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公开(公告)号：US20070105116A1
公开(公告)日：2007-05-10
申请号：US10570172
申请日：2004-03-02
摘要： An object of the present invention is to provide a novel structure that enables one-dimensional arraying of metal atoms and can stably exist. The present invention relates to a double-stranded oligonucleotide derivative, which contains two oligonucleotide derivatives each containing at least one nucleotide derivative wherein a base portion of a nucleotide is substituted with a metal coordination group that is resistant to oxidation and metal atoms, wherein the double strands are formed by coordination of each metal coordination group contained in each oligonucleotide derivative to a metal atom so as to form a complex.
摘要翻译： 本发明的目的是提供能够稳定地存在金属原子的一维排列的新结构。 本发明涉及双链寡核苷酸衍生物，其含有两个寡核苷酸衍生物，每个寡核苷酸衍生物含有至少一个核苷酸衍生物，其中核苷酸的碱基部分被抗氧化的金属配位基和金属原子取代，其中双 通过将各寡核苷酸衍生物中含有的各金属配位基配位成金属原子而形成链，形成络合物。
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公开(公告)号：US20060293510A1
公开(公告)日：2006-12-28
申请号：US10570758
申请日：2003-09-08
IPC分类号： C07H21/02 , C07H19/048 , C12P19/34 , C07H21/04
CPC分类号： C07H19/04 , C07H19/048 , C07H23/00 , C12N15/10
摘要： The present invention relates to a double-stranded oligonucleotide derivative, which contains two oligonucleotide derivatives each containing at least one nucleotide derivative wherein a base portion of a nucleotide is substituted with a metal coordination group that is resistant to oxidation and metal atoms, wherein the double strands are formed by coordination of each metal coordination group contained in each oligonucleotide to a metal atom so as to form a complex.
摘要翻译： 本发明涉及双链寡核苷酸衍生物，其含有两个寡核苷酸衍生物，每个寡核苷酸衍生物含有至少一个核苷酸衍生物，其中核苷酸的碱基部分被抗氧化的金属配位基和金属原子取代，其中双 通过将各寡核苷酸中包含的各金属配位基与金属原子配位而形成链，形成络合物。
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3.发明授权3, 4-di(acylamino)phenyl ribofuranosides, 2'-deoxyribofuranosides, and methods of making 有权3,4-二（酰基氨基）苯基呋喃核糖，2'-脱氧呋喃核糖苷，以及制备方法公开(公告)号：US06350863B1
公开(公告)日：2002-02-26
申请号：US09448596
申请日：1999-11-24
申请人： Mitsuhiko Shionoya , Kentaro Tanaka
发明人： Mitsuhiko Shionoya , Kentaro Tanaka
IPC分类号： C07H1500
摘要： Provided is an artificial nucleic acid which has a double-stranded structure made of two oligonucleotides, where the oligonucleotide has in a sugar-phosphate backbone structure thereof a sugar moiety having a group having a metal-coordinating site, and the two oligonucleotides are bound together through a metal complex structure formed by coordination of the metal-coordinating site to a metal ion. Also provided is a nucleotide useful for synthesizing the artificial nucleic acid.
摘要翻译： 本发明提供了具有由两个寡核苷酸构成的双链结构的人工核酸，其中寡核苷酸在糖 - 磷酸骨架结构中具有具有金属配位部位的糖部分，并且两个寡核苷酸结合在一起 通过金属配位体与金属离子的配位形成的金属络合物结构。 还提供了可用于合成人造核酸的核苷酸。
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公开(公告)号：US6011143A
公开(公告)日：2000-01-04
申请号：US37609
申请日：1998-03-10
申请人： Mitsuhiko Shionoya , Kentaro Tanaka
发明人： Mitsuhiko Shionoya , Kentaro Tanaka
摘要： Provided is an artificial nucleic acid which has a double-stranded structure made of two oligonucleotides, where the oligonucleotide has in a sugar-phosphate backbone structure thereof a sugar moiety having a group having a metal-coordinating site, and the two oligonucleotides are bound together through a metal complex structure formed by coordination of the metal-coordinating site to a metal ion. Also provided is a nucleotide useful for synthesizing the artificial nucleic acid.
摘要翻译： 本发明提供了具有由两个寡核苷酸构成的双链结构的人工核酸，其中寡核苷酸在糖 - 磷酸骨架结构中具有具有金属配位部位的糖部分，并且两个寡核苷酸结合在一起 通过金属配位体与金属离子的配位形成的金属络合物结构。 还提供了可用于合成人造核酸的核苷酸。
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公开(公告)号：US07547784B2
公开(公告)日：2009-06-16
申请号：US11906256
申请日：2007-10-01
IPC分类号： C07D471/22
CPC分类号： C07F9/6596 , C07F3/003 , C07F9/12
摘要： A method for capturing a substance having an anionic substituent by contacting a substance having an anionic substituent with a zinc complex such that the substance binds to the zinc complex, the zinc complex being represented by a formula (I): wherein each R is the same or different from each other and each R represents H; an alkyl group having 1 to 16 carbon atoms; an acyl group, a carboxyalkyl group, an acylalkyl group, a carbamoylalkyl group, a cyanoalkyl group, a hydroxyalkyl group, an aminoalkyl group or a haloalkyl group, wherein an alkyl portion of the acyl group, the carboxyalkyl group, the acylalkyl group, the carbamoylalkyl group, the cyanoalkyl group, the hydroxyalkyl group, the aminoalkyl group and the haloalkyl group has 1 to 16 carbon atoms; a carboxyl group; a carbamoyl group; a hydroxyl group; a cyano group; an amino group; or a halogeno group.
摘要翻译： 通过使具有阴离子取代基的物质与锌络合物接触使得该物质与锌络合物结合的方法，所述锌络合物由式（I）表示：其中每个R相同 或彼此不同，每个R代表H; 具有1至16个碳原子的烷基; 酰基，羧基烷基，酰基烷基，氨基甲酰基烷基，氰基烷基，羟基烷基，氨基烷基或卤代烷基，其中酰基，羧基烷基，酰基烷基， 氨基甲酰基烷基，氰基烷基，羟基烷基，氨基烷基和卤代烷基具有1至16个碳原子; 羧基; 氨基甲酰基; 羟基; 氰基; 氨基; 或卤代基团。
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公开(公告)号：US20080108815A1
公开(公告)日：2008-05-08
申请号：US11906256
申请日：2007-10-01
IPC分类号： C07F3/06
CPC分类号： C07F9/6596 , C07F3/003 , C07F9/12
摘要： A method for capturing a substance having an anionic substituent by contacting a substance having an anionic substituent with a zinc complex such that the substance binds to the zinc complex, the zinc complex being represented by a formula (I): wherein each R is the same or different from each other and each R represents H; an alkyl group having 1 to 16 carbon atoms; an acyl group, a carboxyalkyl group, an acylalkyl group, a carbamoylalkyl group, a cyanoalkyl group, a hydroxyalkyl group, an aminoalkyl group or a haloalkyl group, wherein an alkyl portion of the acyl group, the carboxyalkyl group, the acylalkyl group, the carbamoylalkyl group, the cyanoalkyl group, the hydroxyalkyl group, the aminoalkyl group and the haloalkyl group has 1 to 16 carbon atoms; a carboxyl group; a carbamoyl group; a hydroxyl group; a cyano group; an amino group; or a halogeno group.
摘要翻译： 通过使具有阴离子取代基的物质与锌络合物接触使得该物质与锌络合物结合的方法，所述锌络合物由式（I）表示：其中每个R相同 或彼此不同，每个R代表H; 具有1至16个碳原子的烷基; 酰基，羧基烷基，酰基烷基，氨基甲酰基烷基，氰基烷基，羟基烷基，氨基烷基或卤代烷基，其中酰基，羧基烷基，酰基烷基， 氨基甲酰基烷基，氰基烷基，羟基烷基，氨基烷基和卤代烷基具有1至16个碳原子; 羧基; 氨基甲酰基; 羟基; 氰基; 氨基; 或卤代基团。
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7.发明申请公开(公告)号：US20050038258A1
公开(公告)日：2005-02-17
申请号：US10878131
申请日：2004-06-21
IPC分类号： C07F3/00 , C07F9/12 , C07F9/6596 , C07D211/68
CPC分类号： C07F9/6596 , C07F3/003 , C07F9/12
摘要： A zinc complex represented by formula (I-0): {wherein R may be the same or different from each other and represents H; an alkyl group having 1 to 16 carbon atoms; an acyl group, a carboxyalkyl group, an acylalkyl group, a carbamoylalkyl group, a cyanoalkyl group, a hydroxyalkyl group, an aminoalkyl group or a haloalkyl group (here, a carbon number at an alkyl portion of these groups is 1 to 16); a carboxyl group; a carbamoyl group; a hydroxyl group; a cyano group; an amino group or; a halogeno group (provided that all are Hs are excluded)} which is capable of capturing a substance having an anionic substituent.
摘要翻译： 由式（I-0）表示的锌络合物：其中R可以相同或不同，表示H; 具有1至16个碳原子的烷基; 酰基，羧基烷基，酰基烷基，氨基甲酰基烷基，氰基烷基，羟烷基，氨基烷基或卤代烷基（这里，这些基团的烷基部分的碳数为1〜16）。 羧基; 氨基甲酰基; 羟基; 氰基; 氨基或 能够捕获具有阴离子取代基的物质的卤代基团（除了全部为H以外）}。
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8.发明授权公开(公告)号：US07358363B2
公开(公告)日：2008-04-15
申请号：US10878131
申请日：2004-06-21
IPC分类号： C07D471/22
CPC分类号： C07F9/6596 , C07F3/003 , C07F9/12
摘要： A zinc complex represented by formula (I-0): {wherein R may be the same or different from each other and represents H; an alkyl group having 1 to 16 carbon atoms; an acyl group, a carboxyalkyl group, an acylalkyl group, a carbamoylalkyl group, a cyanoalkyl group, a hydroxyalkyl group, an aminoalkyl group or a haloalkyl group (here, a carbon number at an alkyl portion of these groups is 1 to 16); a carboxyl group; a carbamoyl group; a hydroxyl group; a cyano group; an amino group or; a halogeno group (provided that all are Hs are excluded)} which is capable of capturing a substance having an anionic substituent.
摘要翻译： 由式（I-0）表示的锌络合物：其中R可以相同或不同，表示H; 具有1至16个碳原子的烷基; 酰基，羧基烷基，酰基烷基，氨基甲酰基烷基，氰基烷基，羟烷基，氨基烷基或卤代烷基（这里，这些基团的烷基部分的碳数为1〜16）。 羧基; 氨基甲酰基; 羟基; 氰基; 氨基或 能够捕获具有阴离子取代基的物质的卤代基团（除了全部为H以外）}。
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