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公开(公告)号：US20120135984A1
公开(公告)日：2012-05-31
申请号：US13318457
申请日：2010-05-01
申请人： Mitchell A. deLong , Jill Marie Sturdivant , Susan M. Royalty , Geoffrey Richard Heintzelman , Jeffrey D. Yingling , Casey Kopczynski
发明人： Mitchell A. deLong , Jill Marie Sturdivant , Susan M. Royalty , Geoffrey Richard Heintzelman , Jeffrey D. Yingling , Casey Kopczynski
IPC分类号： A61K31/4725 , C07D217/02 , A61K31/472 , C07D409/12 , C07D417/12 , C07D409/14 , C07C237/42 , A61K31/167 , A61K31/235 , C07C69/74 , A61K31/215 , C07D333/38 , A61K31/381 , A61K31/496 , A61K31/551 , C07D237/28 , A61K31/502 , C07D231/56 , A61K31/416 , C07D317/60 , A61P27/02 , A61P27/06 , A61P9/00 , A61P11/00 , A61P13/12 , A61P29/00 , A61K31/36 , C12N9/99 , C07D401/12
CPC分类号： C07D417/12 , C07C237/20 , C07C237/42 , C07C2601/08 , C07C2601/14 , C07D217/00 , C07D217/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D333/38 , C07D333/40 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Provided are compounds, compositions, and methods for treating diseases and conditions wherein an inhibitor of a kinase, such as rho kinase (ROCK), and an inhibitor of one or more of the monoamine transporters, such as NET or SERT, act in concert to improve the condition.
摘要翻译： 提供用于治疗疾病和病症的化合物，组合物和方法，其中激酶抑制剂如rho激酶（ROCK）和一种或多种单胺转运蛋白（例如NET或SERT）的抑制剂一致地作用于 改善条件。
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2.发明申请6-And 7-amino isoquinoline compounds and methods for making and using the same 有权6-氨基异喹啉化合物及其制备和使用方法公开(公告)号：US20090186917A1
公开(公告)日：2009-07-23
申请号：US12009326
申请日：2008-01-17
IPC分类号： A61K31/472 , C07D217/22 , A61P27/02 , C12N5/00
CPC分类号： C07D217/02 , C07D409/12
摘要： 6- and 7-amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6- and 7-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
摘要翻译： 提供6-和7-氨基异喹啉化合物，其影响，抑制或减少激酶的作用。 还提供包含治疗有效量的6-氨基异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状况或病症如癌症，肥胖症和青光眼的各种方法。
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公开(公告)号：US08455647B2
公开(公告)日：2013-06-04
申请号：US13230105
申请日：2011-09-12
IPC分类号： C07D217/00 , C07D401/00 , C07D215/00
CPC分类号： C07D217/02
摘要： 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
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公开(公告)号：US20110183965A1
公开(公告)日：2011-07-28
申请号：US13017708
申请日：2011-01-31
IPC分类号： A61K31/551 , C07D217/02 , A61K31/472 , C07D413/12 , A61K31/5377 , C07D401/12 , A61K31/4725 , A61K31/496 , A61P9/00 , A61P3/04 , A61P35/00 , A61P19/00 , A61P13/12 , A61P27/02 , A61P17/00
CPC分类号： C07D217/02 , C07D215/38 , C07D217/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
摘要翻译： 提供了影响，抑制或减少激酶作用的6-氨基异喹啉化合物。 还提供包含治疗有效量的6-氨基异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状况或病症如癌症，肥胖症和青光眼的各种方法。
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5.发明授权6-and 7-amino isoquinoline compounds and methods for making and using the same 有权6-氨基异喹啉化合物及其制备和使用方法公开(公告)号：US08871757B2
公开(公告)日：2014-10-28
申请号：US12704822
申请日：2010-02-12
IPC分类号： A61K31/472 , A61K31/4725 , C07D217/02 , C07D409/12
CPC分类号： C07D217/02 , C07D409/12
摘要： 6- and 7-amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6- and 7-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
摘要翻译： 提供6-和7-氨基异喹啉化合物，其影响，抑制或减少激酶的作用。 还提供了包含治疗有效量的6-氨基异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状况或病症如癌症，肥胖症和青光眼的各种方法。
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公开(公告)号：US08357699B2
公开(公告)日：2013-01-22
申请号：US13017708
申请日：2011-01-31
IPC分类号： C07D217/02 , A61K31/4709
CPC分类号： C07D217/02 , C07D215/38 , C07D217/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
摘要翻译： 提供了影响，抑制或减少激酶作用的6-氨基异喹啉化合物。 还提供包含治疗有效量的6-氨基异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状况或病症如癌症，肥胖症和青光眼的各种方法。
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公开(公告)号：US20080167340A1
公开(公告)日：2008-07-10
申请号：US11621887
申请日：2007-01-10
IPC分类号： C07D217/00 , A61K31/472 , C12N5/00
CPC分类号： C07D217/02 , C07D215/38 , C07D217/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
摘要翻译： 提供了影响，抑制或减少激酶作用的6-氨基异喹啉化合物。 还提供包含治疗有效量的6-氨基异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状况或病症如癌症，肥胖症和青光眼的各种方法。
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公开(公告)号：US08455513B2
公开(公告)日：2013-06-04
申请号：US11621887
申请日：2007-01-10
IPC分类号： C07D217/02 , A61K31/4709
CPC分类号： C07D217/02 , C07D215/38 , C07D217/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
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公开(公告)号：US08153654B2
公开(公告)日：2012-04-10
申请号：US12009326
申请日：2008-01-17
IPC分类号： A61K31/47 , C07D401/04
摘要： 6- and 7-amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6- and 7-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
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公开(公告)号：US20110319390A1
公开(公告)日：2011-12-29
申请号：US13230105
申请日：2011-09-12
IPC分类号： A61K31/472 , C07D413/12 , C07D401/12 , A61K31/5377 , A61K31/4725 , A61K31/551 , A61P27/02 , A61P19/08 , A61P3/04 , A61P9/00 , A61P1/16 , A61P13/12 , A61P1/18 , A61P35/00 , A61P9/10 , A61P1/00 , A61P9/12 , A61P15/08 , A61P11/02 , A61P13/10 , A61P17/00 , C07D217/04
CPC分类号： C07D217/02
摘要： 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
摘要翻译： 提供了影响，抑制或减少激酶作用的6-氨基异喹啉化合物。 还提供包含治疗有效量的6-氨基异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状况或病症如癌症，肥胖症和青光眼的各种方法。
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