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12 条记录 (耗时 0.02 秒)

    Nanoparticle-Based Gene Delivery Systems
    1.
    发明申请
    Nanoparticle-Based Gene Delivery Systems 有权
    基于纳米粒子的基因递送系统

    公开(公告)号：US20110229966A1

    公开(公告)日：2011-09-22

    申请号：US12809996

    申请日：2010-03-18

    申请人： Min Su Han ,  Kangseok Lee ,  Dong-Eun Kim

    发明人： Min Su Han ,  Kangseok Lee ,  Dong-Eun Kim

    IPC分类号： C12N5/00

    CPC分类号： C12N15/113 ,  A61K31/7105 ,  A61K31/713 ,  A61K47/6923 ,  C12N15/111 ,  C12N15/87 ,  C12N15/89 ,  C12N2310/11 ,  C12N2310/127 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2310/51 ,  C12N2310/531 ,  C12N2320/32 ,  Y10S977/773

    摘要： The present invention provides a gene delivery system containing nanoparticles. In more detail, the present invention provides a gene delivery system containing (a) a nanomaterial; (b) an oligonucleotide as an universal binding partner covalently linked to the surface of the nanomaterial; and (c) a cargo comprising (i) a complementary oligonucleotide containing a nucleotide sequence complementary to the universal binding partner as a binding counter-partner, and (ii) an inhibitory molecule having a nucleotide sequence complementary to a target gene of interest to be inhibited or an inducible molecule having a nucleotide sequence of a target gene of interest to be expressed. The present invention is a gene delivery system capable of feasibly deliver aptamer, siRNA, shRNA, miRNA, ribozyme, DNAzyme, PNA or gene as well as antisense oligonucleotide into the cells. In addition, the present invention is more efficient than the commercially available gene transfer reagent in respect to the degree of knockdown of target protein expression.

    摘要翻译： 本发明提供含有纳米颗粒的基因递送系统。 更详细地，本发明提供了一种基因递送系统，其包含（a）纳米材料; （b）与纳米材料的表面共价连接的通用结合配偶体的寡核苷酸; （c）货物，其包含（i）含有与通用结合配偶体互补的核苷酸序列作为结合对配体的互补寡核苷酸，和（ii）具有与目的靶基因互补的核苷酸序列的抑制性分子， 或具有待表达的靶基因的核苷酸序列的诱导型分子。 本发明是能够将适体，siRNA，shRNA，miRNA，核酶，DNA酶，PNA或基因以及反义寡核苷酸可行地递送到细胞中的基因递送系统。 此外，与靶蛋白质表达的敲低程度相比，本发明比市售的基因转移试剂更有效。

    Nanoparticle-based gene delivery systems
    2.
    发明授权
    Nanoparticle-based gene delivery systems 有权
    基于纳米粒子的基因传递系统

    公开(公告)号：US08871509B2

    公开(公告)日：2014-10-28

    申请号：US12809996

    申请日：2010-03-18

    申请人： Min Su Han ,  Kangseok Lee ,  Dong-Eun Kim

    发明人： Min Su Han ,  Kangseok Lee ,  Dong-Eun Kim

    IPC分类号： C12N5/00 ,  C12N5/02 ,  C07H21/02 ,  C12N15/11 ,  C12N15/87 ,  C12N15/113 ,  C12N15/89 ,  A61K47/48 ,  A61K31/713 ,  A61K31/7105

    CPC分类号： C12N15/113 ,  A61K31/7105 ,  A61K31/713 ,  A61K47/6923 ,  C12N15/111 ,  C12N15/87 ,  C12N15/89 ,  C12N2310/11 ,  C12N2310/127 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2310/51 ,  C12N2310/531 ,  C12N2320/32 ,  Y10S977/773

    摘要： The present invention provides a gene delivery system containing nanoparticles. In more detail, the present invention provides a gene delivery system containing (a) a nanomaterial; (b) an oligonucleotide as an universal binding partner covalently linked to the surface of the nanomaterial; and (c) a cargo comprising (i) a complementary oligonucleotide containing a nucleotide sequence complementary to the universal binding partner as a binding counter-partner, and (ii) an inhibitory molecule having a nucleotide sequence complementary to a target gene of interest to be inhibited or an inducible molecule having a nucleotide sequence of a target gene of interest to be expressed. The present invention is a gene delivery system capable of feasibly deliver aptamer, siRNA, shRNA, miRNA, ribozyme, DNAzyme, PNA or gene as well as antisense oligonucleotide into the cells. In addition, the present invention is more efficient than the commercially available gene transfer reagent in respect to the degree of knockdown of target protein expression.

    摘要翻译： 本发明提供含有纳米颗粒的基因递送系统。 更详细地，本发明提供了一种基因递送系统，其包含（a）纳米材料; （b）与纳米材料的表面共价连接的通用结合配偶体的寡核苷酸; （c）货物，其包含（i）含有与通用结合配偶体互补的核苷酸序列作为结合对配体的互补寡核苷酸，和（ii）具有与目的靶基因互补的核苷酸序列的抑制性分子， 或具有待表达的靶基因的核苷酸序列的诱导型分子。 本发明是能够将适体，siRNA，shRNA，miRNA，核酶，DNA酶，PNA或基因以及反义寡核苷酸可行地递送到细胞中的基因递送系统。 此外，与靶蛋白质表达的敲低程度相比，本发明比市售的基因转移试剂更有效。

    Detachable mobile terminal for image communication and operating method thereof
    3.
    发明授权
    Detachable mobile terminal for image communication and operating method thereof 失效
    用于图像通信的可拆卸移动终端及其操作方法

    公开(公告)号：US07555312B2

    公开(公告)日：2009-06-30

    申请号：US11009734

    申请日：2004-12-09

    申请人： Eun-Mi Kim ,  Yoo-Seok Cho ,  Dong-Eun Kim ,  Jung-Pil Yun

    发明人： Eun-Mi Kim ,  Yoo-Seok Cho ,  Dong-Eun Kim ,  Jung-Pil Yun

    IPC分类号： H04M1/00

    CPC分类号： H04M1/0237 ,  H04M1/0241 ,  H04M1/0256 ,  H04M1/0264 ,  H04M1/7253 ,  H04M1/72555 ,  H04M2250/02 ,  H04M2250/52

    摘要： A mobile terminal comprising a first body comprising an image receiving unit, an image output unit, a first sound output unit, a first information input unit and a wireless communication module, a second body comprising a second information input unit, a second sound input unit, a second sound output unit and a wireless communication module, wherein the second body is capable of being slidingly mounted to the first body and separated from the first body, and a locking unit for preventing separation of the second body from the first body, wherein the wireless communication modules of the first body and the second body are capable of wirelessly communicating with each other when the first body and the second body are detached from each other.

    摘要翻译： 一种移动终端，包括：第一主体，包括图像接收单元，图像输出单元，第一声音输出单元，第一信息输入单元和无线通信模块;第二主体，包括第二信息输入单元，第二声音输入单元 ，第二声音输出单元和无线通信模块，其中所述第二主体能够滑动地安装到所述第一主体并与所述第一主体分离;以及锁定单元，用于防止所述第二主体与所述第一主体分离，其中， 当第一主体和第二主体彼此分离时，第一主体和第二主体的无线通信模块能够彼此无线地通信。

    Dual phase steel sheet and method of manufacturing the same
    10.
    发明授权
    Dual phase steel sheet and method of manufacturing the same 有权
    双相钢板及其制造方法

    公开(公告)号：US08449698B2

    公开(公告)日：2013-05-28

    申请号：US13530247

    申请日：2012-06-22

    申请人： Dong-Eun Kim ,  Jin-Sung Park ,  Hee-Joong Im ,  Man-Been Moon ,  Hyun-Woon Oh

    发明人： Dong-Eun Kim ,  Jin-Sung Park ,  Hee-Joong Im ,  Man-Been Moon ,  Hyun-Woon Oh

    IPC分类号： C21D8/02 ,  C22C38/38 ,  C22C38/32 ,  C22C38/02 ,  C22C38/22

    CPC分类号： C22C38/02 ,  C21D8/0205 ,  C21D8/0236 ,  C21D8/0273 ,  C21D9/46 ,  C21D2211/005 ,  C21D2211/008 ,  C22C38/04 ,  C22C38/06 ,  C22C38/12 ,  C22C38/22 ,  C22C38/26 ,  C22C38/32 ,  C22C38/38 ,  C23C2/02

    摘要： The present disclosure relates to a dual phase steel sheet and a method of manufacturing the same. The steel sheet comprises C: 0.05˜0.10% wt %, Si: 0.03˜0.50 wt %, Mn: 1.50˜2.00 wt %, P: greater than 0 wt %˜0.03 wt %, S: greater than 0 wt %˜0.003 wt %, Al: 0.03˜0.50 wt %, Cr: 0.1˜0.2 wt %, Mo: 0.1˜0.20 wt %, Nb: 0.02˜0.04 wt %, B: greater than 0 wt %˜0.005 wt %, N: greater than 0 wt %˜0.01 wt %, and the balance of Fe and other unavoidable impurities. To impart excellent formability, bake hardenability, dent resistance, high Ri value and plating characteristics to the steel sheet for exterior and interior panels of automobiles, the steel sheet is processed to have a dual phase structure through cold rolling, annealing, and hot-dip galvanizing.

    摘要翻译： 本发明涉及双相钢板及其制造方法。 该钢板包含C：0.05〜0.10％重量％，Si：0.03〜0.50重量％，Mn：1.50〜2.00重量％，P：大于0重量％〜0.03重量％，S：大于0重量％〜0.003 重量％，Al：0.03〜0.50重量％，Cr：0.1〜0.2重量％，Mo：0.1〜0.20重量％，Nb：0.02〜0.04重量％，B：大于0重量％〜0.005重量％ 0重量％〜0.01重量％，余量为Fe等不可避免的杂质。 为了赋予汽车外板和内板的钢板优异的成形性，烘烤硬化性，耐凹陷性，高Ri值和电镀特性，钢板通过冷轧，退火和热浸加工成具有双相结构 镀锌。