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公开(公告)号：US20160000761A1
公开(公告)日：2016-01-07
申请号：US14770819
申请日：2014-02-26
申请人： Miloud ACHOUR , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Nicola TUFILLI , Thomas ULLRICH
发明人： Miloud ACHOUR , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Nicola TUFILLI , Thomas ULLRICH
IPC分类号： A61K31/428 , A61K9/48 , A61K9/20 , A61K31/19 , A61K9/00
CPC分类号： A61K31/428 , A61K9/0053 , A61K9/2018 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K31/19
摘要： The present invention relates to a pharmaceutical composition in solid oral dosage form comprising (R)-7-(2-(1-(4-butoxyphenyl)-2-methylpropan-2-ylamino)-1-hydroxyethyl)-5-hydroxybenzo[d]thiazol-2(3H)-one acetate salt.
摘要翻译： 本发明涉及一种固体口服剂型的药物组合物，其包含（R）-7-（2-（1-（4-丁氧基苯基）-2-甲基丙-2-基氨基）-1-羟乙基）-5-羟基苯并[ d]噻唑-2（3H） - 酮乙酸盐。
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公开(公告)号：US20150336914A1
公开(公告)日：2015-11-26
申请号：US14817175
申请日：2015-08-03
申请人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
发明人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
IPC分类号： C07D277/68
CPC分类号： A61K31/428 , A61K31/167 , A61K45/06 , C07B2200/07 , C07C53/10 , C07D277/68 , Y02P20/55
摘要： The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.
摘要翻译： 本发明提供游离形式或药学上可接受的盐形式的式（I）化合物，其制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20160075670A1
公开(公告)日：2016-03-17
申请号：US14947458
申请日：2015-11-20
申请人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
发明人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
IPC分类号： C07D277/68 , C07C53/10
CPC分类号： A61K31/428 , A61K31/167 , A61K45/06 , C07B2200/07 , C07C53/10 , C07D277/68 , Y02P20/55
摘要： The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.
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公开(公告)号：US20130245080A1
公开(公告)日：2013-09-19
申请号：US13603990
申请日：2012-09-05
申请人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Xinzhong LAI , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
发明人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Xinzhong LAI , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
IPC分类号： A61K31/428 , A61K45/06 , C07D277/68
CPC分类号： A61K31/428 , A61K31/167 , A61K45/06 , C07B2200/07 , C07C53/10 , C07D277/68 , Y02P20/55
摘要： The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.
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公开(公告)号：US20160279107A1
公开(公告)日：2016-09-29
申请号：US15178579
申请日：2016-06-10
申请人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Xinzhong LAI , Philipp LUSTENBERGER , Bernd Ulrich RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang Wu , Jianguang ZHOU
发明人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Xinzhong LAI , Philipp LUSTENBERGER , Bernd Ulrich RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang Wu , Jianguang ZHOU
IPC分类号： A61K31/428
CPC分类号： A61K31/428 , A61K31/167 , A61K45/06 , C07B2200/07 , C07C53/10 , C07D277/68 , Y02P20/55
摘要： The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.
摘要翻译： 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20150094346A1
公开(公告)日：2015-04-02
申请号：US14566021
申请日：2014-12-10
申请人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
发明人： Jun CAO , Bernhard ERB , Robin Alec FAIRHURST , Arnaud GRANDEURY , Shinji HATAKEYAMA , Magdalena KOZICZAK-HOLBRO , Philipp LUSTENBERGER , Bernd RIEBESEHL , Nicola TUFILLI , Thomas ULLRICH , Xiang WU , Jianguang ZHOU
IPC分类号： C07D277/68 , A61K31/167 , A61K31/428
CPC分类号： A61K31/428 , A61K31/167 , A61K45/06 , C07B2200/07 , C07C53/10 , C07D277/68 , Y02P20/55
摘要： The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.
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公开(公告)号：US20170022199A1
公开(公告)日：2017-01-26
申请号：US15285614
申请日：2016-10-05
申请人： Nigel Graham COOKE , Antonio Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolaus SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
发明人： Nigel Graham COOKE , Antonio Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolaus SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
IPC分类号： C07D471/04 , A61K31/5377 , A61K31/519
CPC分类号： C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要： The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译： 其中Y，R 1，R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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公开(公告)号：US20120065183A1
公开(公告)日：2012-03-15
申请号：US13175050
申请日：2011-07-01
申请人： Nigel Graham COOKE , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolas SOLDERMANN , Frank STOWASSER , Ross STRANG , Nicola TUFILLI , Anette VON MATT , Romain WOLF , Frédéric ZECRI
发明人： Nigel Graham COOKE , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolas SOLDERMANN , Frank STOWASSER , Ross STRANG , Nicola TUFILLI , Anette VON MATT , Romain WOLF , Frédéric ZECRI
IPC分类号： A61K31/519 , A61K31/5377 , A61P19/02 , A61P17/00 , A61P37/08 , A61P7/06 , A61P25/00 , A61P21/04 , A61P35/00 , C07D471/04 , A61P7/04
CPC分类号： C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要： The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译： 本发明涉及式（I）的取代的四氢 - 吡啶并 - 嘧啶衍生物，其中Y，R 1，R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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公开(公告)号：US20170267678A1
公开(公告)日：2017-09-21
申请号：US15613560
申请日：2017-06-05
申请人： Nigel Graham COOKE , Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolas SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
发明人： Nigel Graham COOKE , Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolas SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
IPC分类号： C07D471/04 , A61K31/519 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要： The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
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公开(公告)号：US20140128370A1
公开(公告)日：2014-05-08
申请号：US14151796
申请日：2014-01-09
申请人： Nigel Graham COOKE , Frédéric ZECRI , Nicolas SOLDERMANN , Romain WOLF , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Anette VON MATT , Ross Sinclair STRANG , Alexander Baxter SMITH , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Frank STOWASSER , Nicola TUFILLI
发明人： Nigel Graham COOKE , Frédéric ZECRI , Nicolas SOLDERMANN , Romain WOLF , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Anette VON MATT , Ross Sinclair STRANG , Alexander Baxter SMITH , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Frank STOWASSER , Nicola TUFILLI
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要： The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译： 本发明涉及式（I）的取代的四氢 - 吡啶并 - 嘧啶衍生物，其中Y，R 1，R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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