公开(公告)号：US08802014B2

公开(公告)日：2014-08-12

申请号：US13252195

申请日：2011-10-03

申请人： Ming-Hsin Li ,  Jin-Jenn Lin ,  Ther-Jen Ting ,  I-Lea Dai

发明人： Ming-Hsin Li ,  Jin-Jenn Lin ,  Ther-Jen Ting ,  I-Lea Dai

IPC分类号： G21G4/08 ,  G21G1/00

CPC分类号： G21G4/08 ,  A61K51/02 ,  G21G1/0005 ,  G21G2001/0021 ,  Y10S422/903

摘要： The invention is related a novel structure for Ga-68 radionuclide generator. It allows two washing solutions to pass through two Ge-68 absorbents to wash out different chemical forms of Ga-68 nuclide. The invention comprises the first method that will withdraw hydrochloric acid solution from the washing bottle and pass it through inorganic resin absorbing column to produce the radioisotope solution of Ga-68 gallium chloride, and the second method that will allow the radioisotope solution of Ga-68 gallium citrate to pass the organic resin absorbing column and then the silica-gel cartridge, and be washed by the hydrochloric acid solution to obtain the radioisotope solution of Ga-68 gallium chloride.

摘要翻译： 本发明涉及Ga-68放射性核素发生器的新型结构。 它允许两种洗涤溶液通过两种Ge-68吸收剂以洗出不同化学形式的Ga-68核素。 本发明包括第一种从洗瓶中取出盐酸溶液并将其通过无机树脂吸收塔以产生Ga-68氯化镓的放射性同位素溶液的方法，第二种方法将允许Ga-68的放射性同位素溶液 柠檬酸镓通过有机树脂吸收柱，然后通过硅胶柱，用盐酸溶液洗涤，得到Ga-68氯化镓的放射性同位素溶液。

公开(公告)号：US08894860B2

公开(公告)日：2014-11-25

申请号：US12963263

申请日：2010-12-08

申请人： Ming-Hsin Li ,  Jin-Jenn Lin ,  Ther-Jen Ting ,  I-Lea Dai

发明人： Ming-Hsin Li ,  Jin-Jenn Lin ,  Ther-Jen Ting ,  I-Lea Dai

IPC分类号： B01D15/36 ,  B01D15/04 ,  B01D15/08 ,  G21F5/00 ,  G21G1/00

CPC分类号： B01D15/361 ,  G21G1/0005 ,  G21G2001/0021

摘要： A Gallium-68 (Ga-68) radioisotope generator includes a generating column and a citrate eluent. The generating column is at least partially filled with an ion-exchange resin with glucamine groups to absorb germanium-68 (Ge-68) and Ga-68 radioisotopes. The citrate eluent is added into the generating column to desorb the Ga-68 radioisotope and form an eluent containing the Ga-68 radioisotope in the form of Ga-68 citrate. A method for generating Ga-68 radioisotope is also disclosed.

摘要翻译： 镓68（Ga-68）放射性同位素发生器包括产生柱和柠檬酸盐洗脱液。 生成塔至少部分地填充有具有葡糖胺基团的离子交换树脂以吸收锗-68（Ge-68）和Ga-68放射性同位素。 将柠檬酸盐洗脱液加入产生塔中以解吸Ga-68放射性同位素，形成含有Ga-68柠檬酸盐形式的Ga-68放射性同位素的洗脱液。 还公开了一种生成Ga-68放射性同位素的方法。

公开(公告)号：US20120011965A1

公开(公告)日：2012-01-19

申请号：US12963263

申请日：2010-12-08

申请人： Ming-Hsin LI ,  Jin-Jenn Lin ,  Ther-Jen Ting ,  I-Lea Dai

发明人： Ming-Hsin LI ,  Jin-Jenn Lin ,  Ther-Jen Ting ,  I-Lea Dai

IPC分类号： C22B60/00 ,  B01D15/04

CPC分类号： B01D15/361 ,  G21G1/0005 ,  G21G2001/0021

摘要： A Gallium-68 (Ga-68) radioisotope generator includes a generating column and a citrate eluent. The generating column is at least partially filled with an ion-exchange resin with glucamine groups to absorb germanium-68 (Ge-68) and Ga-68 radioisotopes. The citrate eluent is added into the generating column to desorb the Ga-68 radioisotope and form an eluent containing the Ga-68 radioisotope in the form of Ga-68 citrate. A method for generating Ga-68 radioisotope is also disclosed.

摘要翻译： 镓68（Ga-68）放射性同位素发生器包括产生柱和柠檬酸盐洗脱液。 生成塔至少部分地填充有具有葡糖胺基团的离子交换树脂以吸收锗-68（Ge-68）和Ga-68放射性同位素。 将柠檬酸盐洗脱液加入产生塔中以解吸Ga-68放射性同位素，形成含有Ga-68柠檬酸盐形式的Ga-68放射性同位素的洗脱液。 还公开了一种生成Ga-68放射性同位素的方法。

公开(公告)号：US08367811B2

公开(公告)日：2013-02-05

申请号：US12263573

申请日：2008-11-03

申请人： Tsai-Yueh Luo ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

发明人： Tsai-Yueh Luo ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

IPC分类号： C07F13/00

CPC分类号： A61K51/065 ,  C08B37/003 ,  C08L5/08

摘要： A radioactive material containing chitosan for inhibiting cancer and a preparation method thereof are revealed. The adioactive material containing chitosan is formed by using SOCTA chelating agent to connect chitosan and radionuclides such as 188Re, and Tc-99m etc. The preparation method of the radioactive material containing chitosan includes the steps of: prepare SOCTA-Chitosan compound; and prepare M(radionuclide)-SOCTA-Chitosan compound. By biocompatibility and clotting in alkaline environment of human blood of chitosan, the radioactive material containing chitosan is injected into cancer and staying there for a long time so as to achieve effectively treatment.

摘要翻译： 揭示含有用于抑制癌症的壳聚糖的放射性物质及其制备方法。 通过使用SOCTA螯合剂将壳聚糖与188Re，Tc-99m等放射性核素连接起来形成含有壳聚糖的活性物质。含有脱乙酰壳多糖的放射性物质的制备方法包括以下步骤：制备SOCTA-壳聚糖化合物; 并制备M（放射性核素）-SOCTA-壳聚糖化合物。 通过壳聚糖人血液碱性环境的生物相容性和凝血作用，将含有脱乙酰壳多糖的放射性物质注入癌症并长时间停留，以有效治疗。

公开(公告)号：US20100111860A1

公开(公告)日：2010-05-06

申请号：US12263573

申请日：2008-11-03

申请人： Tsai-Yueh LUO ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

发明人： Tsai-Yueh LUO ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

IPC分类号： A61K51/06 ,  C08B37/08 ,  A61P35/00

CPC分类号： A61K51/065 ,  C08B37/003 ,  C08L5/08

摘要： A radioactive material containing chitosan for inhibiting cancer and a preparation method thereof are revealed. The adioactive material containing chitosan is formed by using SOCTA chelating agent to connect chitosan and radionuclides such as 188Re, and Tc-99m etc. The preparation method of the radioactive material containing chitosan includes the steps of: prepare SOCTA-Chitosan compound; and prepare M(radionuclide)-SOCTA-Chitosan compound. By biocompatibility and clotting in alkaline environment of human blood of chitosan, the radioactive material containing chitosan is injected into cancer and staying there for a long time so as to achieve effectively treatment.

摘要翻译： 揭示含有用于抑制癌症的壳聚糖的放射性物质及其制备方法。 通过使用SOCTA螯合剂将壳聚糖与188Re，Tc-99m等放射性核素连接起来形成含有壳聚糖的活性物质。含有脱乙酰壳多糖的放射性物质的制备方法包括以下步骤：制备SOCTA-壳聚糖化合物; 并制备M（放射性核素）-SOCTA-壳聚糖化合物。 通过壳聚糖人血液碱性环境的生物相容性和凝血作用，将含有脱乙酰壳多糖的放射性物质注入癌症并长时间停留，以有效治疗。