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    METHOD FOR IDENTIFYING AND SELECTING DRUG CANDIDATES FOR COMBINATORIAL DRUG PRODUCTS
    4.
    发明申请
    METHOD FOR IDENTIFYING AND SELECTING DRUG CANDIDATES FOR COMBINATORIAL DRUG PRODUCTS 审中-公开
    识别和选择用于组合药物制品的药物候选药物的方法

    公开(公告)号：US20110224094A1

    公开(公告)日：2011-09-15

    申请号：US13122713

    申请日：2009-10-06

    申请人： Mikkel Wandahl Pedersen ,  Per-Johan Meijer ,  Allan Jensen

    发明人： Mikkel Wandahl Pedersen ,  Per-Johan Meijer ,  Allan Jensen

    IPC分类号： C40B30/04 ,  C40B30/06 ,  C40B30/00 ,  C40B30/08

    CPC分类号： G01N33/6854 ,  A61K2039/507 ,  C07K16/00 ,  C07K16/2863 ,  G01N33/6845

    摘要： A method for identifying and selecting chemical entities that contributes to a functional effect in the development of new combinatorial drugs. The combinations of two or more chemical compounds show a synergistic effect. The compounds can be e.g. antibodies, antibiotics, anti-cancer agents, anti-AIDS agents, anti-growth factors, antiviral agents, soluble receptors, cytokines, RNAi's, vaccines and mixtures thereof. The method comprises a) providing n samples each comprising a chemical entity, b) mixing 2 or more of the n samples in all possible combinations, c) subjecting this mixture to a functional assay in order to identify entities contributing to the functional effect. The steps a-c are repeated on the chemical entities from step c which contribute to the functional effect.

    摘要翻译： 用于鉴定和选择有助于开发新组合药物的功能效应的化学物质的方法。 两种或更多种化合物的组合显示出协同效应。 化合物可以是例如 抗体，抗生素，抗癌剂，抗艾滋病剂，抗生长因子，抗病毒剂，可溶性受体，细胞因子，RNAi，疫苗及其混合物。 该方法包括a）提供每个包含化学实体的n个样品，b）以所有可能的组合混合2个或更多个n个样品，c）使该混合物进行功能测定，以鉴定有助于功能效应的实体。 对来自步骤c的有助于功能效应的化学实体重复步骤a-c。

    Method for Cloning Avian-Derived Antibodies
    9.
    发明申请
    Method for Cloning Avian-Derived Antibodies 审中-公开
    克隆禽类衍生抗体的方法

    公开(公告)号：US20100069262A1

    公开(公告)日：2010-03-18

    申请号：US12549921

    申请日：2009-08-28

    申请人： Lars Soegaard Nielsen ,  Charles Pyke ,  Anne Marie V. Jensen ,  Klaus Koefoed ,  Allan Jensen ,  Mette Thorn

    发明人： Lars Soegaard Nielsen ,  Charles Pyke ,  Anne Marie V. Jensen ,  Klaus Koefoed ,  Allan Jensen ,  Mette Thorn

    IPC分类号： C40B40/08 ,  C40B50/06 ,  C12P19/34 ,  C12N15/74 ,  C12P21/02 ,  C12M1/00

    CPC分类号： C07K16/2875 ,  C07K16/00 ,  C12N15/1093 ,  C12Q2537/143

    摘要： The invention relates to a procedure for linking cognate pairs of VH and VL encoding sequences from a population of avian cells enriched in particular surface antigen markers. The linking procedure involves a multiplex molecular amplification procedure capable of linking nucleotide sequences of interest in connection with the amplification (multiplex PCR). The method is particularly advantageous for the generation of cognate pair libraries as well as combinatorial libraries of antibody variable region encoding sequences from chickens or other birds. The invention also provides methods for generation of chimeric human/avian antibodies and expression libraries generated by such methods.

    摘要翻译： 本发明涉及从富含特定表面抗原标记的禽类细胞群中连接VH和VL编码序列的同源对的方法。 连接方法涉及能够连接扩增（多重PCR）的感兴趣的核苷酸序列的多重分子扩增方法。 该方法特别有利于产生同源对文库以及来自鸡或其他鸟类的抗体可变区编码序列的组合文库。 本发明还提供用于产生嵌合人/禽抗体和通过这些方法产生的表达文库的方法。