公开(公告)号：US20120237518A1

公开(公告)日：2012-09-20

申请号：US13157551

申请日：2011-06-10

申请人： Miki YAMAGUCHI ,  Kazunori Kato ,  Hirofumi HAMADA ,  Kazuyasu NAKAMURA ,  Yoshiyuki SUGIMOTO ,  Tsuguo KUBOTA ,  Masahiro IKEDA

发明人： Miki YAMAGUCHI ,  Kazunori Kato ,  Hirofumi HAMADA ,  Kazuyasu NAKAMURA ,  Yoshiyuki SUGIMOTO ,  Tsuguo KUBOTA ,  Masahiro IKEDA

IPC分类号： A61K39/395 ,  C12N1/21 ,  C12N5/10 ,  A61P35/00 ,  C07K16/30 ,  G01N33/574 ,  C12N15/13 ,  C12N15/63 ,  C12P21/02

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/92

摘要： The present invention relates to a monoclonal antibody or an antibody fragment thereof, which binds to the extracellular region of human Trop-2 with high affinity and exhibits high ADCC activity and high antitumor activity; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent or a diagnostic agent using the antibody fragment thereof.

摘要翻译： 本发明涉及一种单克隆抗体或其抗体片段，其以高亲和力结合人Trop-2的细胞外区域并表现出高ADCC活性和高抗肿瘤活性; 产生抗体的杂交瘤; 编码抗体的DNA; 包含DNA的载体; 通过引入载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及使用其抗体片段的治疗剂或诊断剂。

公开(公告)号：US20150360053A1

公开(公告)日：2015-12-17

申请号：US14761850

申请日：2013-01-22

申请人： Yuehu PU ,  Masahiro IKEDA ,  Taizo HONDA

发明人： Yuehu PU ,  Masahiro IKEDA ,  Taizo HONDA

IPC分类号： A61N5/10

CPC分类号： A61N5/1043 ,  A61N5/103 ,  A61N5/1048 ,  A61N5/1071 ,  A61N5/1077 ,  A61N2005/1074 ,  A61N2005/1087

摘要： A particle beam irradiation system comprising a scanning electromagnet for a particle beam to scan an irradiation objective, a scanning information storage section for storing scanning position information regarding a plurality of scanning positions in a case where a particle beam scans an irradiation objective and scanning order information which is order for scanning a plurality of scanning positions, and a scanning electromagnet control section for controlling a scanning electromagnet based on scanning position information and scanning order information which is stored in the scanning information storage section, wherein the scanning position information which is stored in the scanning information storage section includes a part whose scanning position information is same as the scanning position information of adjacent order.

摘要翻译： 一种粒子束照射系统，包括用于粒子束的扫描电磁体扫描照射物镜;扫描信息存储部分，用于在粒子束扫描照射物镜和扫描命令信息的情况下存储关于多个扫描位置的扫描位置信息 扫描位置信息存储在扫描信息存储部中，扫描位置信息存储在扫描信息存储部中，扫描位置信息存储在扫描信息存储部中， 扫描信息存储部分包括扫描位置信息与相邻次序的扫描位置信息相同的部分。

公开(公告)号：US20150306427A1

公开(公告)日：2015-10-29

申请号：US14439326

申请日：2012-12-26

申请人： Kousuke HIRASAWA ,  Masahiro IKEDA

发明人： Kousuke HIRASAWA ,  Masahiro IKEDA

IPC分类号： A61N5/10 ,  G01T1/204 ,  G01T1/105

CPC分类号： A61N5/1075 ,  A61N2005/1076 ,  A61N2005/1087 ,  G01T1/105 ,  G01T1/204

摘要： A dose distribution measurement device includes at least two cameras arranged on a plane perpendicular to the center axis of irradiation of a water phantom with a particle beam so as to take an image of light emission of a fluorescent substance containing liquid in the water phantom and a dose distribution calculation and evaluation unit having a spot position determination part for determining, from data of the camera image taken with the cameras, the position of a spot Irradiated with the particle beam during its staying and a dose addition part for calculating an irradiation dose distribution at the spot position determined by the spot position determination part using a PDD and an OCR stored in a pencil-beam dose-distribution data storage part, to add the irradiation dose distribution at each of spot positions.

摘要翻译： 剂量分布测量装置包括至少两个照相机，其布置在垂直于具有粒子束的水体的照射的中心轴的平面上，以便在水体中拍摄含有液体的荧光物质的发光图像，以及 剂量分布计算和评估单元，其具有光点位置确定部分，用于根据照相机拍摄的照相机图像的数据确定在其停留期间用粒子束照射的斑点的位置和用于计算照射剂量分布的剂量添加部分 在利用存储在笔形光束剂量分布数据存储部分中的PDD和OCR的光点位置确定部分确定的光点位置，在每个光斑位置添加照射剂量分布。

公开(公告)号：US20120205447A1

公开(公告)日：2012-08-16

申请号：US13417570

申请日：2012-03-12

申请人： Masahiro IKEDA

发明人： Masahiro IKEDA

IPC分类号： G06K7/10 ,  G06K13/06 ,  G06K7/08

CPC分类号： G06K7/10782 ,  G06K7/0004 ,  G06K7/10336 ,  G06K7/14 ,  H04B5/00 ,  H04B5/0056 ,  H04B5/0081

摘要： An information reading apparatus includes: a transfer path for transferring an information recording medium (a passport); an image sensor which is placed in a frame constructing the transfer path and optically reads information recorded in the information recording medium (the passport); and non-contact communication antennas which send and receive information to/from an antenna or an antenna embedded in the information recording medium (the passport), through electromagnetic induction. The plurality of non-contact communication antennas are laid out in the frame constructing the transfer path.

摘要翻译： 信息读取装置包括：用于传送信息记录介质（护照）的传送路径; 图像传感器，其被放置在构成传送路径的框架中，并且光学地读取记录在信息记录介质（护照）中的信息; 以及通过电磁感应向嵌入在信息记录介质（护照）中的天线或天线发送信息的非接触通信天线。 多个非接触通信天线布置在构成传送路径的帧中。

公开(公告)号：US20130068921A1

公开(公告)日：2013-03-21

申请号：US13613557

申请日：2012-09-13

申请人： Masahiro IKEDA

发明人： Masahiro IKEDA

IPC分类号： F16C35/04 ,  F16M13/02

CPC分类号： F16C35/04 ,  F16C19/06 ,  F16C27/066 ,  F16C33/80 ,  F16C33/805 ,  F16C2326/00 ,  F16C2326/30

摘要： The invention provides a center bearing support which can effectively suppress an inflow of a muddy water or the like into a center bearing side even at a time when a rotating shaft stops, without using a contact type seal such as an oil seal or the like. In a center bearing support in which an inner ring retaining a center bearing is provided in an inner periphery of an outer ring fixed to a vehicle body side via an elastic body made of a rubber-like elastic material, a rib guiding a flow of a muddy water or the like in a circumferential direction is formed on a convex surface constructed by a bellow-like bent portion of the elastic body.

摘要翻译： 本发明提供一种即使在旋转轴停止时也能够有效地抑制泥水等进入中心轴承侧的中心轴承座，而不使用诸如油封等的接触型密封。 在通过橡胶状弹性材料制成的弹性体将保持中心轴承的内圈设置在固定于车体侧的外圈的内周的中心轴承座中， 在由弹性体的波纹状弯曲部构成的凸面上形成有圆周方向的泥水等。

公开(公告)号：US20110159972A1

公开(公告)日：2011-06-30

申请号：US12968574

申请日：2010-12-15

申请人： Masahiro IKEDA

发明人： Masahiro IKEDA

IPC分类号： F16F15/14 ,  F16C3/02

CPC分类号： F16F15/1442 ,  F16C3/02 ,  Y10T464/50

摘要： In order to achieve downsizing, and to prevent a cleaning fluid from staying inside, a dynamic damper for a hollow rotating shaft is provided with a mass body floatingly inserted to an inner periphery of the hollow rotating shaft, of which a vibration is to be reduced, and an elastic body structured such that an inner diameter portion is fitly attached to an outer periphery of the mass body and an outer diameter portion is brought into pressure contact with an inner peripheral surface of the hollow rotating shaft, and made of a rubber-like elastic material, wherein grooves having both ends open to spaces at both sides in an axial direction of the elastic body are formed in one of fitted surfaces to each other of the mass body and the elastic body.

摘要翻译： 为了实现小型化，并且为了防止清洗液停留在内部，中空旋转轴的动力阻尼器设置有浮动地插入中空旋转轴的内周的质量体，其中振动将被减小 以及弹性体，其构造成使得内径部分适配地附接到所述质量体的外周，并且外径部与所述中空旋转轴的内周面压力接触，并且由橡胶 - 其特征在于，在所述弹性体的轴向的两侧的空间的两端开口的槽形成在所述质量体和所述弹性体的彼此嵌合的一个表面上。

公开(公告)号：US20090059422A1

公开(公告)日：2009-03-05

申请号：US12193622

申请日：2008-08-18

申请人： Masahiro IKEDA ,  Akihito WADA ,  Hideki Kanebako ,  Hiromi Fukasawa ,  Daisuke Higuchi

发明人： Masahiro IKEDA ,  Akihito WADA ,  Hideki Kanebako ,  Hiromi Fukasawa ,  Daisuke Higuchi

IPC分类号： G11B5/23

CPC分类号： G11B5/00808 ,  G06K7/084 ,  G06Q20/042 ,  G07D7/04

摘要： A media processing device may include a frame with a transport passage in which information recording media are transported and a magnetic head for processing magnetic information signals on the information recording media. The magnetic head may be embedded in the frame and part of the frame may be interposed between the magnetic head and the transport passage.

摘要翻译： 媒体处理装置可以包括具有其中传送信息记录介质的传送通道的框架和用于在信息记录介质上处理磁信息信号的磁头。 磁头可以嵌入在框架中，并且框架的一部分可以插入在磁头和传送通道之间。