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    ION ENTRY/EXIT DEVICE
    1.
    发明公开
    ION ENTRY/EXIT DEVICE 审中-公开

    公开(公告)号：US20240355606A1

    公开(公告)日：2024-10-24

    申请号：US18758956

    申请日：2024-06-28

    申请人： Micromass UK Limited

    发明人： Kevin Giles ,  David J. Langridge ,  Jason Lee Wildgoose

    IPC分类号： H01J49/06 ,  G01N27/622 ,  G01N27/623 ,  H01J49/00 ,  H01J49/42 ,  H01J49/40

    CPC分类号： H01J49/062 ,  G01N27/622 ,  G01N27/623 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/422 ,  H01J49/408

    摘要： A method of introducing and ejecting ions from an ion entry/exit device 4 is disclosed. The ion entry/exit device 4 has at least two arrays of electrodes 20,22. The device is operated in a first mode wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays 20,22 in a first direction such that a potential barrier moves along the at least one array in the first direction and drives ions into and/or out of the device in the first direction. The device is also operated in a second mode, wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays 20,22 in a second, different direction such that a potential barrier moves along the array in the second direction and drives ions into and/or out of the device in the second direction. The device provides a single, relatively simple device for manipulating ions in multiple directions. For example, the device may be used to load ions into or eject ions from an ion mobility separator in a first direction, and may then be used to cause ions to move through the ion mobility separator in the second direction so as to cause the ions to separate.

    Ion entry/exit device
    2.
    发明授权
    Ion entry/exit device 有权

    公开(公告)号：US12051583B2

    公开(公告)日：2024-07-30

    申请号：US18053916

    申请日：2022-11-09

    申请人： Micromass UK Limited

    发明人： Kevin Giles ,  David J. Langridge ,  Jason Lee Wildgoose

    IPC分类号： H01J49/06 ,  G01N27/622 ,  G01N27/623 ,  H01J49/00 ,  H01J49/42 ,  H01J49/40

    CPC分类号： H01J49/062 ,  G01N27/622 ,  G01N27/623 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/422 ,  H01J49/408

    摘要： A method of introducing and ejecting ions from an ion entry/exit device (4) is disclosed. The ion entry/exit device (4) has at least two arrays of electrodes (20,22). The device is operated in a first mode wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays ((20,22) in a first direction such that a potential barrier moves along the at least one array in the first direction and drives ions into and/or out of the device in the first direction. The device is also operated in a second mode, wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays (20,22) in a second, different direction such that a potential barrier moves along the array in the second direction and drives ions into and/or out of the device in the second direction. The device provides a single, relatively simple device for manipulating ions in multiple directions. For example, the device may be used to load ions into or eject ions from an ion mobility separator in a first direction, and may then be used to cause ions to move through the ion mobility separator in the second direction so as to cause the ions to separate.

    Ion Entry/Exit Device
    3.
    发明公开
    Ion Entry/Exit Device 审中-公开

    公开(公告)号：US20230170203A1

    公开(公告)日：2023-06-01

    申请号：US18053916

    申请日：2022-11-09

    申请人： Micromass UK Limited

    发明人： Kevin Giles ,  David J. Langridge ,  Jason Lee Wildgoose

    IPC分类号： H01J49/06 ,  H01J49/42 ,  G01N27/623 ,  G01N27/622 ,  H01J49/00

    CPC分类号： H01J49/062 ,  H01J49/422 ,  G01N27/623 ,  G01N27/622 ,  H01J49/061 ,  H01J49/0031 ,  H01J49/408

    摘要： A method of introducing and ejecting ions from an ion entry/exit device (4) is disclosed. The ion entry/exit device (4) has at least two arrays of electrodes (20,22). The device is operated in a first mode wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays ((20,22) in a first direction such that a potential barrier moves along the at least one array in the first direction and drives ions into and/or out of the device in the first direction. The device is also operated in a second mode, wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays (20,22) in a second, different direction such that a potential barrier moves along the array in the second direction and drives ions into and/or out of the device in the second direction. The device provides a single, relatively simple device for manipulating ions in multiple directions. For example, the device may be used to load ions into or eject ions from an ion mobility separator in a first direction, and may then be used to cause ions to move through the ion mobility separator in the second direction so as to cause the ions to separate.

    METHOD AND APPARATUS FOR SEPARATING IONS BY ION PEAK COMPRESSION OR EXPANSION
    4.
    发明申请
    METHOD AND APPARATUS FOR SEPARATING IONS BY ION PEAK COMPRESSION OR EXPANSION 有权

    公开(公告)号：US20230136546A1

    公开(公告)日：2023-05-04

    申请号：US17911923

    申请日：2021-03-18

    申请人： Micromass UK Limited

    发明人： David J. Langridge ,  Kevin Giles

    IPC分类号： G01N27/622 ,  H01J49/06

    摘要： A method and apparatus for separating ions according to a physicochemical property, such as ion mobility or mass-to-charge-ratio, is disclosed, comprising: repeatedly travelling a transient DC voltage along an ion guide; wherein the transient DC voltage has a first amplitude and first speed whilst it travels along a first region of the ion guide so as to urge ions having different values of said physicochemical property through said first region of the ion guide with different average speeds; and wherein, in a first mode, the transient DC voltage is travelled along a second region of the ion guide that is adjacent to said first region: (i) whilst having a second different amplitude; and/or (ii) at a second different non-zero speed; and/or (iii) at a substantially constant speed but with a different frequency to which it is repeatedly travelled along the first region; so that ions having a given value of said physicochemical property are urged through said second region of the ion guide at a different average speed than they are urged through the first region, thereby causing the ions to be spatially compressed or expanded as they pass from the first region of the ion guide to the second region.

    Quadrupole devices
    6.
    发明授权
    Quadrupole devices 有权

    公开(公告)号：US11201048B2

    公开(公告)日：2021-12-14

    申请号：US16330705

    申请日：2017-09-06

    申请人： MICROMASS UK LIMITED

    发明人： David J. Langridge ,  Martin Raymond Green

    IPC分类号： H01J49/42 ,  H01J49/02

    摘要： A method of operating a quadrupole device is disclosed that comprises operating the quadrupole device in a first mode of operation, and operating the quadrupole device in a second mode of operation. Operating the quadrupole device in the first mode of operation comprises applying one or more first voltages to the quadrupole device such that the quadrupole device is operated in an initial stability region and such that at least some ions are stable within the quadrupole device. Operating the quadrupole device in the second mode of operation comprises applying one or more second voltages to the quadrupole device such that the quadrupole device is operated in a different stability region and such that at least some of the ions that were stable within the quadrupole device in the first mode of operation are stable within the quadrupole device in the second mode of operation.

    Ion Entry/Exit Device
    7.
    发明申请
    Ion Entry/Exit Device 有权

    公开(公告)号：US20210125818A1

    公开(公告)日：2021-04-29

    申请号：US17130636

    申请日：2020-12-22

    申请人： Micromass UK Limited

    发明人： Kevin Giles ,  David J. Langridge ,  Jason Lee Wildgoose

    IPC分类号： H01J49/06 ,  G01N27/622 ,  H01J49/42 ,  H01J49/00

    摘要： A method of introducing and ejecting ions from an ion entry/exit device (4) is disclosed. The ion entry/exit device (4) has at least two arrays of electrodes (20,22). The device is operated in a first mode wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays ((20,22) in a first direction such that a potential barrier moves along the at least one array in the first direction and drives ions into and/or out of the device in the first direction. The device is also operated in a second mode, wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays (20,22) in a second, different direction such that a potential barrier moves along the array in the second direction and drives ions into and/or out of the device in the second direction. The device provides a single, relatively simple device for manipulating ions in multiple directions. For example, the device may be used to load ions into or eject ions from an ion mobility separator in a first direction, and may then be used to cause ions to move through the ion mobility separator in the second direction so as to cause the ions to separate.

    Hybrid mass spectrometer
    9.
    发明授权
    Hybrid mass spectrometer 有权

    公开(公告)号：US10600627B2

    公开(公告)日：2020-03-24

    申请号：US15314359

    申请日：2015-05-29

    申请人： Micromass UK Limited

    发明人： Kevin Giles ,  David J. Langridge ,  Steven Derek Pringle ,  Keith Richardson ,  Jason Lee Wildgoose

    IPC分类号： H01J49/00 ,  H01J49/06 ,  G01N27/62 ,  H01J49/40

    摘要： A method of mass spectrometry is disclosed comprising separating ions temporally in a first device and analysing the mass or mass to charge ratio of the ions or of product or fragment ions derived from the ions in a mass or mass to charge ratio analyser disposed downstream of the first device. The method further comprises obtaining a first set of drift times for the ions through the first device by measuring ion arrival times and determining the transit time of the ions and/or of the product or fragment ions through one or more intermediate regions or devices disposed between the first device and the mass to charge ratio analyser. The method further comprises obtaining a second set of drift times for the ions through the first device by correcting the first set of drift times to account for the determined transit times.

    Ion mobility separator with variable effective length
    10.
    发明授权
    Ion mobility separator with variable effective length 有权
    具有可变有效长度的离子迁移分离器

    公开(公告)号：US09552974B2

    公开(公告)日：2017-01-24

    申请号：US14751530

    申请日：2015-06-26

    申请人： Micromass UK Limited

    发明人： Martin Raymond Green ,  David J. Langridge ,  Jason Lee Wildgoose

    IPC分类号： B01D59/46 ,  B01D59/44 ,  H01J49/36 ,  G01N27/62 ,  H01J49/42 ,  H01J49/06

    CPC分类号： H01J49/36 ,  G01N27/624 ,  H01J49/06 ,  H01J49/42 ,  H01J49/426

    摘要： An ion mobility separator or spectrometer is disclosed comprising an inner cylinder and an outer cylinder defining an annular volume through which ions are transmitted. Spiral electrodes a-f are arranged on a surface of the inner cylinder and/or on a surface of the outer cylinder. A first device is arranged and adapted to maintain a DC electric field and/or a pseudo-potential force which acts to urge ions from a first end of the ion mobility separator or spectrometer to a second end of the ion mobility separator or spectrometer. A second device is arranged and adapted to apply transient DC voltages to the one or more spiral electrodes in order to urge ions towards the first end of the ion mobility separator or spectrometer. The net effect is to extend the effective path length of the ion mobility separator.

    摘要翻译： 公开了一种离子迁移率分离器或光谱仪，其包括限定通过离子传播的环形体积的内圆筒和外圆筒。 螺旋电极a-f布置在内筒的表面上和/或外筒的表面上。 第一装置被布置和适于维持DC电场和/或伪电势力，其用于将离子从离子迁移率分离器或光谱仪的第一端推动到离子迁移率分离器或光谱仪的第二端。 第二装置被布置并适于将瞬态DC电压施加到一个或多个螺旋电极，以便促使离子朝向离子迁移率分离器或光谱仪的第一端。 净效应是延长离子迁移率分离器的有效路径长度。