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35 条记录 (耗时 0.034 秒)

    Block copolymers and preparation thereof
    3.
    发明授权
    Block copolymers and preparation thereof 失效
    嵌段共聚物及其制备方法

    公开(公告)号：US07109280B2

    公开(公告)日：2006-09-19

    申请号：US10697181

    申请日：2003-10-29

    申请人： Mohan Gopalkrishna Kulkarni ,  Jayant Jagannath Khandare

    发明人： Mohan Gopalkrishna Kulkarni ,  Jayant Jagannath Khandare

    IPC分类号： C08F218/00

    CPC分类号： C08F293/005 ,  A61K31/785 ,  C08G2261/126

    摘要： The present invention relates to block copolymers for applications in medicine and biotechnology and synthesis thereof. Block copolymers comprise polyvalent N-Acetyl Glucosamine (NAG) which bind more efficiently to lysozyme than NAG itself. The effective inhibition is possible even at very low ligand concentrations than reported earlier. The block copolymers could be used for prevention and treatment of bacterial and viral infections. Moreover these polymers can be stimuli sensitive and be used for the recovery of biomolecules. The methodology of preparation of block copolymers reported here can be extended to other polymers and ligands such as sialic acid and used for preventing influenza and/or rotavirus infections. It also provides a method for preparation of block copolymers wherein polymers comprising sequences of specific ligands are essential.

    摘要翻译： 本发明涉及用于医药和生物技术及其合成的嵌段共聚物。 嵌段共聚物包括与NAG本身更有效地结合溶菌酶的多价N-乙酰基葡糖胺（NAG）。 即使在比之前报道的非常低的配体浓度下，有效抑制也是可能的。 嵌段共聚物可用于预防和治疗细菌和病毒感染。 此外，这些聚合物可以是刺激敏感的并且用于回收生物分子。 本文报道的嵌段共聚物的制备方法可以扩展到其它聚合物和配体如唾液酸，并用于预防流感和/或轮状病毒感染。 它还提供了制备嵌段共聚物的方法，其中包含特定配体序列的聚合物是必需的。

    Cobalt imprinted polymer composition for selective removal of cobalt, process for preparation thereof, and process for removal of cobalt
    4.
    发明授权
    Cobalt imprinted polymer composition for selective removal of cobalt, process for preparation thereof, and process for removal of cobalt 失效
    用于选择性去除钴的钴印刷聚合物组合物，其制备方法和用于除去钴的方法

    公开(公告)号：US07001963B2

    公开(公告)日：2006-02-21

    申请号：US10976872

    申请日：2004-11-01

    申请人： Mohan Gopalkrishna Kulkarni ,  Rohini Nitin Karmalkar

    发明人： Mohan Gopalkrishna Kulkarni ,  Rohini Nitin Karmalkar

    IPC分类号： C08F126/06

    CPC分类号： C02F1/683 ,  C02F2101/20 ,  C08F30/04

    摘要： The present invention provides a polymer composition for the selective removal of cobalt, a process for the preparation thereof and the process for removal of cobalt, using the said polymer composition. More particularly it relates to a cross-linked polymer composition prepared by the molecular imprinting technique. The preparation of the cross linked polymer involves selection of vinyl monomers bearing functional groups that bind to cobalt, formation of a complex of these monomers with cobalt and subsequent polymerization of the complex in presence of a crosslinker. The process for the removal of cobalt comprises treating the solution containing a mixture of cobalt and other metal ions with the polymer under conditions sufficient for cobalt to form a complex with the polymer and separating the polymer from the cobalt depleted solution.

    摘要翻译： 本发明提供一种用于选择性除去钴的聚合物组合物，其制备方法和使用所述聚合物组合物除去钴的方法。 更具体地说，涉及通过分子印迹技术制备的交联聚合物组合物。 交联聚合物的制备涉及选择具有结合钴的官能团的乙烯基单体，这些单体与钴的络合物的形成以及随后在交联剂存在下复合物的聚合。 除去钴的方法包括在足以使钴形成与聚合物的络合物并从贫钴溶液中分离聚合物的条件下，将含有钴和其它金属离子的混合物的溶液与聚合物一起处理。

    PH SENSITIVE GRAFT COPOLYMER
    7.
    发明申请
    PH SENSITIVE GRAFT COPOLYMER 有权
    PH敏感共聚物

    公开(公告)号：US20120059131A1

    公开(公告)日：2012-03-08

    申请号：US13254630

    申请日：2010-03-05

    申请人： Ramesh Muthusamy ,  Mohan Gopalkrishna Kulkarni

    发明人： Ramesh Muthusamy ,  Mohan Gopalkrishna Kulkarni

    IPC分类号： C08F283/02

    CPC分类号： C08F283/01 ,  C08F220/06

    摘要： Graft copolymer (P) which exhibit pH dependent swelling/dissolution properties comprising a hydrophobic back-bone and graft chains comprising acidic monomer. This Graft copolymer (P) do not swell or dissolve at acidic pH prevalent in the stomach and they swell/dissolve at near neutral pH prevalent in the intestinal region. The graft copolymer (P) is useful for the development of drug delivery formulations particularly for oral drug delivery formulations.

    摘要翻译： 表现出pH依赖性溶胀/溶解性能的接枝共聚物（P），其包含疏水性背骨和包含酸性单体的接枝链。 这种接枝共聚物（P）在胃中普遍存在的酸性pH下不溶胀或溶解，并且它们在肠道中普遍存在的接近中性pH下溶胀/溶解。 接枝共聚物（P）可用于开发特别用于口服药物递送制剂的药物递送制剂。

    Copolymers and preparation thereof
    8.
    发明授权
    Copolymers and preparation thereof 失效
    共聚物及其制备方法

    公开(公告)号：US06825308B1

    公开(公告)日：2004-11-30

    申请号：US10697663

    申请日：2003-10-29

    申请人： Mohan Gopalkrishna Kulkarni ,  Jayant Jagannath Khandare

    发明人： Mohan Gopalkrishna Kulkarni ,  Jayant Jagannath Khandare

    IPC分类号： C08F21800

    CPC分类号： C08F220/60 ,  C08F220/58

    摘要： The present invention relates to copolymers for applications in medicine and biotechnology and preparation thereof. Copolymers comprises polyvalent N-Acetyl Glucosamine(NAG) in polyvalent form and bind more efficiently to lysozyme than NAG itself. The copolymers exhibit effective inhibition even at very low ligand concentrations. The copolymers could be used for prevention and treatment of bacterial and viral infections. Moreover, these copolymers form are stimuli sensitive polymers and can be used for the recovery of biomolecules. The methodology can be extended to other ligands such as sialic acid and used for preventing influenza and/or rotavirus infections. It also provides a method for the synthesis of copolymers wherein polymers comprising sequences of specific ligands are required.

    摘要翻译： 本发明涉及用于医药和生物技术的共聚物及其制备。 共聚物包括多价形式的多价N-乙酰基葡萄糖胺（NAG），并且比NAG本身更有效地与溶菌酶结合。 即使在非常低的配体浓度下，共聚物也显示出有效的抑制作用。 共聚物可用于预防和治疗细菌和病毒感染。 此外，这些共聚物形式是刺激敏感的聚合物，并且可以用于回收生物分子。 该方法可以扩展到其它配体如唾液酸，并用于预防流感和/或轮状病毒感染。 它还提供了合成共聚物的方法，其中需要包含特定配体序列的聚合物。

    Process for the preparation of N-substituted acrylamides
    9.
    发明授权
    Process for the preparation of N-substituted acrylamides 失效
    制备N-取代的丙烯酰胺的方法

    公开(公告)号：US06369249B1

    公开(公告)日：2002-04-09

    申请号：US09495909

    申请日：2000-02-02

    申请人： Bhalchandra Shripad Lele ,  Mohan Gopalkrishna Kulkarni

    发明人： Bhalchandra Shripad Lele ,  Mohan Gopalkrishna Kulkarni

    IPC分类号： C07C23102

    CPC分类号： C07C231/12 ,  C07C233/09 ,  C07C233/91

    摘要： The present invention relates to a process for the preparation of N-substituted acrylamides of the general formula CH2═CH—CONHR, wherein, R is alkyl group having carbon 1 to 22 or acyl group having carbon 1 to 18. The process for the preparation of the N-substituted acrylamides comprises reacting acrylamide with alkyl acyl chloride in the presence of Lewis acid catalyst in an organic solvent at a temperature ranging between room temperature to 50° C. for a period ranging between 1 hour to 24 hours.

    摘要翻译： 本发明涉及制备通式CH 2 = CH-CONHR的N-取代的丙烯酰胺的方法，其中R是具有碳1至22的烷基或具有碳1至18的酰基。制备方法 的N-取代的丙烯酰胺包括在路易斯酸催化剂存在下，在有机溶剂中，在室温至50℃的温度范围内，使丙烯酰胺与烷基酰氯反应1小时至24小时。

    Process for the preparation of diesters of poly(oxyalkylene glycol) and amino acids
    10.
    发明授权
    Process for the preparation of diesters of poly(oxyalkylene glycol) and amino acids 失效
    制备聚（氧亚烷基二醇）和氨基酸二酯的方法

    公开(公告)号：US06346643B1

    公开(公告)日：2002-02-12

    申请号：US09518877

    申请日：2000-03-06

    申请人： Bhalchandra Shripad Lele ,  Mohan Gopalkrishna Kulkarni

    发明人： Bhalchandra Shripad Lele ,  Mohan Gopalkrishna Kulkarni

    IPC分类号： C07C26100

    CPC分类号： C08G65/33396

    摘要： The present invention relates to a process for the preparation of diesters of poly (ethylene glycol) by reacting poly (oxyalkylene glycol) and amino acid hydrochloride in the presence of a condensing agent in a suitable solvent at a temperature in the range of 0° C. to room temperature for a period ranging between 1 hour to 24 hours. The reaction mixture is then filtered and the filtrate poured into another solvent, which is a nonsolvent for the products. The products precipitated thereby are then isolated.

    摘要翻译： 本发明涉及通过在缩合剂存在下，在合适的溶剂中，在0℃的温度下，使聚（氧亚烷基二醇）与氨基酸盐酸盐反应制备聚（乙二醇）二酯的方法 至室温，持续1小时至24小时。 然后将反应混合物过滤并将滤液倒入另一溶剂中，其为产物的非溶剂。 然后分离由此沉淀的产物。