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391 条记录 (耗时 0.04 秒)

    Analgesic compositions containing 2-cyanoalkylbenzomorphan derivatives and salts thereof
    2.
    发明授权
    Analgesic compositions containing 2-cyanoalkylbenzomorphan derivatives and salts thereof 失效
    含有2-氰基烷基苯并喃衍生物及其盐的止痛组合物

    公开(公告)号：US3962446A

    公开(公告)日：1976-06-08

    申请号：US523412

    申请日：1974-11-13

    申请人： Toshio Atsumi ,  Kenji Kobayashi ,  Yoshiaki Takebayashi ,  Hisao Yamamoto

    发明人： Toshio Atsumi ,  Kenji Kobayashi ,  Yoshiaki Takebayashi ,  Hisao Yamamoto

    IPC分类号： A61K31/395 ,  A61K31/485

    CPC分类号： A61K31/395

    摘要： An analgesic composition comprising an analgesically effective amount of at least one 6,7-benzomorphan derivative of the formula: ##SPC1##Wherein R is a hydrogen atom, a hydroxyl group, a C.sup.1 - C.sup.3 alkoxy group or a C.sup.1 - C.sup.8 alkanoyloxy group; R.sub.1 is a hydrogen atom, a C.sup.1 - C.sup.5 alkyl group, a phenyl group, a halophenyl group, an alkylphenyl group wherein the alkyl moiety has 1 to 3 carbon atoms, an alkoxyphenyl group wherein the alkoxy moiety has 1 to 3 carbon atoms, a trifluoromethylphenyl group, an alkylthiophenyl group wherein the alkylthio moiety has 1 to 3 carbon atoms or a group of the formula (C.sub.m H.sub.2m.sub.-p.sub.+1) - (R.sub.9).sub.p wherein m is an integer of 1 - 6, p is an integer of 1 - 2 and R.sub.9 is a C.sup.1 - C.sup.3 alkoxy group; R.sub. 2 is a hydrogen atom or a C.sup.1 - C.sup.3 alkyl group; R.sub.3 is a hydrogen atom, a C.sup.1 - C.sup.3 alkyl group, a phenyl group or an alkoxyphenyl group wherein the alkoxy moiety has 1 to 3 carbon atoms; R.sub.4 is a hydrogen atom or a hydroxyl group, or R.sub.3 and R.sub.4 may form a C.sup.1 - C.sup.3 alkylidene group or a carbonyl group together with a carbon atom to which these substituents are bonded; R.sub.5 is a hydrogen atom or C.sup.1 - C.sup.3 alkyl group; R.sub.6 is a hydrogen atom or a methyl group; R.sub.7 and R.sub.8 are independently a hydrogen atom or a C.sup.1 - C.sup.2 alkyl group; and n is an integer of 0 - 2; or an acid addition salt thereof, and a pharmaceutically acceptable carrier or diluent, is disclosed.

    摘要翻译： 一种止痛组合物，其包含镇痛有效量的至少一种下式的6,7-苯并吗啉衍生物：WHEREIN R是氢原子，羟基，C1-C3烷氧基或C1-C8烷酰氧基; R1为氢原子，C1-C5烷基，苯基，卤代苯基，烷基部分为碳原子数1〜3的烷基苯基，烷氧基部分为碳原子数1〜3的烷氧基苯基， 三氟甲基苯基，其中烷硫基部分具有1至3个碳原子的烷硫基苯基或式（CmH2m-p + 1） - （R9）p的基团，其中m是1-6的整数，p是整数1 - 2和R9是C1-C3烷氧基; R 2是氢原子或C 1 -C 3烷基; R3是氢原子，C1-C3烷基，苯基或烷氧基苯基，其中烷氧基部分具有1至3个碳原子; R4是氢原子或羟基，或者R3和R4可以与这些取代基结合的碳原子一起形成C1-C3亚烷基或羰基; R5是氢原子或C1-C3烷基; R6是氢原子或甲基; R 7和R 8独立地为氢原子或C 1 -C 2烷基; n为0-2的整数; 或其酸加成盐，以及药学上可接受的载体或稀释剂。

    Novel process for producing 2-ketoethylbenzomorphan derivatives and salts thereof
    3.
    发明授权
    Novel process for producing 2-ketoethylbenzomorphan derivatives and salts thereof 失效
    生产2-乙基苯并吡喃衍生物的新方法及其制备方法

    公开(公告)号：US3950346A

    公开(公告)日：1976-04-13

    申请号：US356807

    申请日：1973-05-03

    申请人： Toshio Atsumi ,  Kenji Kobayashi ,  Yoshiaki Takebayashi ,  Hisao Yamamoto

    发明人： Toshio Atsumi ,  Kenji Kobayashi ,  Yoshiaki Takebayashi ,  Hisao Yamamoto

    IPC分类号： C07D221/26

    CPC分类号： C07D221/26

    摘要： 2-Ketoethyl-6,7-benzomorphan derivatives of the formula: ##SPC1##And their pharmaceutically acceptable non-toxic salts, which are useful as non-addictive analgesics and pain-relieving agents and can be prepared by reacting the corresponding 6,7-benzomorphan derivative of the formula: ##SPC2##With a vinyl carbonyl compound of the formula: ##EQU1## [wherein R' is a hydrogen atom or a group of the formula: --OR" (wherein R" is a hydrogen atom, an alkanoyl group, an alkyl group, an aralkyl group, an alkoxycarbonylmethyl group or a tetrahydropyranyl group), R.sub.1 is a hydrogen atom, an alkyl group or a substituted or unsubstituted aryl group, R.sub.2 is a hydrogen atom or an alkyl group and A is an alkyl group, an alkoxy group, a substituted or unsubstituted aryl group or a substituted or unsubstituted amino group].

    Preparation of 2-benzoylalkylbenzomorphan
    4.
    发明授权
    Preparation of 2-benzoylalkylbenzomorphan 失效
    2-苯甲酰基烷基苯并咪唑的制备

    公开(公告)号：US3953441A

    公开(公告)日：1976-04-27

    申请号：US150841

    申请日：1971-06-07

    申请人： Toshio Atsumi ,  Kenji Kobayashi ,  Yoshiaki Takebayashi ,  Hisao Yamamoto

    发明人： Toshio Atsumi ,  Kenji Kobayashi ,  Yoshiaki Takebayashi ,  Hisao Yamamoto

    IPC分类号： C07D211/70 ,  C07D221/26

    CPC分类号： C07D221/26 ,  C07D211/70

    摘要： A novel process for preparing 2-benzoylalkylbenzomorphan derivatives and salts thereof, represented by the formula ##SPC1##Wherein n, R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined in the specification. The process comprises reacting a pyridinium derivative of the formula, ##SPC2##Wherein X is a halogen atom and Y' is an ethylenedioxy group; with a Grignard reagent of the formula, ##SPC3##Wherein R' is a hydrogen atom or a C.sub.1 -C.sub.3 alkoxy group and Z is a halogen atom, to yield a 1,2-dihydropyridine derivative of the formula; ##SPC4##And then reducing the said 1,2-dihydropyridine derivative to give a 1,2,5,6-tetrahydropyridine derivative of the formula, ##SPC5##Wherein Y is an oxygen atom or an ethylenedioxy group, and further cyclizing the obtained 1,2,5,6-tetrahydropyridine derivative.

    摘要翻译： 由式WHEREIN N，R，R1，R2，R3和R4表示的用于制备2-苯甲酰基烷基苯并喃衍生物及其盐的新方法如本说明书中所定义。 该方法包括使下式的吡啶鎓衍生物WHEREIN X是卤素原子，Y'是亚乙二氧基; 与下式的格利雅试剂，其中R'是氢原子或C1-C3烷氧基，Z是卤素原子，得到下式的1,2-二氢吡啶衍生物; 然后减少所得的1,2-二氢吡啶衍生物，得到本发明的1,2,5,6-四氢吡啶衍生物，其中Y是氧原子或亚乙二氧基，进一步环化得到的1,2,5,6-四氢吡啶衍生物， 6-四氢吡啶衍生物。

    Novel 2-substituted 6,7-benzomorphan derivatives and salts thereof in analgesic compositions
    5.
    发明授权
    Novel 2-substituted 6,7-benzomorphan derivatives and salts thereof in analgesic compositions 失效
    新颖的2-取代的6,7-苯并恶嗪衍生物及其盐在止痛组合物中

    公开(公告)号：US3966939A

    公开(公告)日：1976-06-29

    申请号：US558655

    申请日：1975-03-17

    申请人： Kenji Kobayashi ,  Toshitsugu Fukumaru ,  Hiroyuki Mizote ,  Shigeho Inaba ,  Hisao Yamamoto

    发明人： Kenji Kobayashi ,  Toshitsugu Fukumaru ,  Hiroyuki Mizote ,  Shigeho Inaba ,  Hisao Yamamoto

    IPC分类号： A61K31/395 ,  A61K31/485

    CPC分类号： A61K31/395

    摘要： Novel 2-substituted 6,7-benzomorphan derivatives of the formula: ##SPC1##And acid addition salts thereof, which are useful as non-addicting analgesics, pain relieving agents and antitussives and can be prepared by reacting 6,7-benzomorphan derivatives of the formula: ##SPC2##With the reactive derivatives of alcohols of the formula: ##EQU1## [wherein R is a hydrogen atom, a hydroxyl group, an alkoxy group or an alkanoyloxy group; R.sub.1 is a hydrogen atom, an alkyl group, an alkoxyalkyl group or a substituted or unsubstituted aryl group; R.sub.3 is a hydrogen atom or a hydroxyl group; R.sub.4 is a hydrogen atom, an alkyl group or a substituted or unsubstituted aryl group, or R.sub.3 and R.sub.4 may form an alkylidene group or a carbonyl group together with the carbon atom to which these substituents are bonded; R.sub.2, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R.sub.10 are each a hydrogen atom or an alkyl group; A is an alkylene group; and m is an integer of 0 to 2].

    摘要翻译： 具有下式的新颖的2-取代的6,7-苯并吗啉衍生物：

    Pull-on absorbent article and method of making the same
    9.
    发明授权
    Pull-on absorbent article and method of making the same 有权
    吸收性物品及其制作方法

    公开(公告)号：US09011404B2

    公开(公告)日：2015-04-21

    申请号：US13377765

    申请日：2010-06-28

    申请人： Kenji Kobayashi ,  Ryoichi Yamamoto ,  Kenji Ando ,  Takuo Yanashima ,  Akio Morita

    发明人： Kenji Kobayashi ,  Ryoichi Yamamoto ,  Kenji Ando ,  Takuo Yanashima ,  Akio Morita

    IPC分类号： A61F13/15 ,  B32B37/00 ,  A61F13/49 ,  A61F13/496 ,  D04H3/04

    CPC分类号： A61F13/15804 ,  A61F13/49011 ,  A61F13/4902 ,  A61F13/496 ,  D04H3/04 ,  Y10T156/10 ,  Y10T156/1062

    摘要： A pull-on absorbent article including a front outer cover to be worn around a wearer's front side, a rear outer cover to be worn around the wearer's rear side, and an absorbent assembly fixed to the front and the rear outer cover so as to bridge them and having a pair of side seals. The length of each of the front and the outer cover in the longitudinal direction of the article is uniform in the lateral direction and larger than that of the side seals so that the front and the outer cover have extension portions that extend downward from the side seals. The extension portions of the front and/or the rear outer cover have an elasticized region extensible in the lateral direction in a region located laterally outward of each side edge of the absorbent assembly.

    摘要翻译： 一种吸引性物品，其特征在于，包括要佩戴在前方的佩戴的前外盖，穿戴者的后侧佩戴的后外盖以及固定在前后外罩上的吸收体， 他们并有一对侧封。 前盖和外盖每个在纵向方向上的长度在侧向方向上是均匀的，并且大于侧密封件的长度，使得前盖和外盖具有从侧密封件向下延伸的延伸部分 。 前外侧盖和/或后外盖的延伸部分具有沿横向延伸的弹性区域，位于吸收组件的每个侧边缘的横向外侧的区域中。