温度， 76℃，并保持该温度较长时间。 微泡可以通过表面活性剂如片状磷脂来稳定，或者可以包含由合成或天然聚合物或蛋白质制成的膜。 还公开了微泡悬浮液的冷藏方法及其用途。