公开(公告)号：US07740835B2

公开(公告)日：2010-06-22

申请号：US10782899

申请日：2004-02-23

申请人： Minoru Fujimori ,  Shun'ichiro Taniguchi ,  Jun Amano ,  Kazuyuki Yazawa ,  Yasunobu Kano ,  Toshiyuki Nakamura ,  Takayuki Sasaki

发明人： Minoru Fujimori ,  Shun'ichiro Taniguchi ,  Jun Amano ,  Kazuyuki Yazawa ,  Yasunobu Kano ,  Toshiyuki Nakamura ,  Takayuki Sasaki

IPC分类号： A61K48/00 ,  C12P21/04 ,  C12N15/85

CPC分类号： C12R1/01 ,  A61K48/00 ,  C07K14/195

摘要： The present invention provides a bacterium belonging to the genus Bifidobacterium, by which DNA coding for a protein having an antitumor activity or DNA coding for a protein having the activity of converting a precursor of an antitumor substance into the antitumor substance is delivered to tumor tissues specifically under anaerobic conditions thereby expressing the protein encoded by the DNA, as well as a pharmaceutical composition comprising said anaerobic bacterium.

摘要翻译： 本发明提供了属于双歧杆菌属的细菌，通过该细菌将编码具有抗肿瘤活性的蛋白质或编码具有将抗肿瘤物质的前体转化为抗肿瘤物质的蛋白质的DNA进行特异性递送至肿瘤组织 在厌氧条件下，从而表达由DNA编码的蛋白质，以及包含所述厌氧细菌的药物组合物。

公开(公告)号：US20050025745A1

公开(公告)日：2005-02-03

申请号：US10782899

申请日：2004-02-23

申请人： Minoru Fujimori ,  Shun'ichiro Taniguchi ,  Jun Amano ,  Kazuyuki Yazawa ,  Yasunobu Kano ,  Toshiyuki Nakamura ,  Takayuki Sasaki

发明人： Minoru Fujimori ,  Shun'ichiro Taniguchi ,  Jun Amano ,  Kazuyuki Yazawa ,  Yasunobu Kano ,  Toshiyuki Nakamura ,  Takayuki Sasaki

IPC分类号： A61K48/00 ,  C07K14/195 ,  C12N15/85 ,  C12P21/04

CPC分类号： C12R1/01 ,  A61K48/00 ,  C07K14/195

摘要： The present invention provides a bacterium belonging to the genus Bifidobacterium, by which DNA coding for a protein having an antitumor activity or DNA coding for a protein having the activity of converting a precursor of an antitumor substance into the antitumor substance is delivered to tumor tissues specifically under anaerobic conditions thereby expressing the protein encoded by the DNA, as well as a pharmaceutical composition comprising said anaerobic bacterium.

摘要翻译： 本发明提供了属于双歧杆菌属的细菌，通过该细菌将编码具有抗肿瘤活性的蛋白质或编码具有将抗肿瘤物质的前体转化为抗肿瘤物质的蛋白质的DNA进行特异性递送至肿瘤组织 在厌氧条件下，从而表达由DNA编码的蛋白质，以及包含所述厌氧细菌的药物组合物。