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公开(公告)号：US20180064622A1
公开(公告)日：2018-03-08
申请号：US15485298
申请日：2017-04-12
申请人： Mitchell A. deLong , Elise A. Olsen
发明人： Mitchell A. deLong , Elise A. Olsen
IPC分类号： A61K8/64 , A61Q7/02 , A61K8/49 , A61K8/69 , A61K31/198 , A61K31/215 , A61K31/4439 , A61K31/585 , A61K31/7004
CPC分类号： A61K8/64 , A61K8/37 , A61K8/49 , A61K8/69 , A61K31/198 , A61K31/215 , A61K31/4439 , A61K31/585 , A61K31/7004 , A61K45/06 , A61K2300/00 , A61K2800/42 , A61Q5/02 , A61Q5/08 , A61Q7/00 , A61Q7/02 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/10
摘要： A method for inhibiting hair growth in mammals using compositions containing FP receptor antagonists (e.g., prostaglandin F analogs that are block activation of the FP receptor). The compositions can be applied topically to the skin and/or hair. The compositions can arrest hirsutism or hypertrichosis, reverse hirsutism and hypertrichosis, and further prevent hair growth. These compositions can also be used to protect hair from chemical or radiation-induced alopecia or hair loss. These compositions can also be used to inhibit pigmentation of the hair or skin.
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2.发明授权6-and 7-amino isoquinoline compounds and methods for making and using the same 有权6-氨基异喹啉化合物及其制备和使用方法公开(公告)号：US08871757B2
公开(公告)日：2014-10-28
申请号：US12704822
申请日：2010-02-12
IPC分类号： A61K31/472 , A61K31/4725 , C07D217/02 , C07D409/12
CPC分类号： C07D217/02 , C07D409/12
摘要： 6- and 7-amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6- and 7-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
摘要翻译： 提供6-和7-氨基异喹啉化合物，其影响，抑制或减少激酶的作用。 还提供了包含治疗有效量的6-氨基异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状况或病症如癌症，肥胖症和青光眼的各种方法。
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公开(公告)号：US08394826B2
公开(公告)日：2013-03-12
申请号：US12694965
申请日：2010-01-27
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： C07D417/12 , C07C237/20 , C07C237/42 , C07C2601/08 , C07C2601/14 , C07D217/00 , C07D217/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D333/38 , C07D333/40 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.
摘要翻译： 提供作为rH激酶和单胺转运蛋白（MAT）抑制剂的化合物，其用于改善疾病状态或状况。 还提供了包含该化合物的组合物。 还提供了用于治疗疾病或病症的方法，所述方法包括施用本发明的化合物。 一种这样的疾病可以是青光眼，除其他有益效果之外，可以实现眼压显着降低（IOP）。
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公开(公告)号：US08357699B2
公开(公告)日：2013-01-22
申请号：US13017708
申请日：2011-01-31
IPC分类号： C07D217/02 , A61K31/4709
CPC分类号： C07D217/02 , C07D215/38 , C07D217/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
摘要翻译： 提供了影响，抑制或减少激酶作用的6-氨基异喹啉化合物。 还提供包含治疗有效量的6-氨基异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状况或病症如癌症，肥胖症和青光眼的各种方法。
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公开(公告)号：US20080167340A1
公开(公告)日：2008-07-10
申请号：US11621887
申请日：2007-01-10
IPC分类号： C07D217/00 , A61K31/472 , C12N5/00
CPC分类号： C07D217/02 , C07D215/38 , C07D217/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
摘要翻译： 提供了影响，抑制或减少激酶作用的6-氨基异喹啉化合物。 还提供包含治疗有效量的6-氨基异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状况或病症如癌症，肥胖症和青光眼的各种方法。
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公开(公告)号：US10159634B2
公开(公告)日：2018-12-25
申请号：US15485298
申请日：2017-04-12
申请人： Mitchell A. deLong , Elise A. Olsen
发明人： Mitchell A. deLong , Elise A. Olsen
IPC分类号： A61K8/64 , A61Q7/02 , A61K8/49 , A61K8/69 , A61K31/198 , A61K31/215 , A61K31/4439 , A61K31/585 , A61K31/7004 , A61K45/06 , A61Q5/08 , A61Q7/00 , A61Q19/02 , A61K8/37 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： A method for inhibiting hair growth in mammals using compositions containing FP receptor antagonists (e.g., prostaglandin F analogs that are block activation of the FP receptor). The compositions can be applied topically to the skin and/or hair. The compositions can arrest hirsutism or hypertrichosis, reverse hirsutism and hypertrichosis, and further prevent hair growth. These compositions can also be used to protect hair from chemical or radiation-induced alopecia or hair loss. These compositions can also be used to inhibit pigmentation of the hair or skin.
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7.发明授权Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds 有权β-和γ-氨基 - 异喹啉酰胺化合物和取代的苯甲酰胺化合物公开(公告)号：US08759388B2
公开(公告)日：2014-06-24
申请号：US13442263
申请日：2012-04-09
IPC分类号： A61K31/381 , A61K31/16 , C07D333/22 , C07C237/48
CPC分类号： C07D333/24 , A61K31/16 , A61K31/381 , A61K31/47 , A61K31/4709 , C07C237/04 , C07C237/48 , C07D213/56 , C07D217/02 , C07D217/24 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the invention are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, and diseases characterized by abnormal growth, such as cancers. The invention further provides compositions containing the beta or gamma-amino isoquinoline amide compounds or substituted benzamide compounds.
摘要翻译： 公开了β和γ-氨基异喹啉酰胺化合物和取代的苯甲酰胺化合物。 特别地，本发明提供了影响细胞中激酶功能并且可用作治疗剂或与治疗剂有关的化合物。 本发明的化合物可用于治疗各种疾病和病症，包括诸如青光眼，心血管疾病和异常生长特征的疾病如眼癌等眼疾。 本发明还提供含有β或γ-氨基异喹啉酰胺化合物或取代的苯甲酰胺化合物的组合物。
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公开(公告)号：US08722739B2
公开(公告)日：2014-05-13
申请号：US12260522
申请日：2008-10-29
IPC分类号： A61K31/195 , A61K31/5575 , C07C57/26 , C07C229/26
CPC分类号： A61K31/5575 , C07C57/26 , C07C229/26 , C07C279/14 , C07C405/00 , C07C2601/08
摘要： The present invention is directed to novel amino acid prostaglandin salts and methods of making and using them.
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公开(公告)号：US08623918B2
公开(公告)日：2014-01-07
申请号：US12260534
申请日：2008-10-29
IPC分类号： A61K31/5575 , C07C57/26 , C07C229/26
CPC分类号： C07C279/14 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/5575 , C07C57/26 , C07C229/26 , C07C405/0016 , C07C405/0041 , C07C2601/08
摘要： The present invention is directed to novel amino acid prostaglandin salts and methods of making and using them.
摘要翻译： 本发明涉及新型氨基酸前列腺素盐及其制备和使用方法。
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公开(公告)号：US20100280011A1
公开(公告)日：2010-11-04
申请号：US12694965
申请日：2010-01-27
IPC分类号： A61K31/472 , C07D217/02 , C07D409/12 , C07D401/12 , C07D417/12 , A61K31/4725 , C07D217/24 , A61K31/496 , C07D403/12 , A61K31/551 , C12N5/02
CPC分类号： C07D417/12 , C07C237/20 , C07C237/42 , C07C2601/08 , C07C2601/14 , C07D217/00 , C07D217/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D333/38 , C07D333/40 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.
摘要翻译： 提供作为rH激酶和单胺转运蛋白（MAT）抑制剂的化合物，其用于改善疾病状态或状况。 还提供了包含该化合物的组合物。 还提供了用于治疗疾病或病症的方法，所述方法包括施用本发明的化合物。 一种这样的疾病可以是青光眼，除其他有益效果之外，可以实现眼压显着降低（IOP）。
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