-
公开(公告)号：US20090069371A1
公开(公告)日：2009-03-12
申请号：US12274887
申请日：2008-11-20
申请人： Mitchell A. deLong , Marcos L. Sznaidman , Robert H. Oakley , Allen E. Eckhardt , Christine Hudson , Jeffrey D. Yingling , Michael Peel , Thomas E. Richardson , Clare Louise Murray , Byappanahally N. Narasinga Rao , Brian H. Heasley , Paresma R. Patel
发明人： Mitchell A. deLong , Marcos L. Sznaidman , Robert H. Oakley , Allen E. Eckhardt , Christine Hudson , Jeffrey D. Yingling , Michael Peel , Thomas E. Richardson , Clare Louise Murray , Byappanahally N. Narasinga Rao , Brian H. Heasley , Paresma R. Patel
IPC分类号： A61K31/47 , C07D217/22 , A61P27/02 , A61P9/00 , A61P1/00 , A61P15/08 , A61P35/00 , A61P19/08 , C12N5/00
CPC分类号： C07D217/02
摘要： Isoquinoline compounds with G are provided that influence, inhibit or reduce the action of a G-protein receptor kinase. Pharmaceutical compositions including therapeutically effective amounts of the isoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, osteoporosis and glaucoma are also provided.
摘要翻译： 提供了具有G的异喹啉化合物，其影响，抑制或降低G蛋白受体激酶的作用。 还提供包含治疗有效量的异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状态或病症如癌症，骨质疏松症和青光眼的各种方法。
-
2.发明申请PRODRUG DERIVATIVES OF ACIDS USING ALCOHOLS WITH HOMOTOPIC HYDROXY GROUPS AND METHODS FOR THEIR PREPARATION AND USE 审中-公开使用醇与单体羟基组合的酸的原料衍生物及其制备和使用方法公开(公告)号：US20100228015A1
公开(公告)日：2010-09-09
申请号：US12766226
申请日：2010-04-23
IPC分类号： C07H15/18 , C07F7/18 , C07C69/732 , C07D333/54 , C07D307/79 , C07C69/736 , C07C69/73 , C07D309/06 , C07D207/46 , C07D307/20 , C07D333/32 , C07D493/04 , C07D211/42 , C07D241/04 , C07D265/30 , C07D501/18 , C07D401/10 , C07D215/56 , C07D487/04 , C07D277/06 , C07D473/34 , C07D473/28
CPC分类号： C07C219/10 , C07C69/608 , C07C69/738 , C07C69/76 , C07C233/65 , C07C251/48 , C07C317/44 , C07C405/00 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2602/24 , C07D205/095 , C07D215/56 , C07D233/78 , C07D277/06 , C07D295/116 , C07D333/56 , C07D333/64 , C07D473/30 , C07D473/34 , C07D491/056 , C07D501/34
摘要： This invention relates to novel homotopic prodrugs and medicaments and methods for their preparation, testing and use. In one embodiment, the homotopic prodrug has the general formula wherein is a biologically-active moiety comprising a carboxylic acid functional group, and Rb is a homotopically-symmetrical alcohol bonded to the biologically-active moiety through the carboxylic acid functional group to form an ester linkage, as well as optical isomers, enantiomers, pharmaceutically acceptable salts, biohydrolyzable amides, esters, and imides thereof and combinations thereof.
摘要翻译： 本发明涉及新的同位素前药和药物及其制备，测试和使用的方法。 在一个实施方案中，同位物前药具有以下通式：其中是包含羧酸官能团的生物活性部分，Rb是通过羧酸官能团与生物活性部分键合形成酯的同位素对称醇 连接，以及光学异构体，对映异构体，药学上可接受的盐，生物可水解的酰胺，酯和酰亚胺以及它们的组合。
-
公开(公告)号：US20100093790A1
公开(公告)日：2010-04-15
申请号：US12639670
申请日：2009-12-16
申请人： Mitchell A. deLong , Marcos L. Sznaidman , Robert H. Oakley , Allen E. Eckhardt , Christine Hudson , Jeffrey D. Yingling , Michael Peel , Thomas E. Richardson , Clare Louise Murray , Byappanahally N. Narasinga Rao , Brian H. Heasley , Paresma R. Patel
发明人： Mitchell A. deLong , Marcos L. Sznaidman , Robert H. Oakley , Allen E. Eckhardt , Christine Hudson , Jeffrey D. Yingling , Michael Peel , Thomas E. Richardson , Clare Louise Murray , Byappanahally N. Narasinga Rao , Brian H. Heasley , Paresma R. Patel
IPC分类号： A61K31/472 , C07D217/02 , C07D401/12 , C12N5/00 , A61K31/4725 , A61P27/02 , A61P19/00 , A61P9/00 , A61P13/12
CPC分类号： C07D217/02
摘要： Isoquinoline compounds with G are provided that influence, inhibit or reduce the action of a G-protein receptor kinase. Pharmaceutical compositions including therapeutically effective amounts of the isoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, osteoporosis and glaucoma are also provided.
摘要翻译： 提供了具有G的异喹啉化合物，其影响，抑制或降低G蛋白受体激酶的作用。 还提供包含治疗有效量的异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状态或病症如癌症，骨质疏松症和青光眼的各种方法。
-
公开(公告)号：US07470787B2
公开(公告)日：2008-12-30
申请号：US11485172
申请日：2006-07-11
申请人： Mitchell A. deLong , Marcos L. Sznaidman , Robert H. Oakley , Allen E. Eckhardt , Christine Hudson , Jeffrey D. Yingling , Michael Peel , Thomas E. Richardson , Claire Louise Murray , Byappanahally N. Narasinga Rao , Brian H. Heasley , Paresma R. Patel
发明人： Mitchell A. deLong , Marcos L. Sznaidman , Robert H. Oakley , Allen E. Eckhardt , Christine Hudson , Jeffrey D. Yingling , Michael Peel , Thomas E. Richardson , Claire Louise Murray , Byappanahally N. Narasinga Rao , Brian H. Heasley , Paresma R. Patel
IPC分类号： C07D217/00 , C07D401/00 , C07D215/00
CPC分类号： C07D217/02
摘要： Isoquinoline compounds with G are provided that influence, inhibit or reduce the action of a G-protein receptor kinase. Pharmaceutical compositions including therapeutically effective amounts of the isoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, osteoporosis and glaucoma are also provided.
摘要翻译： 提供了具有G的异喹啉化合物，其影响，抑制或降低G蛋白受体激酶的作用。 还提供包含治疗有效量的异喹啉化合物和药学上可接受的载体的药物组合物。 还提供了使用化合物和/或组合物影响疾病状态或病症如癌症，骨质疏松症和青光眼的各种方法。
-
公开(公告)号：US20120135984A1
公开(公告)日：2012-05-31
申请号：US13318457
申请日：2010-05-01
申请人： Mitchell A. deLong , Jill Marie Sturdivant , Susan M. Royalty , Geoffrey Richard Heintzelman , Jeffrey D. Yingling , Casey Kopczynski
发明人： Mitchell A. deLong , Jill Marie Sturdivant , Susan M. Royalty , Geoffrey Richard Heintzelman , Jeffrey D. Yingling , Casey Kopczynski
IPC分类号： A61K31/4725 , C07D217/02 , A61K31/472 , C07D409/12 , C07D417/12 , C07D409/14 , C07C237/42 , A61K31/167 , A61K31/235 , C07C69/74 , A61K31/215 , C07D333/38 , A61K31/381 , A61K31/496 , A61K31/551 , C07D237/28 , A61K31/502 , C07D231/56 , A61K31/416 , C07D317/60 , A61P27/02 , A61P27/06 , A61P9/00 , A61P11/00 , A61P13/12 , A61P29/00 , A61K31/36 , C12N9/99 , C07D401/12
CPC分类号： C07D417/12 , C07C237/20 , C07C237/42 , C07C2601/08 , C07C2601/14 , C07D217/00 , C07D217/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D333/38 , C07D333/40 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Provided are compounds, compositions, and methods for treating diseases and conditions wherein an inhibitor of a kinase, such as rho kinase (ROCK), and an inhibitor of one or more of the monoamine transporters, such as NET or SERT, act in concert to improve the condition.
摘要翻译： 提供用于治疗疾病和病症的化合物，组合物和方法，其中激酶抑制剂如rho激酶（ROCK）和一种或多种单胺转运蛋白（例如NET或SERT）的抑制剂一致地作用于 改善条件。
-
-
-
-
搜索结果
5 条记录 (耗时 0.013 秒)
