摘要:
The present invention relates to a monoclonal antibody or an antibody fragment thereof, which binds to the extracellular region of human Trop-2 with high affinity and exhibits high ADCC activity and high antitumor activity; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent or a diagnostic agent using the antibody fragment thereof.
摘要:
The present invention aims at developing a gene delivery system which has a high selectivity to a target cell and can introduce and express a gene with high efficiency, particularly developing such a system for use in a gene delivery therapy using a viral vector. The present invention provides a method for targeting a drug, which comprises the step of delivering a drug containing a therapeutic gene to a target site using an anti-PAP2a antibody.
摘要:
The present invention aims at developing a gene delivery system which has a high selectivity to a target cell and can introduce and express a gene with high efficiency, particularly developing such a system for use in a gene delivery therapy using a viral vector. The present invention provides a method for targeting a drug, which comprises the step of delivering a drug containing a therapeutic gene to a target site using an anti-PAP2a antibody.
摘要:
An exhaust gas purifying system includes a catalyst arranged on an exhaust pipe of an internal combustion engine; a sensor detecting a state of the exhaust gas passed through the catalyst; and an ECU functioning as an abnormality determining apparatus determining abnormality by monitoring an output of said sensor in an operation under forced air-fuel ratio. When the operation under forced air-fuel control is interrupted before completion of the determination of system abnormality, the abnormality determining apparatus once stores a parameter accumulated during the operation under forced air-fuel ratio control by the time of interruption, and when the internal combustion engine comes to satisfy the prescribed condition again, resumes the operation under forced air-fuel ratio control, and completes determination of system abnormality using the stored parameter and the parameter accumulated after resumption of the forced air-fuel ratio control.
摘要:
A print control data generating apparatus generates first print control data and outputs the generated first print control data. The first print control data includes print control data capable of controlling an output of a print job, and includes a term of validity for the print control data. The print control data generating apparatus determines whether the term of validity for the first print control data is unexpired. The print control data generating apparatus generates second print control data based on the first print control data, when the term of validity for the first print control data has expired and if a reissue of the first print control data is requested, and outputs the generated second print control data.
摘要:
A toner which comprises toner particles containing a binder resin, a colorant, a polar resin and a release agent, wherein the binder resin is a styrene polymer, a styrene copolymer, or a mixture of these, and has a weight average molecular weight Mw.sub.1 of from 10,000 to 1,000,000, the polar resin is a polyester resin containing a tetrahydrofuran-soluble matter of which weight average molecular weight Mw.sub.2 is from 7,000 to 50,000 and an ethyl alcohol-soluble matter of which weight average molecular weight Mw.sub.3 is from 1,000 to 7,000, where Mw.sub.2 /Mw.sub.3 is from 1.2 to 10.
摘要:
A toner for developing an electrostatic image includes toner particles constituted by at least a binder resin, a colorant, a polar resin and a release agent. The polar resin has at least one terminal group which has been modified by a polycarbonate acid having at least three carboxyl groups. The polar resin has an acid value of 3-35 mgKOH/g. The polar resin may preferably be a polyester resin having an acid value of 4-35 mgKOH/g and having a number-average molecular weight (Mn) of 3,000-15,000, a weight-average molecular weight (Mw) of 6,000-50,000, and an Mw/Mn of 1.2-3.0 based on GPC. The polar resin (preferably polyester resin) having modified by a polycarboxylic acid having at least three carboxylic groups to provide a specific acid value is effective in improving resultant toner performances, such as low-temperature fixability, anti-offset characteristic at high temperatures, triboelectric chargeability, and flowability.
摘要:
A toner which comprises toner particles containing a binder resin, a colorant, a polar resin and a release agent, wherein the binder resin is a styrene polymer, a styrene copolymer, or a mixture of these, and has a weight average molecular weight Mw.sub.1 of from 10,000 to 1,000,000, the polar resin is a polyester resin containing a tetrahydrofuran-soluble matter of which weight average molecular weight Mw.sub.2 is from 7,000 to 50,000 and an ethyl alcohol-soluble matter of which weight average molecular weight Mw.sub.3 is from 1,000 to 7,000, where Mw.sub.2 /Mw.sub.3 is from 1.2 to 10.
摘要:
A device management system of the present invention, in which a device which is allowed to shift to a power saving mode and a management apparatus which manages the device are connected to a network, allows the management apparatus to recognize power consumption statuses of devices without making any periodic communications between the management apparatus and devices.
摘要:
According to one embodiment, a display input apparatus includes a display screen. At least one array of light-emitting elements is provided along at least one edge of the display screen, the at least one array of light-emitting elements being configured to irradiate a light beam therefrom. At least one array of light-receiving elements is provided along an edge opposing the at least one edge of the display screen, the at least one array of light-receiving elements being configured to receive the light beam from the at least one array of light-emitting elements and further being configured to generate a detection signal indicating intensity of the received light. A control unit is configured to determine a potential of the detection signal, and further being configured to compensate the potential of the detection signal based on the intensity of the received light. A detection unit is configured to compare the compensated potential of the detection signal with a threshold so as to detect coordinates of a touch position thereby.