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92 条记录 (耗时 0.034 秒)

    2-[(4-piperidyl)methyl]-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole derivatives, and their application in treating depressive state, anxiety state or hypertension
    1.
    发明授权
    2-[(4-piperidyl)methyl]-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole derivatives, and their application in treating depressive state, anxiety state or hypertension 失效
    2 - [（4-哌啶基）甲基] -1,2,3,4-四氢-9H-吡啶并[3,4-b]吲哚衍生物及其在治疗抑郁状态，焦虑状态或高血压中的应用

    公开(公告)号：US4977159A

    公开(公告)日：1990-12-11

    申请号：US228751

    申请日：1988-08-05

    申请人： Mireille Sevrin ,  Pascal George ,  Jacques Menin ,  Claude Morel ,  Dennis Bigg

    发明人： Mireille Sevrin ,  Pascal George ,  Jacques Menin ,  Claude Morel ,  Dennis Bigg

    IPC分类号： A61K31/445 ,  A61P9/00 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  A61P43/00 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： A compound which is a pyrido[3,4-b]derivative of formula (I) ##STR1## in which R is a hydrogen atom or an alkyl carbonyl, arylalkylcarbonyl or arylcarbonyl group of formula COR.sub.1 wherein R.sub.1 is a C.sub.1 -C.sub.6 alkyl group, a benzyl group or a phenyl group unsubstituted or substituted with 1 to 3 substituents chosen from halogen atoms and trifluoromethyl, C.sub.1 -C.sub.3 alkyl and C.sub.1 -C.sub.3 alkoxy groups or R is an alkoxycarbonyl or benzyloxycarbonyl group of formula COOR.sub.2 wherein R.sub.2 is a C.sub.1 -C.sub.6 alkyl group or a benzyl group, or R is a substituted aminocarbonyl group of formula CONHR.sub.3 wherein R.sub.3 is a C.sub.1 -C.sub.6 alkyl group or a phenyl group, or R is an arylsulphonyl group of formula SO.sub.2 R.sub.4 wherein R.sub.4 is a phenyl group, or a pharmacologically acceptable acid addition salt thereof useful for treating hypertension, depressive state or anxiety state.

    摘要翻译： 化合物，其是式（I）的吡啶并[3,4-b]衍生物，其中R是氢原子或式COR1的烷基羰基，芳基烷基羰基或芳基羰基，其中R1是C1- C6烷基，苄基或未取代的或被1至3个选自卤素原子和三氟甲基，C1-C3烷基和C1-C3烷氧基的取代基取代的苯基，或者R是式COOR2的烷氧基羰基或苄氧基羰基，其中R2是 C 1 -C 6烷基或苄基，或R是式CONHR 3的取代的氨基羰基，其中R 3是C 1 -C 6烷基或苯基，或R是式SO 2 R 4的芳基磺酰基，其中R 4是苯基 ，或其可用于治疗高血压，抑郁状态或焦虑状态的药理学上可接受的酸加成盐。

    Alpha.sub.2 -antagonistic 2-(4,5-dihydro-1H-imidazol-2-yl)-pyrrolo[3,2,1-hi]indoles
    4.
    发明授权
    Alpha.sub.2 -antagonistic 2-(4,5-dihydro-1H-imidazol-2-yl)-pyrrolo[3,2,1-hi]indoles 失效
    α2-拮抗性2-（4,5-二氢-1H-咪唑-2-基） - 吡咯并[3,2,1-hi]吲哚

    公开(公告)号：US4617313A

    公开(公告)日：1986-10-14

    申请号：US770079

    申请日：1985-08-28

    申请人： Dennis Bigg ,  Claude Morel ,  Mireille Sevrin

    发明人： Dennis Bigg ,  Claude Morel ,  Mireille Sevrin

    IPC分类号： C07D209/08 ,  C07D487/06 ,  A61K31/415

    CPC分类号： C07D487/06 ,  C07D209/08

    摘要： Pyrrolo[3,2,1-hi]indole derivatives, in the form of racemates or optically active isomers, of formula (I) ##STR1## in which R is a hydrogen atom or C.sub.1 -C.sub.4 alkyl and R.sub.1 and R.sub.2, which may be the same or different, are hydrogen, halogen or C.sub.1 -C.sub.4 alkyl and their pharmaceutically acceptable acid addition salts are useful as .alpha..sub.2 -antagonists.

    摘要翻译： 吡咯并[3,2,1-hi]吲哚衍生物，其为式（I）的外消旋物或光学活性异构体，其中R是氢原子或C 1 -C 4烷基，R 1和R 2 可以相同或不同的是氢，卤素或C 1 -C 4烷基及其药学上可接受的酸加成盐可用作α2拮抗剂。

    2,3-dihydro-1H-isoindole derivatives and their application in therapy
    5.
    发明授权
    2,3-dihydro-1H-isoindole derivatives and their application in therapy 失效
    2,3-二氢-1H-茚-2-酮衍生物及其在治疗中的应用

    公开(公告)号：US5081128A

    公开(公告)日：1992-01-14

    申请号：US377929

    申请日：1989-07-11

    申请人： Pascal George ,  Mireille Sevrin ,  Michel Mangane ,  Jean-Pierre Merly ,  Dennis Bigg

    发明人： Pascal George ,  Mireille Sevrin ,  Michel Mangane ,  Jean-Pierre Merly ,  Dennis Bigg

    IPC分类号： A61K31/4427 ,  A61K31/445 ,  A61K31/55 ,  A61P43/00 ,  C07D401/06

    CPC分类号： C07D401/06

    摘要： A benzazepine derivative which is a compound of formula (I): ##STR1## in which each of m and n denotes the number 1, oreach of m and n denotes the number 2, orm denotes the number 3 and n denotes the number 1; and R denotes hydrogen or a group of formula --Z--R' in which Z denotes a --CO-- or --CH.sub.2 -- group and R' denotes a phenyl group which is unsubtituted or substituted with from one to three substituents selected from halogen atoms, linear or branch (C.sub.1 -C.sub.3) alkyl groups and linear or branched (C.sub.1 -C.sub.3) alkoxy groups, or a pharmacologically acceptable acid addition salt.

    摘要翻译： 作为式（I）的化合物的苯并吖庚因衍生物：其中m和n各自表示数1，或m和n各自表示数2，或m表示数3，n表示数 1; 并且R表示氢或式-ZR'的基团，其中Z表示-CO-或-CH2-基，R'表示未取代或被一至三个选自以下的取代基取代的苯基：卤原子，直链或 支链（C1-C3）烷基和直链或支链（C1-C3）烷氧基，或药理学上可接受的酸加成盐。

    .alpha..sub.2 antagonistic 2-(4,5-dihydro-2-1H-imidazolyl)-2,3-dihydro-1H-indoles
    7.
    发明授权
    .alpha..sub.2 antagonistic 2-(4,5-dihydro-2-1H-imidazolyl)-2,3-dihydro-1H-indoles 失效
    α2拮抗性2-（4,5-二氢-2-1H-咪唑基）-2,3-二氢-1H-吲哚

    公开(公告)号：US4598086A

    公开(公告)日：1986-07-01

    申请号：US639323

    申请日：1984-08-10

    申请人： Dennis Bigg ,  Jacques Menin

    发明人： Dennis Bigg ,  Jacques Menin

    IPC分类号： A61K31/36 ,  A61K31/40 ,  A61K31/415 ,  C07D403/04 ,  C07D405/06 ,  C07D405/14

    CPC分类号： C07D403/04 ,  C07D405/14

    摘要： Indole derivatives, in the form of racemates or optically active isomers, of the formula (I) ##STR1## in which R.sub.1 is a hydrogen atom, a linear or branched (C.sub.1-6) alkyl group, a (C.sub.3-6) cycloalkyl-(C.sub.1-4) alkyl group, a (C.sub.2-6) alkenyl group, the naphthylmethyl group, the phenethyl group or a benzyl group optionally substituted by one or more halogen atom or methyl, methoxyl or methylenedioxy group and R.sub.2 is H or a (C.sub.1-4) alkyl or allyl group, and their pharmaceutically acceptable salts; are .alpha..sub.2 -antagonists and useful for the treatment of depression, hypotension, post-operative paralytic ileum, asthma and obesity.

    摘要翻译： 式（I）的化合物（I）的吲哚衍生物，其中R 1是氢原子，直链或支链（C 1-6）烷基，（C 3-6） ）环烷基 - （C 1-4）烷基，（C 2-6）烯基，萘基甲基，苯乙基或任选被一个或多个卤素原子取代的苄基或甲基，甲氧基或亚甲二氧基，R 2为H 或（C 1-4）烷基或烯丙基，及其药学上可接受的盐; 是α2拮抗剂，可用于治疗抑郁症，低血压，术后麻痹性回肠，哮喘和肥胖。