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    PEPTIDE INHIBITING MATRIX METALLOPROTEANASES ACTIVITY AND USE THEREOF
    1.
    发明申请
    PEPTIDE INHIBITING MATRIX METALLOPROTEANASES ACTIVITY AND USE THEREOF 有权
    肽抑制基质金属蛋白酶活性及其用途

    公开(公告)号：US20140328782A1

    公开(公告)日：2014-11-06

    申请号：US14343850

    申请日：2011-11-02

    申请人： Young Ji Chung ,  Eun Mi Kim

    发明人： Young Ji Chung ,  Eun Mi Kim

    IPC分类号： C07K7/06 ,  A61Q19/00 ,  A61K31/728 ,  A61Q19/02 ,  A61K38/08 ,  A61K8/64

    CPC分类号： C07K7/06 ,  A61K8/64 ,  A61K31/728 ,  A61K38/00 ,  A61K38/08 ,  A61K2800/782 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/06 ,  A61Q19/08

    摘要： The present invention relates to a peptide inhibiting a matrix metalloproteanases activity and use thereof. The peptide inhibiting a matrix metalloproteanases activity exhibits an excellent efficacy of improving the condition of skin by directly inhibiting the matrix metalloproteanases activity. In addition, a composition containing the peptide of the invention has excellent bioactivities of inhibiting the activity of hyaluronic acid degrading enzymes, adipogenesis in fat cells, angiogenesis, and the like, thereby being useful for the treatment of various disease such as anti-obesity, anti-cancer, anti-inflammation, and the like, and skin permeability is excellent due to the small size of the peptide, thereby being useful in various fields. The peptide of the invention having excellent activity and safety can be advantageously applied to drugs, quasi-drugs, and cosmetics.

    摘要翻译： 本发明涉及抑制基质金属蛋白酶活性的肽及其用途。 抑制基质金属蛋白酶活性的肽表现出通过直接抑制基质金属蛋白酶活性来改善皮肤状况的优异功效。 此外，含有本发明的肽的组合物具有优异的抑制透明质酸降解酶的活性，脂肪细胞中脂肪形成，血管发生等的生物活性，因此可用于治疗各种疾病如抗肥胖， 抗癌，抗炎等，并且由于肽的小尺寸，皮肤渗透性优异，因此可用于各种领域。 具有优异的活性和安全性的本发明的肽可以有利地应用于药物，准药物和化妆品。

    EDAR LIGAND DERIVED PEPTIDES AND USE THEREOF
    2.
    发明申请
    EDAR LIGAND DERIVED PEPTIDES AND USE THEREOF 有权
    EDAR配体衍生肽及其用途

    公开(公告)号：US20140255338A1

    公开(公告)日：2014-09-11

    申请号：US14236406

    申请日：2012-05-09

    申请人： Yong Ji Chung ,  Eun Mi Kim

    发明人： Yong Ji Chung ,  Eun Mi Kim

    IPC分类号： C07K14/525 ,  A61Q19/00 ,  A61Q19/08 ,  A61K8/64 ,  A61Q7/00

    CPC分类号： A61Q7/00 ,  A61K8/64 ,  A61K38/00 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08 ,  C07K14/525

    摘要： The present invention relates to novel peptides derived from an EDAR (EDAR receptor) ligand which belongs to TNF (tumor necrosis factor)-α family and to uses of the same. The present peptides of EDA3 derived from EDA and EDphD1 derived from EDAR ligand possess identical or similar activities to naturally occurring EDA and have much higher stability and skin penetration potency than naturally occurring EDA. Therefore, the composition containing the present peptide not only shows excellent effects on improvement in hair loss and promotion of hair growth, but also has superior efficacies on treatment of an EDA signal transduction pathway-related disorder. In addition, the outstanding activity and stability of the present peptide described above may be greatly advantageous in application to pharmaceutical compositions, quasi-drugs and cosmetics.

    摘要翻译： 本发明涉及衍生自属于TNF（肿瘤坏死因子）-α家族的EDAR（EDAR受体）配体的新型肽及其用途。 衍生自EDA的EDA3和源自EDAR配体的EDphD的本发明肽具有与天然存在的EDA相同或相似的活性，并且具有比天然存在的EDA更高的稳定性和皮肤穿透效力。 因此，含有本发明肽的组合物，不仅对改善脱发和促进毛发生长具有优异的效果，而且对于EDA信号转导通路相关病症的治疗也具有优异的效果。 此外，上述本发明肽的突出活性和稳定性在用于药物组合物，准药物和化妆品中可能是非常有利的。

    WNT10-derived peptide and use thereof
    3.
    发明授权
    WNT10-derived peptide and use thereof 有权
    WNT10衍生肽及其用途

    公开(公告)号：US08497241B2

    公开(公告)日：2013-07-30

    申请号：US13393370

    申请日：2009-11-24

    申请人： Young Ji Chung ,  Eun Mi Kim ,  Sang Su Song ,  Kyoung Mi Cho

    发明人： Young Ji Chung ,  Eun Mi Kim ,  Sang Su Song ,  Kyoung Mi Cho

    IPC分类号： A61K38/08 ,  A61P17/00 ,  A61P17/14 ,  A61P35/00 ,  A61P19/10 ,  A61P19/02 ,  A61P3/10 ,  A61Q19/08 ,  C07K7/06

    CPC分类号： A61K8/64 ,  A61K38/18 ,  A61Q7/00 ,  A61Q19/00 ,  C07K14/475

    摘要： The present invention relates to a WNT10-derived peptide, a composition for improving hair loss and skin conditions using the same, and a composition for treating a WNT10 signal transduction pathway-related disorder and DKK-1 protein-induced disorder the same. WNT10-derived peptide of the present invention possesses identical or similar activities to natural-occurring WNT10, and has much higher stability and skin penetration potency than natural-occurring WNT10. Therefore, the composition containing the present peptide not only shows excellent effects on improvement in hair loss (for example, promotion of hair growth or production of hair), but also has superior efficacies on treatment of a WNT10 signal transduction pathway-related disorder and a DKK-1 protein-induced disorder. In addition, the outstanding activity and stability of the present peptide described above may be greatly advantageous in application to pharmaceutical compositions, quasi-drugs and cosmetics.

    摘要翻译： 本发明涉及WNT10衍生肽，用于改善脱发的组合物和使用该组合物的皮肤状态，以及用于治疗WNT10信号转导途径相关病症和DKK-1蛋白诱导障碍的组合物。 本发明的WNT10衍生肽具有与天然存在的WNT10相同或相似的活性，并且具有比天然存在的WNT10高得多的稳定性和皮肤穿透效力。 因此，含有本发明肽的组合物对于改善脱发（例如，促进头发生长或毛发生产）显示出优异的效果，而且对治疗WNT10信号转导通路相关病症和 DKK-1蛋白诱导的病症。 此外，上述本发明肽的突出活性和稳定性在用于药物组合物，准药物和化妆品中可能是非常有利的。

    WNT10-Derived Peptide and Use Thereof
    6.
    发明申请
    WNT10-Derived Peptide and Use Thereof 有权
    WNT10衍生肽及其用途

    公开(公告)号：US20120245086A1

    公开(公告)日：2012-09-27

    申请号：US13393370

    申请日：2009-11-24

    申请人： Young Ji Chung ,  Eun Mi Kim ,  Sang Su Song ,  Kyoung Mi Cho

    发明人： Young Ji Chung ,  Eun Mi Kim ,  Sang Su Song ,  Kyoung Mi Cho

    IPC分类号： A61K38/08 ,  A61P17/00 ,  A61Q19/08 ,  A61P17/14 ,  A61P35/00 ,  A61P19/10 ,  A61P19/02 ,  A61P3/10 ,  C07K7/06 ,  A61P19/00

    CPC分类号： A61K8/64 ,  A61K38/18 ,  A61Q7/00 ,  A61Q19/00 ,  C07K14/475

    摘要： The present invention relates to a WNT10-derived peptide, a composition for improving hair loss and skin conditions using the same, and a composition for treating a WNT10 signal transduction pathway-related disorder and DKK-1 protein-induced disorder using the same. WNT10-derived peptide of the present invention possesses identical or similar activities to natural-occurring WNT10, and has much higher stability and skin penetration potency than natural-occurring WNT10. Therefore, the composition containing the present peptide not only shows excellent effects on improvement in hair loss (for example, promotion of hair growth or production of hair), but also has superior efficacies on treatment of a WNT10 signal transduction pathway-related disorder and a DKK-1 protein-induced disorder. In addition, the outstanding activity and stability of the present peptide described above may be greatly advantageous in application to pharmaceutical compositions, quasi-drugs and cosmetics.

    摘要翻译： 本发明涉及WNT10衍生肽，用于改善脱发的组合物和使用该组合物的皮肤状态，以及使用该组合物治疗WNT10信号转导通路相关病症和DKK-1蛋白质诱导障碍的组合物。 本发明的WNT10衍生肽具有与天然存在的WNT10相同或相似的活性，并且具有比天然存在的WNT10高得多的稳定性和皮肤穿透效力。 因此，含有本发明肽的组合物对于改善脱发（例如，促进头发生长或毛发生产）显示出优异的效果，而且对治疗WNT10信号转导通路相关病症和 DKK-1蛋白诱导的病症。 此外，上述本发明肽的突出活性和稳定性在用于药物组合物，准药物和化妆品中可能是非常有利的。

    Noggin-Derived Peptide and Use Thereof
    7.
    发明申请
    Noggin-Derived Peptide and Use Thereof 有权
    Noggin衍生肽及其用途

    公开(公告)号：US20110312884A1

    公开(公告)日：2011-12-22

    申请号：US13145390

    申请日：2009-11-24

    申请人： Young Ji Chung ,  Young Deug Kim ,  Eun Mi Kim ,  Sang Su Song ,  Il Hong ,  Kyoung Mi Cho ,  Su Mi Kim ,  Sang Min Han

    发明人： Young Ji Chung ,  Young Deug Kim ,  Eun Mi Kim ,  Sang Su Song ,  Il Hong ,  Kyoung Mi Cho ,  Su Mi Kim ,  Sang Min Han

    IPC分类号： A61K38/10 ,  C07K7/08 ,  A61K38/08 ,  A61P29/00 ,  A61K8/64 ,  A61P19/08 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q7/00 ,  C07K7/06 ,  A61P17/00

    CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K5/1019 ,  C07K2319/00

    摘要： Disclosed are a noggin-derived peptide and a composition containing the same for promoting hair growth, improving skin conditions, providing anti-inflammatory function, or preventing or treating bone diseases. The disclosed noggin-derived peptide performs a function identical or similar to that of natural human noggin and is superior in stability and skin permeability as compared thereto. The composition containing the peptide of the present disclosure as an active ingredient exhibits remarkably superior effects in treating, preventing or improving growth factor-related symptoms, e.g. hair loss, skin conditions or cut, or treating, preventing or improving growth factor overexpression-related symptoms. Therefore, the superior activity and stability of the peptide of the present disclosure are greatly advantageous in application to medicine, quasi-drugs and cosmetics.

    摘要翻译： 公开了一种头蛋白衍生肽和含有其的组合物，其用于促进毛发生长，改善皮肤状况，提供抗炎功能，或预防或治疗骨骼疾病。 所公开的头蛋白衍生肽具有与天然人头蛋白相同或相似的功能，并且与其相比具有优异的稳定性和皮肤渗透性。 含有本公开的肽作为活性成分的组合物在治疗，预防或改善生长因子相关症状方面表现出显着的优异效果，例如， 脱发，皮肤状况或切割，或治疗，预防或改善生长因子过表达相关症状。 因此，本公开的肽的优异的活性和稳定性在应用于医药，准药物和化妆品方面是非常有利的。